Mercaptoacyl matrix metalloproteinase inhibitors: The effect of substitution at the mercaptoacyl moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 21, 1997, Pages 2765-2770

  Baxter, Andrew D ^a   Bhogal, Ranjev ^a   Bird, John B ^a   Buckley, George M ^a   Gregory, David S ^b   Hedger, Paul C ^a   Manallack, David T ^a   Massil, Tracy ^a   Minton, Kevin J ^a   Montana, John G ^a   Neidle, Stephen ^b   Owen, David A ^a   Watson, Robert J ^a  

^a Chiroscience Ltd   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE INHIBITOR; METALLOPROTEINASE;

ARTICLE; BINDING SITE; CHEMICAL MODIFICATION; DRUG SYNTHESIS; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION;

EID: 0030736911     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10069-5     Document Type: Article

References (23)

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13. (c) Porter, J. R.; Millican, T. A.; Morphy, J. R. Exp. Opin. Ther. Patents 1995, 5, 1287-1296. Some examples of mercaptoacyl MMP inhibitors similar to 1 are known in the literature. See ref 2(c), above, and Gray, R. D.; Sanelli, H. H.; Spatola, A. F. Biochem. Biophys. Res. Commun., 1981, 101, 1251-1258.
14. 1H NMR and mass spectroscopy. The stereochemical integrity of intermediates shown in Scheme 2 was confirmed by polarimetry and/or chiral hplc.
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