In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: Localization of leptin activity to domains between amino acid residues 106-140

Endocrinology

Volumn 138, Issue 4, 1997, Pages 1413-1418

  Grasso, Patricia ^a   Leinung, Matthew C ^b   Ingher, Stacy P ^b   Lee, Daniel W ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; OBESITY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; WEIGHT GAIN;

EID: 0031003248     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.4.5087     Document Type: Article

References (28)

1. Zhang Y, Proenca R, Maffei M, Leopold L, Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
2. Lonnqvist F 1996 The obese (ob) gene and its product leptin - a new route toward obesity treatment in man? Q J Med 89:327-332
3. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman FM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
4. Pellymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
5. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C, Kuijper JL 1995 Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96:2065-2070
6. Ingalis AM, Dickie MM, Snell GD 1950 Obese, a new mutation in the house mouse. J. Hered 41:317-318
7. Bray GA, York DA 1979 Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev 59:719-809
8. B. Funahashi T, Shimomura I, Hiraoka T, Ari M, Takahashi T, Nakamura S, Nozaki S, Yamashita K, Takamura K, Matsuzawa Y 1995 Enhanced expression of rat obese (ob) gene in adipose tissue of ventromedial hypothalamus (VMH)-lesioned rats. Biochem Biophys Res Commun 221:469-475
9. Hamilton BS, Paglia AY, Kwan M, Deitel M 1995 Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med 1:953-955
10. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549
11. Tartaglia L, Dembski L, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smulko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI 1995 Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271
12. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffman J, Hsiung HM, Kriauciunas A, MacKellar W, Rostech, Jr, PR, Schoner B, Smith D, Tinsley FC, Zhang X-Y, Heiman M 1995 The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377:530-532
13. Swartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Saller G, Prunkard DE, Porte, Jr, D, Woods SC, Seeley RJ, Weigle DS 1996 Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-535
14. Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, Bauer L, Rosato EL, Colberg J, Caro JF 1995 Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 95:2986-2988
15. Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, Mori K, Tamura N, Hosoda K, Yashimasa Y, Jingami H, Kawada T, Nakao K 1995 Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44:855-858
16. Considine RV, Considine EL, Williams CJ, Nyce MR, Zhang P, Opentanova I, Ohassesian JP, Kolaczynski JW, Bauer TL, Moore JH, Caro JF 1996 Mutation screening and identification of a sequence variation in the human ob gene coding region. Biochem Biophys Res Commun 220:735-739
17. Clement K, Garner C, Hager J, Philippi A, LeDuc C, Carey A, Harris TJR, Jury C, Cardon LR, Basdevant A, Deminais F, Guy-Grand B, North M, Froguel P 1996 Indication for linkage of the human OB gene region with extreme obesity. Diabetes 45:687-690
18. Reed DR, Ding Y, Xu W, Cather C, Green ED, Price RA 1996 Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 45:691-694
19. Considine RV, Sinha MK, Heiman ML, Kriaciunas A, Stephens TW, Nyce MR, Ohannisian JP, Marco CC, McKee LJ, Bauer TL, Caro JF 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295
20. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med 1:1155-1161
21. Gwo-Hwa L, Proenca R, Montez JM, Caroll KM, Darvishzadeh JG, Lee JI, Friedman JM 1996 Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635
22. Malik KF, Young III S 1996 Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob) and diabetic (dbldb) C57BL/6J mice. Endocrinology 137:1197-1200
23. Considine RF, Caro JF 1996 Leptin in humans: current progress and future directions. Clin Chem 42:843-844
24. Grasso P, Reichert Jr LE 1996 In vivo effects of follitropin-related synthetic peptides on the mouse estrous cycle. Endocrinology 137:5370-5375
25. Grasso P, Deziel MR, Reichert, Jr, LE 1995 Residues 551 to 555 and 650 to 653 of the rat testicular FSH receptor are sufficient for post-receptor modulation of Sertoli cell responsiveness to FSH stimulation. Regul Pept 60:177-183
26. Grasso P, Reichert, Jr, LE 1994 Evidence that a calmodulin-like binding domain of follicle-stimulating hormone (FSH) beta-subunit is involved in FSH-induced calcium uptake by Sertoli cells. J Mol Endocrinol 13:149-155
27. Hruby VJ, Bonner GG 1994 Design of novel synthetic peptides including cyclic conformationally and topographically constrained analogs. Methods Mol Biol 35:201-240
28. Samson WK, Murphy TC, Robison D, Vargas T, Tau E, Chang J-W 1996 A 35 amino acid fragment of leptin inhibits feeding in the rat. Endocrinology 137:5182-5185