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Volumn 6, Issue 19, 2001, Pages 1005-1024

Tumor angiogenesis as a therapeutic target

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 3 (4 BROMO 2,6 DIFLUOROBENZYLOXY) 5 [3 [4 (1 PYRROLIDINYL)BUTYL]UREIDO] 4 ISOTHIAZOLECARBOXAMIDE; 3 [(4,5 DIMETHYL 1H PYRROL 2 YL)METHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; 4 DEDIMETHYLAMINOSANCYCLINE; ANGIOGENESIS INHIBITOR; ANGIOSTATIN; CGS 27023A; CH 4815; CP 564959; D 1927; ENDOSTATIN; FUMAGILLOL CHLOROACETYLCARBAMATE; GW 2286; MARIMASTAT; METALLOPROTEINASE INHIBITOR; N (4 BROMO 2 FLUOROPHENYL) 6 METHOXY 7 [2 (1H 1,2,3 TRIAZOL 1 YL)ETHOXY] 4 QUINAZOLINAMINE; NSC 683551; OPB 3206; PD 173074; PRINOMASTAT; PROTEIN TYROSINE KINASE INHIBITOR; REBIMASTAT; SOLIMASTAT; SQUALAMINE; TANOMASTAT; THALIDOMIDE; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VATALANIB;

EID: 0035479234     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(01)01939-0     Document Type: Review
Times cited : (124)

References (208)
  • 1
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • (1995) Nat. Med. , vol.1 , pp. 27-31
    • Folkman, J.1
  • 2
    • 84975525035 scopus 로고
    • Seminars in medicine of the Beth Israel Hospital, Boston: clinical applications of research on angiogenesis
    • (1995) New Engl. J. Med. , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 4
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 6
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • (1999) Oncogene , vol.18 , pp. 5356-5362
    • Holash, J.1
  • 7
    • 0034638923 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis
    • (2000) Oncogene , vol.19 , pp. 6122-6129
    • Saaristo, A.1
  • 8
    • 0028899424 scopus 로고
    • Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation
    • (1995) J. Biol. Chem. , vol.270 , pp. 6729-6733
    • Guo, D.1
  • 10
    • 0027288863 scopus 로고
    • Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family
    • (1993) Oncogene , vol.8 , pp. 1631-1637
    • Maisonpierre, P.C.1
  • 11
    • 0030460424 scopus 로고    scopus 로고
    • Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    • (1996) Cell , vol.87 , pp. 1161-1169
    • Davis, S.1
  • 12
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1
  • 13
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1
  • 14
    • 0030851764 scopus 로고    scopus 로고
    • Signaling vascular morphogenesis and maintenance
    • (1997) Science , vol.277 , pp. 48-50
    • Hanahan, D.1
  • 15
    • 0034648793 scopus 로고    scopus 로고
    • Vascular-specific growth factors and blood vessel formation
    • (2000) Nature , vol.407 , pp. 242-248
    • Yancopoulos, G.D.1
  • 16
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • (1999) Oncogene , vol.18 , pp. 5356-5362
    • Holash, J.1
  • 17
    • 0032577571 scopus 로고    scopus 로고
    • Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border
    • (1998) Cell , vol.93 , pp. 661-664
    • Yancopoulos, G.D.1
  • 18
    • 0033135876 scopus 로고    scopus 로고
    • Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
    • (1999) Genes Dev. , vol.13 , pp. 1055-1066
    • Gale, N.W.1    Yancopoulos, G.D.2
  • 19
    • 0032480889 scopus 로고    scopus 로고
    • Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2
    • (1998) Nature , vol.396 , pp. 486-491
    • Himanen, J.P.1
  • 20
    • 0033524982 scopus 로고    scopus 로고
    • Oligomeric structure of the human EphB2 receptor SAM domain
    • (1999) Science , vol.283 , pp. 833-836
    • Thanos, C.D.1
  • 21
    • 0032837028 scopus 로고    scopus 로고
    • Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials
    • (1999) Ann. New York Acad. Sci. , vol.878 , pp. 236-270
    • Shalinsky, D.R.1
  • 22
    • 0000456939 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors
    • Teicher B.A. (Ed.), Antiangiogenic Agents in Cancer Therapy, Humana Press
    • (1999) , pp. 205-223
    • Brown, P.D.1    Whittaker, M.2
  • 24
    • 0028362876 scopus 로고
    • Requirement of vascular integrin for angiogenesis
