메뉴 건너뛰기




Volumn 47, Issue 9, 1999, Pages 1136-1144

What geriatricians should know about the Werner syndrome

Author keywords

Aging; Genetic variation; Helicase; Progeroid syndrome; Werner syndrome

Indexed keywords

AGING; ARTICLE; DIAGNOSTIC APPROACH ROUTE; GENE MUTATION; GENETIC ANALYSIS; GENETIC VARIABILITY; GERIATRICS; HUMAN; MOLECULAR CLONING; PATHOGENESIS; WERNER SYNDROME;

EID: 0032825111     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1532-5415.1999.tb05240.x     Document Type: Article
Times cited : (70)

References (69)
  • 1
    • 0020332293 scopus 로고
    • Syndromes of accelerated aging
    • Martin GM. Syndromes of accelerated aging. Natl Cancer Inst Monogr 1982;60:241-247.
    • (1982) Natl Cancer Inst Monogr , vol.60 , pp. 241-247
    • Martin, G.M.1
  • 2
    • 0017840139 scopus 로고
    • Genetic syndromes in man with potential relevance to the pathobiology of aging
    • Martin GM. Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Orig Artic Ser 1978;14:5-39.
    • (1978) Birth Defects Orig Artic Ser , vol.14 , pp. 5-39
    • Martin, G.M.1
  • 3
    • 0022335895 scopus 로고
    • A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Gilford progeria syndrome
    • Brown WT, Kieras FJ, Houck GE et al. A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Gilford progeria syndrome. Adv Exp Med Biol 1985;190:229-244.
    • (1985) Adv Exp Med Biol , vol.190 , pp. 229-244
    • Brown, W.T.1    Kieras, F.J.2    Houck, G.E.3
  • 4
    • 0029933242 scopus 로고    scopus 로고
    • Premature aging gene discovered
    • Pennisi E. Premature aging gene discovered. Science 1996;272:193-194.
    • (1996) Science , vol.272 , pp. 193-194
    • Pennisi, E.1
  • 5
    • 0030691121 scopus 로고    scopus 로고
    • Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
    • Goto M. Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing. Mech Ageing Dev 1997;98:239-254.
    • (1997) Mech Ageing Dev , vol.98 , pp. 239-254
    • Goto, M.1
  • 6
    • 0030751354 scopus 로고    scopus 로고
    • The Werner syndrome protein is a DNa helicase
    • Gray MD, Shen JC, Kamath-Loeb AS et al. The Werner syndrome protein is a DNA helicase. Nat Genet 1997;17:100-103.
    • (1997) Nat Genet , vol.17 , pp. 100-103
    • Gray, M.D.1    Shen, J.C.2    Kamath-Loeb, A.S.3
  • 7
    • 0032526583 scopus 로고    scopus 로고
    • Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A
    • Shen JC, Gray MD, Oshima J et al. Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A. Nucleic Acids Res 1998;26:2879-2885.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2879-2885
    • Shen, J.C.1    Gray, M.D.2    Oshima, J.3
  • 8
    • 0013907774 scopus 로고
    • Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process
    • Baltimore
    • Epstein CJ, Martin GM, Schultz AL et al. Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltimore) 1966;45:177-221.
    • (1966) Medicine , vol.45 , pp. 177-221
    • Epstein, C.J.1    Martin, G.M.2    Schultz, A.L.3
  • 9
    • 0022293943 scopus 로고
    • Werner's syndrome and aging: A reappraisal
    • Epstein CJ. Werner's syndrome and aging: A reappraisal. Adv Exp Med Biol 1985;190:219-228.
    • (1985) Adv Exp Med Biol , vol.190 , pp. 219-228
    • Epstein, C.J.1
  • 10
    • 0030857408 scopus 로고    scopus 로고
    • The Werner mutation: Does it lead to a "public" or "private" mechanism of aging?
    • Martin GM. The Werner mutation: Does it lead to a "public" or "private" mechanism of aging? Mol Med 1997;3:356-358.
