메뉴 건너뛰기




Volumn 414, Issue 6865, 2001, Pages 821-827

New drug targets for type 2 diabetes and the metabolic syndrome

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; EPIDEMIOLOGY; GLUCOSE; INSULIN; METABOLISM; MUSCLE; PATHOLOGY;

EID: 0035857020     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/414821a     Document Type: Review
Times cited : (925)

References (77)
  • 3
    • 0032511583 scopus 로고    scopus 로고
    • UK prospective diabetes study 33: Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications with type 2 diabetes
    • (1998) Lancet , vol.352 , pp. 837-853
  • 4
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the National Cholesterol Education Prograto Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
    • (2001) J. Am. Med. Assoc. , vol.285 , pp. 2486-2496
  • 8
    • 0030023775 scopus 로고    scopus 로고
    • The roles of insulin and glucagon in the regulation of hepitic glycogen synthesis and turnover in humans
    • (1996) J. Clin. Invest. , vol.97 , pp. 642-648
    • Roden, M.1
  • 11
    • 0028112003 scopus 로고
    • Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycemia in moderately streptozotocin-diabetic rats
    • (1994) Diabetologia , vol.37 , pp. 985-993
    • Brand, C.L.1
  • 17
    • 3543093167 scopus 로고    scopus 로고
    • Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase
    • (1998) Diabetes , vol.47 , pp. 1630-1636
    • Parker, J.C.1
  • 18
    • 0026110135 scopus 로고
    • Banting Lecture 1990: Beta-cells in type II diabetes mellitus
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte, D.J.1
  • 20
    • 0007866067 scopus 로고    scopus 로고
    • Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide knockout mice
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 14843-14847
    • Miyawaki, K.1
  • 21
    • 0032960834 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans
    • (1999) Diabetes , vol.48 , pp. 86-93
    • Edwards, C.M.1
  • 23
    • 0002444399 scopus 로고    scopus 로고
    • Single dose treatment of diabetic patients by the DP IV inhibitor P32/98
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Demuth, H.-U.1
  • 24
    • 0000496911 scopus 로고    scopus 로고
    • Inhibition of DPPIV by NVP DPP728 improves metabolic control over a 4 week period in type 2 diabetes
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 2
    • Ahren, B.1
  • 25
    • 0033532347 scopus 로고    scopus 로고
    • Discovery of a small molecule insulin mimetic with antidiabetic activity in mice
    • (1999) Science , vol.284 , pp. 974-977
    • Zhang, B.1
  • 27
    • 0029049705 scopus 로고
    • Oral vanadyl sulphate improves hepatic and peripheral insulin sensitivity in patients with non-insulin dependent diabetes mellitus
    • (1995) J. Clin. Invest. , vol.95 , pp. 2501-2509
    • Cohen, N.1
  • 28
    • 0033525870 scopus 로고    scopus 로고
    • Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    • (1999) Science , vol.283 , pp. 1544-1548
    • Elchebly, M.1
  • 29
    • 0002174775 scopus 로고    scopus 로고
    • Treatment of Zucker diabetic fatty rats with antisense oligonucleotide to phosphotyrosine phosphatase-1B for 5 weeks halts development of diabetes
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 2
    • Bush, E.N.1
  • 31
    • 0000947325 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 inhibitors potentiate glucose tolerance and muscle glycogen synthase activity in the Zucker Diabetic Fatty Rat
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 2
    • Henriksen, E.J.1
  • 32
    • 0035804251 scopus 로고    scopus 로고
    • The lipid phosphatase SHIP2 controls insulin sensitivity
    • (2001) Nature , vol.409 , pp. 92-97
    • Clement, S.1
  • 33
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity and diet-induced insulin resistance with salicylates or targeted disruption of lkkβ
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1
  • 40
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1
  • 42
    • 0034733730 scopus 로고    scopus 로고
    • Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
    • (2000) Science , vol.288 , pp. 2379-2381
    • Loftus, T.M.1
  • 43
    • 0026468362 scopus 로고
    • What if Minkowski had been ageusic? An alternative angle on diabetes
    • (1992) Science , vol.258 , pp. 766-770
    • McGarry, J.D.1
  • 45
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1
  • 46
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 47
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • (2000) Mol. Cell , vol.6 , pp. 77-86
    • Shimomura, I.1
  • 48
    • 0035937174 scopus 로고    scopus 로고
    • Liporegulation in diet-induced obesity: The antisteatotic role of hyperleptinemia
    • (2000) J. Biol. Chem. , vol.276 , pp. 5629-5635
    • Lee, Y.1
  • 50
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • (2001) J. Clin. Invest. , vol.108 , pp. 1167-1179
    • Zhou, G.1
  • 54
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 2005-2010
    • Fruebis, J.1
  • 56
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • (2001) Nature Med , vol.7 , pp. 941-946
    • Yamauchi, T.1
  • 59
    • 0020353926 scopus 로고
    • Studies on antidiabetic agents. Synthesis of 5-[4-(1-methylcyclohexylmethoxy) benzyl]thiazolidine-2,4-dione (AD-3878) and its derivatives
    • (1982) Chem. Pharm. Bull. , vol.30 , pp. 3580-3600
    • Sohda, T.1
  • 60
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1
  • 62
    • 0028076266 scopus 로고
    • A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat
    • (1994) Diabetes , vol.43 , pp. 1203-1210
    • Oakes, N.D.1
  • 63
    • 4244083125 scopus 로고    scopus 로고
    • Gene expression profile of adipocyte differentiation and its regulation by PPARγ agonist
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Gerhold, D.1
  • 64
    • 0035905758 scopus 로고    scopus 로고
    • The hormone resistin links obesity to diabetes
    • (2001) Nature , vol.409 , pp. 307-312
    • Steppan, C.M.1
  • 65
    • 0035091701 scopus 로고    scopus 로고
    • Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues
    • (2001) Endocrinology , vol.142 , pp. 1269-1277
    • Way, J.M.1
  • 66
    • 0242641149 scopus 로고    scopus 로고
    • Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists
    • (2001) J. Biol. Chem. , vol.276 , pp. 25651-25653
    • Way, J.M.1
  • 68
    • 0035918143 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte IIβ-hydroxysteroid dehydrogenase type 1 expression and activity
    • (2001) J. Biol. Chem. , vol.276 , pp. 12629-12635
    • Berger, J.1
  • 69
    • 0000743792 scopus 로고    scopus 로고
    • Induction of Acrp30 levels by PPARγ agonists: A potential mechanism of insulin sensitization
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 2
    • Combatsiaris, T.1
  • 70
    • 4244174423 scopus 로고    scopus 로고
    • Putative biomarkers to discriminate the PPARα/γ effects of fenofibrate and rosiglitazone in normal volunteers
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 2
    • Wagner, J.A.1
  • 73
    • 0034595980 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α activators improve insulin sensitivity-and reduce adiposity
    • (2000) J. Biol. Chem. , vol.275 , pp. 16638-16642
    • Guerre-Millo, M.1
  • 74
    • 0035141142 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-α activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 2 , pp. 411-417
    • Ye, J.-M.1
  • 75
    • 0031793850 scopus 로고    scopus 로고
    • A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: Effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats
    • (1998) Diabetes , vol.47 , pp. 1841-1847
    • Murakimi, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.