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Volumn 9, Issue 6, 1997, Pages 562-568

Inhibitors of tyrosine kinase

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 BROMOANILINO) 6 (METHYLAMINO)PYRIDO[3,4 D]PYRIMIDINE; 4 AMINOQUINAZOLINE DERIVATIVE; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CGP 59326; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FIBROBLAST GROWTH FACTOR RECEPTOR; GEFITINIB; PD 166285; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PYRIDO[1,2 A]PYRIMIDINE DERIVATIVE; PYRROLOPYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; RPR 108518A; SU 0879; SU 149S; SU 1835; SU 4136; UNCLASSIFIED DRUG; VINBLASTINE; WIN 1662;

EID: 0030783173     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-199711000-00012     Document Type: Review
Times cited : (111)

References (39)
  • 3
    • 0030220783 scopus 로고    scopus 로고
    • Tyrphostins IV-Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines
    • Gazit A, Chen J, App H, McMahon G, Hirth P, Chen I, Levitzki A: Tyrphostins IV-Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines. Bioorg Med Chem 1996, 4:1203-1207.
    • (1996) Bioorg Med Chem , vol.4 , pp. 1203-1207
    • Gazit, A.1    Chen, J.2    App, H.3    McMahon, G.4    Hirth, P.5    Chen, I.6    Levitzki, A.7
  • 4
    • 0029837306 scopus 로고    scopus 로고
    • Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors
    • Han YC, Caday CG, Nanda A, Cavenee WK, Huang HJS. Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res 1996, 56:3859-3861.
    • (1996) Cancer Res , vol.56 , pp. 3859-3861
    • Han, Y.C.1    Caday, C.G.2    Nanda, A.3    Cavenee, W.K.4    Huang, H.J.S.5
  • 5
    • 0030013302 scopus 로고    scopus 로고
    • Structure-activity relationships for 4-anilinoquinazolines as potent inhibitors at the ATP binding site of the epidermal growth factor receptor in vitro
    • Denny WA, Rewcastle GW, Bridges AJ, Fry DW, Kraker AJ: Structure-activity relationships for 4-anilinoquinazolines as potent inhibitors at the ATP binding site of the epidermal growth factor receptor in vitro. Clin Exp Pharmacol Physiol 1996, 23:424-427.
    • (1996) Clin Exp Pharmacol Physiol , vol.23 , pp. 424-427
    • Denny, W.A.1    Rewcastle, G.W.2    Bridges, A.J.3    Fry, D.W.4    Kraker, A.J.5
  • 6
    • 0030039555 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor
    • Bridges AJ, Zhou H, Cody DR, Rewcastle GW, McMichael A, Showalter HDH, Fry DW, Kraker AJ, Denny WA: Tyrosine kinase inhibitors: 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem 1996, 39:267-276.
    • (1996) J Med Chem , vol.39 , pp. 267-276
    • Bridges, A.J.1    Zhou, H.2    Cody, D.R.3    Rewcastle, G.W.4    McMichael, A.5    Showalter, H.D.H.6    Fry, D.W.7    Kraker, A.J.8    Denny, W.A.9
  • 7
    • 13344262678 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor
    • Rewcastle GW, Palmer BD, Bridges AJ, Showalter HDH, Sun L, Nelson J, McMichael A, Kraker AJ, Fry DW, Denny WA. Tyrosine kinase inhibitors: 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor. J Med Chem 1996, 39:918-928.
    • (1996) J Med Chem , vol.39 , pp. 918-928
    • Rewcastle, G.W.1    Palmer, B.D.2    Bridges, A.J.3    Showalter, H.D.H.4    Sun, L.5    Nelson, J.6    McMichael, A.7    Kraker, A.J.8    Fry, D.W.9    Denny, W.A.10
  • 8
    • 0030907052 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: 11. Soluble analogues of pyrrolo- and pyrazoloquinazolines as epidermal growth factor receptor inhibitors: Synthesis, biological evaluation, and modeling of the mode of binding
    • Palmer BD, Trumpp-Kallmeyer S, Fry DW, Nelson JM, Showalter HDH, Denny WA: Tyrosine kinase inhibitors: 11. Soluble analogues of pyrrolo- and pyrazoloquinazolines as epidermal growth factor receptor inhibitors: Synthesis, biological evaluation, and modeling of the mode of binding. J Med Chem 1997, 40:1519-1529.
