The Werner syndrome protein: An update

BioEssays

Volumn 22, Issue 10, 2000, Pages 894-901

  Oshima, Junko ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELICASE; WRN PROTEIN, HUMAN;

ANIMAL; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; WERNER SYNDROME;

ANIMAL; DNA HELICASES; HUMAN; SUPPORT, U.S. GOV'T, P.H.S.; WERNER SYNDROME;

ANIMALIA;

EID: 0033771208     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-1878(200010)22:10<894::AID-BIES4>3.0.CO;2-B     Document Type: Review

References (74)

1. Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ
2. Positional cloning of the Werneris syndrome gene
3. The Bloom's syndrome gene product is homologous to RecQ helicases
4. Cloning of two new human helicase genes of the RecQ family: Biological significance of multiple species in higher eukaryotes
5. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome
6. Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationships to the natural aging process
7. Genetic syndromes in man with potential relevance to the pathology of aging
8. Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal aging
9. Bloom's syndrome
10. Rothmund-Thomson syndrome
11. Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationships to the natural aging process
12. Prevalence of Werner's syndrome heterozygotes in Japan
13. Progeria, a model disease for the study of accelerated aging
14. Excess of rare cancers in Werner syndrome (adult progeria)
15. Premature aging in Werner's syndrome spares the central nervous system
16. The Werneris Syndrome Collaborative Group Mutations in the consensus helicase domains of the Werner's syndrome gene
17. Two related superfamilies of putative helicases involved in replication, recombination, repair, and expression of DNA and RNA genomes
18. Positionally cloned human disease genes: Pattern of evolutionary conservation and functional motifs
19. The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains
20. A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases
21. The premature aging syndrome protein, WRN, is a 3i to 5i exonuclease
22. The Werner syndrome protein is a DNA helicase
23. DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system
24. Transcriptional activation by the Werner syndromegene product in yeast
25. The Werner protein is involved in RNA polymerase II transcription
26. Impaired nuclear localization of defective DNA helicases in Werner's syndrome
27. Characterization of the nuclear localization signal in the DNA helicase involved in Werner's syndrome
28. Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence, and stimulation by replication protein A
29. Functional and physical interaction between WRN helicase and human replication protein A
30. Human Werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n
31. Werner syndrome helicase contains a 5'→3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding
32. Werner syndrome protein. II. Characterization of the integral 3'→5' DNA exonuclease
33. Physical and functional interaction between p53 and the Werner's syndrome protein
34. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I
35. Replication focus-forming activity 1 and the Werner syndrome gene product
36. p53-Mediated apoptosis is attenuated in Werner syndrome cells
37. Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors
38. Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53
39. Defending genome integrity during DNA replication: A proposed role for RecQ family helicases
40. WRN mutations in Werner syndrome
41. Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients
42. Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype-phenotype relations to cell type and race
43. Werner helicase is localized to transcriptionally active nucleoli of cycling cells
44. Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization
45. Nucleolar localization of the Werner syndrome protein in human cells
46. An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants
47. Werner helicase expression in human fetal and adult aortas
48. Accelorated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
49. Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus
50. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
51. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
52. Cellular Werner phenotypes in mice expressing dominant negative human WRN gene
53. The recQ gene of Escherichia coli K12: Molecular cloning and isolation of insertion mutants
54. RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli
55. RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination
56. Role of schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance
57. Evolution of the RECQ family of helicases. A drosophila homolog, dmblm, is similar to the human Bloom syndrome gene
58. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases
59. recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli
60. RecQ and RecJ process blocked replication forks prior to the resumption of replication in UV-irradiated Escherichia coli
61. Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts
62. Impaired S-phase transit of Werner syndrome cells expressed in lympohoblastoid cell lines
63. A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture
64. Spontaneous and induced chromosomal instability in Werner syndrome
65. Differential effects of cytotoxic drugs on mortal and immortalized B-lymphoblastoid cell lines from normal and Werner's syndrome patients
66. Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase
67. Enzymatic and DNA binding properties of purified WRN protein: High affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO
68. Evidence against a role for the Werner syndrome gene product in DNA mismatch repair
69. DNA recombination: The replication connection
70. rqh1+, A fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
71. Sgs1: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation
72. Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population
73. A polymorphic variant C1367R of the Werner helicase gene and atherosclerotic diseases in the Japanese population