Leptin depolarizes rat hypothalamic paraventricular nucleus neurons

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 274, Issue 5 43-5, 1998, Pages

  Powis, Jeff E ^a   Bains, Jaideep S ^a   Ferguson, Alastair V ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Electrophysiology; Feeding; Hypothalamus

Indexed keywords

LEPTIN; SODIUM CHANNEL;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DEPOLARIZATION; FEEDING; GENE EXPRESSION; HYPOTHALAMUS; MALE; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; THALAMUS MIDLINE NUCLEUS; VOLTAGE CLAMP;

EID: 0031832087     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.5.r1468     Document Type: Article

References (33)

1. Aravich, P. F., and A. Sclafani. Paraventricular hypothalamic lesions and medial hypothalamic knife cuts produce similar hyperphagia syndromes. Behav. Neurosci. 97: 970-983, 1983.
2. Bains, J. S., and A. V. Ferguson. Nitric oxide regulates NMDA-driven GABAergic inputs to type I neurons of the rat paraventricular nucleus. J. Physiol. (Lond.) 499: 733-746, 1997.
3. Banks, W. A., A. J. Kastin, W. Huang, J. B. Jaspan, and L. M. Maness. Leptin enters the brain by a saturable system independent of insulin. Peptides 17: 305-311, 1996.
4. Campfield, L. A., F. J. Smith, Y. Guisez, R. Devos, and P. Burn. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549, 1995.
5. Elmquist, J. K., R. S. Ahima, E. Maratos-Flier, J. S. Flier, and C. B. Saper. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138: 839-842, 1997.
6. Frederich, R. C., A. Hamann, S. Anderson, B. Lollmann, B. Lowell, and J. S. Flier. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1: 1311-1314, 1995.
7. Frederich, R. C., B. Lollmann, A. Hamann, A. Napolitano-Rosen, B. B. Kahn, B. Lowell, and J. S. Flier. Expression of ob mRNA and its encoded protein in rodents. J. Clin. Invest. 96: 1658-1663, 1995.
8. Glaum, S. R., M. Hara, V. P. Bindokas, C. C. Lee, K. S. Polonsky, G. I. Bell, and R. J. Miller. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol. Pharmacol. 50: 230-235, 1996.
9. Gold, R. M., P. M. Quackenbush, and G. Kapatos. Paraventricular nucleus: critical focus of a longitudinal neurocircuitry mediating food intake. Physiol. Behav. 18: 1111-1119, 1977.
10. Golden, P. L., T. J. Maccagnan, and W. M. Pardridge. Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J. Clin. Invest. 99: 14-18, 1997.
11. Hakansson, M. L., A. L. Hulting, and B. Meister. Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus: relationship with NPY neurones. Neuroreport 7: 3087-3092, 1996.
12. Halaas, J. L., K. S. Gajiwala, M. Maffei, S. L. Cohen, B. T. Chait, D. Rabinowitz, R. L. Lallone, S. K. Burley, and J. M. Friedman. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546, 1995.
13. Heinbecker, P., H. L. White, and J. P. Rolinat. Experimental obesity in the dog. Am. J. Physiol. 141: 549-565, 1944.
14. Huang, X. F., I. Koutcherov, S. Lin, H. Q. Wang, and L. Storlien. Localization of leptin receptor mRNA expression in mouse brain. Neuroreport 7: 2635-2638, 1996.
15. Kelly, J., J. Rothstein, and S. P. Grossman. GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol. Physiol. Behav. 23: 1123-1134, 1979.
16. Lee, G. H., R. Proenca, J. M. Montez, K. M. Carroll, J. G. Darvishzadeh, J. I. Lee, and J. M. Friedman. Abnormal splicing of the leptin receptor in the diabetic mice. Nature 379: 632-635, 1996.
17. Leibowitz, S. F. The paraventricular nucleus: a primary site mediating adrenergic stimulation of feeding and drinking. Pharmacol. Biochem. Behav. 8: 163-175, 1978.
18. Leibowitz, S. F. Brain monoamines and peptides: role in the control of eating behavior. Federation Proc. 45: 1396-1403, 1986.
19. Leibowitz, S. F., N. J. Hammer, and K. Chang. Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat. Physiol. Behav. 27: 1031-1040, 1981.
20. Maffei, M., J. L. Halaas, E. Ravussin, R. E. Pratley, G. H. Lee, Y. Zhang, H. Fei, S. Kim, R. Lallone, S. Ranganathan, P. A. Kern, and J. M. Freidman. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1: 1155-1161, 1995.
21. Moss, R. L., I. Urban, and B. A. Cross. Microelectrophoresis of cholinergic and aminergic drugs on paraventricular neurons. Am. J. Physiol. 223: 310-317, 1972.
22. Pelleymounter, M. A., M. J. Cullen, M. B. Baker, R. Hecht, D. Winters, T. Boone, and F. Collins. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995.
23. Pittman, Q. J., J. D. Hatton, and F. E. Bloom. Morphine and opioid peptides reduce paraventricular neuronal activity: studies on the rat hypothalamic slice preparation. Proc. Natl. Acad. Sci. USA 77: 5527-5531, 1980.
24. Pronchuk, N., and W. F. Colmers. Actions of neuropeptide Y receptors in paraventricular nucleus of rat hypothalamus. Soc. Neurosci. Abstr. 22: 612, 1996.
25. Samson, W. K., T. C. Murphy, D. Robison, T. Vargas, E. Tau, and J. K. Chang. A 35 amino acid fragment of leptin inhibits feeding in the rat. Endocrinology 137: 5182-5185, 1996.
26. Sclafani, A., and C. N. Berner. Hyperphagia and obesity produced by parasaggital and coronal hypothalamic knife cuts: further evidence for a longitudinal feeding inhibitory pathway. J. Comp. Physiol. Psychol. 91: 1000-1118, 1977.
27. Sinha, M. K., I. Opentanova, J. P. Ohannesian, J. W. Kolaczynski, M. L. Heiman, J. Hale, G. W. Becker, R. R. Bowsher, T. W. Stephens, and J. F. Caro. Evidence of free and bound leptin in human circulation. J. Clin. Invest. 98: 1277-1282, 1996.
28. Stanley, B. G., and S. F. Leibowitz. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. USA 82: 3940-3943, 1985.
29. Tasker, J. G., and F. E. Dudek. Electrophysiological properties of neurones in the region of the paraventricular nucleus in slices of rat hypothalamus. J. Physiol. (Lond.) 434: 271-293, 1991.
30. Van Dijk, G., T. E. Thiele, J. C. K. Donahey, L. A. Campfield, F. J. Smith, P. Burn, I. L. Bernstein, S. C. Woods, and R. J. Seeley. Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R1096-R1100, 1996.
31. Woods, A. J., and M. J. Stock. Leptin activation in hypothalamus. Nature 381: 745, 1996.
32. Woods, J. S., and S. F. Leibowitz. Hypothalamic sites sensitive to morphine and naloxone: effects on feeding behavior. Pharmacol. Biochem. Behav. 23: 431-438, 1984.
33. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.