The angiogenesis inhibitor TNP-470 (AGM-1470) improves long-term survival of rats with liver metastasis

Journal of Surgical Research

Volumn 64, Issue 1, 1996, Pages 35-41

  Ahmed, Motahar H ^a   Konno, Hiroyuki ^a   Nahar, Lutfun ^a   Tanaka, Tatsuo ^a   Naito, Yasuhisa ^a   Nakamura, Satoshi ^a   Baba, Shozo ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FUMAGILLOL CHLOROACETYLCARBAMATE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCITES HEPATOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; DOSE CALCULATION; DRUG EFFECT; ENDOTHELIUM CELL; IMPLANTATION; LIVER METASTASIS; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; SURVIVAL TIME; TREATMENT FAILURE; TUMOR GROWTH; VASCULAR ENDOTHELIUM;

EID: 0030586076     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0303     Document Type: Article

References (16)

1. 1. August, D. A., Sugarbaker, P. H., and Schneider, P. D. Lymphatic dissemination of hepatic metastases: Implications for follow-up and treatment of patients with colorectal cancer. Cancer 55: 1490-1494, 1985.
2. 2. Levason, S. H., Wiggins, P. A., Giles, G. R., Parkin, A., and Robinson, P. J. Deranged liver blood flow patterns in the detection of liver metastasis. Br. J. Surg. 72: 128-130, 1985.
3. 3. Yamashita, R., Hiraoka, T., Kamimoto, I., and Miyauchi, Y. Prevention of growth of metastases in rat liver by perioperative immunoactivation. Cancer Res. 46: 3138-3141, 1986.
4. 4. Folkman, J. How is blood vessel growth regulated in normal and neoplastic tissue? Cancer Res. 46: 467-473, 1986.
5. 5. Blood, C. H., and Zetter, B. R.. Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim. Biophys. Acta 1032: 89-118, 1990.
6. 6. Yanase, T., Tamura, M., Fujita, K., Kodama, S., and Tanaka, K. Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res. 53: 2566-2570, 1993.
7. 7. Tanaka, T., Konno, H., Matsuda, I., Nakamura, S., and Baba, S. Prevention of hepatic metastasis of human colon cancer by angiogenesis inhibitor TNP-470. Cancer Res. 55: 836-839, 1995.
8. 8. Konno, H., Tanaka, T., Matsuda, I., Kanai, T., Maruo, Y., Nishino, N., Nakamura, S., and Baba, S. Comparison of the inhibitory effect of the angiogenesis inhibitor, TNP-470, and Mitomycin on the growth and liver metastasis of human colon cancer. Int. J. Cancer 61: 268-271, 1995.
9. 9. Yamaoka, M., Yamamoto, T., Masaki, T., Ikeyama, S., Sudo, K., and Fujita, T. Inhibition of growth and metastasis of rodent tumors by the angiogenesis inhibitor o-(chloroacetyl-carbamoyl) fumagilol (TNP-470). Cancer Res. 53: 4262-4267, 1993.
10. 10. Ingber, D., Fujita, T., Kishimoto, S., Sudo, K., Kanamaru, T., Brem, H., and Folkman, J. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature (London) 348: 555-557, 1990.
11. 11. Finlay, I. G., Meek, D. R., Gray, H. W., Duncan, J. G., and McArdle, C. S. Incidence and detection of occult hepatic metastases in colorectal cancer. Br. Med. J. 284: 803-805, 1982.
12. 12. Kusaka, M., Sudo, K., Matsutani, E., Kozai, Y., Marui, S., Fujita, T., Ingber, D., and Folkman, J. Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470). Br. J. Cancer 69: 212-216, 1994.
13. 13. Tessitore, L., Valente, G., Bonelli, G., Costelli, P., and Baccino, F. M. Regulation of cell turnover in the livers of tumour-bearing rats: occurrence of apoptosis. Int. J. Cancer 44: 697-700, 1989.
14. 14. Antoine, N., Bours, V., Heinen, E., Simar, L. J., and Castronovo, V. Stimulation of human B-lymphocyte proliferation by AGM-1470, a potent inhibitor of angiogenesis. J. Natl. Cancer Inst. 87: 136-139, 1995.
15. 15. Kato, T., Sato, K., Kakinoma, H., and Matsuda, Y. Enhanced suppression of tumor growth by combination of angiogenesis inhibitor 0-(chloroacetyl-carbamoyl) fumagillol (TNP-470) and cytotoxic agents in mice. Cancer Res. 54: 5143-5147, 1994.
16. 16. Wilson, J. T., and Penar, P. L. The effect of AGM-1470 in an improved intracranial 9L gliosarcoma rat model. Neurol. Res. 16: 121-124, 1994.