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Volumn 5, Issue 8, 1998, Pages 1105-1113

Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice

Author keywords

Angiogenesis; Cancer; Cell invasion; Recombinant adenovirus; Urokinase

Indexed keywords

CELL SURFACE RECEPTOR; UROKINASE; UROKINASE RECEPTOR;

EID: 7344262560     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300742     Document Type: Article
Times cited : (129)

References (53)
  • 1
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med 1995; 1: 27-31.
    • (1995) Nature Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 2
    • 0030484797 scopus 로고    scopus 로고
    • Reciprocal paracrine interactions between tumor cells and endothelial cells: The 'angiogenesis progression hypothesis'
    • Rak J, Filmus JRJ, Kerbel RS. Reciprocal paracrine interactions between tumor cells and endothelial cells: the 'angiogenesis progression hypothesis'. Eur J Cancer 1996; 32A: 2438-2450.
    • (1996) Eur J Cancer , vol.32 A , pp. 2438-2450
    • Rak, J.1    Filmus, J.R.J.2    Kerbel, R.S.3
  • 3
    • 0031025998 scopus 로고    scopus 로고
    • Gene therapy for cancer: What have we done and where are we going?
    • Roth JA, Christiano RJ. Gene therapy for cancer: what have we done and where are we going? J Natl Cancer Inst 1997; 88: 21-39.
    • (1997) J Natl Cancer Inst , vol.88 , pp. 21-39
    • Roth, J.A.1    Christiano, R.J.2
  • 4
    • 0027970092 scopus 로고
    • Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • O'Reilly MS et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994; 79: 315-328.
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.S.1
  • 5
    • 17344385367 scopus 로고    scopus 로고
    • Blockage of urokinase receptor reduces in vitro the motility and deformability of endothelial cells
    • Lu H et al. Blockage of urokinase receptor reduces in vitro the motility and deformability of endothelial cells. FEES Lett 1996; 380: 21-24.
    • (1996) FEES Lett , vol.380 , pp. 21-24
    • Lu, H.1
  • 6
    • 0001453577 scopus 로고    scopus 로고
    • Urokinase receptor antagonists inhibit angiogenesis and primary rumor growth in syngeneic mice
    • Min HY et al. Urokinase receptor antagonists inhibit angiogenesis and primary rumor growth in syngeneic mice. Cancer Res 1996; 56: 2428-2433.
    • (1996) Cancer Res , vol.56 , pp. 2428-2433
    • Min, H.Y.1
  • 7
    • 0025166396 scopus 로고
    • Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides
    • Maione TE et al. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science 1990; 247: 77-79.
    • (1990) Science , vol.247 , pp. 77-79
    • Maione, T.E.1
  • 8
    • 0028609624 scopus 로고
    • Transfection of thrombospondin I complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential and angiogenesis
    • Weinstat-Saslow DL et al. Transfection of thrombospondin I complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential and angiogenesis. Cancer Res 1994; 54: 6504-6511.
    • (1994) Cancer Res , vol.54 , pp. 6504-6511
    • Weinstat-Saslow, D.L.1
  • 9
    • 0027283371 scopus 로고
    • Prevention of metastasis by inhibition of the urokinase receptor
    • Crowley CW et al. Prevention of metastasis by inhibition of the urokinase receptor. Proc Natl Acad Sci USA 1993; 90: 5021-5025.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5021-5025
    • Crowley, C.W.1
  • 10
    • 0028287392 scopus 로고
    • Inhibition of metastasis of Lewis lung carcinoma by a synthetic peptide within the growth factor-like domain of urokinase in an experimental and spontaneous metastasis model
    • Kobayashi H et al. Inhibition of metastasis of Lewis lung carcinoma by a synthetic peptide within the growth factor-like domain of urokinase in an experimental and spontaneous metastasis model. Int J Cancer 1994; 57: 727-733.
    • (1994) Int J Cancer , vol.57 , pp. 727-733
    • Kobayashi, H.1
  • 11
    • 0028126445 scopus 로고
    • Blockage of the urokinase receptor on the cell surface: Construction and characterization of a hybrid protein consisting of the N-terminal fragment of human urokinase and human albumin
    • Lu H et al. Blockage of the urokinase receptor on the cell surface: construction and characterization of a hybrid protein consisting of the N-terminal fragment of human urokinase and human albumin. FEBS Lett 1994; 356: 56-59.
    • (1994) FEBS Lett , vol.356 , pp. 56-59
    • Lu, H.1
  • 12
    • 0025883277 scopus 로고
    • Plasminogen activation by receptor-bound urokinase, a kinetic study with cell-associated and isolated receptor