    • (1997) Mol Med , vol.3 , pp. 356-358
    • Martin, G.M.1
  • 12
    • 0022309571 scopus 로고
    • On cataract in conjunction with scleroderma. Otto Werner, doctoral dissertation, 1904. Royal Ophthalmology Clinic, Royal Christian Albrecht University of Kiel
    • Hoehn H (translator). On cataract in conjunction with scleroderma. Otto Werner, doctoral dissertation, 1904. Royal Ophthalmology Clinic, Royal Christian Albrecht University of Kiel. Adv Exp Med Biol 1985;190:1-14.
    • (1985) Adv Exp Med Biol , vol.190 , pp. 1-14
    • Hoehn, H.1
  • 13
    • 0016678691 scopus 로고
    • Variegated translocation mosaicism in human skin fibroblast cultures
    • Hoehn H, Bryant EM, Au K et al. Variegated translocation mosaicism in human skin fibroblast cultures. Cytogenet Cell Genet 1975;15:282-298.
    • (1975) Cytogenet Cell Genet , vol.15 , pp. 282-298
    • Hoehn, H.1    Bryant, E.M.2    Au, K.3
  • 14
    • 0019440557 scopus 로고
    • Cytogenetics of Werner's syndrome cultured skin fibroblasts: Variegated translocation mosaicism
    • Salk D, Au K, Hoehn H et al. Cytogenetics of Werner's syndrome cultured skin fibroblasts: Variegated translocation mosaicism. Cytogenet Cell Genet 1981;30:92-107.
    • (1981) Cytogenet Cell Genet , vol.30 , pp. 92-107
    • Salk, D.1    Au, K.2    Hoehn, H.3
  • 15
    • 0003128111 scopus 로고
    • Werner's syndrome and human aging
    • Proceedings of a United States-Japan cooperative seminar. December 1982:10-12. Kobe, Japan
    • Salk D, Fujiwara Y, Martin GM (eds). Werner's syndrome and human aging. Proceedings of a United States-Japan cooperative seminar. December 1982:10-12. Kobe, Japan. Adv Exp Med Biol 1985;190:1-656.
    • (1985) Adv Exp Med Biol , vol.190 , pp. 1-656
    • Salk, D.1    Fujiwara, Y.2    Martin, G.M..3
  • 16
    • 0026502062 scopus 로고
    • Genetic linkage of Werner's syndrome to five markers on chromosome 8
    • Goto M, Rubenstein M, Weber J et al. Genetic linkage of Werner's syndrome to five markers on chromosome 8. Nature 1992;355:735-738.
    • (1992) Nature , vol.355 , pp. 735-738
    • Goto, M.1    Rubenstein, M.2    Weber, J.3
  • 18
    • 15844409553 scopus 로고    scopus 로고
    • Positional cloning of the Werner's syndrome gene
    • Yu CE, Oshima J, Fu YH et al. Positional cloning of the Werner's syndrome gene. Science 1996;272:258-262.
    • (1996) Science , vol.272 , pp. 258-262
    • Yu, C.E.1    Oshima, J.2    Fu, Y.H.3
  • 19
    • 0030757524 scopus 로고    scopus 로고
    • DNa helicase activity in Werner's syndrome gene product synthesized in a baculovirus system
    • Suzuki N, Shimamoto A, Imamura O et al. DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system. Nucleic Acids Res 1997;25:2973-2978.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2973-2978
    • Suzuki, N.1    Shimamoto, A.2    Imamura, O.3
  • 21
    • 0023762632 scopus 로고    scopus 로고
    • Werner's syndrome associated with malignancies: Five case reports with a survey of case histories in Japan
    • Sato K, Goto M, Nishioka K et al. Werner's syndrome associated with malignancies: Five case reports with a survey of case histories in Japan. Gerontology 1998;34:212-218.
    • (1998) Gerontology , vol.34 , pp. 212-218
    • Sato, K.1    Goto, M.2    Nishioka, K.3
  • 22
    • 0014816132 scopus 로고
    • Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype
    • Martin GM, Sprague CA, Epstein CJ. Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest 1970;23: 86-92.
    • (1970) Lab Invest , vol.23 , pp. 86-92
    • Martin, G.M.1    Sprague, C.A.2    Epstein, C.J.3
  • 23
    • 0021171248 scopus 로고
    • Werner's syndrome: An underdiagnosed disorder resembling premature aging
    • Tollefsbol TO, Cohen HJ. Werner's syndrome: An underdiagnosed disorder resembling premature aging. Age 1984;7:75-88.
