T cell activation and the cytoskeleton

Annual Review of Immunology

Volumn 18, Issue , 2000, Pages 165-184

  Acuto, Oreste ^a   Cantrell, Doreen ^b  

^a INSTITUT PASTEUR   (France)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

CD28; Protein kinase C; Protein tyrosine kinases; Rho GTPases; T cell antigen receptor

Indexed keywords

ACTIN; CD28 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOSKELETON; ENZYME ACTIVITY; HUMAN; LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

CYTOSKELETON; HUMANS; LYMPHOCYTE ACTIVATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0034046180     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.18.1.165     Document Type: Review

References (124)

1. Davis SJ, Ikemizu S, Wild MK, van der Merwe PA. 1998. CD2 and the nature of protein interactions mediating cell-cell recognition, Immunol. Rev. 163:217-36
2. Shaw AS, Dustin ML. 1997. Making the T cell receptor go the distance: a topological view of T cell activation. Immunity 6:361-69
3. Cerottini JC, Brunner KT. 1972. Reversible inhibition of lymphocyte-mediated cytotoxicity by cytochalasin B. Nat. New Biol. 237:272-73
4. Kupfer A, Singer SJ. 1989. Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. Annu. Rev. Immunol 7:309-37
5. Serrador JM, Nieto M, Sanchez-Madrid F. 1999. Cytoskeletal rearrangement during migration and activation of T lymphocytes. Trends Cell Biol. 9:228-33
6. Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. 1998. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395:82-86
7. Chu DH, Monta CT, Weiss A. 1998. The Syk family of protein tyrosine kinases in T-cell activation and development. Immunol. Rev. 165:167-80
8. Clements JL, Boerth NJ, Lee JR, Koretzky GA. 1999. Integration of T cell receptor-dependent signaling pathways by adapter proteins. Annu. Rev. Immunol. 17:89-108
9. van Leeuwen JE, Samelson LE. 1999. T cell antigen-receptor signal transduction Curr. Opin. Immunol. 11:242-48
10. Duplay P, Thome M, Herve F, Acuto O. 1994. p561ck interacts via its src homology 2 domain with the ZAP-70 kinase. J. Exp. Med. 179:1163-72
11. Straus DB, Chan AC, Patai B, Weiss A. 1996. SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction. J. Biol. Chem. 271:9976-81
12. Iwashima M, Irving BA, van Oers NS, Chan AC, Weiss A. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263:1136-39
13. Chan AC, Dalton M, Johnson R, Kong GH, Wang T, Thoma R, Kurosaki T. 1995. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J. 14:2499-2508
14. Qian D, Mollenauer MN, Weiss A. 1996. Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling. J. Exp. Med. 183:611-20
15. Mege D, Di Bartolo V, Germain V, Tuosto L, Michel F, Acuto O. 1996. Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways. J. biol. Chem. 271:32644-52
16. Wong J, Straus D, Chan AC. 1998. Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases. Mol. Cell. Biol. 18:2855-66
17. Pelosi M, Di Bartolo V, Mounier V, Mege D, Pascussi JM, Dufour E, Blondel A, Acuto O. 1999. Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck. J. Biol. Chem. 274:14229-37
18. Di Bartolo V, Mege D, Germain V, Pelosi M, Dufour E, Michel F, Magistrelli G, Isacchi A, Acuto O. 1999. Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling. J. Biol. Chem. 274:6285-94
19. Heyeck SD, Wilcox HM, Bunnell SC, Berg LJ. 1997. Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J. Biol. Chem. 272:25401-8
20. Sloan-Lancaster J, Shaw AS, Rothbard JB, Allen PM. 1994. Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy. Cell 79:913-22
21. Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. 1995. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515-18
22. Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. 1997. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185:219-29
23. Scharenberg AM, Lin S, Cuenod B, Yamamura H, Kinet JP. 1995. Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering. EMBO J. 14:3385-94
24. Davis SJ, van der Merwe PA. 1996. The structure and ligand interactions of CD2: implications for T-cell function. Immunol Today 17:177-87
25. Stone JD, Conroy LA, Byth KF, Hederer RA, Howlett S, Takemoto Y, Holmes N, Alexander DR. 1997. Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70. J. Immunol. 158:5773-82
26. Veillette A, Horak ID, Horak EM, Bookman MA, Bolen JB, 1988. Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation. Mol. Cell. Biol. 8:4353-61
27. Weil R, Veillette A. 1994. Intramolecular and extramolecular mechanisms repress the catalytic function of p56lck in resting T-lymphocytes. J. Biol. Chem. 269: 22830-38
