CD28 affects the earliest signaling events generated by TCR engagement

European Journal of Immunology

Volumn 28, Issue 7, 1998, Pages 2131-2142

  Tuosto, Loretta ^a   Acuto, Oreste ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

CD28; TCR; Tyrosine phosphorylation

Indexed keywords

CD28 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD80; DNA-BINDING PROTEINS; GENES, FOS; HUMANS; INTERLEUKIN-2; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; MAP KINASE KINASE 4; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE TISSUE PROTEINS; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROTEIN KINASES; RECEPTORS, ANTIGEN, T-CELL; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 0031874024     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199807)28:07<2131::AID-IMMU2131>3.0.CO;2-Q     Document Type: Article

References (71)

1. June, C. H., Bluestone, J. A., Nadler, L. M. and Thompson, C. B., The B7 and CD28 receptor families. Immunol. Today 1994. 15:321-331.
2. Lenschow, D. J., Walunas, T. L. and Bluestone, J. A., CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 1996. 14: 233-258.
3. Chambers, C. A. and Allison, J. P., Co-stimulation in T cell responses. Curr. Opin. Immunol. 1997. 9: 396-404.
4. Schwartz, R. H., Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992. 71: 1065-1068.
5. Schwartz, R. H., A cell culture model for T lymphocyte clonal anergy. Science 1990. 248: 1349-1356.
6. Harding, F. A., McArthur, J. G., Gross, J. A., Raulet, D. H. and Allison, J. P., CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992. 356: 607-609.
7. Boussiotis, V. A., Freeman, G. J., Gray, G., Gribben, J. and Nadler, L. M., B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J. Exp. Med. 1993. 178: 1753-1763.
8. Boussiotis, V. A., Barber, D. L., Nakarai, T., Freeman, G. J., Gribben, J. G., Bernestein, G. M., D'Andrea, A. D., Ritz, J. and Nadler, L. M., Prevention of T cell anergy by signaling through the γc chain of the IL-2 receptor. Science 1994. 266: 1039-1042.
9. Shahinian, A., Phehher, K., Lee, K. P., Kûndig, T. M., Kishihara, K., Wakeham, A., Kawai, K., Ohashi, P., Thompson, C. B. and Mak, T. W., Differential T cell costimulatory requirements in CD28-deficient mice. Science 1993. 261: 609-612.
10. Green, J. M., Noel, P. J., Sperling, A. I., Gray, G. S., Bluestone, J. A. and Thompson, C. B., Absence of B7-dependent responses in CD28-deficient mice. Immunity 1994. 1: 501-508.
11. Lucas, P. J., Negishi, I., Nakayama, K.-I., Fields, L. E. and Loh, D. Y., Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 1995. 154: 5757-5768.
12. Kündig, T. M., Shahinian, A., Kawai, K., Mittrucker, H.-W., Sebzda, E., Bachmann, M. F., Mak, T. W. and Ohashi, P. S., Duration of TCR stimulation determines co-stimulatory requirements of T cells. Immunity 1996. 5: 41-52.
13. Bachmann, M. F., Sebzda, E., Kündig, T. M., Shahinian, A., Speiser, D. E., Mak, T. W. and Ohashi, P. S., T cell responses are governed by avidity and co-stimulatory threshold. Eur. J. Immunol. 1996. 26: 2017-2022.
14. Viola, A. and Lanzavecchia, A., T cell activation determined by T cell receptor numbers and tunable thresholds. Science 1996. 273: 104-106.
15. Linsley, P. S., Clark, E. A. and Ledbetter, J. A., T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Prac. Natl. Acad. Sci. USA 1990. 87: 5031-5035.
16. Shimizu, Y., van Seventer, G. A., Ennis, E., Newman, W., Horgan, K. J. and Shaw, S., Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion. J. Exp. Med. 1992. 175: 577-582.
17. Rudd, C. E., Upstream-downstream: CD28 cosignal pathways and T cell function. Immunity 1996. 4: 527-534.
18. Hutchcroft, J. E. and Bierer, B. E., Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins. Proc. Natl. Acad. Sci. USA 1994. 91: 3260-3264.
19. August, A. and DuPont, B., Activation of the src kinase lck following CD28 crosslinking in the Jurkat leukemic cell line. Biochem. Biophys. Res. Commun. 1994. 199: 1466-1473.
20. Nunès, J. A., Truneh, A., Olive, D. and Cantrell, D. A., Signal transduction by CD28 costimulatory receptor on T cells. J. Biol. Chem. 1996. 271: 1591-1598.
21. Raab, M., Cai, Y.-C., Bunnell, S. C., Heyeck, S. D., Berg, L. J. and Rudd, C. E., p56lck and p59fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell cost-imulation. J. biol. Chem. 1995. 92: 8891-8895.