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1
  • 25
    • 0028670833 scopus 로고
    • 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1
  • 29
    • 0032792360 scopus 로고    scopus 로고
    • The rationale and future potential of angiogenesis inhibitors in neoplasia
    • (1999) Drugs , vol.58 , pp. 17-38
    • Gasparini, G.1
  • 32
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1
  • 34
    • 0031957879 scopus 로고    scopus 로고
    • Current progress towards the development of tyrosine kinase inhibitors as anticancer agents
    • (1998) Emerg. Drugs , vol.3 , pp. 279-292
    • Bridges, A.J.1
  • 37
    • 19244370071 scopus 로고    scopus 로고
    • Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases
    • (1999) J. Med. Chem. , vol.42 , pp. 5120-5130
    • Sun, L.1
  • 39
    • 0033103867 scopus 로고    scopus 로고
    • Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis
    • (1999) Structure , vol.7 , pp. 319-330
    • McTigue, M.A.1
  • 40
    • 0033525530 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues
    • (1999) J. Biol. Chem. , vol.274 , pp. 6453-6460
    • Kendall, R.L.1
  • 41
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • (1999) Cancer Res. , vol.59 , pp. 99-106
    • Fong, T.A.1
  • 42
    • 0033229939 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas
    • (1999) Cancer Res. , vol.59 , pp. 5536-5541
    • Angelov, L.1
  • 43
    • 0033231069 scopus 로고    scopus 로고
    • Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis
    • (1999) Cancer Res. , vol.59 , pp. 5412-5416
    • Shaheen, R.M.1
  • 44
    • 0032761526 scopus 로고    scopus 로고
    • Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy
    • (1999) Invest. New Drugs , vol.17 , pp. 121-135
    • Dimitroff, C.J.1
  • 45
    • 0003668889 scopus 로고    scopus 로고
    • Wood, J. et al. (1998) Pharmacological profile of a potent and orally active inhibitor of VEGF receptor tyrosine kinases. Proc. Am. Soc. Cancer Res. 39 (Abstract no. 655)
  • 46
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • (2000) Cancer Res. , vol.60 , pp. 2178-2189
    • Wood, J.1
  • 47
    • 0033947625 scopus 로고    scopus 로고
    • New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis
    • (2000) J. Med. Chem. , vol.43 , pp. 2310-2323
    • Bold, G.1
  • 48
    • 0030945871 scopus 로고    scopus 로고
    • Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
    • (1997) Science , vol.276 , pp. 955-960
    • Mohammadi, M.1
  • 49
    • 0032531929 scopus 로고    scopus 로고
    • Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
    • (1998) EMBO J. , vol.17 , pp. 5896-5904
    • Mohammadi, M.1
  • 51
    • 14444281388 scopus 로고    scopus 로고
    • Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors
    • (1997) J. Med. Chem. , vol.40 , pp. 2296-2303
    • Hamby, J.M.1
  • 52
    • 0031821631 scopus 로고    scopus 로고
    • In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase
    • (1998) J. Pharmacol. Exp. Ther. , vol.286 , pp. 569-577
    • Panek, R.L.1
  • 56
    • 0001183851 scopus 로고    scopus 로고
    • Batimastat and Marimastat in cancer: summary of early clinical trials
    • Teicher B.A. (Ed.), Antiangiogenic Agents in Cancer Therapy, Humana Press
    • (1999) , pp. 399-405
    • Rasmussen, H.S.1
  • 57
    • 15644374838 scopus 로고    scopus 로고
    • Discovery of CGS27023A, a non-peptidic, potent and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits
    • (1997) J. Med. Chem. , vol.40 , pp. 2525-2532
    • MacPherson, L.J.1
  • 58
    • 0003501562 scopus 로고    scopus 로고
    • Wood, J.M. et al. (1998) CGS 27023A, a potent and orally active matrix metalloprotease inhibitor with antitumor activity. Proc. Am. Assoc. Cancer Res. 39 (Abstract no. 567)
  • 59
    • 0032791421 scopus 로고    scopus 로고
    • Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1905-1917
    • Shalinsky, D.R.1
  • 60
    • 0032449008 scopus 로고    scopus 로고
    • Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations
    • (1999) Invest. New Drugs , vol.16 , pp. 303-316