    • (1997) J Med Chem , vol.40 , pp. 1519-1529
    • Palmer, B.D.1    Trumpp-Kallmeyer, S.2    Fry, D.W.3    Nelson, J.M.4    Showalter, H.D.H.5    Denny, W.A.6
  • 9
    • 85036684239 scopus 로고    scopus 로고
    • Quinazoline derivatives. Newark, DE: Zeneca Limited; Patent WO 96/33980, 1996
    • Gibson K: Quinazoline derivatives. Newark, DE: Zeneca Limited; Patent WO 96/33980, 1996.
    • Gibson, K.1
  • 11
    • 85036680826 scopus 로고    scopus 로고
    • Quinazoline derivatives. New York, NY: Pfizer Inc.; Patent WO 96/30347, 1996
    • Schnur RC, Arnold LD: Quinazoline derivatives. New York, NY: Pfizer Inc.; Patent WO 96/30347, 1996.
    • Schnur, R.C.1    Arnold, L.D.2
  • 14
    • 0029975029 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor
    • Rewcastle GW, Palmer BD, Thompson AM, Bridges AJ, Cody DR, Zhou H, Fry DW, McMichael A, Denny WA: Tyrosine kinase inhibitors: 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor. J Med Chem 1996, 39:1823-1835.
    • (1996) J Med Chem , vol.39 , pp. 1823-1835
    • Rewcastle, G.W.1    Palmer, B.D.2    Thompson, A.M.3    Bridges, A.J.4    Cody, D.R.5    Zhou, H.6    Fry, D.W.7    McMichael, A.8    Denny, W.A.9
  • 15
    • 0037752200 scopus 로고    scopus 로고
    • Specific suppression of the epidermal growth factor receptor tyrosine kinase in tumor cells and ensuing inhibition of clone formation in soft agar
    • Fry DW, Nelson JM, McMichael A, Rewcastle GW, Denny WA, Zhou HR, Bridges AJ: Specific suppression of the epidermal growth factor receptor tyrosine kinase in tumor cells and ensuing inhibition of clone formation in soft agar. Proc Am Assoc Cancer Res 1996, 37:424.
    • (1996) Proc Am Assoc Cancer Res , vol.37 , pp. 424
    • Fry, D.W.1    Nelson, J.M.2    McMichael, A.3    Rewcastle, G.W.4    Denny, W.A.5    Zhou, H.R.6    Bridges, A.J.7
  • 16
    • 9844250309 scopus 로고    scopus 로고
    • PD 158780 is a potent inhibitor of heregulin-dependent tyrosine phosphorylation of erbB2, erbB3, and erbB4
    • Slintak V, Keller PR, Rewcastle GW, Denny WA, Fry DW: PD 158780 is a potent inhibitor of heregulin-dependent tyrosine phosphorylation of erbB2, erbB3, and erbB4. Proc Am Assoc Cancer Res 1997, 38:470.
    • (1997) Proc Am Assoc Cancer Res , vol.38 , pp. 470
    • Slintak, V.1    Keller, P.R.2    Rewcastle, G.W.3    Denny, W.A.4    Fry, D.W.5
  • 19
    • 85036678889 scopus 로고    scopus 로고
    • Pyrazole derivatives and processes for the preparation thereof. East Hannover, NJ: Ciba-Geigy AG; Patent WO96/31510, 1996
    • Traxler P: Pyrazole derivatives and processes for the preparation thereof. East Hannover, NJ: Ciba-Geigy AG; Patent WO96/31510, 1996.
    • Traxler, P.1
  • 20
    • 0030008414 scopus 로고    scopus 로고
    • 4-(Phenylamino)pyrrolopyrimidines: Potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase
    • Traxler PM, Furet P, Mett H, Buchdunger E, Meyer T, Lydon N: 4-(Phenylamino)pyrrolopyrimidines: Potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase. J Med Chem 1996, 39:2285-2292.
    • (1996) J Med Chem , vol.39 , pp. 2285-2292
    • Traxler, P.M.1    Furet, P.2    Mett, H.3    Buchdunger, E.4    Meyer, T.5    Lydon, N.6
  • 21
    • 0027215414 scopus 로고
    • Platelet-derived growth factor: Structure, function and implications in normal and malignant cell growth
    • Westermark B, Heldin CH: Platelet-derived growth factor: Structure, function and implications in normal and malignant cell growth. Acta Oncol 1993, 32:101-105.
