메뉴 건너뛰기




Volumn 15, Issue 1, 1997, Pages 61-75

Matrix metalloproteinase inhibitors

Author keywords

Angiogenesis; Clinical trials; Human malignancies; Matrix metalloproteinase inhibitors

Indexed keywords

BATIMASTAT; BRYOSTATIN; COLLAGEN; FIBRONECTIN; LAMININ; MARIMASTAT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MEMBRANE PROTEIN; PROTEIN KINASE C; TISSUE INHIBITOR OF METALLOPROTEINASE;

EID: 0030929371     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005722729132     Document Type: Review
Times cited : (432)

References (94)
  • 1
    • 0028040432 scopus 로고
    • Calcium influx modulates expression of matrix metalloproteinase-2 (72-kDa type IV collagenase, gelatinase A)
    • Kohn EC, Jacobs W, Kim YS, Alessandro R, Stetler-Stevenson WG, Liotta LA: Calcium influx modulates expression of matrix metalloproteinase-2 (72-kDa type IV collagenase, gelatinase A). J Biol Chem 269:21505-21511, 1994
    • (1994) J Biol Chem , vol.269 , pp. 21505-21511
    • Kohn, E.C.1    Jacobs, W.2    Kim, Y.S.3    Alessandro, R.4    Stetler-Stevenson, W.G.5    Liotta, L.A.6
  • 3
    • 0027140406 scopus 로고
    • Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis
    • Stetler-Stevenson WG, Liotta LA, Kleiner DE, Jr: Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J 7:1434-1441, 1993
    • (1993) FASEB J , vol.7 , pp. 1434-1441
    • Stetler-Stevenson, W.G.1    Liotta, L.A.2    Kleiner Jr., D.E.3
  • 4
    • 0028322352 scopus 로고
    • Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas
    • Freije JM, Diez-Itza I, Balbin M, Sanchez LM, Blasco R, Tolivia J, Lopez-Otin C: Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem 269:16766-16773, 1994
    • (1994) J Biol Chem , vol.269 , pp. 16766-16773
    • Freije, J.M.1    Diez-Itza, I.2    Balbin, M.3    Sanchez, L.M.4    Blasco, R.5    Tolivia, J.6    Lopez-Otin, C.7
  • 5
    • 0029005284 scopus 로고
    • Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression
    • Belaaouaj A, Shipley JM, Kobayashi DK, Zimonjic DB, Popescu N, Silverman GA, Shapiro SD: Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression. J Biol Chem 270:14568-14575, 1995
    • (1995) J Biol Chem , vol.270 , pp. 14568-14575
    • Belaaouaj, A.1    Shipley, J.M.2    Kobayashi, D.K.3    Zimonjic, D.B.4    Popescu, N.5    Silverman, G.A.6    Shapiro, S.D.7
  • 6
    • 0028085533 scopus 로고
    • Stromelysin-3 in stromal tissue as a control factor in breast cancer behavior
    • Basset P, Wolf C, Rouyer N, Bellocq JP, Rio MC, Chambon P: Stromelysin-3 in stromal tissue as a control factor in breast cancer behavior. Cancer 74:1045-1049, 1994
    • (1994) Cancer , vol.74 , pp. 1045-1049
    • Basset, P.1    Wolf, C.2    Rouyer, N.3    Bellocq, J.P.4    Rio, M.C.5    Chambon, P.6
  • 7
    • 0028935326 scopus 로고
    • Membrane-type matrix and metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas
    • Okada A, Bellocq JP, Rouyer N, Chenard MP, Rio MC, Chambon P, Basset P: Membrane-type matrix and metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci USA 92:2730-2734, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2730-2734
    • Okada, A.1    Bellocq, J.P.2    Rouyer, N.3    Chenard, M.P.4    Rio, M.C.5    Chambon, P.6    Basset, P.7
  • 8
    • 0029118269 scopus 로고
    • Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library - MT-MMPs form a unique membrane-type sublcass in the MMP family
    • Takino T, Sato H, Shinagawa A, Seiki M: Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library - MT-MMPs form a unique membrane-type sublcass in the MMP family. J Biol Chem 270:23013-23020, 1995
    • (1995) J Biol Chem , vol.270 , pp. 23013-23020
    • Takino, T.1    Sato, H.2    Shinagawa, A.3    Seiki, M.4
  • 9
    • 0029034457 scopus 로고
    • Activation of progelatinase B (MMP-9) by gelatinase a (MMP-2)
