TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis

International Journal of Cancer

Volumn 75, Issue 2, 1998, Pages 246-253

  Valente, Piera ^a   Fassina, Gianfranco ^a,e   Melchiori, Antonella ^a   Masiello, Luciana ^a   Cilli, Michele ^b   Vacca, Angelo ^c   Onisto, Maurizio ^d   Santi, Leonardo ^a,b   Stetler Stevenson, William G ^f   Albini, Adriana ^a,b,g  

^a UNIVERSITY OF GENOA   (Italy)

^b ADVANCED BIOTECHNOLOGY CENTER   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d UNIVERSITY OF PADOVA   (Italy)

^e CNR   (Italy)

^f NATIONAL CANCER INSTITUTE   (United States)

^g CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE INHIBITOR OF METALLOPROTEINASE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER INVASION; CONTROLLED STUDY; DNA TRANSFECTION; EXPRESSION VECTOR; GENE OVEREXPRESSION; MELANOMA; MELANOMA B16; METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CELL DIVISION; FEMALE; HUMANS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NECROSIS; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032545643     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980119)75:2<246::AID-IJC13>3.0.CO;2-B     Document Type: Article

References (32)

1. ALBINI, A., FONTANINI, G., MASIELLO, L., TACCHETTI, C., BIGINI, D., LUZZI, P., NOONAN, D.M. and STETLER-STEVENSON, W.O., Angiogenic potential in vivo by Kaposi's sarcoma cell-free supernatants and HIV-1 tat product: inhibition of KS-like lesions by tissue inhibitor of metalloproteinase-2. AIDS, 8, 1237-1244 (1994).
2. ALBINI, A., IWAMOTO, Y., KLEINMAN, H.K., MARTIN, G.R., AARONSON, S.A., KOZLOWSKY, J.M. and MCEWAN, R.N., A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res., 47, 3239-3245 (1987).
3. ALBINI, A., MELCHIORI, A., SANTI, L., LIOTTA, A.L., BROWN, P.D. and STETLER-STEVENSON, W.G., Tumor cell invasion inhibited by TIMP-2. J. nat. Cancer Inst., 83, 775-779 (1991).
4. ALEXANDER, C.M., HANSELL, E.J., BEHRENDTSEN, O., FLANNERY, M.L., KISHNANI, N.S., HAWKES, S.P. and WERB, Z., Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation. Development, 122, 1723-1736 (1996a).
5. ALEXANDER, C.M., HOWARD, E.W., BISSELL, M.J. and WERB, Z., Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinase-1 transgene. J. Cell Biol., 135, 1669-1677 (1996b).
6. APTE, S.S., MATTEI, M.G. and OLSEN, B.R., Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the timp3 gene to chromosome 22. Genomics, 19, 56-90 (1994).
7. AZNAVOORIAN, S., MURPHY, A.N., STETLER-STEVENSON, W.G. and LIOTTA, L., Molecular aspects of tumor cell invasion and metastasis. Cancer, 71, 1368-1383 (1993).
8. BASBAUM, C.B. and WERB, Z., Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface. Curr. Opinions Cell Biol. 8, 731-738 (1996).
9. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell, 79, 1157-1164 (1994).
10. 3. Cell, 85, 683-693 (1996).
11. 3 on human melanoma cells. Cancer Metastasis Rev., 10, 3-10 (1991).
12. CORCORAN, M.L. and STETLER-STEVENSON, W.G., Tissue inhibitor of metalloproteinase-2 stimulates fibroblast proliferation via a cAMP-dependent mechanism. J. biol. Chem., 270, 13453-13459 (1995).
13. DECLERCK, Y.A., PEREZ, N., SHIMADA, H., BOONE, T.C., LANGLEY, K.E. and TAYLOR, S.M., Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases. Cancer Res., 52, 701-708 (1992).
