Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN

Seminars in Immunology

Volumn 14, Issue 1, 2002, Pages 27-36

  Seminario, Maria Cristina ^a   Wange, Ronald L ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Phosphoinositide 3 kinases; Phospholipids; PTEN; Signaling; T cells

Indexed keywords

CHEMOKINE RECEPTOR; CYTOKINE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOLIPID; PLECKSTRIN;

CATALYSIS; CELL PROLIFERATION; CELL SURVIVAL; CHEMOTAXIS; CYTOSKELETON; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; LYMPHOCYTE FUNCTION; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0036201223     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.2001.0339     Document Type: Article

References (79)

1. Synthesis and funcion of 3-phosphorylated inositol lipids
2. Phosphoinositide-3 kinases in T lymphocyte activation
3. Phoxy lipids; revelaing PX domains as phosphoinositide binding modules
4. The role of phosphoinositide 3-kinase lipid products in cell function
5. Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction
6. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
7. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane
8. The T-cell receptor regulates Akt(Protein Kinase B) via a pathway involving Racl and phosphotidylinositide 3-kinase
9. Rho-family GTPases bind to phosphoinositide kinases
10. Activation of phosphoinositide 3-kinase activity by CDC42HS binding to p85
11. New role for Shc in activation of the phosphotidylinositol 3-kinase/Akt pathway
12. The docking molecule Gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines
13. Phosphoinositide 3-kinase: A key biochemical signal for cell migration in response to chemokines
14. Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphotidylinositol 3-kinase
15. Signaling through CD28/CTLA-4 family receptors: Puzzling participation of phosphatidylinositol-3 kinase
16. Deficiency of PTEN in jurkat T cells causes constitutive localization of itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
17. Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to turner generation in vivo
18. Function of PI3K gamma in thymocyte development, T cell activation and neutrophil migration
19. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
20. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
21. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
22. Critical requirement for the membrane proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo
23. Tec kinases: A family with multiple roles in immunity
24. T cell antigen-receptor signal transduction
25. Tec kinases: Modulators of lymphocyte signaling and development
26. Tec kinase signaling in T cells is regulated by phophotidylinositol 3-kinase and the Tec pleckstrin homology domain
27. A novel function for the Tec family tyrosine kinase Itk in activation of beta1 integrins by the T-cell receptor
28. T cell activation and the cytoskeleton
29. Polarized distribution of endogenous Racl and RhoA at the cell surface
30. The Src homology 2 domain of vav is required for its compartmentation in the plasma membrane and activation of c-Jun NH2-terminal kinase 1
31. Regulation of phospholipase C isozymes: Activation of phospholipase Cgamma in the absence of tyrosine phosphorylation
32. 2+ mobilization in antigen-stimulated mast cells
33. 2+ entry mechanism
34. Involvement of phosphatidylinositol 3-kinase in NFAT activation in T cells
35. Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells
36. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the drosophila DSTPK61 kinase
37. Translocation of PDK1 to the plasma membrane is important in allowing PDK1 to activate protein kinase B
38. Role of phosphotidylinostol 3,4,5-triphosphate in regulating the activity and localization of 3-phosphoinositide dependent protein kinase-1
39. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k
40. Phosphorylation and activation of P70S6K by PDK1
41. Ribosomal S6kinase signaling and the control of translation
42. A direct linkage between the phosphoinositide 3-kinase-Akt signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and trasnformed cells
43. The modular phosphorylation and activation of p70(S6K)
44. Mechanism of activation of protein kinase B by insulin and IGF-1
45. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
46. Akt/Protein Kinase B is regulated by antophosphorylation at the hypothetical PDK2 site
47. Akt protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
48. Regulation of cell death protease caspase-9 by phosphorylation
49. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
50. NF-kappa B antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and C-IAP2 to suppress caspase-8 activation
51. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines
52. Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphotidylinositol 3-kinase for ubiquitination in T cells
53. Structure, function and biology of SHIP proteins
54. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
55. A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: Aberrant development and enhanced function of B lymphocytes in SHIP-/- mice
56. CD28 stimulates tyrosine phosphorylation, cellular redistribution and catalytic activity of the inositol lipid 5-phosphatase SHIP
57. The multiple roles of PTEN in tumor suppression
58. Impaired Fas response and autoimmunity in Pten+/- mice
59. Pten is essential for embryonic development and tumour suppression
60. The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells
61. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
62. Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of P27kip1 into cyclin E/cdk2 complexes
63. Transcriptional activation of p21Waf1 by PTEN/MMAC1 tumor suppresor
64. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
65. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
66. Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation
67. Protein kinase B regualtes T lymphocyte survival, nuclear factor kappa B activation, and Bcl-XI levels in vivo
68. Genetic control of cell size
69. The conserved phosphoinositide 3-kinase pathway determines heart size in mice
70. eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
71. TOR signalling and control of cell growth
72. Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
73. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
74. PTEN and integrin signaling in cancer
75. 2+ events and cytoskeletal reorganization
76. Impaired Fas response and autoimmunity in PTEN4+/- mice
77. T cell specific loss of PTEN leads to defects in central and peripheral tolerance
78. Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and Lck signaling
79. The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase