2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: Possible role for stress- activated protein kinase signaling pathway and Fas expression

Molecular Pharmacology

Volumn 51, Issue 6, 1997, Pages 951-962

  Yue, Tian Li ^a   Wang, Xinkang ^a   Louden, Calvert S ^a   Gupta, Shalley ^a   Pillarisetti, Kodandaram ^a   Gu, Juan Li ^a   Hart, Timothy K ^a   Lysko, Paul G ^a   Feuerstein, Giora Z ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL;

ANGIOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CATTLE; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRESS; VASCULAR ENDOTHELIUM;

EID: 0030949341     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.6.951     Document Type: Article

References (45)

1. Gelbke, H. P., and R. Knuppen. The excretion of five different 2-hydroxyoestrogen monomethyl ethers in human pregnancy urine. J. Steroid Biochem. 7:457-463 (1976).
2. 125I-labelled ligand. Acta Endocrinol. 103:282-288 (1983).
3. Fotsis, T., Y. Zhang, M. S. Pepper, H. Adlercreutz, R. Montesano, P. P. Nawroth, and L. Schwelgerer. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature (Lond.) 368:237-239 (1994).
4. Wheeler, W. J., T. C. Hsu, A. Tousson, and B. R. Brinkley. Mitotic inhibition and chromosome displacement induced by estradiol in Chinese hamster cells. Cytoskeleton 7:235-247 (1987).
5. Seegers, J. C., M. L. Aveling, C. H. van Aswegen, M. Cross, F. Koch, and W. S. Joubert. The cytotoxic effects of estradiol-17β, catecholestradiols and methoxyestradiols on dividing MCF-7 and Hella cells. J. Steroid Biochem. 32:797-809 (1989).
6. D'Amato, R. J., C. M. Lin, E. Flynn, J. Folkman, and E. Hamel. 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc. Natl. Acad. Sci. USA 91:3964-3968 (1994).
7. Folkman, J., and Y. Shing. Angiogenesis. J. Biol. Chem. 267:10931-10934 (1992).
8. Fan, T.-P.D., R. Jagger, and R. Bicknell. Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends Pharmacol. Sci. 16:57-66 (1995).
9. Bischoff, J. Approaches to studying cell adhesion molecules in angiogenesis. Trends Cell Biol. 5:69-73 (1995).
10. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79:1157-1164 (1994).
11. 3 during angiogenesis. J. Clin. Invest. 98:426-433 (1996).
12. Gerchenson, L. E., and R. J. Rotello. Apoptosis: a different type of cell death. FASEB J. 6:2450-2455 (1992).
13. Thompson, C. B. Apoptosis is the pathogenesis and treatment of disease. Science (Washington D. C.) 267:1456-1462 (1995).
14. Hibi, M., A. Lin, T. Smeal, A. Minden, and M. Karin. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:2135-2148 (1993).
15. Kyriakis, J. M., P. Banerjee, E. Nikolakaki, T. Dai, E. A. Rubie, M. F. Ahmad, J. Avruch, and J. R. Woodgett. The stress-activated protein kinase subfamily of c-Jun kinases. Nature (Lond.) 369:156-160 (1994).
16. Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (Washington D. C.) 270:1326-1331 (1995).
17. Derijard, B., M. Hibi, I. H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. J. Davis. JNK-1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037 (1994).
18. Nagata, S, and P. Golstein. The Fas death factor. Science (Washington D. C.) 267:1449-1456 (1995).
19. Reed, J. C., T. Miyashita, S. Takayama, H. G. Wang, T. Sato, S. Krajewski, C. Aime-Sempe, S. Bodrug, S. Kitada, and M. Hanada. Bcl-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J. Cell. Biochem. 60:23-32 (1996).
20. Leavesley, D. I., M. A. Schwartz, M. Rosenfeld, and D. A. Cheresh. Integrin β1-and β3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J. Cell Biol. 121:163-170 (1993).
21. Yue, T. L., P. J. McKenna, J. L. Gu, H. Y. Cheng, R. E. Ruffolo, and G. Z. Feuerstein. Carvedilol, a new vasodilating β adrenoceptor blocker antihypertensive drug, protects endothelial cells from damage initiated by xanthine-xanthine oxidase and neutrophils. Cardiovasc. Res. 28:400-406 (1994).
22. Polunovsky, V. A., C. H. Wendt, D. H. Ingbar, M. S. Peterson, and P. B. Bitterman. Induction of endothelial cell apoptosis by TNFα: modulation by inhibitors of protein synthesis. Exp. Cell Res. 214:584-594 (1994).
23. Varani, J., M. K. Dame, C. G. Taylor, V. Sarma, R. Merino, R. G. Kunkel, G. Nunez, and V. M. Dixit. Age-dependent injury in human umbilical vein endothelial cells: relationship to apoptosis and correlation with a lack of A20 expression. Lab. Invest. 73:851-858 (1995).
