Sympathetic and Cardiorenal Actions of Leptin

Hypertension

Volumn 30, Issue 3, 1997, Pages 619-623

  Haynes, William G ^a   Sivitz, William I ^a   Morgan, Donald A ^a   Walsh, Susan A ^a   Mark, Allyn L ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CATECHOLAMINE; CORTICOSTEROID; CORTICOTROPIN RELEASING FACTOR; CYTOKINE; GLUCOSE; INSULIN; LEPTIN; MESSENGER RNA; NEUROPEPTIDE; NORADRENALIN; PROTEIN; RECEPTOR; SODIUM; WATER;

ADRENERGIC SYSTEM; BLOOD BRAIN BARRIER; BLOOD PRESSURE; BODY FAT; BODY WEIGHT; BROWN ADIPOSE TISSUE; CONFERENCE PAPER; ENERGY EXPENDITURE; FEEDBACK SYSTEM; HUMAN; INSULIN SENSITIVITY; KIDNEY; NONHUMAN; OBESITY; PRESSOR RESPONSE; PRIORITY JOURNAL; THERMOGENESIS;

ADIPOSE TISSUE; ANIMALS; BLOOD PRESSURE; HUMANS; INSULIN; KIDNEY; LEPTIN; OBESITY; PROTEINS; SYMPATHETIC NERVOUS SYSTEM;

EID: 0030847881     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/01.HYP.30.3.619     Document Type: Article

References (45)

1. Wood JE, Cash JR. Obesity and hypertension: clinical and experimental observations. Ann Intern Med. 1939;13:81-91.
2. Reisen E, Abel R, Modan M, Silverberg DS, Eliahou HE, Modan B. Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. N Engl J Med. 1978;298:1-6.
3. Stamler RA, Stamler J, Riedlinger WF, Algera G, Roberts RH. Weight and blood pressure findings in hypertension screening of 1 million Americans. JAMA. 1978;240:1607-1610.
4. Rocchini AP, Moorhead CP, DeRemer S, Blondie S. Pathogenesis of weight-related changes in blood pressure in dogs. Hypertension. 1989;13:922-928.
5. Hsueh WA, Buchanan TA. Obesity and hypertension. Endocrine Hypertens. 1994;23:405-427.
6. Manson JE, Willett WC, Stampfer MJ, Colditz GA, Hunter DJ, Hankinson SE, Hennekens CH, Speizer PE. Body weight and mortality among women. N Engl J Med. 1995;333:677-685.
7. Anderson EA, Mark AL. The vasodilator action of insulin: implications for the insulin hypothesis of hypertension. Hypertension. 1993;21:136-141.
8. Kassab S, Kato T, Wilkins FC, Chen R, Hall JE, Granger JP. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension. 1995;25:893-895.
9. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-432.
10. Stephens TW, Basinski M, Bristow PK, Bue-Vallesky JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hslung HM, Kriauciunas A, MacKellar W, Rosteck PR, Schoner B, Smith D, Tinsley FC, Zhang X-Y, Heiman M. The role of neuropeptide Y in the anti-obesity action of the obese gene product. Nature. 1995;377:530-532.
11. Schwartz M, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest. 1996;98:1101-1106.
12. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997;88:131-141.
13. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 1997;385:165-168.
14. Arner P. The beta3-adrenergic receptor: a cause and cure of obesity. N Engl J Med. 1995;333:382-383.
15. Hirsch J. Some heat but not enough light. Nature. 1997;387:27-28.
16. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levimeyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 1997;15:269-272.
17. Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 1973;9:294-298.
18. Sinha MK, Opentanova I, Ohannesian JP, Kolaczynski JW, Heiman ML, Hale J, Becker GW, Bowsher RR, Stephens TW, Caro JF. Evidence of free and bound leptin in human circulation: studies in lean and obese subjects and during short-term fasting. J Clin Invest. 1996;98:1277-1282.
19. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fai Y, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM. Leptin levels in human and rodent: measurement of plasma leptin and Ob RNA in obese and weight-reduced subjects. Nat Med. 1995;1:1155-1161.
20. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J. Transient increase in expression in obese gene expression after food intake or insulin expression. Nature. 1995;377:527-529.
21. Cusin I, Sainsbury A, Doyle P, Rohner-Jeanrenaud F, Jeanrenaud B. The ob gene and insulin: a relationship leading to clues to the understanding of obesity. Diabetes. 1995;44:1467-1470.
22. De Vos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by weight loss and reduced food intake. J Biol Chem. 1995;270:15958-15961.
23. Trayhurn P, Duncan JS, Rayner DV. Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem J. 1995;311:729-733.
24. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang P, Sinha MK, Considine RV. Decreased cerebrospinal fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 1996;348:159-161.
25. Schwartz MW, Peskind E, Raskind M, Boyko E, Porte D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med. 1996;2:589-593.
26. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides. 1996;17:305-311.
27. Golden P, Maccagnan TJ, Pardridge WM. Human blood-brain barrier leptin receptor: binding and endocytosis in isolated human brain microvessels. J Clin Invest. 1997;99:14-18.
28. Tartaglia LA, Dembski M, Weng X, Deng N, Culpapper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995;83:1263-1271.
29. Chen H, Charlatb O, Tartaglia LA, Wolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin recpetor in db/db mice. Cell. 1996;84:491-495.
30. Lee G-H, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 1996;379:632-635.
31. Vaisse C, Halaas JL, Horvath CM, Darnell JE Jr, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice, but not db/db mice. Nat Genet. 1996;14:95-97.
32. Emilsson V, Liu YL, Cawthorne MA, Morton NM, Davenport M. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes. 1997;46:313-316.
33. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540-543.
34. Halaas JL, Gajiwalla KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269:543-546.
35. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546-549.
36. Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS. Role of leptin in fat regulation. Nature. 1996;380:677.
37. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest. 1997;100:270-278.
38. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Haskey CT, Hess JF. Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet. 1996;13:18-19.
39. Jackson EK, Li P. Human leptin may function as a diuretic/natriuretic hormone. Hypertension. 1996;28:517. Abstract.
40. Reams G, Villarreal D, Taraben A, Freeman RH, Knoblich P. Renal effects of leptin in normotensive and spontaneously hypertensive rats. FASEB J. 1997;11:A258. Abstract.
41. Chen GX, Koyama K, Yuan X, Lee Y, Zhou YT, Odoherty R, Newgard CB, Unger RH. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci U S A. 1996;93:14795-14799.
42. Sivitz WI, Walsh SA, Morgan DA, Thomas MJ, Haynes WG. Effects of leptin on insulin sensitivity in normal rats. Endocrinology. 1997;138:3395-3401.
43. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-295.
44. Ravussin E, Pratley RE, Maffei M, Wang H, Friedman JM, Bennett PH, Bogardus C. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med. 1997;3:238-240.
45. Vanheek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis HR. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest. 1997;99:385-390.