    • Ellis V, Behrendt N, Dano K. Plasminogen activation by receptor-bound urokinase, a kinetic study with cell-associated and isolated receptor. J Biol Chem 1991; 266: 12752-12758.
    • (1991) J Biol Chem , vol.266 , pp. 12752-12758
    • Ellis, V.1    Behrendt, N.2    Dano, K.3
  • 13
    • 0027535914 scopus 로고
    • Biology and biochemistry of proteinases in tumor invasion
    • Mignatti PRM, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993; 73: 161-195.
    • (1993) Physiol Rev , vol.73 , pp. 161-195
    • Mignatti, P.R.M.1    Rifkin, D.B.2
  • 14
    • 0004553618 scopus 로고
    • Tissue cooperation in a proteolytic cascade activating human interstitial collagenase
    • He C et al. Tissue cooperation in a proteolytic cascade activating human interstitial collagenase. Proc Natl Acad Sci USA 1989; 86: 2632-2636.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2632-2636
    • He, C.1
  • 15
    • 0030977009 scopus 로고    scopus 로고
    • Control of type IV collagenase activity by components of the urokinase-plasmin system: A regulatory mechanism with cell-bound reactants
    • Mazzieri R et al. Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants. EMBO J 1997; 16: 2319-2332.
    • (1997) EMBO J , vol.16 , pp. 2319-2332
    • Mazzieri, R.1
  • 16
    • 0025336879 scopus 로고
    • The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes
    • Estreicher A et al. The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol 1990; 111- 783-792.
    • (1990) J Cell Biol , vol.111 , pp. 783-792
    • Estreicher, A.1
  • 17
    • 0028569183 scopus 로고
    • Identification of the urokinase receptor as an adhesion receptor for vitronectin
    • Wei Y et al. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem 1994; 269: 32380-32388.
    • (1994) J Biol Chem , vol.269 , pp. 32380-32388
    • Wei, Y.1
  • 18
    • 0029958368 scopus 로고    scopus 로고
    • Macl (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells
    • Simon DI et al. Macl (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood 1996; 88: 3185-3194.
    • (1996) Blood , vol.88 , pp. 3185-3194
    • Simon, D.I.1
  • 19
    • 0029764639 scopus 로고    scopus 로고
    • Regulation of integrin function by the urokinase receptor
    • Wei Y et al. Regulation of integrin function by the urokinase receptor. Science 1996; 273: 1551-1555.
    • (1996) Science , vol.273 , pp. 1551-1555
    • Wei, Y.1
  • 20
    • 0030757506 scopus 로고    scopus 로고
    • Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
    • Waltz DA et al. Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest 1997; 100: 58-67.
    • (1997) J Clin Invest , vol.100 , pp. 58-67
    • Waltz, D.A.1
  • 21
    • 0025675962 scopus 로고
    • Growth factor control of extracellular proteolysis
    • Rifkin D et al Growth factor control of extracellular proteolysis. Cell Diff Dev 1990; 32: 313-318.
    • (1990) Cell Diff Dev , vol.32 , pp. 313-318
    • Rifkin, D.1
  • 22
    • 0026443723 scopus 로고
    • In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis
    • Bacharach E, Itin A, Keshet E. In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis. Proc Natl Acad Sci USA 1992; 89: 10686-10690.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10686-10690
    • Bacharach, E.1    Itin, A.2    Keshet, E.3
  • 23
    • 0027077443 scopus 로고
    • Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
    • Naldini L et al. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J 1992; 11: 4825-4833.
    • (1992) EMBO J , vol.11 , pp. 4825-4833
    • Naldini, L.1
  • 24
    • 0029670093 scopus 로고    scopus 로고
    • Cooperative effect of TNFalpha, bFGF and VEGF on the formation of tubular structure of human microvasculature endothelial cells in a fibrin matrix: Role of urokinase activity
    • Koolwijk P et al. Cooperative effect of TNFalpha, bFGF and VEGF on the formation of tubular structure of human microvasculature endothelial cells in a fibrin matrix: role of urokinase activity. J Cell Biol 1996; 132: 1177-1188.
    • (1996) J Cell Biol , vol.132 , pp. 1177-1188
    • Koolwijk, P.1
  • 25
    • 0030976894 scopus 로고    scopus 로고
    • Extracellular cleavage of the vascular endothelial growth factor 189 amino acid form by urokinase is required for its mitogenic effect
    • Plouet J et al. Extracellular cleavage of the vascular endothelial growth factor 189 amino acid form by urokinase is required for its mitogenic effect. J Biol Chem 1997; 272: 13390-13396.
    • (1997) J Biol Chem , vol.272 , pp. 13390-13396
    • Plouet, J.1
  • 26
    • 0023236992 scopus 로고
    • Increase of urokinase-type plasminogen activator gene expression in human lung and breast carcinomas
