Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases

Journal of Clinical Investigation

Volumn 101, Issue 5, 1998, Pages 1055-1063

  Cao, Yihai ^a,b   O'Reilly, Michael S ^b   Marshall, Blair ^b   Flynn, Evelyn ^b   Ji, Richard Weidong ^b   Folkman, Judah ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Angiogenesis; Angiostatin; Gene therapy; Tumor dormancy; Tumor metastasis

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOSTATIN; COMPLEMENTARY DNA;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DNA DETERMINATION; FIBROSARCOMA; GENE TRANSFER; LUNG METASTASIS; MALE; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

EID: 0032031748     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1558     Document Type: Article

References (36)

1. Hanahan, D., and J. Folkman. 1996. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 86:353-364.
2. Folkman, J. 1971. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285:1182-1186.
3. Folkman, J. 1992. The role of angiogenesis in tumor growth. Semin. Cancer Biol. 3:65-71.
4. Folkman, J. 1995. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1:27-31.
5. O'Reilly, M.S., L. Holmgren, Y. Shing, C. Chen, R.A. Rosenthal, M. Moses, W.S. Lane, Y. Cao, E.H. Sage, and J. Folkman. 1994. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 79:315-328.
6. Folkman, J. 1995. Clinical applications of research on angiogenesis. N. Engl. J. Med. 333:1757-1763.
7. Kandel, J., E. Bossy-Wetzel, F. Radvanyi, M. Klagsbrun, J. Folkman, and D. Hanahan. 1991. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell. 66:1095-1104.
8. Ferrara, N., L. Houck, L. Jakeman, and D.W. Leung. 1992. Molecular and biological properties of the vascular endothelial cell growth factor family of proteins. Endocr. Rev. 13:18-32.
9. Dvorak, H.F., L.F. Brown, M. Detmar, and A.M. Dvorak. 1995. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146:1029-1039.
10. Rastinejad, F., P. Polverini, and N.P. Bouck. 1989. Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene. Cell. 56: 345-355.
11. Sharpe, R.J., H.R. Byer, C.F. Scott, S.I. Bauer, and T.E. Maione. 1990. Growth inhibition of murine melanoma and human colon carcinoma by recombinant human platelet factor 4. J. Natl. Cancer Inst. 82:848-853.
12. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 79:1157-1164.
13. Holmgren, L., M.S. O'Reilly, and J. Folkman. 1995. Dormancy of metastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat. Med. 1:149-153.
14. Cao, Y., R.-W. Ji, D. Davidson, J. Schaller, D. Marti, S. Sohndel, S.G. McCance, M.S. O'Reilly, M. Llinás, and J. Folkman. 1996. Kringle domains of human angiostatin: characterization of the anti-proliferative activity on endothelial cells. J. Biol. Chem. 271:29461-29467.
15. Gately, S., P. Twardowski, M.S. Stack, M. Patrick, L. Boggio, D.L. Cundiff, H.W. Schnaper, L. Madison, O. Volpert, N. Bouck, et al 1996. Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor angiostatin. Cancer Res. 56:4887-4890.
16. Dong, Z., R. Kumar, X. Yang, and I.J. Fidler. 1997. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma. Cell. 88:801-810.
17. O'Reilly, M.S., T. Boehm, Y. Shing, N. Fukai, G. Vasios, W.S. Lane, E. Flynn, J.R. Birkhead, B.R. Olsen, and J. Folkman. 1997. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 88:277-285.
18. Cao, Y. 1990. Direct cloning of a chimera gene fused by the polymerase chain reaction. Technique (Phila.). 2:109-111.
19. Cao, Y., and R.F. Pettersson. 1993. Release and subcellular localization of acidic fibroblast growth factor expressed to high levels in HeLa cells. Growth Factors. 8:277-290.
20. Chen, Y.T., C. Holcomb, and H.P. Moore. 1993. Expression and localization of two molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. Proc. Narl. Acad. Sci. USA. 90:6508-6512.
21. Cao, Y., C. Chen, J.A. Weatherbee, M. Tsang, and J. Folkman. 1995. gro-β, a -C-X-C-chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice. J. Exp. Med. 182:2069-2077.
22. Chen, C., S. Parangi, M. Tolentino, and J. Folkman. 1995. A strategy to discover circulating angiogenesis inhibitors generated by human tumors. Cancer Res. 55:4230-4233.
23. Ginsburg, D., R.I. Handin, D.T. Bonthron, T.A. Dolon, G.A.P. Bruns, S.A. Latt, and S.H. Orkin. 1985. Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization. Science. 288:140-145.
24. Ponting, C.P., J.M. Marshall, and S.A. Cederholm-Williams. 1992. Plasminogen: a structure review. Blood Coagul. Fibrinolysis. 3:605-614.
25. Key, G., M.H.G. Becher, B. Beron, M. Duchrow, G. Schluter, H.-D. Flad, and J. Gerdes. 1993. New Ki-67-equivalent murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three 62 base pair-repetitive elements encoding for the Ki-67. Lab. Invest. 68:629-636.
26. Gavrieli, Y., Y. Sherman, and S.A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
27. Bursh, W., S. Paffe, B. Putz, G. Barthel, and R. Schulte-Hermann. 1990. Determination of the length of the histological stages of apoptosis in normal liver and altered hepatic foci of rats. Carcinogenesis. 11:847-853.
28. Barres, B.A., I.K. Hart, H.S.R. Coles, J.F. Burne, J.F. Voyvodic, W.D. Richardson, and M.C. Raff. 1992. Cell death and control of cell survival in the oligodendrocyte lineage. Cell. 70:31 46.
29. Dameron, K.M., O.V. Volpert, M.A. Tainsky, and N. Bouck. 1994. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science. 265:1582-1584.
30. Auerbach, W., and R. Auerbach, 1994. Angiogenesis inhibition: a review. Pharmacol. Ther. 63:265-311.
31. Shweiki, D., A. Itin, D. Soffer, and E. Keshet. 1992. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-induced angiogenesis. Nature. 359:843-845.
32. O'Reilly, M.S., L. Holmgren, C. Chen, and J. Folkman. 1996. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat. Med. 2:689-692.
33. Kim, K.J., B. Li, J. Winer, M. Armanini, N. Gillett, H.S. Philips, and N. Ferrara. 1993. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature. 362:841-844.
34. Millauer, B., L.K. Shawver, K.H. Plate, W. Risau, and A. Ullrich. 1994. Glioma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature. 367:576-579.
35. Weinstat-Saslow, D.L., V.S. Zabrenetzky, K. VanHoutte, W.A. Frazier, D.D. Roberts, and P.S. Steeg. 1994. Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis. Cancer Res. 54:6504-6511.
36. Gu, Y., C.W. Turk, and D.O.Morgan. 1993. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature. 366:707-710.