    • Shalinsky, D.R.1
  • 61
    • 0003576137 scopus 로고    scopus 로고
    • Hibner, B. et al. (1998) BAY 12-9566, a novel, biphenyl matrix metalloproteinase inhibitor, demonstrates anti-invasive and anti-angiogenic properties. Proc. Am. Assoc. Cancer Res. 39 (Abstract no. 2063)
  • 62
    • 0003503650 scopus 로고    scopus 로고
    • Flynn, C.C. et al. (1998) Anti-metastatic activity of BAY 12-9566 in a human colon carcinoma HCT116 orthotopic model. Proc. Am. Assoc. Cancer Res. 39 (Abstract no. 2057)
  • 63
    • 0033986165 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies
    • (2000) J. Clin. Oncol. , vol.18 , pp. 178-186
    • Rowinsky, E.K.1
  • 64
    • 0032832479 scopus 로고    scopus 로고
    • Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance
    • (1999) J. Biol. Chem. , vol.274 , pp. 29568-29571
    • O'Reilly, M.S.1
  • 65
    • 0025204095 scopus 로고
    • Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth
    • (1990) Nature , vol.348 , pp. 555-557
    • Ingber, D.1
  • 66
    • 0028013224 scopus 로고
    • Cytostatic inhibition of endothelial cell growth by the angiogenesis TNP-470 (AGM-1470)
    • (1994) Br. J. Cancer , vol.69 , pp. 212-216
    • Kusaka, M.1
  • 68
    • 0030452904 scopus 로고    scopus 로고
    • Inhibition of lymphatic metastasis in a syngeneic rat fibrosarcoma model by an angiogenesis inhibitor, AGM-1470
    • (1996) Invasion Metastasis , vol.16 , pp. 73-82
    • Futami, H.1
  • 69
    • 0030586076 scopus 로고    scopus 로고
    • The angiogenesis inhibitor TNP-470 (AGM-1470) improves long-term survival of rats with liver metastasis
    • (1996) J. Surg. Res. , vol.64 , pp. 35-41
    • Ahmed, M.H.1
  • 70
    • 0029972404 scopus 로고    scopus 로고
    • Effects of AGM-1470 and pentosan polysulfate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells
    • (1996) Br. J. Cancer , vol.73 , pp. 1053-1062
    • McLeskey, S.W.1
  • 72
    • 0033617532 scopus 로고    scopus 로고
    • Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
    • (1999) Science , vol.284 , pp. 808-812
    • Bergers, G.1
  • 73
    • 0031036591 scopus 로고    scopus 로고
    • The increase of apoptosis and the decrease of proliferation by angiogenesis inhibitor in rat mammary-tumors
    • (1997) Oncol. Res. , vol.4 , pp. 111-114
    • Saji, S.1
  • 74
    • 0028305809 scopus 로고
    • Potentiation of cytotoxic cancer therapy by TNP-470 alone and with other anti-angiogenic agents
    • (1994) Int. J. Cancer , vol.57 , pp. 920-925
    • Teicher, B.A.1
  • 75
    • 0030989933 scopus 로고    scopus 로고
    • Increased growth and incidence of lymph node metastases due to the angiogenesis inhibitor AGM-1470
    • (1997) Br. J. Cancer , vol.75 , pp. 1730-1734
    • Hori, K.1
  • 76
    • 0031171961 scopus 로고    scopus 로고
    • Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin
    • (1997) Chem. Biol. , vol.4 , pp. 461-471
    • Griffith, E.C.1
  • 77
    • 0028176358 scopus 로고
    • A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells
    • (1994) Cancer Res. , vol.54 , pp. 3407-3412
    • Abe, J.1
  • 79
    • 0003460126 scopus 로고    scopus 로고
    • Thalidomide and analogs
    • Teicher B.A. (Ed.), Antiangiogenic Agents in Cancer Therapy, Humana Press
    • (1999) , pp. 263-274
    • Udagawa, T.1
  • 80
    • 0029087486 scopus 로고
    • Effect of thalidomide on tumor necrosis factor production and antitumor activity induced by 5,6-dimethylxanthenone-4-acetic acid
    • (1995) Br. J. Cancer , vol.72 , pp. 339-343
    • Ching, L.M.1
  • 81
    • 0030915633 scopus 로고    scopus 로고
    • Thalidomide and chemotherapy combination: preliminary results of preclinical and clinical studies
    • (1997) Int. J. Oncol. , vol.10 , pp. 965-969
    • Nguyen, M.1
  • 82
    • 0032889225 scopus 로고    scopus 로고
    • Combination oral antiangiogenic therapy with thalidomide and sulindac inhibits tumour growth in rabbits
    • (1999) Br. J. Cancer , vol.79 , pp. 114-118
    • Verheul, H.M.1
  • 83
    • 0029925419 scopus 로고    scopus 로고
    • Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade
    • (1996) Immunopharmacology , vol.31 , pp. 213-221
    • Geitz, H.1
  • 85
    • 0000074961 scopus 로고    scopus 로고
    • Squalamine: a new angiostatic steroid
    • Teicher B.A. (Ed.), Antiangiogenic Agents in Cancer Therapy, Humana Press
    • (1999) , pp. 153-174
    • Williams, J.I.1
  • 87
    • 0033376890 scopus 로고    scopus 로고
    • Potentiation of platinum effects in human lung tumor xenografts by the angiogenesis inhibitor squalamine: effects of tumor neovascularization
    • (1999) Clin. Cancer Res. , vol.5 , pp. 4287-4294
    • Schiller, J.H.1
  • 89
    • 0027970092 scopus 로고
    • Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.S.1
  • 90
    • 4244082524 scopus 로고    scopus 로고
    • Angiostatin protein and other plasminogen fragments
    • Teicher B.A. (Ed.), Antiangiogenic Agents in Cancer Therapy, Humana Press
    • (1999) , pp. 225-236
    • Sim, B.K.L.1
  • 92
    • 0030935029 scopus 로고    scopus 로고
    • A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer
    • (1997) Cancer Res. , vol.57 , pp. 1329-1334
    • Sim, B.K.L.1
  • 93
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    • (1997) Cell , vol.88 , pp. 277-285
    • O'Reilly, M.S.1
  • 94
    • 0003092713 scopus 로고    scopus 로고
    • Angiostatin and Endostatin: endothelial cell-specific endogenous inhibitors of angiogenesis and tumor growth
    • (1998) Angiogenesis , vol.2 , pp. 37-48
    • Sim, B.K.L.1
  • 96
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • (1997) Nature , vol.390 , pp. 404-407
    • Boehm, T.1
  • 97
    • 0032848409 scopus 로고    scopus 로고
    • Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and metastases in a pre-clinical model
    • (1999) J. Urol. , vol.161 , pp. 960-963
    • Melnyk, O.1
  • 98
    • 0027437920 scopus 로고
    • The combination of antiangiogenic agents to inhibit primary tumor growth and metastasis
    • (1993) J. Pediatr. Surg. , vol.28 , pp. 1253-1257
    • Brem, H.1
  • 99
    • 0024343441 scopus 로고
    • Treatment of haemangioendotheliomas with alpha interferon
    • (1989) Lancet , vol.2 , pp. 565-567
    • Orchard, P.J.1
  • 100
  • 101
    • 0031406307 scopus 로고    scopus 로고
    • Antiangiogenic drugs as a novel anticancer therapeutic strategy. Which are the more promising agents? What are the clinical developments and indications?
    • (1997) Crit. Rev. Oncol. Hematol. , vol.26 , pp. 147-162
    • Gasparini, G.1
  • 102
    • 0030722076 scopus 로고    scopus 로고
    • Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis
    • (1997) Am. J. Pathol. , vol.151 , pp. 1417-1423
    • Pezzella, F.1
  • 104
    • 17544387877 scopus 로고    scopus 로고
    • Design and structure-activity relationship of a new class of potent VEGF receptor-tyrosine kinase inhibitors
    • (1999) J. Med. Chem. , vol.42 , pp. 5369-5389
    • Hennequin, L.F.1
  • 105
    • 0034652716 scopus 로고    scopus 로고
    • ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy
    • (2000) Cancer Res. , vol.60 , pp. 970-975
    • Wedge, S.R.1
  • 106
    • 0003501956 scopus 로고    scopus 로고
    • Rakesh, K. et al. (2001) An orally active inhibitor of VEGF receptor tyrosine kinase with potent anti-tumor activity. Proc. Am. Assoc. Cancer Res. 42, 587 (Abstract no. 3154)
  • 107
    • 0003654685 scopus 로고    scopus 로고
    • Bilodeau, M.T. et al. (2001) Design and synthesis of 1,5-Diarylbenzimidazoles as inhibitors of VEGF-receptor KDR. Am. Chem. Soc. 221st MEDI-147
  • 110
  • 111
    • 0033559205 scopus 로고    scopus 로고
    • Correlation of antiangiogenic and antitumor efficacy of N-biphenyl sulfonyl-phenylalanine hydroxiamic acid (BPHA), an orally-active, selective matrix metalloproteinase inhibitor
    • (1999) Cancer Res. , vol.59 , pp. 1231-1235
    • Maekawa, R.1
  • 112
    • 0000174013 scopus 로고    scopus 로고
    • A novel synthetic matrix metalloproteinase inhibitor OPB-3206: inhibition of tumor growth metastasis, and angiogenesis
    • Abstract no. 3523