    • Fridman R, Toth M, Pena D, Mobashery S: Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). Cancer Res 55:2548-2555, 1995
    • (1995) Cancer Res , vol.55 , pp. 2548-2555
    • Fridman, R.1    Toth, M.2    Pena, D.3    Mobashery, S.4
  • 10
    • 0025230509 scopus 로고
    • Metalloproteinases and their inhibitors in matrix remodeling
    • Matrisian LM: Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 6:121-125, 1990
    • (1990) Trends Genet , vol.6 , pp. 121-125
    • Matrisian, L.M.1
  • 11
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta LA, Steeg PS, Stetler-Stevenson WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64:327-336, 1991
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 12
    • 0028948844 scopus 로고
    • Gelatinase A activity directly modulates melanoma cell adhesion and spreading
    • Ray JM, Stetler-Stevenson WG: Gelatinase A activity directly modulates melanoma cell adhesion and spreading. EMBO J 14:908-917, 1995
    • (1995) EMBO J , vol.14 , pp. 908-917
    • Ray, J.M.1    Stetler-Stevenson, W.G.2
  • 14
    • 0028924956 scopus 로고
    • The C-terminal region of membrane type matrix metalloproteinase is a functional transmembrane domain required for pro-gelatinase a activation
    • Cao J, Sato H, Takino T, Seiki M: The C-terminal region of membrane type matrix metalloproteinase is a functional transmembrane domain required for pro-gelatinase A activation. J Biol Chem 270:801-805, 1995
    • (1995) J Biol Chem , vol.270 , pp. 801-805
    • Cao, J.1    Sato, H.2    Takino, T.3    Seiki, M.4
  • 15
    • 0026025755 scopus 로고
    • Growth factors in development, transformation, and tumorigenesis
    • Cross M, Dexter TM: Growth factors in development, transformation, and tumorigenesis. Cell 64:271-280, 1991
    • (1991) Cell , vol.64 , pp. 271-280
    • Cross, M.1    Dexter, T.M.2
  • 16
    • 0026651498 scopus 로고
    • Molecular determinants of growth, angiogenesis and metastases in breast cancer
    • Dickson RB, Lippman ME: Molecular determinants of growth, angiogenesis and metastases in breast cancer. Semin Oncol 3:286-298, 1992
    • (1992) Semin Oncol , vol.3 , pp. 286-298
    • Dickson, R.B.1    Lippman, M.E.2
  • 17
    • 0025286753 scopus 로고
    • Tumor interactions with the vasculature: Angiogenesis and tumor metastasis
    • Blood CH, Zetter BR: Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim Biophys Acta 1032:89-118, 1990
    • (1990) Biochim Biophys Acta , vol.1032 , pp. 89-118
    • Blood, C.H.1    Zetter, B.R.2
  • 18
    • 0025141337 scopus 로고
    • What is the evidence that tumours are angiogenesis dependent?
    • Folkman J: What is the evidence that tumours are angiogenesis dependent? J Natl Cancer Inst 82:4-6, 1990
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 20
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J, Klagsburn M: Angiogenic factors. Science 235: 442-447, 1987
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsburn, M.2
  • 21
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma
    • Weidner N, Semple JP, Welch WR, Folkman J: Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Eng J Med 324:1-8, 1990
    • (1990) N Eng J Med , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3    Folkman, J.4
  • 22
    • 0025913891 scopus 로고
    • Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma
    • Candle J, Bossy-Weasel E, Radvanyi F, Klagsburn M, Folkman J, Hanahan D: Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell 66:1095-1104, 1991
    • (1991) Cell , vol.66 , pp. 1095-1104
    • Candle, J.1    Bossy-Weasel, E.2    Radvanyi, F.3    Klagsburn, M.4    Folkman, J.5    Hanahan, D.6
  • 23
    • 0020449692 scopus 로고
    • Endothelial-cell proliferation in experimental tumors
    • Denekamp J, Hobson B: Endothelial-cell proliferation in experimental tumors. Br J Cancer 46:711-720, 1982