    • (1984) Age , vol.7 , pp. 75-88
    • Tollefsbol, T.O.1    Cohen, H.J.2
  • 24
    • 0024465870 scopus 로고
    • Mutator phenotype of Werner syndrome is characterized by extensive deletions
    • USA
    • Fukuchi K, Martin GM, Monnat RJ Jr. Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci USA 1989; 86:5893-5897.
    • (1989) Proc Natl Acad Sci , vol.86 , pp. 5893-5897
    • Fukuchi, K.1    Martin, G.M.2    Monnat R.J., Jr.3
  • 25
    • 0025169778 scopus 로고
    • Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients
    • Fukuchi K, Tanaka K, Kumahara Y et al. Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients. Hum Genet 1990;84:249-252.
    • (1990) Hum Genet , vol.84 , pp. 249-252
    • Fukuchi, K.1    Tanaka, K.2    Kumahara, Y.3
  • 26
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961;25:585-621.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 27
    • 0022222407 scopus 로고
    • The cell biology of aging
    • Hayflick L. The cell biology of aging. Clin Geriatr Med 1985;1:15-27.
    • (1985) Clin Geriatr Med , vol.1 , pp. 15-27
    • Hayflick, L.1
  • 28
    • 0028898823 scopus 로고
    • Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors
    • Oshima J, Campisi J, Tannock TC et al. Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J Cell Physiol 1995;162:277-283.
    • (1995) J Cell Physiol , vol.162 , pp. 277-283
    • Oshima, J.1    Campisi, J.2    Tannock, T.C.3
  • 29
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar AG, Ouellette M, Frolkis M et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3
  • 30
    • 0029971241 scopus 로고    scopus 로고
    • Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
    • Schulz VP, Zakian VA, Ogburn CE et al. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum Genet 1996;97:750-754.
    • (1996) Hum Genet , vol.97 , pp. 750-754
    • Schulz, V.P.1    Zakian, V.A.2    Ogburn, C.E.3
  • 31
    • 0020306698 scopus 로고
    • Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts
    • Takeuchi F, Hanaoka F, Goto M et al. Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts. Exp Gerontol 1982;17:473-480.
    • (1982) Exp Gerontol , vol.17 , pp. 473-480
    • Takeuchi, F.1    Hanaoka, F.2    Goto, M.3
  • 32
    • 0026702210 scopus 로고
    • Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
    • Poot M, Hoehn H, Runger TM et al. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res 1992; 202:267-273.
    • (1992) Exp Cell Res , vol.202 , pp. 267-273
    • Poot, M.1    Hoehn, H.2    Runger, T.M.3
  • 33
    • 0030915681 scopus 로고    scopus 로고
    • Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs
    • USA
    • Mushegian AR, Bassett DE Jr, Boguski MS et al. Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs. Proc Natl Acad Sci USA 1997;84:5831-5836.
    • (1997) Proc Natl Acad Sci , vol.84 , pp. 5831-5836
    • Mushegian, A.R.1    Bassett D.E., Jr.2    Boguski, M.S.3
  • 34
    • 0031574363 scopus 로고    scopus 로고
    • The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains
    • Moser MJ, Holley WR, Chatterjee A et al. The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains. Nucleic Acids Res 1997;25:5110-5118.
    • (1997) Nucleic Acids Res , vol.25 , pp. 5110-5118
    • Moser, M.J.1    Holley, W.R.2    Chatterjee, A.3
  • 35
    • 0031686571 scopus 로고    scopus 로고
    • The premature aging syndrome protein, WRN, is a 3′ to 5′ exonuclease
    • Huang S, Li B, Gray MD et al. The premature aging syndrome protein, WRN, is a 3′ to 5′ exonuclease. Nat Genet 1998;20:114-116.
    • (1998) Nat Genet , vol.20 , pp. 114-116
    • Huang, S.1    Li, B.2    Gray, M.D.3
  • 36
    • 0032545515 scopus 로고    scopus 로고
    • Werner syndrome protein: 1. DNA helicase and DNA exonuclease reside on the same polypeptide
    • Shen JC, Gray MD, Oshima J et al. Werner syndrome protein: 1. DNA helicase and DNA exonuclease reside on the same polypeptide. J Biol Chem 1998;273:34139-34144.