28. Janeway CA Jr. 1992. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 10:645-74
29. Hampl J, Chien YH, Davis MM. 1997. CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 7:379-85
30. Garcia KC, Teyton L, Wilson IA. 1999. Structural basis of T cell recognition. Annu. Rev. Immunol. 17:369-97
31. Zamoyska R. 1994. The CD8 coreceptor revisited: one chain good, two chains better. Immunity 1:243-46
32. Thome M, Duplay P, Guttinger M, Acuto O. 1995, Syk and ZAP-70 mediate recruitment of p561ck/CD4 to the activated T cell receptor/CD3/zeta complex. J. Exp. Med. 181:1997-2006
33. Xu H, Littman DR. 1993. A kinaseindependent function of Lck in potentiating antigen-specific T cell activation. Cell 74:633-43
34. Viola A, Salio M, Tuosto L, Linken S, Acuto O, Lanzavecchia A. 1997. Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering. J. Exp. Med. 186:1775-79
35. Scharenberg AM, Kinet JP. 1998. PtdIns-3, 4, 5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. Cell 94:5
36. Debnath J, Chamorro M, Czar MJ, Schaeffer EM, Lenardo MJ, Varmus HE, Schwartzberg PL. 1999. rlk/ TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Mol. Cell. Biol. 19:1498-1507
37. Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR, Sher A, Varmus HE, Lenardo MJ, Schwartzberg PL. 1999. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284:638-41
38. Finco TS, Kadlecek T, Zhang WG, Samelson LE, Weiss A. 1998. LAT is required for TCR-mediated activation of PLC gamma 1 and the Ras pathway. Immunity 9:617-26
39. Zhang WG, Sommers CL, Burshtyn DN, Stebbins CC, DeJarnette JB, Trible RP, Grinberg A, Tsay HC, Jacobs HM, Kessler CM, Long EO, Love PE, Samelson LE. 1999. Essential role of LAT in T cell development. Immunity 10:323-32
40. Clements JL, Yang B, Rossbarta SE, Eliason SL, Hrstka RF, Williamson RA, Koretzky GA. 1998. Requirement for the leukocyte-specific adapter protein slp-76 for normal T-cell development. Science 281:416-19
41. Yablonski D, Kuhne MR, Kadlecek T, Weiss A. 1998. Uncoupling of non-receptor tyrosine kinases from picgamma-1 in an slp-76-deficient T-cell. Science 281:413-16
42. Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83-92
43. Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K. 1999. Grf40, a novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. J. Exp. Med. 189:1383-90
44. Liu SK, Fang N, Koretzky GA, McGlade CJ. 1999. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol. 9:67-75
45. Law CL, Ewings MK, Chaudhary PM, Solow SA, Yun TJ, Marshall AJ, Hood L, Clark EA. 1999. GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. J. Exp. Med. 189:1243-53
46. 2+ , calcineurin, and NF-AT. Cell 96: 611-14
47. Golstein P, Smith ET. 1977. Mechanism of T-cell-mediated cytolysis: the lethal hit stage. Contemp. Top. Immunobiol. 7:273-300
48. Rao A, Luo C, Hogan PG. 1997. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15:707-47
49. Izquierdo Pastor M, Reif K, Cantrell D. 1995. The regulation and function of p21ras during T-cell activation and growth. Immunol. Today 16:159-64
50. Mellor H, Parker PJ. 1998. The extended protein kinase C superfamily. Biochem. J. 332:281-92
51. Newton AC, Johnson JE. 1998. Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. Biochim. Biophys. Acta 1376:155-72
52. Oancea E, Meyer T. 1998. Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell 95:307-18
53. Monks CPF, Kupfer H, Tamir I, Barlow A, Kupfer A. 1997. Selective modulation of protein-kinase C-theta during T-cell activation. Nature 385:83-86
54. Rozengurt E, Sinnett-Smith J, Zugaza JL. 1997. Protein kinase D: a novel target for diacylglycerol and phorbol esters. Biochem. Soc. Trans. 25:565-71
55. Henning SW, Cantrell DA. 1998. GTPases in antigen receptor signalling. Curr. Opin. Immunol. 10:322-29
56. Alberola-Ila J, Hogquist KA, Swan KA, Bevan MJ, Perlmutter RG. 1996. Positive and negative selection invoke distinct signalling pathways. J. Exp. Med. 184:9-18
57. Gartner F, Alt FW, Monroe R, Chu M, Sleckman BP, Davidson L, Swat W. 1999. Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion. Immunity 10:537-46
58. Downward J. 1996. Control of ras activation. Cancer Surv. 27:87-100
59. Cantrell D. 1996. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14:259-74
60. Yablonski D, Kane LP, Qian D, Weiss A. 1998. A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK. EMEO J. 17:5647-57
61. Genot E, Cleverley S, Henning S, Cantrell DA. 1996. Multiple p21ras effector pathways regulate nuclear factor of activated T cells. EMBO J. 15:3923-33
62. Genot E, Reif K, Beach S, Kramer I, Cantrell D. 1998. p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/ PKB, mediated signaling pathways in T lymphocytes. Oncogene 17:1731-38
63. Ward SG, June CH, Olive D. 1996. PI 3-kinase: a pivotal pathway in T cell activation, Immunol. Today 17:187-98
64. Reif K, Nobes CD, Thomas G, Hall A, Cantrell D. 1996. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6:1445-55
65. Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B. 1998. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane. J. Exp. Med. 188:561-75
66. Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC. 1999. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science 283: 393-97
67. Suzuki H, Terauchi Y, Fujiwara M, Aizawa S, Yazaki Y, Kadowaki T, Koyasu S. 1999. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science 283:390-92
68. Rameh LE, Arvidsson A-K, Carraway KL, Couvillon AD, Rathbun G, Crompton A, VanRenterghem B, Czech M-P, Ravichandran KS, Burakoff SJ, Wang D-S, Chen C-S, Cantley LC. 1997. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J. Biol. Chem. 272:22059-66
69. Holland S, Pearse RN, Kurosaki T, Ravetch JV. 1998. SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity 8:509-16
70. Reif K, Burgering BMT, Cantrell DA. 1997. Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase. J. Biol. Chem. 272:14426-38
71. Alessi DR, Cohen P. 1998. Mechanism of activation and function of protein kinase B. Curr. Opin. Genet. Dev. 8:55-62
72. Coffer PJ, Jin J, Woodgett JR. 1998. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 335:1-13
73. Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P. 1998. Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17:313-25
74. Brennan P, Babbage JW, Burgering BM, Groner B, Reif K, Cantrell DA. 1997. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7:679-89
75. Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR. 1997. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275:1930-34
76. Cerione R, Zheng Y. 1996. The Dbl family of oncogenes. Curr. Opin. Cell Biol. 8:216-22
77. Nobes C, Hall A. 1995. Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibres, lamellipodia and filopodia. Cell 81:53-62
78. Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidson L, Lewis RS, Alt FW, Crabtree GR. 1998. Defects in actincap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr. Biol. 8:563-72
79. Fischer K-D, Kong Y-Y, Nishina H, Tedford K, Marengere LEM, Kozieradzki I, Sasaki T, Starr M, Chan G, Gardener S, Nghiem MP, Bouchard D, Barbacid M, Bernstein A, Penninger JM. 1998. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol. 8:554-62
80. Kirchhausen T, Rosen FS. 1996. Disease mechanism: unravelling Wiskott-Aldrich syndrome. Curr. Biol. 6:676-78
81. Snapper SB, Rosen FS. 1999. The Wiskott-Aldrich Syndrome Protein (WASP): roles in signaling and cytoskeletal organization. Annu. Rev. Immunol. 17:905-29
82. Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW. 1999. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 97:221-31
83. Machesky LM, Gould KL. 1999. The Arp2/3 complex: a multifunctional actin organizer. Curr. Opin. Cell Biol. 11:117-21
84. Stowers L, Yelon D, Berg LJ, Chant J. 1995. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl. Acad. Sci. USA 92:5027-31
85. Parsey MV, Lewis GK. 1993. Actin polymerization and pseudopod reorganization accompany anti-CD3-induced growth arrest in Jurkat T cells. J. Immunol. 151:1881-93
86. Lowin-Kropf B, Shapiro VS, Weiss A. 1998. Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism. J. Cell Biol. 140:861-71
87. Kaga S, Ragg S, Rogers KA, Ochi A. 1998. Stimulation of CD28 with B7-2 promotes focal adhesion-like cell contacts where Rho family small G proteins accumulate in T cells. J. Immunol. 160:24-27
88. Donnadieu E, Bismuth G, Trautmann A. 1994. Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium. Curr. Biol. 4:584-95
89. Negulescu PA, Krasieva TB, Khan A, Kerschbaum HH, Cahalan MD. 1996. Polarity of T cell shape, motility, and sensitivity to antigen. Immunity 4:421-30
90. 2+ responses triggered in T cells by dendritic cells compared with B cells. J. Exp. Med. 188:1473-84
91. Delon J, Bercovici N, Liblau R, Trautmann A. 1998. Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response. Eur. J. Immunol. 28:716-29
92. Montes M, McIlroy D, Hosmalin A, Trautmann A. 1999. Calcium responses elicited in human T cells and dendritic cells by cell-cell interaction and soluble ligands. Int. Immunol. 11:561-68
