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Volumn 214, Issue 2, 1997, Pages 99-106

Replicative senescence and cell immortality: The role of telomeres and telomerase

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

EID: 0031047426     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-214-44075     Document Type: Short Survey
Times cited : (176)

References (81)
  • 1
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 25:585-621, 1961.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 2
    • 0027163464 scopus 로고
    • Replicative senescence of human fibroblast-like cells in culture
    • Cristofalo VJ, Pignolo RJ. Replicative senescence of human fibroblast-like cells in culture. Physiol Rev 73:617-638, 1993.
    • (1993) Physiol Rev , vol.73 , pp. 617-638
    • Cristofalo, V.J.1    Pignolo, R.J.2
  • 5
    • 0026753051 scopus 로고
    • Cloning and expression of SAG: A novel marker of cellular senescence
    • Wistrom C, Villeponteau B. Cloning and expression of SAG: A novel marker of cellular senescence. Exp Cell Res 199:355-362, 1992.
    • (1992) Exp Cell Res , vol.199 , pp. 355-362
    • Wistrom, C.1    Villeponteau, B.2
  • 6
    • 0024445960 scopus 로고
    • Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity
    • West MD, Pereira-Smith OM, Smith JR. Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity. Exp Cell Res 184:138-147, 1989.
    • (1989) Exp Cell Res , vol.184 , pp. 138-147
    • West, M.D.1    Pereira-Smith, O.M.2    Smith, J.R.3
  • 8
    • 0023276258 scopus 로고
    • Cellular senescence revisited: A review
    • Stanulis-Praeger BM. Cellular senescence revisited: A review. Mech Ageing Dev 38:1-48, 1987.
    • (1987) Mech Ageing Dev , vol.38 , pp. 1-48
    • Stanulis-Praeger, B.M.1
  • 9
    • 0015977307 scopus 로고
    • Aging in vitro: Growth of cultured cells from the Galapagos tortoise
    • Goldstein S. Aging in vitro: Growth of cultured cells from the Galapagos tortoise. Exp Cell Res 89:297-302, 1974.
    • (1974) Exp Cell Res , vol.89 , pp. 297-302
    • Goldstein, S.1
  • 10
    • 0000299214 scopus 로고
    • Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo
    • Rohme D. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc Natl Acad Sci USA 78:5009-5013, 1981.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 5009-5013
    • Rohme, D.1
  • 11
    • 0017840139 scopus 로고
    • Genetic syndromes in man with potential relevance to the pathobiology of aging
    • Martin GM. Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Orig Artic Ser 14:5-39, 1978.
    • (1978) Birth Defects Orig Artic Ser , vol.14 , pp. 5-39
    • Martin, G.M.1
  • 13
    • 0001934324 scopus 로고
    • Telomeres and Aging
    • New York: Cold Spring Harbor Laboratory Press
    • Harley CB. Telomeres and Aging. In: Telomeres. New York: Cold Spring Harbor Laboratory Press, pp247-263, 1995.
    • (1995) Telomeres , pp. 247-263
    • Harley, C.B.1
  • 15
    • 0028044767 scopus 로고
    • The cellular and molecular biology of skin aging
    • West MD. The cellular and molecular biology of skin aging. Arch Dermatol 130:87-95, 1994.
    • (1994) Arch Dermatol , vol.130 , pp. 87-95
    • West, M.D.1
  • 16
    • 0026054961 scopus 로고
    • A role for both RB and p53 in the regulation of human cellular senescence
    • Shay JW, Pereira-Smith OM, Wright WE. A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 196:33-39, 1991.
    • (1991) Exp Cell Res , vol.196 , pp. 33-39
    • Shay, J.W.1    Pereira-Smith, O.M.2    Wright, W.E.3
  • 17
    • 0017710978 scopus 로고
    • Characteristics of a human cell line transformed by DNA from human adenovirus type 5
    • Graham FL, Smiley J. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 36:59-74, 1977.
    • (1977) J Gen Virol , vol.36 , pp. 59-74
    • Graham, F.L.1    Smiley, J.2
  • 18
    • 0024437219 scopus 로고
    • Human telomeres: Fusion, resolution and interstitial sites
    • Hastie ND, Allshire RC. Human telomeres: Fusion, resolution and interstitial sites. Trends Genet Sci 5:326-331, 1989.
    • (1989) Trends Genet Sci , vol.5 , pp. 326-331
    • Hastie, N.D.1    Allshire, R.C.2
  • 19
    • 0024788528 scopus 로고
    • Structure and function of telomeres
    • Zakian VA. Structure and function of telomeres. Annu Rev Genet 23:579-604, 1989.
    • (1989) Annu Rev Genet , vol.23 , pp. 579-604
    • Zakian, V.A.1
  • 20
    • 0026377841 scopus 로고
    • The human telomere
    • Moyzis R. The human telomere. Sci Am 265:48-55, 1991.
    • (1991) Sci Am , vol.265 , pp. 48-55
    • Moyzis, R.1
  • 21
    • 0030006735 scopus 로고    scopus 로고
    • In situ analysis of changes in telomere size during replicative aging and cell transformation
    • Henderson S, Allsopp R, Spector D, Wang S-S, Harley C. In situ analysis of changes in telomere size during replicative aging and cell transformation. J Cell Biol 134:1-12, 1996.
    • (1996) J Cell Biol , vol.134 , pp. 1-12
    • Henderson, S.1    Allsopp, R.2    Spector, D.3    Wang, S.-S.4    Harley, C.5
  • 22
    • 0024362809 scopus 로고
    • Human telomeres contain at least three types of G-rich repeats distributed non-randomly
    • Allshire RC, Dempster M, Hastie ND. Human telomeres contain at least three types of G-rich repeats distributed non-randomly. Nucleic Acid Res 17:4611-4627, 1989.
    • (1989) Nucleic Acid Res , vol.17 , pp. 4611-4627
    • Allshire, R.C.1    Dempster, M.2    Hastie, N.D.3
  • 24
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley C, Futcher A, Greider C. Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460, 1990.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.1    Futcher, A.2    Greider, C.3
  • 25
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
    • Greider C, Blackburn E. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337:331-337, 1989.
    • (1989) Nature , vol.337 , pp. 331-337
    • Greider, C.1    Blackburn, E.2
  • 26
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in tetrahymena extracts
    • Grieder C, Blackburn E. Identification of a specific telomere terminal transferase activity in tetrahymena extracts. Cell 43:405-413, 1985.
    • (1985) Cell , vol.43 , pp. 405-413
    • Grieder, C.1    Blackburn, E.2
  • 27
    • 0024325562 scopus 로고
    • The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    • Morin GB. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59:521-529, 1989.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 28
    • 0025021235 scopus 로고
    • Functional evidence for an RNA template in telomerase
    • Shippen-Lentz D, Blackburn EH. Functional evidence for an RNA template in telomerase. Science 247:546-552, 1990.
    • (1990) Science , vol.247 , pp. 546-552
    • Shippen-Lentz, D.1    Blackburn, E.H.2
  • 29
    • 0029033695 scopus 로고
    • An in vitro assay for Saccharomyces telomerase requires EST1
    • Lin JJ, Zakian VA. An in vitro assay for Saccharomyces telomerase requires EST1. Cell 81:1127-1135, 1995.
    • (1995) Cell , vol.81 , pp. 1127-1135
    • Lin, J.J.1    Zakian, V.A.2
  • 30
    • 0029155795 scopus 로고
    • Telomerase in yeast
    • Cohn M, Blackburn EH. Telomerase in yeast. Science 269:396-400, 1995.
    • (1995) Science , vol.269 , pp. 396-400
    • Cohn, M.1    Blackburn, E.H.2
  • 32
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet 18:173-179, 1996.
    • (1996) Dev Genet , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 33
    • 0015844590 scopus 로고
    • A theory of marginotomy: The incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon
    • Olovnikov A. A theory of marginotomy: The incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 41:181-190, 1973.
    • (1973) J Theor Biol , vol.41 , pp. 181-190
    • Olovnikov, A.1
  • 34
    • 0015515155 scopus 로고
    • Origin of Concatemeric T7 DNA
    • Watson J. Origin of Concatemeric T7 DNA. Nat New Biol 239:197-201, 1972.
    • (1972) Nat New Biol , vol.239 , pp. 197-201
    • Watson, J.1
  • 37
    • 0025787643 scopus 로고
    • Telomere loss: Mitotic clock or genetic time bomb?