    • (1982) Br J Cancer , vol.46 , pp. 711-720
    • Denekamp, J.1    Hobson, B.2
  • 24
    • 84982614048 scopus 로고
    • Proliferation kinetics of endothelial cells and tumor cells in three mouse mammary carcinomas
    • Hirst DG, Denekamp J, Hobson B: Proliferation kinetics of endothelial cells and tumor cells in three mouse mammary carcinomas. Cell Tissue Kinet 15:251-261, 1982
    • (1982) Cell Tissue Kinet , vol.15 , pp. 251-261
    • Hirst, D.G.1    Denekamp, J.2    Hobson, B.3
  • 25
    • 0012042467 scopus 로고
    • Fibroblast growth factors and breast cancer
    • Broder S (ed), Williams and Wilkins, Baltimore
    • Wellstein A, Lippman ME: Fibroblast growth factors and breast cancer. In: Broder S (ed), Molecular Foundations of Oncology. Williams and Wilkins, Baltimore, 1991, p 403
    • (1991) Molecular Foundations of Oncology , pp. 403
    • Wellstein, A.1    Lippman, M.E.2
  • 26
    • 0025799689 scopus 로고
    • The current status of targeting tumor vasculature as a means of cancer therapy: An overview
    • Denekamp J: The current status of targeting tumor vasculature as a means of cancer therapy: an overview. Int J Radiat Biol 60:401-408, 1991
    • (1991) Int J Radiat Biol , vol.60 , pp. 401-408
    • Denekamp, J.1
  • 27
    • 0025000576 scopus 로고
    • Development of angiogenesis inhibitors for clinical applications
    • Maione ET, Sharpe RJ: Development of angiogenesis inhibitors for clinical applications. TIPS 11:457-461, 1990
    • (1990) TIPS , vol.11 , pp. 457-461
    • Maione, E.T.1    Sharpe, R.J.2
  • 28
    • 0029154908 scopus 로고
    • Increased levels of stromelysin-1 and tissue inhibitor of metalloproteinases-1 in sera from patients with rheumatoid arthritis
    • Yoshihara Y, Obata K, Fujimoto N, Yamashita K, Hayakawa T, Shimmei M: Increased levels of stromelysin-1 and tissue inhibitor of metalloproteinases-1 in sera from patients with rheumatoid arthritis. Arthritis Rheum 38:969-975, 1995
    • (1995) Arthritis Rheum , vol.38 , pp. 969-975
    • Yoshihara, Y.1    Obata, K.2    Fujimoto, N.3    Yamashita, K.4    Hayakawa, T.5    Shimmei, M.6
  • 29
    • 0028854885 scopus 로고
    • Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis
    • Hembry RM, Bagga MR, Reynolds JJ, Hamblen DL: Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis. Ann Rheum Dis 54:25-32, 1995
    • (1995) Ann Rheum Dis , vol.54 , pp. 25-32
    • Hembry, R.M.1    Bagga, M.R.2    Reynolds, J.J.3    Hamblen, D.L.4
  • 30
    • 0028109319 scopus 로고
    • Serum levels of collagenase, stromelysin-1, and TIMP-1. Age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of antigenic keratan sulfate in patients with osteoarthritis
    • Manicourt DH, Fujimoto N, Obata K, Thonar EJ: Serum levels of collagenase, stromelysin-1, and TIMP-1. Age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of antigenic keratan sulfate in patients with osteoarthritis. Arthritis Rheum 37:1774-17783, 1994
    • (1994) Arthritis Rheum , vol.37 , pp. 1774-17783
    • Manicourt, D.H.1    Fujimoto, N.2    Obata, K.3    Thonar, E.J.4
  • 31
    • 0028957812 scopus 로고
    • Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: Implications for bone resorption
    • Okada Y, Naka K, Kawamura K, Matsumoto T, Nakanishi I, Fujimoto N, Sato H, Seiki M: Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption. Lab Invest 72:311-322, 1995
    • (1995) Lab Invest , vol.72 , pp. 311-322
    • Okada, Y.1    Naka, K.2    Kawamura, K.3    Matsumoto, T.4    Nakanishi, I.5    Fujimoto, N.6    Sato, H.7    Seiki, M.8
  • 32
    • 0028933149 scopus 로고
    • Activated gelatinase-B (MMP-9) and urokinase-type plasminogen activator in synovial fluids of patients with arthritis. Correlation with clinical and experimental variables of inflammation
    • Koolwijk P, Miltenburg AM, van Erck MG, Oudshoorn M, Niedbala MJ, Breedveld FC, van Hinsbergh VW: Activated gelatinase-B (MMP-9) and urokinase-type plasminogen activator in synovial fluids of patients with arthritis. Correlation with clinical and experimental variables of inflammation. J Rheumatol 22:385-393, 1995
    • (1995) J Rheumatol , vol.22 , pp. 385-393
    • Koolwijk, P.1    Miltenburg, A.M.2    Van Erck, M.G.3    Oudshoorn, M.4    Niedbala, M.J.5    Breedveld, F.C.6    Van Hinsbergh, V.W.7
  • 33
    • 0029004841 scopus 로고
    • Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease
    • Sepper R, Konttinen YT, Ding Y, Takagi M, Sorsa T: Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease. Chest 107:1641-1647, 1995
    • (1995) Chest , vol.107 , pp. 1641-1647
    • Sepper, R.1    Konttinen, Y.T.2    Ding, Y.3    Takagi, M.4    Sorsa, T.5
  • 34
    • 0027971976 scopus 로고
    • Elastolytic metalloproteinases produced by human mononuclear phagocytes. Potential roles in destructive lung disease
    • Shapiro SD: Elastolytic metalloproteinases produced by human mononuclear phagocytes. Potential roles in destructive lung disease. Am J Respir Crit Care Med 150:160-164, 1994
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 160-164
    • Shapiro, S.D.1
  • 35
    • 0028347680 scopus 로고
    • Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intenstine
    • Bailey CJ, Hembry RM, Alexander A, Irving MH, Grant ME, Shuttleworth CA: Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intenstine. J. Clin Pathol 47:113-116, 1994
    • (1994) J. Clin Pathol , vol.47 , pp. 113-116
    • Bailey, C.J.1    Hembry, R.M.2    Alexander, A.3    Irving, M.H.4    Grant, M.E.5    Shuttleworth, C.A.6
  • 38
    • 0028188441 scopus 로고
    • Matrix metalloproteinases in abdominal aortic aneurysm: Characterization, purification, and their possible sources
    • Newman KM, Malon AM, Shin RD, Scholes JV, Ramey WG, Tilson MD: Matrix metalloproteinases in abdominal aortic aneurysm: characterization, purification, and their possible sources. Connect Tissue Res 30:265-276, 1994
    • (1994) Connect Tissue Res , vol.30 , pp. 265-276
    • Newman, K.M.1    Malon, A.M.2    Shin, R.D.3    Scholes, J.V.4    Ramey, W.G.5    Tilson, M.D.6
  • 40
    • 0027202705 scopus 로고
    • Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9
    • Wysocki AB, Staiano-Coico L, Grinnell F: Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J Invest Dermatol 101:64-68, 1993
    • (1993) J Invest Dermatol , vol.101 , pp. 64-68
    • Wysocki, A.B.1    Staiano-Coico, L.2    Grinnell, F.3
  • 41
    • 0027388922 scopus 로고
    • r 92,000 Type IV collagenase is increased in plasma of patients with colon and breast cancer
    • r 92,000 Type IV collagenase is increased in plasma of patients with colon and breast cancer. Cancer Res 53:140-146, 1993
    • (1993) Cancer Res , vol.53 , pp. 140-146
    • Zucker, S.1    Lysik, R.M.2    Zarrabi, M.H.3    Moll, U.4
  • 42
    • 0027469921 scopus 로고
    • Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small cell lung carcinoma
    • Brown PD, Bloxidge RE, Stuart NSA, Gatter KC, Carmichael J: Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small cell lung carcinoma. J Natl Cancer Inst 85:574-578, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 574-578
    • Brown, P.D.1    Bloxidge, R.E.2    Stuart, N.S.A.3    Gatter, K.C.4    Carmichael, J.5
  • 44
    • 0028854873 scopus 로고
    • Correlation of the in situ detection of polymerase chain reactionamplified metalloproteinase complementary DNAs and their inhibitors with prognosis in cervical carcinoma
    • Nuovo GJ, MacConnell PB, Simsir A, Valea F, French DL: Correlation of the in situ detection of polymerase chain reactionamplified metalloproteinase complementary DNAs and their inhibitors with prognosis in cervical carcinoma. Cancer Res 55:267-275, 1995
    • (1995) Cancer Res , vol.55 , pp. 267-275
    • Nuovo, G.J.1    MacConnell, P.B.2    Simsir, A.3    Valea, F.4    French, D.L.5
  • 45
    • 0028658361 scopus 로고
    • Plasma assay of matrix metalloproteinases (MMPs) and MMP-inhibitor complexes in cancer. Potential use in predicting metastasis and monitoring treatment
    • Zucker S, Lysik RM, Zarrabi HM, Moll U, Tickle SP, Stetler-Stevenson W, Baker TS, Docherty AJ: Plasma assay of matrix metalloproteinases (MMPs) and MMP-inhibitor complexes in cancer. Potential use in predicting metastasis and monitoring treatment. Ann N Y Acad Sci 732:248-262, 1994
    • (1994) Ann N Y Acad Sci , vol.732 , pp. 248-262
    • Zucker, S.1    Lysik, R.M.2    Zarrabi, H.M.3    Moll, U.4    Tickle, S.P.5    Stetler-Stevenson, W.6    Baker, T.S.7    Docherty, A.J.8
  • 46
    • 0027451998 scopus 로고
    • Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production
    • Azzam HS, Arand G, Lippman ME, Thompson EW: Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production. J Natl Cancer Inst 85:1758-1764, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1758-1764
    • Azzam, H.S.1    Arand, G.2    Lippman, M.E.3    Thompson, E.W.4
  • 48
    • 0029847630 scopus 로고    scopus 로고
    • Phase I study of batimastat (BB-94), a novel matrix metalloproteinase inhibitor in patients with advanced cancer
    • Wojtowicz-Praga S, Low J, Dickson R, Ness E, Barter J, McCann P, Hawkins MJ: Phase I study of batimastat (BB-94), a novel matrix metalloproteinase inhibitor in patients with advanced cancer. Invest New Drugs 14:193-202, 1996
    • (1996) Invest New Drugs , vol.14 , pp. 193-202
    • Wojtowicz-Praga, S.1    Low, J.2    Dickson, R.3    Ness, E.4    Barter, J.5    McCann, P.6    Hawkins, M.J.7
  • 50
    • 0024495311 scopus 로고
    • Human fibroblast collagenase-alpha-macroglobulin interactions: Localization of cleavage sites in the bait regions of five mammalian alpha-macroglobulins
    • Sottrup JL, Birkedal HH: Human fibroblast collagenase-alpha-macroglobulin interactions: localization of cleavage sites in the bait regions of five mammalian alpha-macroglobulins. J Biol Chem 264:393-401, 1989
    • (1989) J Biol Chem , vol.264 , pp. 393-401
    • Sottrup, J.L.1    Birkedal, H.H.2
  • 52
    • 0028277720 scopus 로고
    • The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction
    • Khokha R, Waterhouse P: The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction. J Neurooncol 18:123-127, 1993
    • (1993) J Neurooncol , vol.18 , pp. 123-127
    • Khokha, R.1    Waterhouse, P.2
  • 53
    • 0028126675 scopus 로고
    • Structure-function relationships in the tissue inhibitors of metalloproteinases
    • Willenbrock F, Murphy G: Structure-function relationships in the tissue inhibitors of metalloproteinases. Am J Respir Crit Care Med 150:165-170, 1994
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 165-170
    • Willenbrock, F.1    Murphy, G.2
  • 54
    • 0027435065 scopus 로고
    • Tissue inhibitor of metalloproteinases (TIMP, aka EPA): Structure, control of expression and biological functions
    • Denhardt DT, Feng B, Edwards DR, Cocuzzi ET, Malyankar UM: Tissue inhibitor of metalloproteinases (TIMP, aka EPA): structure, control of expression and biological functions. Pharmacol Ther 59:329-341, 1993
    • (1993) Pharmacol Ther , vol.59 , pp. 329-341
    • Denhardt, D.T.1    Feng, B.2    Edwards, D.R.3    Cocuzzi, E.T.4    Malyankar, U.M.5
  • 55
    • 0028476829 scopus 로고
    • Connective tissue degradation in health and periodontal disease and the roles of matrix metalloproteinases and their natural inhibitors
    • Reynolds JJ, Hembry RM, Meikle MC: Connective tissue degradation in health and periodontal disease and the roles of matrix metalloproteinases and their natural inhibitors. Adv Dent Res 8:312-319, 1994