    • Sappino AP, Busso N, Belin D, Vassalli JD. Increase of urokinase-type plasminogen activator gene expression in human lung and breast carcinomas. Cancer Res 1987; 47: 4043-4046.
    • (1987) Cancer Res , vol.47 , pp. 4043-4046
    • Sappino, A.P.1    Busso, N.2    Belin, D.3    Vassalli, J.D.4
  • 28
    • 0027268709 scopus 로고
    • Increased cell-surface urokinase in advanced ovarian cancer
    • Kobayashi H et al. Increased cell-surface urokinase in advanced ovarian cancer. Jpn J Cancer Res 1993; 84: 633-640.
    • (1993) Jpn J Cancer Res , vol.84 , pp. 633-640
    • Kobayashi, H.1
  • 29
    • 0028026686 scopus 로고
    • Expression and localization of urokinasetype plasminogen activator in human astrocytomas in vivo
    • Yamamoto M et al. Expression and localization of urokinasetype plasminogen activator in human astrocytomas in vivo. Cancer Res 1994; 54: 3656-3661.
    • (1994) Cancer Res , vol.54 , pp. 3656-3661
    • Yamamoto, M.1
  • 30
    • 0029021196 scopus 로고
    • Urokinase-type plasminogen activator and its inhibitor PAI-1: Predictors of poor response to tamoxifen therapy in recurrent breast cancer
    • Foekens JA et al. Urokinase-type plasminogen activator and its inhibitor PAI-1: predictors of poor response to tamoxifen therapy in recurrent breast cancer. J Natl Cancer Inst 1995; 87: 751-756.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 751-756
    • Foekens, J.A.1
  • 31
    • 0030914794 scopus 로고    scopus 로고
    • Co-expression of urokinase-type plasminogen activator and its receptor in human gastric cancer cell lines correlates with their invasiveness and tumorigenicity
    • Park IK et al. Co-expression of urokinase-type plasminogen activator and its receptor in human gastric cancer cell lines correlates with their invasiveness and tumorigenicity. Int J Cancer 1997; 71: 867-873.
    • (1997) Int J Cancer , vol.71 , pp. 867-873
    • Park, I.K.1
  • 32
    • 0025853770 scopus 로고
    • Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas
    • Pyke C et al. Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas. Am J Pathol 1991; 138: 1059-1067.
    • (1991) Am J Pathol , vol.138 , pp. 1059-1067
    • Pyke, C.1
  • 33
    • 0029682495 scopus 로고    scopus 로고
    • Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA) deficient and wild-type mice: Cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals
    • Shapiro RL et al. Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA) deficient and wild-type mice: cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals. Cancer Res 1996; 56: 3597-3604.
    • (1996) Cancer Res , vol.56 , pp. 3597-3604
    • Shapiro, R.L.1
  • 34
    • 0021914983 scopus 로고
    • Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase-type plasminogen activator
    • Belin D et al. Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase-type plasminogen activator. Eur J Biochem 1985; 148: 225-232.
    • (1985) Eur J Biochem , vol.148 , pp. 225-232
    • Belin, D.1
  • 35
    • 0023223148 scopus 로고
    • The receptor binding sequence of urokinase: A biological function for the growth factor module of proteases
    • Appella E et al. The receptor binding sequence of urokinase: a biological function for the growth factor module of proteases. J Biol Chem 1987; 262: 4437-4440.
    • (1987) J Biol Chem , vol.262 , pp. 4437-4440
    • Appella, E.1
  • 36
    • 9344234400 scopus 로고    scopus 로고
    • Systemic mutational analysis of the receptorbinding region of the human urokinase-type plasminogen activator
    • Magdolen V et al. Systemic mutational analysis of the receptorbinding region of the human urokinase-type plasminogen activator. Eur J Biochem 1996; 237: 743-751.
    • (1996) Eur J Biochem , vol.237 , pp. 743-751
    • Magdolen, V.1
  • 37
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis correlation in invasive breast carcinoma
    • Weidner N, Semple JP, Welch WR. Tumor angiogenesis and metastasis correlation in invasive breast carcinoma. New Engl J Med 1991; 324: 1-8.
    • (1991) New Engl J Med , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3
  • 39
    • 0028670833 scopus 로고
    • 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994; 79: 1157-1164.
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1
  • 40
    • 0031051143 scopus 로고    scopus 로고
    • Radioimmunotherapy and fractionated radiotherapy of human colon cancer liver metastases in nude mice
    • Vogel CA, Galmiche MC, Buchegger F. Radioimmunotherapy and fractionated radiotherapy of human colon cancer liver metastases in nude mice. Cancer Res 1997; 57: 447-453.
    • (1997) Cancer Res , vol.57 , pp. 447-453
    • Vogel, C.A.1    Galmiche, M.C.2    Buchegger, F.3
  • 41
    • 0027368441 scopus 로고
    • Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature
    • Burrows FJ, Thorpe PE. Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature. Proc Natl Acad Sci USA 1993; 90: 8996-9000.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8996-9000
    • Burrows, F.J.1    Thorpe, P.E.2
  • 42
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factorinduced angiogenesis suppresses tumor growth in vivo
    • Kim KJ et al. Inhibition of vascular endothelial growth factorinduced angiogenesis suppresses tumor growth in vivo. Nature 1993; 362: 841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1
  • 43
    • 0031026481 scopus 로고    scopus 로고
    • Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • Huang X et al. Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science 1997; 275: 547-550.
    • (1997) Science , vol.275 , pp. 547-550
    • Huang, X.1
  • 44
    • 0023788067 scopus 로고
    • Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
    • Dvorak HF, Nagy JA, Dvorak JT, Dvorak AM. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am J Pathol 1988; 133: 95-109.
    • (1988) Am J Pathol , vol.133 , pp. 95-109
    • Dvorak, H.F.1    Nagy, J.A.2    Dvorak, J.T.3    Dvorak, A.M.4
  • 45
    • 0016218630 scopus 로고
    • Quantitative relationships of intravascular tumor cells, tumor vessels and pulmonary metastases following tumor implantation
    • Liotta L, Kleinerman J, Saidel G. Quantitative relationships of intravascular tumor cells, tumor vessels and pulmonary metastases following tumor implantation. Cancer Res 1974; 34: 997-1004.
    • (1974) Cancer Res , vol.34 , pp. 997-1004
    • Liotta, L.1    Kleinerman, J.2    Saidel, G.3
  • 46
    • 0028951043 scopus 로고
    • Dormancy of micrometastasis: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastasis: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med 1995; 1: 149-153.
    • (1995) Nature Med , vol.1 , pp. 149-153
    • Holmgren, L.1    O'Reilly, M.S.2    Folkman, J.3
  • 47
    • 0030937456 scopus 로고    scopus 로고
    • Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth
    • Tanaka T et al. Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth. Nature Med 1997; 3: 437-442.
    • (1997) Nature Med , vol.3 , pp. 437-442
    • Tanaka, T.1
  • 48
    • 0032568632 scopus 로고    scopus 로고
    • Angiostatin gene transfer: Inhibition of tumor growth in vivo by blockage of endothelial cell proliferation asso- Ciated with a mitosis arrest
    • Griscelli F et al. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation asso- ciated with a mitosis arrest. Proc Natl Acad Sci USA 1998; 95: 6367-6372.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6367-6372
    • Griscelli, F.1
  • 49
    • 0030923808 scopus 로고    scopus 로고
    • Long-term gene delivery into the liver of immunocompetent mice with El/E4-defective adenoviruses
    • Dedieu J-F et al. Long-term gene delivery into the liver of immunocompetent mice with El/E4-defective adenoviruses. J Virol 1997; 71: 4626-4637.
    • (1997) J Virol , vol.71 , pp. 4626-4637
    • Dedieu, J.-F.1
  • 50
    • 0030775646 scopus 로고    scopus 로고
    • Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector
    • Feng M et al. Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector. Nature Biotechnol 1997; 15: 866-870.
    • (1997) Nature Biotechnol , vol.15 , pp. 866-870
    • Feng, M.1
  • 51
    • 0027183188 scopus 로고
    • Upregulation of urokinase receptor expression on migrating endothelial cells
    • Pepper MS et al. Upregulation of urokinase receptor expression on migrating endothelial cells. J Cell Biol 1993; 122: 673-684.
    • (1993) J Cell Biol , vol.122 , pp. 673-684
    • Pepper, M.S.1
  • 52
    • 0026782439 scopus 로고
    • Widespread long-term gene transfer to mouse skeletal muscles and heart via an adenovirus vector
    • Stratford-Perricaudet LD, Makeh I, Perricaudet M, Briand P. Widespread long-term gene transfer to mouse skeletal muscles and heart via an adenovirus vector. J Clin Invest 1992; 90: 626-630.
    • (1992) J Clin Invest , vol.90 , pp. 626-630
    • Stratford-Perricaudet, L.D.1    Makeh, I.2    Perricaudet, M.3    Briand, P.4
  • 53
    • 0030752379 scopus 로고    scopus 로고
    • Advances in adenoviral vectors: From genetic engineering to their biology
    • Yeh P, Perricaudet M. Advances in adenoviral vectors: from genetic engineering to their biology. FASEB J 1997; 11: 615-623.
    • (1997) FASEB J , vol.11 , pp. 615-623
    • Yeh, P.1    Perricaudet, M.2


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