Generation of C-terminally truncated amyloid-β peptides is dependent on γ-secretase activity

Journal of Neurochemistry

Volumn 82, Issue 3, 2002, Pages 563-575

  Beher, Dirk ^a   Wrigley, Jonathan D J ^a   Owens, Andrew P ^a   Shearman, Mark S ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

APP processing; secretase inhibitor; Alzheimer's disease; Surface enhanced laser desorption ionization time of flight mass spectrometry

Indexed keywords

[[(1 CARBAMOYL 2 PHENYLETHYLCARBAMOYL) 3 METHYLBUTYLCARBAMOYL]HYDROXY 5 PHENYLPENTYL]]CARBAMIC ACID TERT BUTYL ESTER; [[2 (3,5 DIFLUOROPHENYL)ACETYLAMINO]PROPIONYLAMINO] 3 PHENYLPROPIONIC ACID METHYL ESTER; [[2 (3,5 DIFLUOROPHENYL)ACETYLAMINO]PROPIONYLAMINO] 4 METHYLPENTANOIC ACID METHYL ESTER; ALPHA SECRETASE; AMYLOID BETA PROTEIN; BATIMASTAT; DIFLUOROKETONE; ENZYME INHIBITOR; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; METALLOPROTEINASE INHIBITOR; MONOCLONAL ANTIBODY; MW 167; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CELL CULTURE; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MEMBRANE BINDING; NEUROBLASTOMA CELL; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN PROCESSING;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ASPARTIC ENDOPEPTIDASES; CELL LINE; CULTURE MEDIA, CONDITIONED; ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME INHIBITORS; FLUOROBENZENES; HUMANS; KIDNEY; MASS SPECTROMETRY; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; PENTANOIC ACIDS; PEPTIDE FRAGMENTS; PEPTIDES; PHENYLALANINE; RECOMBINANT PROTEINS; THIOPHENES; TRANSFECTION;

EID: 0036322138     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00985.x     Document Type: Article

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