Tec kinases: Modulators of lymphocyte signaling and development

Current Opinion in Immunology

Volumn 13, Issue 3, 2001, Pages 317-325

  Lewis, Carol M ^a,b   Broussard, Christine ^a   Czar, Michael J ^a   Schwartzberg, Pamela L ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHOLIPASE C; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE TEC; UNCLASSIFIED DRUG;

B LYMPHOCYTE; CELL MATURATION; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0035366249     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00221-1     Document Type: Review

References (65)

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5. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
6. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK - Functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
7. Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment
8. Interaction of SLP adaptors with the SH2 domain of tec family kinases
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11. Signaling network of the btk family kinases
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14. Tec kinases: A family with multiple roles in immunity
15. PtdIns-3,4,5-P3: A regulatory nexus between tyrosine kinases and sustained calcium signals
16. Regulation of a PH-domain-containing tyrosine kinase Etk by Focal Adhesion Kinase through the FERM domain
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18. Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the tec pleckstrin homology domain
19. Xid-like phenotypes: A B cell signalosome takes shape
20. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
21. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
22. The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro
23. A specific intermolecular association between the regulatory domains of a Tec family kinase
24. Rlk/Txk encodes two forms of a novel cysteine-string tyrosine kinase activated by Src family kinases
25. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes
26. Nucleocytoplasmic shuttling of Bruton's tyrosine kinase
27. Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase
28. The transcription factor bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease
29. Pleckstrin homology domains of tec family protein kinases
30. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk
31. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
32. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity
33. Phosphoinositide-specific phospholipase C and mitogenic signaling
34. A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection
35. Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase
36. Association of Grb2, Gads, and phospholipase C-γ1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling
37. RasGRP links T-cell receptor signaling to Ras
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39. Involvement of LAT, gads, and grb2 in compartmentation of SLP-76 to the plasma membrane
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41. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase
42. TCR/CD3-Induced activation and binding of Emt/Itk to linker of activated T cell complexes: Requirement for the Src homology 2 domain
43. Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells
44. Inaugural article: T-cell receptor antagonists induce vav phosphorylation by selective activation of fyn kinase
45. The role of Tec protein-tyrosine kinase in T cell signaling
46. Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors
47. Drosophila ring canal growth requires Src and Tec kinases
48. Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases
49. Pleckstrin homology domains interact with filamentous actin
50. Involvement of Wiskott-Aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway
51. Identification of Itk/Tsk Src homology 3 domain ligands
52. Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation
53. Phospholipase C-γ2 couples Bruton's tyrosine kinase to the NF-kappa B signaling pathway in B lymphocytes
54. Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells
55. BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement
56. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation
57. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex
58. Severe B cell deficiency in mice lacking the tec kinase family members tec and Btk
59. An essential role for BLNK in human B cell development
60. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice
61. Tec family kinases modulate thresholds for thymocyte development and selection
62. A novel function for the Tec family tyrosine kinase Itk in activation of beta1 integrins by the T-cell receptor
63. MEKK2 associates with the adapter protein Lad/RIBP, and regulates the MEK5-BMK1/ERK5 pathway
64. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation
65. Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase