Discovery of CGS 27023A, a non, peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits

Journal of Medicinal Chemistry

Volumn 40, Issue 16, 1997, Pages 2525-2532

  MacPherson, Lawrence J ^a   Bayburt, Erol K ^a   Capparelli, Michael P ^a   Carroll, Brian J ^a   Goldstein, Robert ^a   Justice, Michael R ^a   Zhu, Lijuan ^a   Hu, Shou Ih ^a   Melton, Richard A ^a   Fryer, Lynn ^a   Goldberg, Ron L ^a   Doughty, John R ^a   Spirito, Salvatore ^a   Blancuzzi, Vincent ^a   Wilson, Doug ^a   O'Byrne, Elizabeth M ^a   Ganu, Vishwas ^a   Parker, David T ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CGS 27023A; COLLAGEN; STROMELYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTHROPATHY; ARTICLE; BONE REMODELING; BONE TURNOVER; CARTILAGE; DNA TEMPLATE; NONHUMAN; OSTEOARTHRITIS; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; CARTILAGE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROXAMIC ACIDS; KINETICS; MATRIX METALLOPROTEINASE 3; MODELS, CHEMICAL; PROTEASE INHIBITORS; PYRAZINES; RABBITS; RATS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANCE P; SULFONAMIDES;

EID: 15644374838     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960871c     Document Type: Article

References (31)

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