    • (1994) Adv Dent Res , vol.8 , pp. 312-319
    • Reynolds, J.J.1    Hembry, R.M.2    Meikle, M.C.3
  • 56
    • 0023597374 scopus 로고
    • Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts
    • Clark SD, Kobayashi DK, Welgus HG: Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts. J Clin Invest 80:1280-1288, 1987
    • (1987) J Clin Invest , vol.80 , pp. 1280-1288
    • Clark, S.D.1    Kobayashi, D.K.2    Welgus, H.G.3
  • 57
    • 0028178968 scopus 로고
    • Expression and activity of MMPS and their regulators in ovarian cancer
    • Naylor MS, Stamp GW, Davies BD, Balkwill FR: Expression and activity of MMPS and their regulators in ovarian cancer. Int J Cancer 58:50-56, 1994
    • (1994) Int J Cancer , vol.58 , pp. 50-56
    • Naylor, M.S.1    Stamp, G.W.2    Davies, B.D.3    Balkwill, F.R.4
  • 58
    • 0027382490 scopus 로고
    • Localization by in situ hybridization of mRNAs encoding stromelysin 3 and tissue inhibitors of metallo-proteinases TIMP-1 and TIMP-2 in human head and neck carcinomas
    • Polette M, Clavel C, Birembaut P, De Clerck YA: Localization by in situ hybridization of mRNAs encoding stromelysin 3 and tissue inhibitors of metallo-proteinases TIMP-1 and TIMP-2 in human head and neck carcinomas. Pathol Res Pract 189:1052-1057, 1993
    • (1993) Pathol Res Pract , vol.189 , pp. 1052-1057
    • Polette, M.1    Clavel, C.2    Birembaut, P.3    De Clerck, Y.A.4
  • 59
  • 61
    • 0026573378 scopus 로고
    • Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases
    • DeClerck YA, Perez N, Shimada H, Boone TC, Langley KE, Taylor SM: Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases. Cancer Res 52:701-708, 1992
    • (1992) Cancer Res , vol.52 , pp. 701-708
    • DeClerck, Y.A.1    Perez, N.2    Shimada, H.3    Boone, T.C.4    Langley, K.E.5    Taylor, S.M.6
  • 63
    • 0025238632 scopus 로고
    • Inhibition of collagenolytic activity and metastasis of tumour cells by a recombinant tissue inhibitor of metalloproteinases
    • Alvarez OA, Carmichael DF, DeClerck YA: Inhibition of collagenolytic activity and metastasis of tumour cells by a recombinant tissue inhibitor of metalloproteinases. J Natl Cancer Inst 82:589-595, 1990
    • (1990) J Natl Cancer Inst , vol.82 , pp. 589-595
    • Alvarez, O.A.1    Carmichael, D.F.2    DeClerck, Y.A.3
  • 64
    • 0028140295 scopus 로고
    • Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the over-expression of the tissue inhibitor of the metalloproteinases-1
    • Khokha R: Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the over-expression of the tissue inhibitor of the metalloproteinases-1. J Natl Cancer Inst 86:299-304, 1994
    • (1994) J Natl Cancer Inst , vol.86 , pp. 299-304
    • Khokha, R.1
  • 65
    • 0028500581 scopus 로고
    • Serum levels of a tissue inhibitor of metalloproteinases-1 (TIMP-1) in bladder cancer patients
    • Naruo S, Kanayama H, Takigawa H, Kagawa S, Yamashita K, Hayakawa T: Serum levels of a tissue inhibitor of metalloproteinases-1 (TIMP-1) in bladder cancer patients. Int J Urol 1:228-231, 1994
    • (1994) Int J Urol , vol.1 , pp. 228-231
    • Naruo, S.1    Kanayama, H.2    Takigawa, H.3    Kagawa, S.4    Yamashita, K.5    Hayakawa, T.6
  • 66
    • 0028130051 scopus 로고
    • Serum metalloproteinases and their inhibitors: Markers for malignant potential
    • Baker T, Tickle S, Wasan H, Docherty A, Isenberg D, Waxman J: Serum metalloproteinases and their inhibitors: markers for malignant potential. Br J Cancer 70:506-512, 1994
    • (1994) Br J Cancer , vol.70 , pp. 506-512
    • Baker, T.1    Tickle, S.2    Wasan, H.3    Docherty, A.4    Isenberg, D.5    Waxman, J.6
  • 67
    • 0028104790 scopus 로고
    • Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line
    • Montgomery AM, Mueller BM, Reisfeld RA, Taylor SM, De Clerck YA: Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line. Cancer Res 54:5467-5473, 1994