22. Pages, F., Ragueneau, M., Rottapel, R., Truneh, A., Nunès, J., Imbert, J. and Olive, D., Binding of phosphatidyl-3-OH kinase to CD28 is required for T cell signaling. Nature 1994. 369: 327-329.
23. Cai, Y.-C., Cefai, D., Schneider, H., Raab, M., Nabavi, N. and Rudd, C. E., Selective CD28p YMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation. Immunity 1995. 3: 417-426.
24. Cefai, D., Cai, Y.-C., Hu, H. and Rudd, C., CD28 Co-stimulatory regimes differ in their dependence on phosphatidylinositol 3-kinase: common co-signals induced by CD80 and CD86. Int. Immunol. 1996. 8: 1609-1616.
25. Ghiotto-Ragueneau, M., Battifora, M., Truneh, A., Waterfield, M. D. and Olive, D., Comparison of CD28-B7.1 and B7.2 functional interaction in resting human T cells: phosphatidylinositol 3-kinase association to CD28 and cytokine production. Eur. J. Immunol. 1996. 26: 34-41.
26. Lu, Y., Phillips, C. A. and Trevillyan, J. M., Phosphati-dylinositol 3-kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor wortmannin. Eur. J. Immunol. 1995. 25: 533-537.
27. Ward, S. G., Wilson, A., Turner, L, Westwick, J. and Sansom, D. M., Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin. Eur. J. Immunol. 1995. 25: 526-532.
28. Ni, H.-T., Deeths, M. J. and Mescher, M., Phosphatidylinositol 3-kinase activity is not essential for B7-1-mediated costimulation of proliferation or development of cytotoxicity in murine T cells. J. Immunol. 1996. 157: 2243-2246.
29. Truitt, K. E., Shi, J., Gibson, S., Segal, L. G., Mills, G. B. and Imboden, J. B., CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. J. Immunol. 1995. 155: 4702-4710.
30. ras. Eur. J. Immunol. 1995. 25: 1044-1050.
31. ras. J. Exp. Med. 1994. 180: 1067-1076.
32. Nunès, J. A., Battifora, M., Woodgett, J. R., Truneh, A., Olive, D. and Cantrell, D. A., CD28 signal transduction pathways. A comparison of B7.1 and B7.2 regulation of the map kinases: ERK2 and jun kinases. Mol. Immunol. 1996. 33: 63-70.
33. Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M. and Ben-Neriah, Y., JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994. 77: 727-736.
34. Rincon, M. and Flavell, R., AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J. 1994. 13: 4370-4381.
35. Herman, A., Croteau, G., Sekaly, R.-P., Kappler, J. and Marrack, P., HLA-DR alleles differ in their ability to pressent Staphylococcal enterotoxins to T cells. J. Exp. Med. 1990. 172: 709-717.
36. Umlauf, S. W., Beverly, B., Lantz, O. and Schwarte, R. H., Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics. Mol. Cell. Biol. 1995. 15: 3197-3205.
37. Jain, J., Loh, C. and Rao, A., Transcriptional regulation of the II-2 gene. Curr. Opin. Immunol. 1995. 7: 333-342.
38. Karin, M., The regulation of AP-1 activity by mitogen-activated protein kinase. J. Biol. Chem. 1995. 270: 16843-16848.
39. Charta, G. S., Spies, A. G., Chang, S., Mize, G. J., Linsley, P. S., Ledbetter, J. A. and Morris, D. R., Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28. J. Immunol. 1994. 153: 5393-5401.
40. Deschamps, J., Meijlink, F. and Verma, I. M., Identification of transcriptional enhancer element upstream from the proto-oncogene fos. Science 1985. 230: 1174-1177.
41. Imbert, V., Peyron, R, Farahi Far, D., Mari, B., Auberger, P. and Rossi, B., Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibition of protein tyrosine phosphatases. Biochem. J. 1994. 297: 163-173.
42. ras during T-cell activation and growth, Immunol. Today 1995. 16: 159-164.
43. Su, B. and Karin, M., Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 1996. 8: 402-411.
44. Derijard, B. B., Hibi, M., Wu, H. I., Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R. J., JNK1 : a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-jun activation domain. Cell 1994. 76: 1025-1027.
45. Kallunki, T., Su, B., Sluss, H. K., Derijard, D., Moore, G., Davis, R. J. and Karin, M., JNK2 contains a specificity-determining region responsible for efficient c-jun binding and phosphorylation. Genes Dev. 1994. 8: 2996-3007.
46. Watson, A., Eilers, A., Lallemand, D., Kyriakis, J., Rubin, L. L. and Ham, J., Phosphorylation of c-jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J. Neurosci. 1998. 18: 751-762.
