13C NMR study of the effects of leptin treatment on kinetics of hepatic intermediary metabolism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 13, 1998, Pages 7385-7390

  Cohen, Sheila M ^a   Werrmann, Jeffrey G ^a   Tota, Michael R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUTAMIC ACID; KETONE BODY; LEPTIN; PROTEIN; ACETYL COENZYME A CARBOXYLASE; FATTY ACID SYNTHASE; GLYCOGEN SYNTHASE; LEPTIN RECEPTOR;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECT; GLYCOGEN LIVER LEVEL; IN VITRO STUDY; KINETICS; LIVER; METABOLISM; MOUSE; MOUSE MUTANT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; UPREGULATION; ANIMAL TISSUE; CARBOHYDRATE METABOLISM; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ACTIVITY; ENZYME ASSAY; FATTY ACID SYNTHESIS; GLUCONEOGENESIS; GLYCOGEN SYNTHESIS; LIPID METABOLISM; LIVER METABOLISM; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; FATTY ACIDS; GLUTAMIC ACID; KETONE BODIES; KINETICS; LEPTIN; LIVER; LIVER GLYCOGEN; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED C57BL; MICE, OBESE; MODELS, BIOLOGICAL; OBESITY; PROTEINS; UP-REGULATION;

EID: 0032560448     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.13.7385     Document Type: Article

References (23)

1. Lee, G. H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I. & Friedman, J. M. (1996) Nature (London) 379, 632-635.
2. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K. & Friedman, J. M. (1995) Science 269, 543-546.
3. Levin, N., Nelson, C., Gurney, A., Vandlen, R. & de Sauvage, F. (1996) Proc. Natl. Acad. Sci. USA 93, 1726-1730.
4. Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Jr., Woods, S. C., Seeley, R. J. & Weigle, D. S. (1996) Diabetes 45, 531-535.
5. Fei, H., Okano, H. J., Li, C., Lee, G. H., Zhao, C., Darnell, R. & Friedman, J. M. (1997) Proc. Natl. Acad. Sci. USA 94, 7001-7005.
6. Cohen, S. M. (1987) Biochemistry 26, 563-572.
7. Cohen, S. M. (1991) in Research in Perfused Liver, eds. Ballet, F. & Thurman, R. G. (Libbey, London), pp. 43-68.
8. Rosenblum, C. I., Tota, M., Cully, D., Smith, T., Colum, R., Qureshi, S., Hess, J. F., Phillips, M. S., Hey, P. J., Vongs, A., et al. (1996) Endocrinology 137, 5178-5181.
9. Overloop, K., Vanstapel, F. & Van Hecke, P. (1996) Magn. Reson. Med. 36, 45-51.
10. Cohen, S. M. (1987) Biochemistry 26, 581-589
11. Nuttall, F. Q. & Gannon, M. C. (1989) Anal. Biochem. 178, 311-319
12. Hems, D. A., Rodrigues, L. M. & Whitton, P. D. (1976) Biochem. J. 160, 367-374.
13. Nepokroeff, C. M., Lakshmanan, M., R. & Porter, J. W. (1975) Methods Enzymol. 35, 37-44.
14. Jamil, H. & Madsen, N. B. (1987) J. Biol. Chem. 262, 638-642.
15. Lopez-Casillas, F., Bai, D.-H., Luo, X., Kong, I.-S., Hermodson, M. A. & Kim, K.-H. (1988) Proc. Natl. Acad. Sci. USA 85, 5784-5788.
16. Cohen, S. M. (1983) J. Biol. Chem. 258, 14294-14308.
17. Cohen, S. M. (1987) Biochemistry 26, 573-580.
18. Goodridge, A. G. (1991) in Biochemistry of Lipids, Lipoproteins, and Membranes, eds. Vance, D. E. & Vance, J. (Elsevier, New York), Vol. 20, pp. 111-139.
19. Moule, S. K., Edgell, N. J., Welsh, G. I., Diggle, T. A., Foulstone, E. J., Heesom, K. J., Proud, C. G. & Denton, R. M. (1995) Biochem. J. 311, 595-601.
20. Grunfeld, C., Soued, M., Adi, S., Moser, A. H., Dinarello, C. A. & Feingold, K. R. (1990) Endocrinology 127, 46-54.
21. Shimabukuro, M., Koyama, K., Chen, G., Wang, M. Y., Trieu, F., Lee, Y., Newgard, C. B. & Unger, R. H. (1997) Proc. Natl. Acad. Sci. USA 94, 4637-4641.
22. Olson, M. S. (1992) in Textbook of Biochemistry with Clinical Correlations, ed. Devlin, T. M. (Wiley, New York), pp. 237-289.
23. Cook, H. W. (1996) in Biochemistry of Lipids, Lipoproteins, and Membranes, eds. Vance, D. E. & Vance, J. E. (Elsevier, New York), Vol. 31, pp. 129-152.