    • (1994) Cancer Res , vol.54 , pp. 5467-5473
    • Montgomery, A.M.1    Mueller, B.M.2    Reisfeld, R.A.3    Taylor, S.M.4    De Clerck, Y.A.5
  • 68
    • 0028639176 scopus 로고
    • TIMP-2 expression modulates human melanoma cell adhesion and motility
    • Ray JM, Stetler-Stevenson WG: TIMP-2 expression modulates human melanoma cell adhesion and motility. Ann N Y Acad Sci 732:233-247, 1994
    • (1994) Ann N Y Acad Sci , vol.732 , pp. 233-247
    • Ray, J.M.1    Stetler-Stevenson, W.G.2
  • 69
    • 0028148301 scopus 로고
    • Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence
    • Visscher DW, Hoyhtya M, Ottosen SK, Liang CM, Sarkar FH, Crissman JD, Fridman R: Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence. Int J Cancer 59:339-344, 1994
    • (1994) Int J Cancer , vol.59 , pp. 339-344
    • Visscher, D.W.1    Hoyhtya, M.2    Ottosen, S.K.3    Liang, C.M.4    Sarkar, F.H.5    Crissman, J.D.6    Fridman, R.7
  • 71
    • 0028650376 scopus 로고
    • Identification and characterization of human tissue inhibitor of metalloproteina-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix
    • Kishnani NS, Staskus PW, Yang TT, Masiarz FR, Hawkes SP: Identification and characterization of human tissue inhibitor of metalloproteina-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix. Matrix Biol 14:479-488, 1995
    • (1995) Matrix Biol , vol.14 , pp. 479-488
    • Kishnani, N.S.1    Staskus, P.W.2    Yang, T.T.3    Masiarz, F.R.4    Hawkes, S.P.5
  • 72
    • 0028244447 scopus 로고
    • Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues
    • Leco KJ, Khokha R, Pavloff N, Hawkes SP, Edwards DR: Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J Biol Chem 269:9352-9360, 1994
    • (1994) J Biol Chem , vol.269 , pp. 9352-9360
    • Leco, K.J.1    Khokha, R.2    Pavloff, N.3    Hawkes, S.P.4    Edwards, D.R.5
  • 73
    • 0027932836 scopus 로고
    • Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10
    • Apte SS, Hayashi K, Seldin MF, Mattei MG, Hayashi M, Olsen BR: Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10. Dev Dyn 200:177-197, 1994
    • (1994) Dev Dyn , vol.200 , pp. 177-197
    • Apte, S.S.1    Hayashi, K.2    Seldin, M.F.3    Mattei, M.G.4    Hayashi, M.5    Olsen, B.R.6
  • 74
    • 0028641280 scopus 로고
    • Treatment of destructive arthritic disorders with MMP inhibitors. Potential role of tetracyclines
    • Greenwald RA: Treatment of destructive arthritic disorders with MMP inhibitors. Potential role of tetracyclines. Ann N Y Acad Sci 732:181-198, 1994
    • (1994) Ann N Y Acad Sci , vol.732 , pp. 181-198
    • Greenwald, R.A.1
  • 76
    • 0025042561 scopus 로고
    • Basement membrane collagen-degrading activity from a malignant tumor is inhibited by anthracycline antibiotics
    • Karakiulakis G, Missirlis E, Maragoudakis ME: Basement membrane collagen-degrading activity from a malignant tumor is inhibited by anthracycline antibiotics. Biochim Biophys Acta 1035:218-222, 1990
    • (1990) Biochim Biophys Acta , vol.1035 , pp. 218-222
    • Karakiulakis, G.1    Missirlis, E.2    Maragoudakis, M.E.3
  • 77
    • 0027631530 scopus 로고
    • Mechanistic studies on the inhibition of stromelysin by a peptide phosphonamidate
    • Izquierdo-Martin M, Stein RL: Mechanistic studies on the inhibition of stromelysin by a peptide phosphonamidate. Bioorg Med Chem 1:19-26, 1993
    • (1993) Bioorg Med Chem , vol.1 , pp. 19-26
    • Izquierdo-Martin, M.1    Stein, R.L.2
  • 79
    • 0000278013 scopus 로고
    • Matrix metalloproteinase inhibitors: A new class of anticancer agents
    • Brown PD: Matrix metalloproteinase inhibitors: a new class of anticancer agents. Curr Opin Invest Drugs 2:617-626, 1993
    • (1993) Curr Opin Invest Drugs , vol.2 , pp. 617-626
    • Brown, P.D.1