47. Weiss, A. and Littman, D. R., Signal transduction by lymphocytes antigen receptors. Cell 1994. 76: 263-274.
48. Chan, A. C., Iwashima, M., Turck, C. W. and Weiss, A., ZAP-70: a 70 Kd protein-tyrosine kinase that associates with the TCR ζ chain. Cell 1992. 71: 649-662.
49. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 1989. 341: 746-749.
50. Franklin, R. A., Tordai, A., Patel, H., Gardner, A. M., Johnson, G. L. and Gelfand, E. W., Ligation of the T cell receptor complex results in activation of the Ras/Raf/MEK/MAPK cascade in human T lymphocytes. J. Clin. Invest. 1994. 93: 2134-2140.
51. Perez, V. L., Parijs, L. V., Biuckians, A., Zheng, X. X., Strom, T. B. and Abbas, A. K., Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 1997. 6: 411-417.
52. + splenic T cells after CD28 receptor Iigation. J. Immunol. 1995. 154: 985-997.
53. Nunès, J., Klasen, S., Ragueneau, M., Pavon, C., Couez, D., Mawas, C. and Olive, D., CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events. Int. Immunol. 1993. 5: 311-315.
54. Kawai, K., Shaninian, A., Mak, T. W. and Ohashi, P. S., Skin allograft rejection in CD28-deficient mice. Transplantation 1996. 61: 352-355.
55. Davis, S. J. and van der Merve, P. A., The structure and Iigand interactions of CD2: implications for T-cell functions, Immunol. Today 1996. 17: 177-187.
56. Shaw, A. S. and Dustin, M. L, Making the T cell receptor go the distance: a topological view of T cell activation. Immunity 1997. 6: 361-369.
57. van der Merve, P. A., Bodian, D. L., Daenke, S., Linsley, P. and Davis, S. J., CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 1997. 185: 393-404.
58. Boussiotis, V. A., Barber, D. L., Lee, B. J., Gribben, J. G., Freeman, G. J. and Nadler, L. M., Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation. J. Exp. Med. 1996. 184: 365-376.
59. Zell, T., Hunt III, S. W., Mobley, J. L., Finkelstein, L. D. and Shimizu, Y., CD28-mediated up-regulation of b1-integrin adhesion involves phosphatidylinositol 3-kinase. J. Immunol. 1996. 156: 883-886.
60. Kupfer, A. and Singer, S. J., Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. Annu. Rev. Immunol. 1989. 7: 309-337.
61. Molina, I. J., Sancho, J., Terhorst, C., Rosen, F. S. and Remold-O'Donnell, E., T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses. J. Immunol. 1993. 151: 4383-4390.
62. Aspenström, P., Lindberg, U. and Hall, A., Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome. Curr. Biol. 1996. 6: 70-75.
63. Symons, M., Derry, J. M., Karlak, B., Jiang, S., Lemahieu, V., McCormick, F., Francke, U. and Abo, A., Wiskott-Aldrich syndrome protein, a novel effector for the GTPaseCdc42Hs, is implicated in actin polimerization. Cell 1996. 84: 723-734.
64. Kolluri, R. S., Fuchs Tolias, K., Carpenter, C. L., Rosen. F. S. and Kirchhausen, T., Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42. Proc. Natl. Acad. Sci. USA 1996. 93: 5615-5618.
65. Symons, M., Rho family GTPases: the cytoskeleton and beyond. Trends Biochem. Sci. 1996. 21: 178-181.
66. Stowers, L., Yelon, D., Berg, L. J. and Chant, J., Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl. Acad. Sci. USA 1995. 92: 5027-5031.
67. Crespo, P., Schuebel, K. E., Ostrom, A. A., Gutkind, J. S. and Bustelo, X. R., Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav protooncogene product. Nature 1997. 385: 169-172.
68. Man, J., Das, B., Wei, W., Van Aelst, L., Mosteller, R. D., Khosravi-Far, R., Westwick, J. K., Der, C. J. and Broeck, D., Lck regulates Vav activation of members of the rho family of GTPases. Mol. Cell Biol. 1997. 17: 1346-1353.
69. Tuosto, L., Piazza, C., Moretti, S., Modesti, A., Greenlaw, R., Lechler, R., Lombardi, G. and Piccolella, E., Ligation of either CD2 and CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis. Eur. J. Immunol. 1995. 25: 2917-2922.
70. Emmel, E. A., Verweij, C. L., Durand, D. B., Higgins, K. M., Lacy, E. and Crabtree, G. R., Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 1989. 246: 1617-1619.
71. Saron, M. F., Truffa-Bachi, P. and Guillon, J. C., Rapid enrichment of mouse natural killer cells by use of wheat germ agglutinin. J. Immunol. Methods 1983. 59: 151-158.