Structural insights into the promiscuity and function of the human pregnane X receptor

Current Opinion in Drug Discovery and Development

Volumn 5, Issue 1, 2002, Pages 150-158

  Watkins, Ryan E ^a   Noble, Schroeder M ^a   Redinbo, Matthew R ^a  

^a The University of North Carolina at Chapel Hill   (United States)

Author keywords

Cytochrome P450; Drug metabolism; Drug recognition; Nuclear receptor; Promiscuity; X ray crystallography

Indexed keywords

CELL NUCLEUS RECEPTOR; COUMESTROL; CYTOCHROME P450 2B6; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DEXAMETHASONE ACETATE; DRUG METABOLIZING ENZYME; HYPERFORIN; HYPOCHOLESTEROLEMIC AGENT; INDINAVIR; MEVINOLIN; MIFEPRISTONE; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; PHENOBARBITAL; PREGNANE X RECEPTOR; RIFAMPICIN; RITONAVIR; SR 12813; TRABECTEDIN; TROGLITAZONE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

BILE ACID METABOLISM; BINDING SITE; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; ENZYME SUBSTRATE COMPLEX; GENE EXPRESSION REGULATION; GENETIC CONSERVATION; LIGAND BINDING; RECEPTOR UPREGULATION; REVIEW; XENOBIOTIC METABOLISM;

ANIMALS; DRUG INTERACTIONS; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS;

EID: 0036240393     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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