    • (1998) J Biol Chem , vol.273 , pp. 34139-34144
    • Shen, J.C.1    Gray, M.D.2    Oshima, J.3
  • 37
    • 0032545423 scopus 로고    scopus 로고
    • Werner syndrome protein: 2. Characterization of the integral 3′->5′ DNA exonuclease
    • Kamath-Loeb AS, Shen JC, Loeb LA et al. Werner syndrome protein: 2. Characterization of the integral 3′->5′ DNA exonuclease. J Biol Chem 1998;273:34145-34150.
    • (1998) J Biol Chem , vol.273 , pp. 34145-34150
    • Kamath-Loeb, A.S.1    Shen, J.C.2    Loeb, L.A.3
  • 38
    • 0029944713 scopus 로고    scopus 로고
    • DNA repair fine structure in Werner's syndrome cell lines
    • Webb DK, Evans MK, Bohr VA. DNA repair fine structure in Werner's syndrome cell lines. Exp Cell Res 1996;224:272-278.
    • (1996) Exp Cell Res , vol.224 , pp. 272-278
    • Webb, D.K.1    Evans, M.K.2    Bohr, V.A.3
  • 39
    • 0030829431 scopus 로고    scopus 로고
    • Mismatch repair in extracts of Werner syndrome cell lines
    • Bennett SE, Umar A, Oshima J et al. Mismatch repair in extracts of Werner syndrome cell lines. Cancer Res 1997;57:2956-2960.
    • (1997) Cancer Res , vol.57 , pp. 2956-2960
    • Bennett, S.E.1    Umar, A.2    Oshima, J.3
  • 40
    • 0030888233 scopus 로고    scopus 로고
    • RecQ DNa helicase is a suppresser of illegitimate recombination in Escherichia coli
    • USA
    • Hanada K, Ukita T, Kohno Y et al. RecQ DNA helicase is a suppresser of illegitimate recombination in Escherichia coli. Proc Natl Acad Sci USA 1997; 94:3860-3865.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 3860-3865
    • Hanada, K.1    Ukita, T.2    Kohno, Y.3
  • 41
    • 0030994386 scopus 로고    scopus 로고
    • rhq1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
    • Stewart E, Chapman CR, Al-Khodairy F et al. rhq1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J 1997;16:2682-2692.
    • (1997) EMBO J , vol.16 , pp. 2682-2692
    • Stewart, E.1    Chapman, C.R.2    Al-Khodairy, F.3
  • 42
    • 0032555220 scopus 로고    scopus 로고
    • Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs 1 mutant: Implication for genomic instability in human diseases
    • USA
    • Yamagata K, Kato J, Shimamoto A et al. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs 1 mutant: Implication for genomic instability in human diseases. Proc Natl Acad Sci USA 1998;95: 8733-8738.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 8733-8738
    • Yamagata, K.1    Kato, J.2    Shimamoto, A.3
  • 43
    • 0031459980 scopus 로고    scopus 로고
    • Extrachromosomal rDNa circles: A cause of aging in yeast
    • Sinclair DA, Guarente L. Extrachromosomal rDNA circles: A cause of aging in yeast. Cell 1997;91:1033-1042.
    • (1997) Cell , vol.91 , pp. 1033-1042
    • Sinclair, D.A.1    Guarente, L.2
  • 44
    • 0032499703 scopus 로고    scopus 로고
    • Nucleolar localization of the Werner's syndrome protein in human cells
    • USA
    • Marciniak RA, Lombard DB, Johnson FB et al. Nucleolar localization of the Werner's syndrome protein in human cells. Proc Natl Acad Sci USA 1998; 95:6887-6892.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 6887-6892
    • Marciniak, R.A.1    Lombard, D.B.2    Johnson, F.B.3
  • 45
    • 0032146147 scopus 로고    scopus 로고
    • Werner helicase is localized to transcriptionally active nucleoli of cycling cells
    • Gray MD, Wang L, Youssoufian H et al. Werner helicase is localized to transcriptionally active nucleoli of cycling cells. Exp Cell Res 1998;242:487-494.