    • Harley C. Telomere loss: mitotic clock or genetic time bomb? Mutat Res 256:271-282, 1991.
    • (1991) Mutat Res , vol.256 , pp. 271-282
    • Harley, C.1
  • 43
    • 0028856794 scopus 로고    scopus 로고
    • Telomere length and replicative aging in human vascular tissues
    • Chang E, Harley C. Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci USA 92:11190-11194, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.92 , pp. 11190-11194
    • Chang, E.1    Harley, C.2
  • 45
    • 0029127226 scopus 로고
    • Mild hypoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
    • von Zglinicki T, Saretzki G, Docke W, Lotze C. Mild hypoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 220:186-193, 1995.
    • (1995) Exp Cell Res , vol.220 , pp. 186-193
    • Von Zglinicki, T.1    Saretzki, G.2    Docke, W.3    Lotze, C.4
  • 46
    • 0028198679 scopus 로고
    • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
    • Counter CM, Botelho FM, Wang P, Harley CB, Bacchetti S. Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol 68:3410-3414, 1994.
    • (1994) J Virol , vol.68 , pp. 3410-3414
    • Counter, C.M.1    Botelho, F.M.2    Wang, P.3    Harley, C.B.4    Bacchetti, S.5
  • 48
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter C, Avilion A, LeFeuvre C, Stewart N, Greider C, Harley C, Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 11:1921-1929, 1992.
    • (1992) EMBO J , vol.11 , pp. 1921-1929
    • Counter, C.1    Avilion, A.2    Lefeuvre, C.3    Stewart, N.4    Greider, C.5    Harley, C.6    Bacchetti, S.7
  • 51
    • 0028303112 scopus 로고
    • Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma, and gynecomastia. Relationship to histologic grade and clinical parameters
    • Odagiri E, Kanada N, Jibiki K, Demura R, Aikawa E, Demura H. Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma, and gynecomastia. Relationship to histologic grade and clinical parameters. Cancer 73:2978-2984, 1994.
    • (1994) Cancer , vol.73 , pp. 2978-2984
    • Odagiri, E.1    Kanada, N.2    Jibiki, K.3    Demura, R.4    Aikawa, E.5    Demura, H.6
  • 52
    • 0027266848 scopus 로고
    • Immortalization of human mammary epithelial cells by SV40 large T-antigen involved a two step mechanism
    • Van Der Haegen BA, Shay JW. Immortalization of human mammary epithelial cells by SV40 large T-antigen involved a two step mechanism. In Vitro Cell Devel Biol 29A:180-182, 1993.
    • (1993) In Vitro Cell Devel Biol , vol.29 A , pp. 180-182
    • Van Der Haegen, B.A.1    Shay, J.W.2
  • 53
    • 0027298979 scopus 로고
    • Changes of telomere lengths in human intracranial tumours
    • Numberg P, Thiel G, Weber F, Epplen JT. Changes of telomere lengths in human intracranial tumours. Hum Genet 91:190-192, 1993.
    • (1993) Hum Genet , vol.91 , pp. 190-192
    • Numberg, P.1    Thiel, G.2    Weber, F.3    Epplen, J.T.4
  • 55
  • 56
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 14:4240-4248, 1995.
    • (1995) EMBO J , vol.14 , pp. 4240-4248
    • Bryan, T.M.1    Englezou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.R.5
  • 58
    • 0025235355 scopus 로고
    • Telomeres: Structure and synthesis
    • Blackburn EH. Telomeres: Structure and synthesis. J Biol Chem 265:5919-5921, 1990.
    • (1990) J Biol Chem , vol.265 , pp. 5919-5921
    • Blackburn, E.H.1
  • 59
    • 0027399643 scopus 로고
    • Cell immortalization as a key, rate-limiting event in malignant transformation: Approaches toward a molecular genetic analysis
    • Newbold RF, Cuthbert AP, Themis M, Trott DA, Blair AL, Li W. Cell immortalization as a key, rate-limiting event in malignant transformation: Approaches toward a molecular genetic analysis. Toxicol Lett 67:211-230, 1993.
    • (1993) Toxicol Lett , vol.67 , pp. 211-230
    • Newbold, R.F.1    Cuthbert, A.P.2    Themis, M.3    Trott, D.A.4    Blair, A.L.5    Li, W.6
  • 61
    • 0027484484 scopus 로고
    • Loss of telomeric DNA during aging may predispose cells to cancer
    • Shay JW, Wright WE, Werbin H. Loss of telomeric DNA during aging may predispose cells to cancer. (review) Int J Oncol 3:559-563, 1993.