    • (1997) Proc. Am. Assoc. Cancer Res. , vol.38 , pp. 525
    • Shono, T.1
  • 113
    • 0034131079 scopus 로고    scopus 로고
    • Accidental' antiangiogenic drugs: anti-oncogene directed signal transduction inhibitors
    • (2000) Eur. J. Cancer , vol.36 , pp. 1248-1257
    • Kerbel, R.S.1
  • 114
    • 0032750920 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing
    • (1999) Nat. Med. , vol.5 , pp. 1418-1423
    • Jones, M.K.1
  • 116
    • 0027465078 scopus 로고
    • Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation
    • (1993) Cancer Res. , vol.53 , pp. 826-832
    • Bouillon, M.1    Audette, M.2
  • 117
    • 0028306887 scopus 로고
    • Retinoids modulate endothelial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP)
    • (1994) J. Biol. Chem. , vol.269 , pp. 13472-13479
    • Braunhut, S.J.1    Moses, M.A.2
  • 118
    • 0030069882 scopus 로고    scopus 로고
    • Inhibition of squamous cell carcinoma angiogenesis by direct interaction of retinoic acid with endothelial cells
    • (1996) Lab. Invest. , vol.74 , pp. 476-483
    • Lingen, M.W.1
  • 119
    • 0032404102 scopus 로고    scopus 로고
    • Retinoic acid and interferon-α act synergistically as antiangiogenic and antitumor agents against human head and neck squamous cell carcinoma
    • (1998) Cancer Res. , vol.58 , pp. 5551-5558
    • Lingen, M.W.1
  • 120
    • 0029775672 scopus 로고    scopus 로고
    • Potent, selective, orally active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa integrin antagonists
    • (1996) J. Med. Chem. , vol.39 , pp. 4867-4870
    • Samenen, J.M.1
  • 121
    • 0033065782 scopus 로고    scopus 로고
    • v integrin antagonists: comparative anti-cancer efficacy with known angiogenesis inhibitors
    • (1999) Anticancer Res. , vol.19 , pp. 959-968
    • Kerr, J.S.1
  • 124
  • 125
    • 0003564265 scopus 로고    scopus 로고
    • Okuno, T. et al. (2000) Methods and pharmaceutical compositions using bisphosphonates for the treatment of angiogenesis. PCT Int. Appl. WO 0071104 A2 20001130
  • 126
    • 0003661446 scopus 로고    scopus 로고
    • Gill, P.S. et al. (1997) Preliminary results of a randomized study of IM-862 nasal solution in the treatment of patients with AIDS-related Kaposi's sarcoma, Ann. Meet. Am. Soc. Hematol. (Abstract no. 592)
  • 127
    • 0003578078 scopus 로고    scopus 로고
    • Tulpule, A. et al. (1998) Results of a randomised study of IM862 nasal solution in the treatment of AIDS-related Kaposi's sarcoma. Blood 92 (Abstract no. 2214)
  • 128
    • 0029066171 scopus 로고
    • Inhibition of angiogenesis and metastases of the Lewis-lung cell carcinoma by the quinoline-3-carboxamide, Linomide
    • (1995) Anticancer Res. , vol.15 , pp. 719-728
    • Borgstrom, P.1
  • 129
    • 0030891344 scopus 로고    scopus 로고
    • Potentiation of the antiangiogenic ability of linomide by androgen ablation involves down-regulation of vascular endothelial growth factor in human androgen-responsive prostatic cancers
    • (1997) Cancer Res. , vol.57 , pp. 1054-1057
    • Joseph, I.B.1    Isaacs, J.T.2
  • 130
    • 0031929820 scopus 로고    scopus 로고
    • Linomide blocks angiogenesis by breast carcinoma vascular endothelial growth factor transfectants
    • (1998) Br. J. Cancer , vol.77 , pp. 1123-1129
    • Ziche, M.1
  • 131
    • 0031969932 scopus 로고    scopus 로고
    • Reduction in basic fibroblast growth factor mediated angiogenesis in vivo by linomide
    • (1998) Connect. Tissue Res. , vol.37 , pp. 61-68
    • Nagler, A.1
  • 132
    • 0033036759 scopus 로고    scopus 로고
    • Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent
    • (1999) Pharmacol. Ther. , vol.82 , pp. 293-301
    • Fabbro, D.1
  • 133
    • 0000379427 scopus 로고    scopus 로고
    • Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor
    • (1999) Am. J. Pathol. , vol.154 , pp. 1743-1753
    • Seo, M.S.1
  • 134
    • 0030666022 scopus 로고    scopus 로고
    • Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor carboxyamido-triazole
    • (1997) Clin. Cancer Res. , vol.3 , pp. 1915-1921
