Thalidomide and chemotherapy combination: Preliminary results of preclinical and clinical studies

International Journal of Oncology

Volumn 10, Issue 5, 1997, Pages 965-969

  Nguyen, Mai ^a,b   Tran, Chanh ^a   Barsky, Sanford ^a   Sun, J I Rong ^a   McBride, William ^a   Pegram, Mark ^a   Pietras, Richard ^a   Love, Susan ^a   Glaspy, John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

angiogenesis; breast cancer; combination therapy; thalidomide

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL; THALIDOMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG POTENTIATION; ERYTHEMA; FEMALE; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL;

EID: 0030915633     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Folkman J: Angiogcnesis in cancer, vascular, rheumatoid and other disease. Nature Med I: 27-31, 1995.
2. Folkman J: Clinical applications of research on angiogenesis. New Engl J Med 333: 1757-1763, 1995.
3. Christie GA: Thalidomide and congenital abnormalities. Lancet ii: 249, 1962.
4. Stephens TD: Proposed mechanisms of action in thalidomide embryopathy. Teratology 38: 229-239, 1988.
5. D'Amato RJ, Loughnan MS, Flynn E and Folkman J: Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA 91: 4082-4085, 1994.
6. Yamamoto Y, Toi M, Yamada R and Tominaga T: Combination effect of an angiogenesis inhibitor AGM-1470 with 5′-deoxy-5-fluorouridine, and with hormonal drugs in DMBA-induced rat mammary tumors. Oncol Rep 2: 793-796, 1995.
7. Ching LM, Xu ZF, Gummer BH, Palmer BD, Joseph WR and Baguley BC: Effect of thalidomide on tumour necrosis factor production and anti-tumour activity induced by 5, 6-dimethylxanthenone-4-acetic acid. Br J Cancer 72: 339-343, 1995.
8. Grabstald H and Golbey R: Clinical experiences with thalidomide in patients with cancer. Clin Pharmacol Ther 6: 298-302, 1995.
9. Olson KB, Hall TC, Horton J, Khung CL and Hosley HF: Thalidomide (N-phthaloylglutamimide) in the treatment of advanced cancer. Clin Pharmacol Ther 6: 292-297, 1965.
10. Powell RJ and Gardner-Medwin JMM: Guideline for the clinical use and dispensing of thalidomide. Postgrad Med J 70: 901-904, 1994.