    • (1993) Int J Oncol , vol.3 , pp. 559-563
    • Shay, J.W.1    Wright, W.E.2    Werbin, H.3
  • 63
    • 0028938262 scopus 로고
    • Telomerase activity in normal leukocytes and in hematologic malignancies
    • Counter CM, Gupta J, Harley CB, Leber B, Bacchetti S. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 85:2315-2320, 1995.
    • (1995) Blood , vol.85 , pp. 2315-2320
    • Counter, C.M.1    Gupta, J.2    Harley, C.B.3    Leber, B.4    Bacchetti, S.5
  • 64
    • 0029066169 scopus 로고
    • Telomerase activity in normal and malignant hematopoietic cells
    • Broccoli D, Young JW, deLange T. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 92:9082-9086, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9082-9086
    • Broccoli, D.1    Young, J.W.2    DeLange, T.3
  • 68
    • 0029019717 scopus 로고
    • Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas
    • Tahara H, Nakanishi T, Kitamoto M, Nakashio R, Shay JW, Tahara E, Kajiyama G, Ide T. Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res 55:2734-2736, 1995.
    • (1995) Cancer Res , vol.55 , pp. 2734-2736
    • Tahara, H.1    Nakanishi, T.2    Kitamoto, M.3    Nakashio, R.4    Shay, J.W.5    Tahara, E.6    Kajiyama, G.7    Ide, T.8
  • 71
    • 0029013631 scopus 로고
    • Telomerase activity associated with acquisition of malignancy in human colorectal cancer
    • Chadeneau C, Hay K, Hirte HW, Gallinger S, Bacchetti S. Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res 55:2533-2536, 1995.
    • (1995) Cancer Res , vol.55 , pp. 2533-2536
    • Chadeneau, C.1    Hay, K.2    Hirte, H.W.3    Gallinger, S.4    Bacchetti, S.5
  • 72
    • 0027944347 scopus 로고
    • TLCl: Template RNA component of Saccharomyces cerevisiae telomerase
    • Singer MS, Gottschling DE. TLCl: Template RNA component of Saccharomyces cerevisiae telomerase. Science 266:404-409, 1994.
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 73
    • 0025279059 scopus 로고
    • In vivo alteration of telomere sequences and senescence caused by mutated telomerase RNAs
    • Yu G-L, Bradley JD, Attardi LD, Blackburn EH. In vivo alteration of telomere sequences and senescence caused by mutated telomerase RNAs. Nature 344:126-132, 1990.
    • (1990) Nature , vol.344 , pp. 126-132
    • Yu, G.-L.1    Bradley, J.D.2    Attardi, L.D.3    Blackburn, E.H.4
  • 74
    • 0029102354 scopus 로고
    • Runaway telomere elongation caused by telomerase RNA gene mutations
    • McEachem MJ, Blackburn EH. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376:403-409, 1995.
    • (1995) Nature , vol.376 , pp. 403-409
    • McEachem, M.J.1    Blackburn, E.H.2
  • 75
    • 0029154735 scopus 로고
    • Functional characterization and developmental regulation of mouse telomerase RNA
    • Blasco MA, Funk W, Villeponteau B, Greider CW. Functional characterization and developmental regulation of mouse telomerase RNA. Science 269:1267-1270, 1995.
    • (1995) Science , vol.269 , pp. 1267-1270
    • Blasco, M.A.1    Funk, W.2    Villeponteau, B.3    Greider, C.W.4
  • 77
    • 0029040101 scopus 로고
    • Developmental and tissue-specific regulation of mouse telomerase and telomere length
    • Prowse KR, Greider CW. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci USA 92:4818-822, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 79
    • 0026623323 scopus 로고
    • Does stem cell exhaustion result from combining hematopoietic growth factors with chemotherapy? If so, how do we prevent it?
    • Moore MAS. Does stem cell exhaustion result from combining hematopoietic growth factors with chemotherapy? If so, how do we prevent it? Blood 80:3-7, 1992.
    • (1992) Blood , vol.80 , pp. 3-7
    • Moore, M.A.S.1


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