    • Wu, Y.1
  • 135
    • 0030991528 scopus 로고    scopus 로고
    • Phase I trial of micronized formulation carboxyamidotriazole in patients with refractory solid tumors: pharmacokinetics, clinical outcome, and comparison of formulations
    • (1997) J. Clin. Oncol. , vol.15 , pp. 1985-1993
    • Kohn, E.C.1
  • 136
    • 0031015772 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of oral carboxyamidotriazole, a signal transduction inhibitor
    • (1997) J. Clin. Oncol. , vol.15 , pp. 781-789
    • Berlin, J.1
  • 137
    • 0026729378 scopus 로고
    • Suramin prevents neovascularization and tumor growth through blocking of basic fibroblast growth factor activity
    • (1992) Br. J. Cancer , vol.66 , pp. 367-372
    • Pesenti, E.1
  • 138
    • 0028318791 scopus 로고
    • Suramin, an anticancer and angiosuppressive agent, inhibits endothelial cell binding of basic fibroblast growth factor, migration, proliferation, and induction of urokinase-type plasminogen activator
    • (1994) Cancer Res. , vol.54 , pp. 2654-2660
    • Takano, S.1
  • 140
    • 0029127207 scopus 로고
    • Phase I and clinical evaluation of a pharmacologically guided regimen of suramin in patients with hormone-refractory prostate cancer
    • (1995) J. Clin. Oncol. , vol.13 , pp. 2174-2186
    • Eisenberger, M.A.1
  • 142
    • 0032483474 scopus 로고    scopus 로고
    • Solution structure of acidic fibroblast growth factor bound to 1,3,6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas
    • (1998) J. Mol. Biol. , vol.281 , pp. 899-915
    • Lozano, R.M.1
  • 143
    • 0027270034 scopus 로고
    • Detectable inhibition of heparin-binding growth factor activity in sera from patients treated with pentosan polysulfate
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 1068-1073
    • Parker, B.W.1
  • 144
    • 0029972404 scopus 로고    scopus 로고
    • Effects of AGM-1470 and pentosan polysulfate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells
    • (1996) Br. J. Cancer , vol.73 , pp. 1053-1062
    • McLeskey, S.W.1
  • 145
    • 0003503656 scopus 로고    scopus 로고
    • Pentosan polysulfate: A polysaccharide that inhibits angiogenesis by binding growth factors
    • Teicher B.A. (Ed.), Antiangiogenic Agents in Cancer Therapy, Humana Press
    • (1999) , pp. 371-383
    • Figg, W.D.1
  • 146
    • 0003651380 scopus 로고    scopus 로고
    • Tsuda, M. et al. (1999) Novel functional antitumor nucleosides TAS-102, a combined form of FTD and its modulator: Species difference in pharmacokinetics. Proc. Am. Assoc. Cancer Res. 40, March (Abstract 46)
  • 147
    • 0033561512 scopus 로고    scopus 로고
    • The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors
    • (1999) Cancer Res. , vol.59 , pp. 1911-1916
    • Matsushita, S.1
  • 148
    • 0026446094 scopus 로고
    • Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents
    • (1992) J. Med. Chem. , vol.35 , pp. 4259-4263
    • Jiang, J.B.1
  • 150
    • 0031171663 scopus 로고    scopus 로고
    • Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization
    • (1997) Exp. Eye Res. , vol.64 , pp. 971-978
    • Kenyon, B.M.1
  • 151
    • 0028220858 scopus 로고
    • The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumor growth
    • (1994) Nature , vol.368 , pp. 237-239
    • Fotsis, T.1
  • 152
    • 0031015504 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol
    • (1997) Cancer Res. , vol.57 , pp. 81-86
    • Klauber, N.1
  • 153
    • 0030949341 scopus 로고    scopus 로고
    • 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression
    • (1997) Mol. Pharmacol. , vol.51 , pp. 951-962
    • Yue, T.L.1
  • 154
    • 0032493654 scopus 로고    scopus 로고
    • 2′-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain
    • (1998) J. Biol. Chem. , vol.273 , pp. 20556-20567
    • Ruckman, J.1
  • 156
    • 0033605677 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo
    • (1999) J. Biol. Chem. , vol.274 , pp. 9116-9121
    • Xin, X.1
  • 157
    • 0029583096 scopus 로고
    • Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor
    • (1995) Ophthalmic Res. , vol.27 , pp. 330-334
    • Murata, T.1
  • 158
    • 8944249296 scopus 로고    scopus 로고
    • A phase I clinical and pharmacokinetic study of the angiogenesis inhibitor, tecogalan sodium
    • (1996) Ann. Oncol. , vol.7 , pp. 491-496
    • Eckhardt, S.G.1
  • 159
    • 0028824336 scopus 로고
    • Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor 121
    • (1995) Cancer Res. , vol.55 , pp. 5296-5301
    • Asano, M.1
  • 160
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 14765-14770
    • Yuan, F.1
  • 161
    • 0031898292 scopus 로고    scopus 로고
    • Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo
    • (1998) Prostate (N.Y.) , vol.35 , pp. 1-10
    • Borgstrom, P.1
  • 162
    • 0033018871 scopus 로고    scopus 로고
    • Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans
    • (1999) Toxicol. Pathol. , vol.27 , pp. 14-21
    • Mordenti, J.1
  • 165
    • 0032145315 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single-chain antibodies from a phage display library
    • (1998) Cancer Res. , vol.58 , pp. 3209-3214
    • Zhu, Z.1
  • 166
    • 0032962388 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor induced mitogenesis of human endothelial cells by a chimeric anti-kinases insert domain-containing receptor antibody
    • (1999) Cancer Lett. , vol.136 , pp. 203-213
    • Zhu, Z.1
  • 167
    • 0033396950 scopus 로고    scopus 로고
    • Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonists to the receptors of vascular endothelial growth factor
    • (1999) Invest. New Drugs , vol.17 , pp. 195-212
    • Zhu, Z.1    Witte, L.2
  • 168
    • 0032698140 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
    • (1999) Cancer Res. , vol.59 , pp. 5209-5218
    • Prewett, M.1
  • 169
    • 0024343441 scopus 로고
    • Treatment of haemangioendotheliomas with alpha interferon
    • (1989) Lancet , vol.2 , pp. 565-567
    • Orchard, P.J.1
  • 170
  • 172
    • 0032404102 scopus 로고    scopus 로고
    • Retinoic acid and interferon alpha act synergistically as antiangiogenic and antitumor agents against human head and neck squamous cell carcinoma
    • (1998) Cancer Res. , vol.58 , pp. 5551-5558
    • Lingen, M.W.1
  • 173
    • 0026069006 scopus 로고
    • Somatostatin analogues inhibit angiogenesis in the chick chorioallantoic membrane
    • (1991) J. Surg. Res. , vol.50 , pp. 245-251
    • Woltering, E.A.1
  • 174
    • 0027453942 scopus 로고
    • Inhibition of IGF-I and b-FGF stimulated growth of human retinal endothelial cells by the somatostatin analogue, octreotide; a potential treatment for ocular neovascularization
    • (1993) Regul. Pept. , vol.48 , pp. 267-278
    • Grant, M.B.1
  • 175
    • 0031019186 scopus 로고    scopus 로고
    • Inhibition of experimental angiogenesis by the somatostatin analogue octreotide acetate (SMS 201-995)
    • (1997) Clin. Cancer Res. , vol.3 , pp. 265-272
    • Danesi, R.1
  • 176
    • 0031965353 scopus 로고    scopus 로고
    • Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor
    • (1998) Cell Growth Differ , vol.9 , pp. 49-58
    • Lin, P.1
  • 177
    • 13144262858 scopus 로고    scopus 로고
    • Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 8795-8800
    • Goldman, C.K.1
  • 179
    • 0033578910 scopus 로고    scopus 로고
    • Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
    • (1999) Science , vol.285 , pp. 1926-1928
    • O'Reilly, M.S.1
  • 180
    • 0033979905 scopus 로고    scopus 로고
    • Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth
    • (2000) J. Biol. Chem. , vol.275 , pp. 1209-1215
    • Kamphaus, G.D.1
  • 181
    • 0033554723 scopus 로고    scopus 로고
    • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
    • (1999) Nature , vol.401 , pp. 670-677
    • Lyden, D.1
  • 182
    • 0031858141 scopus 로고    scopus 로고
    • Enhancement of the anti-tumor effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs
    • (1998) Br. J. Cancer , vol.78 , pp. 439-445
    • Lash, C.J.1
  • 183
