RecQ-like helicases: The DNA replication checkpoint connection

Journal of Cell Science

Volumn 113, Issue 15, 2000, Pages 2641-2646

  Frei, C ^a   Gasser, S M ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

Bloom's syndrome; Checkpoint; DNA replication; Helicase; S phase; Sgs1p; Werner's syndrome

Indexed keywords

FUNGAL ENZYME; HELICASE; RECQ HELICASE; UNCLASSIFIED DRUG;

ARTICLE; BLOOM SYNDROME; CANCER SUSCEPTIBILITY; CELL CYCLE S PHASE; CELL DIVISION; CONTROLLED STUDY; DNA REPLICATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ESCHERICHIA COLI; EUKARYOTE; GENETIC STABILITY; MAMMAL; NONHUMAN; PRIORITY JOURNAL; WERNER SYNDROME; YEAST;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CELL DIVISION; DNA HELICASES; DNA REPLICATION; EUKARYOTIC CELLS; HUMANS; RECQ HELICASES;

ESCHERICHIA COLI; EUKARYOTA; MAMMALIA;

EID: 0033841114     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
2. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
3. Physical and functional interaction between p53 and the Werner's syndrome protein
4. Functional and physical interaction between WRN helicase and human replication protein
5. A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function
6. Defending genome integrity during DNA replication: A proposed role for RecQ family helicases
7. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
8. Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene
9. A genome-wide transcriptional analysis of the mitotic cell cycle
10. The importance of repairing stalled replication forks
11. DNA damage-induced cell cycle checkpoint and DNA strand break repair in development and tumorigenesis
12. Fission yeast rad12+ regulates cell cycle checkpoint control and is homologous to the Bloom's syndrome disease gene
13. The regulation of replication origin activation
14. The Bloom's syndrome gene product is homologous to RecQ helicases
15. Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process
16. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
17. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
18. Bloom syndrome: A mendelian prototype of somatic mutational disease
19. A retarded rate of DNA chain growth in Bloom's syndrome
20. RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination
21. Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast
22. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
23. Rothmund-Thomson syndrome
24. Integrated map of the chromosome 8p12-p21 region, a region involved in human cancers and Werner syndrome
25. Functional interaction between the Werner Syndrome protein and DNA polymerase δ
26. Substrate specificities and identification of putative substrates of ATM kinase family members
27. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome
28. Rothmund-Thomson syndrome responsible gene, RECQL4: Genomic structure and products
29. Radiation effects on DNA synthesis in a defined chromosomal replicon
30. ATM: The protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia
31. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
32. The Werner syndrome gene product Co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I
33. Requirement of yeast SGSI and SRS2 genes for replication and transcription
34. An abnormal profile of DNA replication intermediates in Bloom's syndrome
35. Human homologues of yeast helicase
36. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
37. A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases
38. Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance
39. DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint
40. The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells
41. Radiosensitivity in ataxia-telangiectasia: A new explanation
42. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage
43. ATM and RPA in meiotic chromosome synapsis and recombination
44. Changes in protein composition of meiotic nodules during mammalian meiosis
45. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
46. Replication fork pausing and recombination or 'gimme a break'
47. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms
48. Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization
49. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants
50. Aging in Saccharomyces cerevisiae
51. p53-mediated apoptosis is attenuated in Werner syndrome cells
52. rqhl+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
53. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs
54. Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes
55. BASC, a super complex of BRCA-1 associated proteins involved in the recognition and repair of aberrant DNA structures
56. SGS1: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation
57. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae
58. DNA damage checkpoints update: Getting molecular
59. Genetic recombination: Helicases and topoisomerases link up
60. The Bloom's syndrome gene product interacts with topoisoimerase III
61. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases
62. Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53
63. Positional cloning of the Werner's syndrome gene
64. Biochemical function analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity