The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase

Molecular and Cellular Biology

Volumn 20, Issue 15, 2000, Pages 5469-5478

  Genot, Elisabeth M ^a,b   Arrieumerlou, Cecile ^c   Ku, Gregory ^d   Burgering, Boudewijn M T ^e   Weiss, Arthur ^d   Kramer, Ijsbrand M ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c Laboratoire d'Immunologie Cellulaire et Tissulaire CNRS URA 625   (France)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVATOR; GUANOSINE TRIPHOSPHATASE; MEMBRANE RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE B; RHO FACTOR; T LYMPHOCYTE RECEPTOR;

ARTICLE; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CHROMONES; CYTOSKELETON; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MORPHOLINES; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; THREONINE; TUMOR CELLS, CULTURED;

EID: 0033912699     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.15.5469-5478.2000     Document Type: Article

References (47)

1. Ahmed, N. N., H. L. Grimes, A. Bellacosa, T. O. Chan, and P. N. Tsichlis. 1997. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA 94:3627-3632.
2. Alessi, D. R., M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, and B. A. Hemmings. 1996. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15:6541-6551.
3. Arrieumerlou, C., E. Donnadieu, P. Brennan, G. Keryer, G. Bismuth, D. A. Cantrell, and A. Trautmann. 1998. Involvement of phosphoinositides 3-kinase and rac in membrane ruffling induced by IL2 in T cells. Eur. J. Immunol. 28:1877-1885.
4. Arudchandran, R., M. J. Brown, M. J. Peirce, J. S. Song, J. Zhang, R. P. Siraganian, U. Blank, and J. Rivera. 2000. The src homology 2 domain of vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1. J. Exp. Med. 191:47-60.
5. Bellacosa, A., T. O. Chan, N. N. Ahmed, K. Datta, S. Malstrom, D. Stokoe, F. McCormick, J. Feng, and P. Tsichlis. 1998. Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17:313-325.
6. Bokoch, G. M., C. J. Vlahos, Y. Wang, U. G. Knaus, and A. E. Traylor-Kaplan. 1996. Rac GTPase interacts specifically with phosphatidylinositol 3-kinase. Biochem. J. 315:775-779.
7. Brennan, P., J. W. Babbage, B. M. T. Burgering, B. Groner, K. Reif, and D. A. Cantrell. 1997. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7:679-689.
8. Burgering, B. M., and P. J. Coffer. 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602.
9. Cantrell, D. A. 1996. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14:259-274.
10. Coffer, P. J., J. Jin, and J. R. Woodgett. 1998. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 335:1-13.
11. De Aos, I. M., H. Metzger, M. Exley, C. E. Dahl, S. Misra, D. Zheng, L. Varticovski, C. Terhorst, and J. Sancho. 1997. Tyrosine phosphorylation of the CD3-epsilon subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells. J. Biol. Chem. 272:25310-25318.
12. Downward, J., J. D. Graves, P. H. Warne, S. Rayter, and D. A. Cantrell. 1990. Stimulation of p21ras upon T-cell activation. Nature 346:719-723.
13. D'souza-schorey, C., B. Boettner, and L. Van Aelst. 1998. Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes. Mol. Cell. Biol. 18:3936-3946.
14. Filippa, N., C. L. Sable, C. Filloux, B. Hemmings, and E. Van Obberghen. 1999. Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol. Cell. Biol. 19:4989-5000.
15. Génot, E., K. Reif, S. Beach, I. M. Kramer, and D. A. Cantrell. 1998. p21ras initiates Rac-1 but not phosphatidylinositol 3-kinase/PKB mediated signaling pathways in T lymphocytes. Oncogene 17:1731-1738.
16. Génot, E., S. Cleverley, S. Henning, and D. A. Cantrell. 1996. Multiple p21ras effector pathways regulate Nuclear Factor of Activated T cell, NFAT. EMBO J. 15:3923-3933.
17. Gold, M. R., M. P. Scheid, L. Santos, M. Dang-Lawson, R. A. Roth, L. Matsuuchi, V. Duronio, and D. L. Krebs. 1999. The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase. J. Immunol. 163:1894-1905.
18. Goldsmith, M. A., D. M. Desai, T. Schultz, and A. Weiss. 1989. Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants. J. Biol. Chem. 264:17190-17197.
19. Keely, P. J., J. K. Westwick, I. P. Whitehead, C. J. Der, and L. Parise. 1997. Cdc42 and Racl induce integrin-mediated cell motility and invasiveness through P1(3)K. Nature 390:632-636.
20. Klippel, A., W. M. Kavanaugh, D. Pot, and L. T. Williams. 1997. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol. Cell. Biol. 17:338-344.
21. Kuhne, M., G. Ku, and A. Weiss. 1999. A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation. J. Biol. Chem. 275:2185-2190.
22. Lamarche, N., N. Tapon, L. Stowers, P. D. Burbelo, P. Aspenstrom, T. Bridges, J. Chant, and A. Hall. 1996. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independent of p65PAK and the JNK/ SAPK MAPkinase cascade. Cell 87:519-529.
23. Manser, E., T. H. Loo, C. G. Koh, Z. S. Zhao, X. Q. Chen, L. Tan, T. Leung, and L. Lim. 1998. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1:183-192.
24. Nobes, C., and A. Hall. 1995. Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular complexes associated with actin stress fibers lamellipodia and filopodia. Cell 81:53-62.
25. Osman, N., H. Turner, S. Lucas, K. Reif, and D. A. Cantrell. 1996. The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor zeta subunits and the CD3 gamma, delta and epsilon chains. Eur. J. Immunol. 26:1063-1068.
26. Reif, K., S. Lucas, and D. A. Cantrell. 1997. A negative role for phosphatidylinositol 3-kinase in T cell antigen receptor function. Curr. Biol. 7:285-293.
27. Reif, K., K. Nobes, G. Thomas, A. Hall, and D. A. Cantrell. 1996. Phosphatidylinositol 3-kinase activates a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6:1445-1455.
28. Reif, K., I. Gout, M. D. Waterfield, and D. A. Cantrell. 1993 Divergent regulation of phosphatidylinositol 3-kinase p85 alpha and p85 beta isoforms upon T cell activation. J. Biol. Chem. 268:10780-10788.
29. Ren, X. D., and M. A. Schwartz. 1998. Regulation of inositol lipid kinases by Rho and Rac. Curr. Opin. Genet. Dev. 8:63-67.
30. Ridley, A. J., H. F. Paterson, C. L. Johneson, D. Dieckman, and A. Hall. 1992. The small GTP-binding protein Rac regulates growth factor induced membrane ruffling. Cell 70:401-410.
31. Rodriguez-Viciana, P., P. Warne, A. Khwaja, M. M. Marte, D. Pappin, P. Das, P. M. Waterfield, A. Ridley, and J. Downward. 1997. Role of phosphoinositide 3-OH kinase in cell transformation and control of the aclin cytoskeleton. Cell 89:457-467.
32. Rodriguez-Viciana, P., P. H. Warne, R. Dhand, B. Vanhaesebroeck, I. Gout, M. J. Fry, M. D. Waterfield, and J. Downward. 1994. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532.
33. Rodriguez-Viciana, P., P. H. Warne, B. Vanhaesebroeck, M. D. Waterfield, and J. Downward. 1996. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J. 15:2442-2451.
34. Stokoe, D. L., R. Stephens, T. Copeland, P. R. Gaffney, C. B. Reese, G. F. Painter, A. B. Holmes, F. McCormick, and P. T. Hawkins. 1997. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277:567-570.
35. Tolias, K, F., L. C. Cantley, and C. L. Carpenter. 1995. Rho family GTPases bind to phosphoinositide kinases. J. Biol. Chem. 270:17656-17659.
36. Van Aelst, L., and C. D'souza-schorey. 1997. Rho GTPases and signaling networks. Genes Dev. 11:2295-2322.
37. Vanhaesebroeck, B., G. Jones, W. E. Alen, D. Zicha, R. Hooshmand-Rad, T. Sawyer, C. Wells, M. Waterfield, and A. Ridley. 1999. Distinct P13K mediate mitogenic signalling and cell migration in macrophages. Nat. Cell. Biol. 1:69-72.
38. Van Weering, D. H., J. De Rooij, B. M. Marte, J. Downward, J. L. Bos, and B. M. Burgering. 1998. Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras. Mol. Cell. Biol. 18:1802-1811.
39. Welch, H., A. Eguinoa, L. R. Stephens, and P. T. Hawkins. 1998. Protein kinase B and Rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway. J. Biol. Chem. 273:11248-11256.
40. Westwick, J. K., Q. T. Lambert, G. J. Clark, M. Symons, L. Van Aelst, R. G. Pestell, and C. J. Der. 1997. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-indepcndent pathways. Mol. Cell. Biol. 17:1324-1335.
41. Whitehead, J. P., S. F. Clark, B. Urso, and D. E. James. 2000. Signalling through the insulin receptor. Curr. Opin. Cell Biol. 12:222-228.
42. Williams, M., J. Simon, C. Arthur, A. Balendran, J. Van der Kaay, A. Poli, P. Coher, and D. Alessi. 2000. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr. Biol. 10:439-448.
43. Wymann, M. P., and L. Pirola. 1998. Structure and function of phosphoinositide 3-kinases. Biochim. Biophys. Acta 1436:127-150.
44. Yablonski, D., L. P. Kane, D. Qian, and A. Weiss. 1998. A Nck-Pak 1 signalling module is required for T cell receptor mediated activation of NFAT, but not of JNK. EMBO J. 17:5647-5657.
45. Yano, S., H. Tokumitsu, and T. R. Soderling. 1998. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396:584-587.
46. Zhang, W., J. Sloan-Lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83-92.
47. Zheng, Y., S. Bagrodia, and R. A. Cerione. 1994. Activation of phosphoinositide 3-kinase activity by Cdc42HS binding to p85. J. Biol. Chem. 269:18727-18730.