93. Hauss P, Selz F, Cavazzana-Calvo M, Fischer A. 1995. Characteristics of antigen-independent and antigen-dependent interaction of dendritic cells with CD4 + T cells. Eur. J. Immunol. 25:2285-94
94. Matzinger P. 1998. An innate sense of danger. Semin, Immunol. 10: 399-415
95. Valitutti S, Dessing M, Aktories K, Gallati H, Lanzavecchia A. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181:577-84
96. Davis MM, Boniface JJ, Reich Z, Lyons D, Hampl J, Arden B, Chien Y-h. 1998. Ligand recognition by aβ T cell receptors. Annu. Rev. Immunol, 16:523-44
97. Nunes JA, Collette Y, Truneh A, Olive D, Cantrell DA. 1994. The role of p21ras in CD28 signal transduction: Triggering of CD28 with antibodies, but not the ligand B7-1 activates p21ras. J. Exp. Med. 180:1067-76
98. Tuosto L, Michel F, Acuto O. 1996. p95vav associates with tyrosine-phosphorylated SLP-76 in antigenstimulated T cells. J. Exp. Med. 184:1161-66
99. Michel F, Grimaud L, Tuosto L, Acuto O. 1998. Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells. J. Biol. Chem. 273:31932-38
100. Tuosto L, Acuto O. 1998. CD28 affects the earliest signaling events generated by TCR engagement. Eur. J. Immunol. 28:2131-42
101. Viola A, Lanzavecchia A. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104-6
102. Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A. 1999. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283: 680-82
103. Bachmann MF, McKall-Faienza K, Schmits R, Bouchard D, Beach J, Speiser DE, Mak TW, Ohashi PS. 1997. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 7:549-57
104. Wu J, Motto DG, Koretzky GA, Weiss A. 1996. Vav and SLP-76 interact and functionally cooperate in JL-2 gene activation. Immunity 4:593-602
105. Wardenburg JB, Pappu R, Bu JY, Mayer B, Chernoff J, Straus D, Chan AC. 1998. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity 9:607-16
106. Sanders LC, Matsumura F, Bokoch GM, de Lanerolle P. 1999. Inhibition of myosin light chain kinase by p21-activated kinase. Science 283:2083-85
107. Rottner K, Hall A, Small JV. 1999. Interplay between Rac and Rho in the control of substrate contact dynamics. Curr. Biol. 9:640-48
108. Dustin ML, Bromley SK, Kan Z, Peterson DA, Unanue ER. 1997. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc. Natl. Acad. Sci. USA 94:3909-13
109. Grakoui A, Bromley SK, Sumen C, Davis MM, SA, Allen PM, Dustin ML. 1999. The immunological synapse: a molecular mechanism machine controlling T cell activation. Science 285: In press
110. Hotchin NA, Hall A. 1995. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell. Biol. 131:1857-65
111. Bretscher A. 1999. Regulation of cortical structure by the ezrin-radixin-moesin protein family. Curr. Opin. Cell Biol. 11:109-16
112. Montixi C, Langlet C, Bernard AM, Thimonier J, Dubois C, Wurbel MA, Chauvin JP, Pierres M, He HT. 1998. Engagement of T cell receptor triggers its recruitment to low-density detergentinsoluble membrane domains. EMBO J. 17:5334-48
113. Xavier R, Brennan T, Li QQ, McCormack C, Seed B. 1998. Membrane compartmentation is required for efficient T cell activation. Immunity 8:723-32
114. Simons K, Ikonen E. 1997. Functional rafts in cell membranes. Nature 387:569-72
115. Kabouridis PS, Magee AL, Ley SC. 1997. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J. 16:4983-98
116. Zhang W, Trible RP, Samelson LE. 1998. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 9:239-46
117. Stauffer TP, Meyer T. 1997. Compartmentalized IgE receptor-mediated signal transduction in living cells. J. Cell Biol. 139:1447-54
118. Xavier R, SeedB. 1999. Membrane compartmentation and the response to antigen. Curr. Opin. Immunol. 11:265-69
119. Jacobson K, Dietrich C. 1999. Looking at lipid rafts? Trends Cell Biol. 9:87-91
120. Moran M, Miceli MC. 1998. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: a role for lipid rafts in T cell activation. Immunity 9:787-96
121. Harder T, Simons K. 1999. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur. J. Immunol. 29:556-62
122. Powell JD, Ragheb JA, KitagawaSakakida S, Schwartz RH. 1998. Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy. Immunol Rev. 165:287-300
123. Teh SJ, Killeen N, Tarakhovsky A, Littman DR, Teh HS. 1997. CD2 regulates the positive selection and function of antigen-specific CD4-CD8 + T cells. Blood 89:1308-18
124. Dubey C, Croft M, Swain SL. 1995. Costimulatory requirements of naive CD4 + T cells. ICAM-1 or B7-1 cancostimulate naive CD4 T cell activation but both are required for optimum response. J. Immu-nol. 155:45-57