  • 80
    • 0027251836 scopus 로고
    • A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts
    • Davies B, Brown PD, East N, Crimmin MJ, Balkwill FR: A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res 53:2087-2091, 1993
    • (1993) Cancer Res , vol.53 , pp. 2087-2091
    • Davies, B.1    Brown, P.D.2    East, N.3    Crimmin, M.J.4    Balkwill, F.R.5
  • 81
    • 0027994031 scopus 로고
    • Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice
    • Wang X, Fu X, Brown PD, Crimmin MJ, Hoffman RM: Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res 54:4726-4728, 1994
    • (1994) Cancer Res , vol.54 , pp. 4726-4728
    • Wang, X.1    Fu, X.2    Brown, P.D.3    Crimmin, M.J.4    Hoffman, R.M.5
  • 82
    • 0028129059 scopus 로고
    • Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor
    • Chirivi RGS, Garofalo A, Crimmin MJ, Bawden LJ, Stoppacciaro A, Brown PD, Giavazzi R: Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor. Int J Cancer 58:460-464, 1994
    • (1994) Int J Cancer , vol.58 , pp. 460-464
    • Chirivi, R.G.S.1    Garofalo, A.2    Crimmin, M.J.3    Bawden, L.J.4    Stoppacciaro, A.5    Brown, P.D.6    Giavazzi, R.7
  • 83
    • 0029165411 scopus 로고
    • Inhibition of organ invasion by matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models
    • Watson SA, Morris TM, Robinson G, Crimmin MJ, Brown PD, Hardcastle JD: Inhibition of organ invasion by matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models. Cancer Res 55:3629-3633, 1995
    • (1995) Cancer Res , vol.55 , pp. 3629-3633
    • Watson, S.A.1    Morris, T.M.2    Robinson, G.3    Crimmin, M.J.4    Brown, P.D.5    Hardcastle, J.D.6
  • 85
    • 1542703420 scopus 로고
    • Pharmacokinetics of batimastat (BB-94), a novel matrix metalloproteinase inhibitor in patients with advanced cancer
    • Wojtowicz S, Ness E, Dickson R, Low J, Barter J, McCann P, Hawkins M: Pharmacokinetics of batimastat (BB-94), a novel matrix metalloproteinase inhibitor in patients with advanced cancer. Proceedings of ASCO 14:474, 1995
    • (1995) Proceedings of ASCO , vol.14 , pp. 474
    • Wojtowicz, S.1    Ness, E.2    Dickson, R.3    Low, J.4    Barter, J.5    McCann, P.6    Hawkins, M.7
  • 88
    • 0026532012 scopus 로고
    • Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor lines: In Vitro versus in Vivo activity
    • Hornung RL, Pearson JW, Beckwith M, Longo DL: Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor lines: In Vitro versus In Vivo activity. Cancer Res 52:101-107, 1992
    • (1992) Cancer Res , vol.52 , pp. 101-107
    • Hornung, R.L.1    Pearson, J.W.2    Beckwith, M.3    Longo, D.L.4
  • 89
    • 0023270192 scopus 로고
    • Bryostatin induces change in protein kinase C location and activity without altering cmyc gene expression in human promyelocytic (HL-60) cells
    • Kraft AS, Baker VV, May WS: Bryostatin induces change in protein kinase C location and activity without altering cmyc gene expression in human promyelocytic (HL-60) cells. Oncogene 1:111-118, 1987
    • (1987) Oncogene , vol.1 , pp. 111-118
    • Kraft, A.S.1    Baker, V.V.2    May, W.S.3
  • 90
    • 0027488490 scopus 로고
    • Bryostatin-1: Will the oceans provide a cancer cure?
    • Kraft AS: Bryostatin-1: Will the oceans provide a cancer cure? J Natl Cancer Inst 85:1700-1792, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1700-1792
    • Kraft, A.S.1
  • 91
    • 0023673928 scopus 로고
    • Tumor-promoter induced membrane bound protein kinase C regulates hematogenous metastasis
    • Gopalakrishna R, Barsky SH: Tumor-promoter induced membrane bound protein kinase C regulates hematogenous metastasis. Proc Natl Acad Sci 85:612-616, 1988
    • (1988) Proc Natl Acad Sci , vol.85 , pp. 612-616
    • Gopalakrishna, R.1    Barsky, S.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.