    • (1998) Exp Cell Res , vol.242 , pp. 487-494
    • Gray, M.D.1    Wang, L.2    Youssoufian, H.3
  • 46
    • 0031848284 scopus 로고    scopus 로고
    • Replication of focus-forming activity 1 and the Werner syndrome gene product
    • Yan H, Chen CY, Kobayashi R et al. Replication of focus-forming activity 1 and the Werner syndrome gene product. Nat Genet 1998;19:375-378.
    • (1998) Nat Genet , vol.19 , pp. 375-378
    • Yan, H.1    Chen, C.Y.2    Kobayashi, R.3
  • 47
    • 0031820438 scopus 로고    scopus 로고
    • The three faces of the WS helicase
    • Fry M, Loeb LA. The three faces of the WS helicase. Nat Genet 1998;19: 308-309.
    • (1998) Nat Genet , vol.19 , pp. 308-309
    • Fry, M.1    Loeb, L.A.2
  • 48
    • 0031204917 scopus 로고    scopus 로고
    • Impaired nuclear localization of defective DNA helicases in Werner's syndrome
    • Matsumoto T, Shimamoto A, Goto M et al. Impaired nuclear localization of defective DNA helicases in Werner's syndrome. Nat Genet 1997;16:335-336.
    • (1997) Nat Genet , vol.16 , pp. 335-336
    • Matsumoto, T.1    Shimamoto, A.2    Goto, M.3
  • 49
    • 0032145990 scopus 로고    scopus 로고
    • Structure and function of the human Werner syndrome gene promoter: Evidence for transcriptional modulation
    • Wang L, Hunt KE, Martin GM et al. Structure and function of the human Werner syndrome gene promoter: Evidence for transcriptional modulation. Nucleic Acids Res 1998;26:3480-3485.
    • (1998) Nucleic Acids Res , vol.26 , pp. 3480-3485
    • Wang, L.1    Hunt, K.E.2    Martin, G.M.3
  • 50
    • 0031792774 scopus 로고    scopus 로고
    • Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53
    • Yamabe Y, Shimamoto A, Goto M, et al. Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53. Mol Cell Biol 1998;18: 6191-200.
    • (1998) Mol Cell Biol , vol.18 , pp. 6191-6200
    • Yamabe, Y.1    Shimamoto, A.2    Goto, M.3
  • 51
    • 0033545238 scopus 로고    scopus 로고
    • Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization
    • Shiratori M, Sakamoto S, Suzuki N et al. Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization. J Cell Biol 1999;144:1-9.
    • (1999) J Cell Biol , vol.144 , pp. 1-9
    • Shiratori, M.1    Sakamoto, S.2    Suzuki, N.3
  • 52
    • 0023712434 scopus 로고    scopus 로고
    • Spontaneous and induced chromosomal instability in Werner syndrome
    • Gebhart E, Bauer R, Raub U et al. Spontaneous and induced chromosomal instability in Werner syndrome. Hum Genet 1998;80:135-139.
    • (1998) Hum Genet , vol.80 , pp. 135-139
    • Gebhart, E.1    Bauer, R.2    Raub, U.3
  • 53
    • 0031453968 scopus 로고    scopus 로고
    • An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants
    • Ogburn CE, Oshima J, Poot M et al. An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. Hum Genet 1997;101:121-125.
    • (1997) Hum Genet , vol.101 , pp. 121-125
    • Ogburn, C.E.1    Oshima, J.2    Poot, M.3
  • 54
    • 0033010781 scopus 로고    scopus 로고
    • Werner syndrome lymphoblastoid cells are sensitive to camptothecin induced apoptosis in S phase
    • Poot M, Gollahon KA, Rabinovitch PS. Werner syndrome lymphoblastoid cells are sensitive to camptothecin induced apoptosis in S phase. Hum Genet 1999;104:10-4.
    • (1999) Hum Genet , vol.104 , pp. 10-14
    • Poot, M.1    Gollahon, K.A.2    Rabinovitch, P.S.3
  • 55
    • 0023052281 scopus 로고
    • Studies on environmental chemical carcinogenesis in Japan
    • Sugimura T. Studies on environmental chemical carcinogenesis in Japan. Science 1986;233:312-318.
    • (1986) Science , vol.233 , pp. 312-318
    • Sugimura, T.1
  • 56
    • 0019507754 scopus 로고
    • Family analysis of Werner's syndrome: A survey of 42 Japanese families with a review of the literature
    • Goto M, Tanimoto K, Horiuchi Y et al. Family analysis of Werner's syndrome: A survey of 42 Japanese families with a review of the literature. Clin Genet 1981;19:8-15.