24. Verheij, M., R. Bose, X. H. Lin, B. Yao, W. D. Jarvis, S. Grant, M. J. Birrer, E. Szabo, L. I. Zon, J. M. Kyriakis, A. Haimovitz-Friedman, Z. Fuks, and R. N. Kolesnick. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature (Lond.) 380:75-79 (1996).
25. Yue, T. L., X. K. Wang, C. P. Sung, B. Olson, P. J. McKenna, J. L. Gu, and G. Z. Feuerstein. Interleukin-8: a mitogen and chemoattractant for vascular smooth muscle cells. Circ. Res. 75:1-7 (1994).
26. Crum, R., S. Szabo, and J. Folkman. A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment. Science (Washington D. C.) 230:1375-1378 (1985).
27. Merriam, G. R., N. J. MacLusky, M. K. Picard, and F. Naftolin. Comparative properties of the catechol, estrogens: I. Methylation by catechol-o-methyltransferase and binding to cytosol, estrogen receptors. Steroids 36:1-11 (1980).
28. McConkey, D. J., and S. Orrenius. Signal transduction pathways in apoptosis. Stem Cells 14:619-631 (1996).
29. Zanke, B. W., K. Boudreau, E. Rubie, E. Winnett, L. A. Tibbles, L. Zon, J. Kyriakis, F. F. Liu, and J. R. Woodgett. The stress-activated protein kinase pathway mediates cell-death following injury-induced by cisplatinum, UV irradiation or heat. Curr. Biol. 6:606-613 (1996).
30. Johnson, N. L., A. M. Gardner, K. M. Diener, C. A. Lange-Carter, J. Gleavy, M. B. Jarpe, A. Minden, M. Karin, L. I. Zon, and G. L. Johnson. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J. Biol. Chem. 271: 3229-3237 (1996).
31. Westwick, J. K., A. E. Bielawska, G. Dbaibo, Y. A. Hannun, and D. A. Brenner. Ceramide activates the stress-activated protein kinases. J. Biol. Chem. 270:22689-22692 (1995).
32. Sawai, H., T. Okazaki, H. Yamamoto, H. Okano, Y. Takeda, M. Tashima, H. Sawada, M. Okuma, H. Ishikura, H. Umehara, and N. Domae. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. J. Biol. Chem. 270:27326-27331 (1995).
33. Latinis, K. M., and G. A. Koretzky. Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. Blood 87:871-875 (1996).
34. Peter, M. E., F. C. Kischkel, S. Hellbardt, A. M. Chinnaiyan, P. H. Krammer, and V. M. Dixit. CD95 (APO-1/Fas)-associating signalling proteins. Cell Death. Diff. 3:161-170 (1996).
35. Wilson, D. J., K. A. Fortner, D. H. Lynch, R. R. Mattingly, I. G. Macara, J. A. Posada, and R. C. Budd. JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells. Eur. J. Immunol. 26:989-994 (1996).
36. Tian, Q., J. C. Taupin, S. Elledge, M. Roberson, and P. Anderson. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. J. Exp. Med. 182:865-874 (1995).
37. Reed, J. C. Bcl-2 and the regulation of programmed cell death. J. Cell. Biol. 124:1-5 (1994).
38. Wang, T. T. Y., and J. M. Phang. Effects of estrogen on apoptotic pathways in human breast cancer cell. Cancer Res. 55:2487-2489 (1995).
39. Teixeira, C., J. C. Reed, and M. A. C. Pratt. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 protooncogene expression in human breast cancer cells. Confer Res. 55:3902-3907 (1995).
40. Jaattela, M., C. M. Benedic, M. Tewari, J. A. Shayman, and V. M. Dixit. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene 10:2297-2305 (1995).
41. Strasser, A., A. W. Harris, D. C. Huang, P. H. Krammer, and S. Cory. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14:6136-6147 (1995).
42. Suzuki, A., A. Matsuzawa, and T. Iguchi. Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract. Oncogene 13:31-37 (1996).
43. Kajstura, J., W. Cheng, K. Reiss, W. A. Clark, E. H. Sonneblick, S. Krajewski, J. C. Reed, G. Olivetti, and P. Anversa. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab. Invest. 74:86-107 (1996).
44. Herbette, L. G., Y. M. H. Van Erve, and D. G. Rhodes. Interaction of 1,4-dihydropyridine calcium channel antagonists with biological membranes: lipid bilayer partitioning could occur before drug binding to receptors. J. Mol. Cell. Cardiol. 21:187-201 (1989).
45. Pruett, J. K., T. Walle, and U. Walle. Propranolol effects on membrane repolarization time in isolated canine Purkinje fibers: threshold tissue content and the influence of exposure time. J. Pharmacol. Exp. Ther. 215:539-543 (1980).