Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia

American Journal of Physiology - Endocrinology and Metabolism

Volumn 278, Issue 3 41-3, 2000, Pages

  Buettner, Roland ^a   Newgard, Christopher B ^a,b   Rhodes, Christopher J ^a   O'Doherty, Robert M ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Insulin action; Leptin action; Obesity; Tissue triglycerides

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LEPTIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; FAT INTAKE; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0034061685     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.278.3.e563     Document Type: Article

References (33)

1. Barzilai, N., J. Wang, D. Massilon, P. Vuguin, M. Hawkins, and L. Rossetti. Leptin selectively decreases visceral adiposity and enhances insulin action. J. Clin. Invest. 100: 3105-3110, 1997.
2. Bjorntorp, P., and B. N. Brodoff (Editors). Obesity. Philadelphia: Lippincott, 1992.
3. Bray, G. (Editor). Obesity. Endocrinol. Metab. Clin. North Am. 25, 1996.
4. Campfield, L. A., F. J. Smith, Y. Guisez, R. Devos, and P. Burn. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549, 1995.
5. Chen, G., K. Koyama, X. Yuan, Y. Lee, Y. T. Zhou, R. M. O'Doherty, C. B. Newgard, and R. H. Unger. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc. Natl. Acad. Sci. USA 93: 14795-14799, 1996.
6. Frederich, R. C., A. Hamann, S. Anderson, B. Lollman, B. B. Lowell, and J. S. Flier. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Med. 1: 1311-1314, 1995.
7. Friedman, J. M., and J. L. Halaas. Leptin and the regulation of body weight in mammals. Nature 395: 763-770, 1998.
8. Halaas, J. L., C. Boozer, J. Blair-West, N. Fidahusein, D. A. Denton, and J. M. Friedman. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA 94: 8878-8883, 1997.
9. Henriksen, E. J., and M. E. Tischler. Glucose uptake in rat soleus: effect of acute unloading and subsequent reloading. J. Appl. Physiol. 64: 1428-1432, 1988.
10. Herz, J., and R. D. Gerard. Adenovirus-mediated transfer of low density lipoprotein lipase receptor gene acutely accelerates cholesterol clearance in normal mice. Proc. Natl. Acad. Sci. USA 90: 2812-2816, 1993.
11. Heydrick, S. J., D. Jullien, N. Gautier, J. F. Tanti, S. Giorgetti, E. van Obberghen, and Y. Le Marchand-Brustel. Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin resistant mice. J. Clin. Invest. 91: 1358-1366, 1993.
12. Koyama, K., G. Chen, Y. Lee, and R. H. Unger. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinaemia of obesity. Am. J. Physiol. Endocrinol. Metab. 273: E708-E713, 1997.
13. Lee, Y., M. Hirose, J. H. Ohneda, J. H. Johnson, J. D. McGarry, and R. H. Unger. β-Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment of adipocyte-β-cell relationships. Proc. Natl. Acad. Sci. USA 91: 10878-10882, 1994.
14. Matsui, H., K. Okumura, K. Kawakami, M. Hibnio, Y. Toki, and T. Ito. Improved insulin sensitivity by bezafibrate in rats. Relationship to fatty acid composition of skeletal muscle triglycerides. Diabetes 46: 348-353, 1997.
15. McGarry, J. D. Disordered metabolism in diabetes: have we underemphasized the fat cell component? J. Cell. Biochem. 555: 29-38, 1994.
16. Morsy, M. A., M. C. Gu, J. Z. Zhao, D. J. Holder, I. T. Rogers, W. J. Pouch, S. L. Motzel, H. J. Klein, S. K. Gupta, X. Liang, M. R. Tota, C. I. Rosenblum, and C. T. Caskey. Leptin gene therapy and daily protein administration: a comparative study in the ob/ob mouse. Gene Ther. 5: 8-18, 1997.
17. Murphy, J. E., Z. Shangzen, K. Giese, L. T. Williams, J. A. Escobedo, and J. Dwarki. Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin. Proc. Natl. Acad. Sci. USA 94: 13921-13926, 1997.
18. Oakes, N. D., G. J. Cooney, S. Camilleri, D. J. Chisholm, and E. W. Kraegen. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46: 1768-1774, 1997.
19. O'Doherty, R. M., P. R. Anderson, A. Z. Zhao, K. E. Bornfeldt, and C. B. Newgard. Sparing effect of leptin on liver glycogen stores during the fed-to-fasted transition. Am. J. Physiol. Endocrinol. Metab. 277: E544-E550, 1999.
20. Pan, D. A., A. D. Lillioja, M. R. Kriketos, L. A. Baur, A. B. Bogardus, A. B. Jenkins, and L. H. Storlein. Skeletal muscle triglyceride levels are inversely related to insulin action. J. Clin. Invest. 46: 983-987, 1997.
21. Pelleymounter, M. A., M. J. Cullen, M. B. Baker, R. Hecht, D. Winters, T. Boone, and F. Collins. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995.
22. Phillips, D. I. W., S. Caddy, V. Ilic, K. N. Fielding, A. C. Borthwick, and R. Taylor. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45: 947-950, 1996.
23. Randle, P. J., P. B. Garland, C. N. Hales, and E. A. Newsholme. The glucose fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i: 785-794, 1963.
24. Schwartz, M. W., D. G. Baskin, T. R. Bukoski, J. L. Kuijber, D. Foster, G. Lasser, D. E. Prunkard, D. Porte, Jr., S. C. Woods, R. J. Seely, and D. S. Weigle. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45: 531-535, 1996.
25. Shrago, E., G. Woldegiorgis, A. E. Ruoho, and C. C. Di-Russo. Fatty acyl-CoA esters as regulators of cell metabolism. Prostaglandins Leukotrienes Essent. Fatty Acids 52: 163-166, 1995.
26. Sivitz, W. I., S. A. Walsh, D. A. Morgan, M. J. Thomas, and W. G. Haynes. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 138: 3395-3401, 1997.
27. Storlein, L. H., N. D. Oakes, D. A. Pan, M. Kusunoki, and A. B. Jenkins. Syndromes of insulin resistance in the rat. Inducement by diet and amelioration with benfluorex. Diabetes 42: 457-462, 1993.
28. Trinh, K., R. M. O'Doherty, P. R. Anderson, A. J. Lange, and C. B. Newgard. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. J. Biol. Chem. 273: 31615-31620, 1998.
29. Turinsky, J., W. Nagel, J. S. Elmendorf, A. Damrau-Abney, and T. Smith. Sphingomyelinase stimulates 2-deoxyglucose uptake by skeletal muscle. Biochem. J. 313: 215-222, 1996.
30. Van Heek, M., D. S. Compton, C. F. France, R. P. Tedesco, A. B. Fawzi, M. P. Graziano, E. J. Sybertz, C. D. Strader, and H. R. Davis, Jr. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J. Clin. Invest. 99: 385-390, 1997.
31. 125I-leptin administration to ob/ob and dbldb mice. Horm. Metab. Res. 28: 653-658, 1996.
32. Wititsuwannakul, D., and K. Kim. Mechanism of palmitoyl coenzyme A inhibition of liver glycogen synthase. J. Biol. Chem. 252: 7812-7817, 1977.
33. Zierath, J. R., K. L. Houseknecht, L. Gnudi, and B. B. Kahn. High fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect. Diabetes 46: 215-223, 1997.