Multiple roles of the tumor suppressor p53

Current Opinion in Oncology

Volumn 14, Issue 1, 2002, Pages 86-91

  Bargonetti, Jill ^a   Manfredi, James J ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CANCER CELL; DNA REPAIR; GENE ACTIVATION; GENE CONTROL; GROWTH INHIBITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; REVIEW; SENESCENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CELL AGING; CELL DIVISION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION;

EID: 0036145018     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-200201000-00015     Document Type: Review

References (58)

1. Stress signals use multiple pathways to stabilize p53
2. p53 accumulates but is functionally impaired when DNA synthesis is blocked
3. Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
4. DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Set20, requires tetramerization
5. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
6. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
7. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
8. Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase: Effect on Mdm2 binding
9. Phosphorylation of mur ne p53 at ser-18 regulates the p53 responses to DNA damage
10. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
11. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system
12. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
13. Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription
14. Regulation of the specific DNA binding function of p53
15. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1
16. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
17. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
18. The function of PML in p53-dependent apoptosis
19. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
20. Deacetylation of p53 modulates its effect on cell growth and apoptosis
21. Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF
22. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
23. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
24. Regulation of p53 activity in nuclear bodies by a specific PML isoform
25. PML is induced by oncogenic ras and promotes premature senescence
26. BRCA1 physically associates with p53 and stimulates its transcriptional activity
27. BRCA1 regulates p53-dependent gene expression
28. The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter
29. BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer
30. High mobility group protein-1 (HMG-1) is a unique activator of p53
31. Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells
32. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest
33. JunD protects cells from p53-dependent senescence and apoptosis
34. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
35. Cooperative effects of genes controlling the G(2)/M checkpoint
36. p53 downregulates CHK1 through p21 and the retinoblastoma protein
37. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
38. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
39. P53 and PML: New partners in tumor suppression
40. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
41. A transactivation-deficient mouse model provides insights into Trp53 regulation and function
42. Bax-deficient mice with lymphoid hyperplasia and male germ cell death
43. Thymocyte apoptosis induced by p53-dependent and independent pathways
44. p53 is required for radiation-induced apoptosis in mouse thymocytes
45. The combined functions of proapoptotic Bcf-2 family members bak and bax are essential for normal development of multiple tissues
46. Role of BAX in the apoptotic response to anticancer agents
47. Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria
48. Apaf-1 is a transcriptional target for E2F and p53
49. PUMA, a novel proapoptotic gene, is induced by p53
50. PUMA induces the rapid apoptosis of colorectal cancer cells
51. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis
52. A ribonucleotide reductase gene is a transcriptional target of p53 and p73
53. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
54. p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV
55. A role for p53 in base excision repair
56. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
57. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
58. Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study