    • (1993) Acta Oncol , vol.32 , pp. 101-105
    • Westermark, B.1    Heldin, C.H.2
  • 22
    • 0031026055 scopus 로고    scopus 로고
    • Potent and selective inhibitors of the abl-kinase: Phenylaminopyrimidine (PAP) derivatives
    • Zimmermann J, Buchdunger E, Mett H, Meyer T, Lydon NB: Potent and selective inhibitors of the abl-kinase: Phenylaminopyrimidine (PAP) derivatives. Bioorg Med Chem Lett 1997, 7:187-192. Well characterized and highly specific PDGF receptor tyrosine kinase inhibitor.
    • (1997) Bioorg Med Chem Lett , vol.7 , pp. 187-192
    • Zimmermann, J.1    Buchdunger, E.2    Mett, H.3    Meyer, T.4    Lydon, N.B.5
  • 23
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Buchdunger E, Zimmermann J, Mett H, Meyer T, Mueller M, Druker BJ, Lydon NB: Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 1996, 56:100-104.
    • (1996) Cancer Res , vol.56 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Mueller, M.5    Druker, B.J.6    Lydon, N.B.7
  • 24
    • 85036683406 scopus 로고    scopus 로고
    • Method and compositions for inhibiting protein kinases. World Pat Appl WO 9613259, 9 May, 1996
    • Giese NA, Lokker N: Method and compositions for inhibiting protein kinases. World Pat Appl WO 9613259, 9 May, 1996.
    • Giese, N.A.1    Lokker, N.2
  • 25
    • 85036681187 scopus 로고    scopus 로고
    • Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases. World Pat Appl WO 9614843, 23 May, 1996
    • Giese NA, Lokker N, Laibelman AM, Scarborough RM: Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases. World Pat Appl WO 9614843, 23 May, 1996.
    • Giese, N.A.1    Lokker, N.2    Laibelman, A.M.3    Scarborough, R.M.4
  • 27
    • 85036676831 scopus 로고    scopus 로고
    • Pyrido[2,3-d]pyrimidines as protein tyrosine kinase mediated cell proliferation inhibitors. World Pat App WO 9634867, 7 Nov, 1996
    • Blankley CJ, Boschelli DH, Doherty AM, Hamby JM, Klutchko S, Panek RL: Pyrido[2,3-d]pyrimidines as protein tyrosine kinase mediated cell proliferation inhibitors. World Pat App WO 9634867, 7 Nov, 1996.
    • Blankley, C.J.1    Boschelli, D.H.2    Doherty, A.M.3    Hamby, J.M.4    Klutchko, S.5    Panek, R.L.6
  • 28
    • 85036682110 scopus 로고    scopus 로고
    • 6-Aryl pyrido[2,3-d]pyrimidines and naphthyridines for inhibiting protein tyrosine kinase-mediated cellular proliferation. World Pat Appl WO 9615128, 23 May, 1996
    • Blankley CJ, Doherty AM, Hamby JM, Panek RL, Schroeder MC, Showalter HDH, Connolly C: 6-Aryl pyrido[2,3-d]pyrimidines and naphthyridines for inhibiting protein tyrosine kinase-mediated cellular proliferation. World Pat Appl WO 9615128, 23 May, 1996.
    • Blankley, C.J.1    Doherty, A.M.2    Hamby, J.M.3    Panek, R.L.4    Schroeder, M.C.5    Hdh, S.6    Connolly, C.7
  • 34
    • 0010545020 scopus 로고    scopus 로고
    • Signal transduction by the src family of tyrosine protein kinases
    • Edited by Bertino J. San Diego: Academic Press
    • Bolen JB, Penhallow RC, Burkhardt AL: Signal transduction by the src family of tyrosine protein kinases. In Encyclopedia of Cancer. Edited by Bertino J. San Diego: Academic Press; 1997:1657-1668.
    • (1997) Encyclopedia of Cancer , pp. 1657-1668
    • Bolen, J.B.1    Penhallow, R.C.2    Burkhardt, A.L.3
  • 36
    • 0027172209 scopus 로고
    • The src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cell
    • Twamley-Stein GM, Pepperkok R, Ansorge W, Courtneidge SA: The src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cell. Proc Natl Acad Sci U S A 1993, 90:7696-7700.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 7696-7700
    • Twamley-Stein, G.M.1    Pepperkok, R.2    Ansorge, W.3    Courtneidge, S.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.