    • 0033565644 scopus 로고    scopus 로고
    • Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice
    • (1999) Cancer Res. , vol.59 , pp. 3304-3307
    • Ching, L.M.1
  • 184
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
    • (1997) Cancer Res. , vol.57 , pp. 1829-1834
    • Dark, G.G.1
  • 185
    • 0034667456 scopus 로고    scopus 로고
    • CM101 treatment overrides tumor-induced immunoprivilege leading to apoptosis
    • (2000) Cancer Res. , vol.60 , pp. 5740-5745
    • Yakes, F.M.1
  • 186
    • 0003587282 scopus 로고    scopus 로고
    • Blaschuk, O.W. and Gour, B.J. (1999) Compounds and methods for modulating occludin-related tissue permeability. WO9935166-A 99.07.15 (9931)
  • 188
    • 0032535999 scopus 로고    scopus 로고
    • Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
    • (1998) Science , vol.279 , pp. 377-380
    • Arap, W.1
  • 190
    • 0031026481 scopus 로고    scopus 로고
    • Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • (1997) Science , vol.275 , pp. 547-550
    • Huang, X.1
  • 191
    • 0031564123 scopus 로고    scopus 로고
    • Targeting the tumor vasculature: inhibition of tumor growth by a vascular endothelial growth factor-toxin conjugate
    • (1997) Int. J. Cancer , vol.73 , pp. 865-870
    • Olson, T.A.1
  • 193
    • 0031985127 scopus 로고    scopus 로고
    • Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src
    • (1998) J. Biol. Chem. , vol.273 , pp. 1052-1057
    • Ellis, L.M.1
  • 194
    • 0030746972 scopus 로고    scopus 로고
    • A secreted FGF-binding protein can serve as the angiogenic switch in human cancer
    • (1997) Nat. Med. , vol.3 , pp. 1137-1140
    • Czubayko, F.1
  • 196
    • 0033026070 scopus 로고    scopus 로고
    • Increased gene transfer in acute myeloid leukemic cells by an adenovirus vector containing a modified fiber protein
    • (1999) Gene Ther. , vol.6 , pp. 314-320
    • Gonzalez, R.1
  • 197
    • 0033019077 scopus 로고    scopus 로고
    • Targeting an adenoviral gene vector to cytokine-activated vascular endothelium via E-selectin
    • (1999) Gene Ther. , vol.6 , pp. 801-807
    • Harari, O.A.1
  • 198
    • 0032794784 scopus 로고    scopus 로고
    • Insertion of an RGD motif into the HI loop of adenovirus fiber protein alters the distribution of transgene expression of the systemically administered vector
    • (1999) Gene Ther. , vol.6 , pp. 1336-1339
    • Reynolds, P.N.1
  • 199
    • 0032830473 scopus 로고    scopus 로고
    • Considerations and challenges for the achievement of targeted gene delivery
    • (1999) Gene Ther. , vol.6 , pp. 1497-1498
    • Curiel, D.T.1
  • 200
    • 0030768124 scopus 로고    scopus 로고
    • Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins
    • (1997) J. Virol. , vol.71 , pp. 8221-8229
    • Wickham, T.J.1
  • 201
    • 0029863730 scopus 로고    scopus 로고
    • Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo
    • (1996) Cancer Res. , vol.56 , pp. 1615-1620
    • Millauer, B.1
  • 202
    • 0030937456 scopus 로고    scopus 로고
    • Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth
    • (1997) Nat. Med. , vol.3 , pp. 437-442
    • Tanaka, T.1
  • 203
    • 0028609624 scopus 로고
    • Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis
    • (1994) Cancer Res. , vol.54 , pp. 6504-6511
    • Weinstat-Saslow, D.L.1
  • 204
    • 0032545643 scopus 로고    scopus 로고
    • TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis
    • (1998) Int. J. Cancer , vol.75 , pp. 246-253
    • Valente, P.1
  • 205
    • 0032031748 scopus 로고    scopus 로고
    • Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases
    • (1998) J. Clin. Invest. , vol.101 , pp. 1055-1063
    • Cao, Y.1
  • 206
    • 7344262560 scopus 로고    scopus 로고
    • Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice
    • (1998) Gene Ther. , vol.5 , pp. 1105-1113
    • Li, H.1
  • 208
    • 0032568632 scopus 로고    scopus 로고
    • Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 6367-6372
    • Griscelli, F.1


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