The age of cancer

Nature

Volumn 408, Issue 6809, 2000, Pages 248-254

  DePinho, R A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; CANCER; CANCER GENETICS; CANCER INCIDENCE; CARCINOGENESIS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC STABILITY; HUMAN; MUTATION RATE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; TELOMERE;

AGING; ANIMALS; GENOME; HUMANS; INCIDENCE; MICE; NEOPLASMS; TELOMERE;

EID: 0034626769     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35041694     Document Type: Review

References (95)

1. Molecular themes in oncogenesis
2. The clonal evolution of tumor cell populations
3. Genetic alterations during colorectal-tumor development
4. Karyotypic evolution in human malignant melanoma
5. Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer
6. Clonal genomic alterations in glioma malignancy stages
7. Progression to cancer in Barrett's esophagus is associated with genomic instability
8. Aging: A theory based on free-radical and radiation chemistry
9. Oxidants, antioxidants and the degenerative diseases of aging
10. DNA synthesis errors, mutators and cancer
11. A statistical model to estimate variance in long term-low dose mutation assays: Testing of the model in a human lymphoblastoid mutation assay
12. The mutation rate and cancer
13. The age distribution of cancer and a multi-stage theory of carcinogenesis
14. How many mutations are required for tumorigenesis? Implications from human cancer data
15. The hallmarks of cancer
16. Mutator phenotype may be required for multistage carcinogenesis
17. Lessons from hereditary colorectal cancer
18. Genetic instability in colorectal cancers
19. Genome changes and gene expression in human solid tumors
20. The cat and mouse games that genes, viruses, and cells play
21. Estimation of mutation frequencies in normal mammalian cells and the development of cancer
22. Rapid accumulation of genome rearrangements in liver but not in brain of old mice
23. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine
24. Chromosome aberrations in liver cells in relation to the somatic mutation theory of aging
25. Mitotic misregulation and human aging
26. The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting
27. Change of human chromosome count distributions with age: Evidence for a sex difference
28. Frequency of spontaneous chromosome aberrations in mice: Effects of age
29. The effect of donor age on the processing of UV-damaged DNA by cultured human cells: Reduced DNA repair capacity and increased DNA mutability
30. Mechanisms and implications of the age-associated decrease in DNA repair capacity
31. DNA repair response in human epidermal keratinocytes from donors of different age
32. Germ-line msh6 mutations in colorectal cancer families
33. DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
34. Cancer epigenetics comes of age
35. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
36. Aging, DNA methylation and cancer
37. Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1 (AKR) resistance allele
38. Suppression of intestinal neoplasia by DNA hypomethylation
39. CpG methylation is maintained in human cancer cells lacking DNMT1
40. Cellular senescence: Mitotic clock or culture shock?
41. Solid tumor cytogenetics. Progress since 1979
42. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
43. Telomerase activity, cell proliferation, and cancer
44. Telomeres shorten during ageing of human fibroblasts
45. Telomere reduction in human colorectal carcinoma and with ageing
46. Telomere length predicts replicative capacity of human fibroblasts
47. Telomerase activity associated with acquisition of malignancy in human colorectal cancer
48. Hypervariable ultra-long telomeres in mice
49. Developmental and tissue-specific regulation of mouse telomerase and telomere length
50. Telomerase activation in mouse mammary tumors: Lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation
51. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation
52. Expression of mouse telomerase catalytic subunit in embryos and adult tissues
53. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
54. The stability of broken ends of chromosomes in Zea mays
55. Genetic alterations in primary breast cancers and their metastases: Direct comparison using modified comparative genomic hybridization
56. Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways
57. Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases
58. Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis
59. Essential role of mouse telomerase in highly proliferative organs
60. Longevity, stress response, and cancer in aging telomerase-deficient mice
61. Activation of telomerase in a human tumor
62. Two MAD tails: What the recent knockouts of Mad 1 and Mxil tell us about the MYC/MAX/MAD network
63. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
64. Telomere shortening in chronic liver diseases
65. Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis
66. Telomere length in human liver diseases
67. The retinoblastoma protein and cell cycle control
68. Wild-type p53 mediates apoptosis by EIA, which is inhibited by EIB
69. p53-Dependent apoptosis suppresses tumor growth and progression in vivo
70. p53-Dependent apoptosis produced by Rb-deficiency in the developing mouse lens
71. Specific association of human telomerase activity with immortal cells and cancer
72. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
73. Short dysfunctional telomeres impair tumorigenesis in the INK4a(Δ2/3) cancer-prone mouse
74. Creation of human tumour cells with defined genetic elements
75. Flipping the oncogene switch: Illumination of tumor maintenance and regression
76. Essential role for oncogenic RAS in tumour maintenance
77. Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
78. Murine chromosomal regions correlated with longevity
79. Role of mesenchymal-epithelial interactions in mammary gland development
80. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
81. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
82. Microarray analysis of replicative senescence
83. Aging and cancer: The double-edged sword of replicative senescence
84. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
85. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
86. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
87. Matrix metalloprotein-9 triggers the angiogenic switch during carcinogenesis
88. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
89. Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts
90. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
91. DNA methylation: Past, present and future directions
92. Cancer and aging: From the kinetics of biological parameters to the kinetics of cancer incidence and mortality