Insulin-degrading enzyme: Embarking on amyloid destruction

Trends in Biochemical Sciences

Volumn 26, Issue 7, 2001, Pages 421-425

  Kurochkin, Igor V ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID PROTEIN; AMYLOID PROTEIN ABRI; ATRIAL NATRIURETIC FACTOR; CALCITONIN; CHAPERONE; GLUCAGON; INSULIN; INSULINASE; METALLOPROTEINASE; PROTEIN MEDIN; PROTEINASE; PROTEINASE III; UNCLASSIFIED DRUG; ZINC;

AMINO ACID SEQUENCE; AMYLOIDOSIS; BETA SHEET; CROSS LINKING; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMYLOID; ANIMALS; EVOLUTION, MOLECULAR; HUMANS; INSULYSIN; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EUKARYOTA; LEUCISCUS IDUS;

EID: 0035399887     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(01)01876-X     Document Type: Review

References (45)

1. The genetics of the amyloidoses
2. Amyloid fibrillogenesis: Themes and variations
3. Posttranslational quality control: Folding, refolding, and degrading proteins
4. Alzheimer's β-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
5. Atrial natriuretic peptide (ANP) is a high-affinity substrate for rat insulin-degrading enzyme
6. Degradation of amylin by insulin-degrading enzyme
7. Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III
8. A high molecular weight metalloendoprotease from the cytosol of mammalian cells
9. The inactivation of insulin by tissue extracts. I. The distribution and properties of insulin inactivating extracts (insulinase)
10. Insulin-degrading enzyme
11. Insulin degradation: Progress and potential
12. Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites
13. Purification and characterization of protease III from Escherichia coli
14. Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme
15. The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts
16. Identification of the metal associated with the insulin degrading enzyme
17. An unusual active site identified in a family of zinc metalloendopeptidases
18. Functional analysis of conserved residues in the active site of insulin-degrading enzyme
19. Identification of glutamate-169 as the third zinc-binding residue in proteinase III, a member of the family of insulin-degrading enzymes
20. Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding
21. Families of zinc metalloproteases
22. An evolutionarily conserved enzyme degrades transforming growth factor-α as well as insulin
23. 2+-dependent ATPase
24. Identification of γ-endorphin-generating enzyme as insulin-degrading enzyme
25. Purification of a protease in red blood cells that degrades oxidatively damaged haemoglobin
26. Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins
27. Identification of insulin intermediates and sites of cleavage of native insulin by insulin protease from human fibroblasts
28. Identification of residues in the insulin molecule important for binding to insulin-degrading enzyme
29. Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme
30. Iatrogenic, insulin-dependent, local amyloidosis
31. Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient
32. Atrial natriuretic peptide deposited as atrial amyloid fibrils
33. Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid
34. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
35. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats
36. Insulysin hydrolyzes amyloid β peptides to products that are neither neurotoxic nor deposit on amyloid plaques
37. Solution conformations and aggregational properties of synthetic amyloid β-peptides of Alzheimer's disease. Analysis of circular dichroism spectra
38. Infrared spectroscopic evidence of conformational transitions of an atrial natriuretic peptide
39. Binding of the dye Congo Red to the amyloid protein pig insulin reveals a novel homology amongst amyloid-forming peptide sequences
40. Degradation of Alzheimer's β-amyloid protein by human and rat brain peptidases: Involvement of insulin-degrading enzyme
41. Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease β A4 peptides
42. A stop-codon mutation in the BRI gene associated with familial British dementia
43. Medin: An integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid
44. Functional human insulin-degrading enzyme can be expressed in bacteria
45. Degradation of intraendosomal insulin by insulin-degrading enzyme without acidification