Identification of a β-secretase activity, which truncates amyloid β-peptide after its presenilin-dependent generation

Journal of Biological Chemistry

Volumn 278, Issue 8, 2003, Pages 5531-5538

  Fluhrer, Regina ^a   Multhaup, Gerd ^b,e   Schlicksupp, Andrea ^b   Okochi, Masayasu ^c   Takeda, Masatoshi ^c   Lammich, Sven ^a   Willem, Michael ^a   Westmeyer, Gil ^a   Bode, Wolfram ^d   Walter, Jochen ^a,f   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^e FREIE UNIVERSITÄT BERLIN   (Germany)

^f UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; GAMMA RAYS; MASS SPECTROMETRY;

PEPTIDES;

PROTEINS;

AMINO ACID; AMYLOID BETA PROTEIN; BETA SECRETASE; GAMMA SECRETASE; PRESENILIN 1; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE2 PROTEIN, HUMAN; BETA SITE APP CLEAVING ENZYME 2; BETA-SITE APP CLEAVING ENZYME 2; MEMBRANE PROTEIN; PROTEINASE; PSEN1 PROTEIN, HUMAN; RECOMBINANT PROTEIN; SECRETASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL CULTURE; CORRELATION ANALYSIS; EMBRYO; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; BIOSYNTHESIS; CELL LINE; CELL MEMBRANE; ENZYME SPECIFICITY; GENETIC TRANSFECTION; GENETICS; KIDNEY; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELL MEMBRANE; ENDOPEPTIDASES; HUMANS; KIDNEY; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PRESENILIN-1; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0037458732     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211485200     Document Type: Article

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