    • (1981) Clin Genet , vol.19 , pp. 8-15
    • Goto, M.1    Tanimoto, K.2    Horiuchi, Y.3
  • 57
    • 0031561143 scopus 로고    scopus 로고
    • Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients
    • Yamabe Y, Sugimoto M, Satoh M et al. Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients. Biochem Biophys Res Commun 1997;236:151-154.
    • (1997) Biochem Biophys Res Commun , vol.236 , pp. 151-154
    • Yamabe, Y.1    Sugimoto, M.2    Satoh, M.3
  • 58
  • 60
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection and the evolution of senescence
    • Williams GC. Pleiotropy, natural selection and the evolution of senescence. Evolution 1957;11:398-411.
    • (1957) Evolution , vol.11 , pp. 398-411
    • Williams, G.C.1
  • 61
    • 0029920370 scopus 로고    scopus 로고
    • Genetic analysis of ageing: Role of oxidative damage and environmental stresses
    • Martin GM, Austad SN, Johnson TE. Genetic analysis of ageing: Role of oxidative damage and environmental stresses. Nat Genet 1996;13:25-34.
    • (1996) Nat Genet , vol.13 , pp. 25-34
    • Martin, G.M.1    Austad, S.N.2    Johnson, T.E.3
  • 62
    • 0033582750 scopus 로고    scopus 로고
    • Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians
    • Castro E, Ogburn CE, Hunt KE et al. Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians. Am J Med Genet 1999;82: 399-403.
    • (1999) Am J Med Genet , vol.82 , pp. 399-403
    • Castro, E.1    Ogburn, C.E.2    Hunt, K.E.3
  • 63
    • 17344379792 scopus 로고    scopus 로고
    • Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population
    • Ye L, Nakura J, Oshima J et al. Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Am J Med Genet 1997;68:494-498.
    • (1997) Am J Med Genet , vol.68 , pp. 494-498
    • Ye, L.1    Nakura, J.2    Oshima, J.3
  • 64
    • 0028359655 scopus 로고
    • Genetic associations with human longevity at the APOE and ACE loci
    • Schacter F, Faure-Delanef L, Gu'enot F et al. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 1994;6:29-32.
    • (1994) Nat Genet , vol.6 , pp. 29-32
    • Schacter, F.1    Faure-Delanef, L.2    Gu'enot, F.3
  • 65
    • 0028174812 scopus 로고
    • Aging and genetic variation of plasma apolipoproteins: Relative loss of the apolipoprotein E4 phenotype in centenarians
    • Louhija J, Miettinen HE, Kontula K et al. Aging and genetic variation of plasma apolipoproteins: Relative loss of the apolipoprotein E4 phenotype in centenarians. Arterioscler-Thromb 1994;14:1084-1089.
    • (1994) Arterioscler-Thromb , vol.14 , pp. 1084-1089
    • Louhija, J.1    Miettinen, H.E.2    Kontula, K.3
  • 66
    • 0031972522 scopus 로고    scopus 로고
    • Cancer cells exhibit a mutator phenorype
    • Loeb LA. Cancer cells exhibit a mutator phenorype. Adv Cancer Res 1998; 72:25-26.
    • (1998) Adv Cancer Res , vol.72 , pp. 25-26
    • Loeb, L.A.1
  • 67
    • 0032573157 scopus 로고    scopus 로고
    • A deletion within the mutine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
    • USA
    • Lebel M, Leder P. A deletion within the mutine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci USA 1998;95:13097-13102.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 13097-13102
    • Lebel, M.1    Leder, P.2
  • 69
    • 0022839958 scopus 로고
    • Elevation of urinary hyaluronic acid in Werner's syndrome and Progeria
    • Kieras FJ, Brown WT, Houck GE Jr et al. Elevation of urinary hyaluronic acid in Werner's syndrome and Progeria. Biochem Med Metab Bio 1986;36: 276-282.
    • (1986) Biochem Med Metab Bio , vol.36 , pp. 276-282
    • Kieras, F.J.1    Brown, W.T.2    Houck G.E., Jr.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.