Homologous recombination: From model organisms to human disease

Genome Biology

Volumn 2, Issue 5, 2001, Pages

  Modesti, Mauro ^a   Kanaar, Roland ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DNA; DNA POLYMERASE; DOUBLE STRANDED DNA; HELICASE; NUCLEIC ACID BINDING PROTEIN; OLIGONUCLEOTIDE; RAD51 PROTEIN; RAD52 PROTEIN; RESOLVASE; RP A PROTEIN; SINGLE STRANDED DNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BIOCHEMISTRY; BLOOM SYNDROME; BREAST CANCER; CAENORHABDITIS ELEGANS; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; CYTOLOGY; DNA BINDING; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DNA SYNTHESIS; DROSOPHILA; EMBRYO; EMBRYO CELL; ENZYME ACTIVITY; GENE SEQUENCE; GENE TARGETING; GENETIC CONSERVATION; GENETIC RECOMBINATION; GENETIC STABILITY; GENETIC SUSCEPTIBILITY; HETEROZYGOSITY LOSS; HOLLIDAY JUNCTION; HUMAN; HUMAN CELL; MAMMAL CELL; MEDICAL GENETICS; MODEL; MOUSE; NONHUMAN; REVIEW; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; STEM CELL; YEAST CELL;

ANIMALS; BRCA1 PROTEIN; BRCA2 PROTEIN; DNA DAMAGE; DNA HELICASES; DNA-BINDING PROTEINS; HUMANS; MODELS, GENETIC; NEOPLASM PROTEINS; NEOPLASMS; RAD51 RECOMBINASE; RECOMBINATION, GENETIC; TRANSCRIPTION FACTORS;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0034981048     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (32)

1. Chromosome breaks and genomic instability
2. The importance of repairing stalled replication forks
3. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
4. Genes and Disease
5. DNA repair: Rad52 - The means to an end
6. Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase
7. Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase
8. Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A
9. Stimulation by Rad52 of yeast Rad51-mediated recombination
10. A single-stranded DNA-binding protein is needed for efficient presynaptic complex formation by the Saccharomyces cerevisiae Rad51 protein
11. Synergistic actions of Rad51 and Rad52 in recombination and DNA repair
12. Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation
13. Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52
14. A surfeit of RAD51-like genes?
15. The translocating RecBCD enzyme stimulates recombination by directing RecA protein onto ssDNA in a chi-regulated manner
16. Protein interactions in genetic recombination in Escherichia coli. Interactions involving RecO and RecR overcome the inhibition of RecA by single-stranded DNA-binding protein
17. Insights into the functions of BRCA1 and BRCA2
18. Brca1 controls homology-directed DNA repair
19. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene
20. BRCA2 is required for homology-directed repair of chromosomal breaks
21. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein
22. Rad51 accumulation at sites of DNA damage and in postreplicative chromatin
23. Cancer predisposition caused by elevated mitotic recombination in Bloom mice
24. RecQ family helicases: Roles in cancer and aging
25. Possible association of BLM in decreasing DNA double strand breaks during DNA replication
26. The RuvABC proteins and Holliday junction processing in Escherichia coli
27. Resolution of synthetic Holliday junctions in DNA by an endonuclease activity from calf thymus
28. Branch migration and Holliday junction resolution catalyzed by activities from mammalian cells