14. DOCHERTY, A.J.P., LYONS, A., SMITH, B.J., WRIGHT, E.M., STEPHENS, P.E., HARRIS, T.J., MURPHY, G. and REYNOLDS, J.J., Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature (Lond.), 318, 66-69 (1985).
15. FRIDMAN, R., SWEENEY, T.M., ZAIN, M., MARTIN, G.R. and KLEINMAN, H.K., Malignant transformation of NIH-3T3 cells after subcutaneous co-injection with a reconstituted basement membrane (Mutrigel). Int. J. Cancer, 51, 740-744 (1992).
16. FRISCH, S.M. and FRANCIS, H., Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol., 124, 619-626 (1994).
17. GOLDBERG, G.I., MARMER, B.L., GRANT, G.A., EISEN, A.Z., WILHELM, S. and HE, C., Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2. Proc. nat. Acad. Sci. (Wash.), 86, 8207-8211 (1989).
18. GREENE, J., WANG, M., LIU, Y.E., RAYMOND, L.A., ROSEN, C. and SHI, Y.E., Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. J. biol. Chem., 271, 30375-30380 (1996).
19. GÚEDEZ, L., MANSOOR, A., STETLER-STEVENSON, W.G. and STETLER-STEVENSON, M., TIMP-1 inhibit apoptosis in Burkitt's lymphomas. Proc. 88th Ann. Meet. Amer. Assoc. Cancer Res., San Diego. 38, 165 (1997).
20. IMREN, S., KOHN, D.B., SHIMADA, H., BLAVIER, L. and DECLERCK, Y.A., Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion. Cancer Res., 56, 2891-2895 (1996).
21. MATRISIAN, L.M., The matrix-degrading metalloproteinases. BioEssays, 14, 455-463 (1992).
22. MCGAHON, A., MARTIN, S., BISSONETTE, S., MAHBOUBI, A., SHI, Y. MOGIL, R., NISHIOKA, W. and GREEN D., The end of the (cell) line: methods for the study of apoptosis in vitro. Methods Cell Biol., 46, 153-185 (1995).
23. MONTGOMERY, A.M., MUELLER, B.M., REISFELD, R.A., TAYLOR. S.M. and DECLERCK, Y.A., Effects of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line. Cancer Res., 54, 5467-5473 (1994a).
24. 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc. nat. Acad. Sci. (Wash.), 91, 8856-8860 (1994b).
25. MURPHY, A.N., UNSWORTH, E.J. and STETLER-STEVENSON, W.G., Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation. J. cell. Physiol., 157, 351-358 (1993).
26. NEMETH, J.A. and GOOLSBY, C.L., TIMP-2, a growth-stimulatory protein from SV40-transformed human fibroblasts. Exp. Cell Res., 207, 376-382 (1993).
27. RAY, J.M. and STETLER-STEVENSON, W.G., The role of matrix metalloproteases and their inhibitors in tumour invasion, metastasis and angiogenesis. Europ. Respir. J., 7, 2062-2072 (1994).
28. RAY, J.M. and STETLER-STEVENSON, W.G., Gelatinase A activity directly modulates melanoma cell adhesion and spreading. EMBO J., 14, 908-917 (1995).
29. STETLER-STEVENSON, W.G., KRUTZSCH, H.C., WACHER, M.P., MARGULIES, I.M. and LIOTTA, L.A., The activation of human type IV collagenase proenzyme. J. biol. Chem., 264, 1353-1356 (1989).
30. STRONGIN, A.Y., COLLIER, I., BANNIKOV, G., MARMER, B.L., GRANT, G.A. and GOLDBERG, G.I., Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease. J. biol., Chem., 270, 5331-5338 (1995).
31. TRYGGVASON, K., HÖYHTYÄ, M. and PYKE, C., Type IV collagenase in invasive tumors. Breast Cancer Res. Treat., 24, 209-218 (1993).
32. VACCA, A., DI LORETO, M., RIBATTI, D., DI STEFANO, R., GADALETA-CALDAROLA, G., IODICE, G., CALORO, D. and DAMMACCO, F., Bone marrow of patients with active multiple myeloma: angiogenesis and plasma cell adhesion molecules LFA-1, VLA-4, LAM-1 and CD44. Amer. J. Hematol., 50, 9-14 (1995).