Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue

Carcinogenesis

Volumn 23, Issue 1, 2002, Pages 213-216

  Lebel, Michel ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOBENZAMIDE; CAMPTOTHECIN; DNA; GENE PRODUCT; HELICASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE INHERITANCE; CANCER; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA REPLICATION; DNA STRUCTURE; DNA TRANSCRIPTION; EMBRYO; ENZYME INHIBITION; EYE COLOR; GENE DELETION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC STABILITY; MOUSE; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; SKIN; WERNER SYNDROME; WILD TYPE;

EID: 0036200960     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/23.1.213     Document Type: Article

References (30)

1. Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process
2. Excess of rare cancers in Werner syndrome (adult progeria)
3. Positional cloning of the Werner's syndrome gene
4. The Werner syndrome protein is a DNA helicase
5. DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system
6. The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease
7. Werner syndrome protein. II. Characterization of the integral 3′→5′ DNA exonuclease
8. Werner syndrome protein. I. DNA helicase and DNA exonuclease reside on the same polypeptide
9. Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts
10. Werner's syndrome: Proliferation in vitro of clones of cells bearing chromosome translocations
11. Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome
12. An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants
13. Genetic instability and hematologic disease risk in Werner syndrome patients and heterozygotes
14. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
15. Abnormal fibroblast aging and DNA replication in the Werner syndrome
16. Autoradiographic studies of DNA replication in Werner's syndrome cells
17. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
18. Carcinogens induce reversion of the mouse pink-eyed unstable mutation
19. Cigarette smoke induces DNA deletions in the mouse embryo
20. Effects of 10-hydroxycamptothecin on induced chromosome aberrations in Chinese hamster ovary cells and micronuclei in mouse bone marrow and fetal liver
21. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan
22. Cellular responses to DNA damage in the absence of poly(ADP-ribose) polymerase
23. Ku complex interacts with and stimulates the Werner protein
24. Functional interaction between Ku and the werner syndrome protein in DNA end processing
25. Poly(ADP-ribose)-mediated post-translational modification of chromatin-associated human topoisomerase I. Inhibitory effects on catalytic activity
26. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I
27. Inhibition of poly(ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects
28. Tumorigenic effect of p53 or p21 in mice mutant in the Werner syndrome helicase
29. The Werner syndrome gene: The molecular basis of RecQ helicase-deficiency diseases
30. Studies on intrachromosomal recombination in SP5/V79 Chinese hamster cells upon exposure to different agents related to carcinogenesis