Neuroendocrine responses to starvation and weight loss

New England Journal of Medicine

Volumn 336, Issue 25, 1997, Pages 1802-1811

  Schwartz, Michael W ^a,b   Seeley, Randy J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; NEUROPEPTIDE Y; PROTEIN;

ADRENAL DISEASE; DIABETES MELLITUS; DIAGNOSIS; DISEASE MANAGEMENT; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; NEGATIVE FEEDBACK; NEUROENDOCRINE SYSTEM; OBESITY; PRIORITY JOURNAL; REVIEW; STARVATION; WEIGHT REDUCTION; ADIPOSE TISSUE; ANIMAL; BODY WEIGHT; ENDOCRINE DISEASE; HOMEOSTASIS; HYPOPHYSIS ADRENAL SYSTEM; PATHOPHYSIOLOGY; PHYSIOLOGY; WASTING SYNDROME;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; ENDOCRINE SYSTEM DISEASES; HOMEOSTASIS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LEPTIN; NEUROPEPTIDE Y; PITUITARY-ADRENAL SYSTEM; PROTEINS; STARVATION; WASTING SYNDROME; WEIGHT LOSS;

EID: 0031578276     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199706193362507     Document Type: Review

References (87)

1. Keys A, Brǒek J, Henschel A, Mickclson O, Taylor HL. The biology of human starvation. Minneapolis: University of Minnesota Press, 1950.
2. Cahill GF Jr, Herrcra MG, Morgan AP, et al. Hormone-fuel interrelationships during fasting. J Clin Invest 1966;45:1751-69.
3. Sakaguchi T, Arase K, Fisler JS, Bray GA. Effect of starvation and food intake on sympathetic activity. Am J Physiol 1988;255:R284-R288.
4. Pirke K, Schweiger U, Strowitzki T, et al. Dieting causes menstrual irregularities in normal weight young u-omen through impairment of episodic lutcinizing hormone secretion. Fertil Steril 1989;51:263-8.
5. Dallman MF, Strack AM, Akana SF, et al. Feast and famine: critical role of glucocorticoids with insulin in daily energy flow. Front Neu roc n docrinol 1993;14:303-47.
6. Bcrgendahl M, Vancc ML, Iranmanesh A, Thorner MO, Vcldhuis JD. Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemcral cortisol concentrations in healthy men. J Clin Endocrinol Metab 1996;81:692-9.
7. Harris RBS, Kasser TR, Martin RJ. Dynamics of recovery of body composition after overfeeding, food restriction or starvation of mature female rats. JNutr 1986;116:2536-46.
8. Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc RSoc Lond (Biol) 1953;140:578-96.
9. Colcman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973;9:294-8.
10. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32. [Erratum, Nature 1995;374:479.]
11. Considine RV, Sinha MK, Heiman ML, et al. Scrum immunorcactiveleptin concentrations in normal-weight and obese humans. N Engi J Med 1996;334:292-5.
12. Rosenbaum M, Nicolson M, Hirsch J, et al. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 1996;81:3424-7,
13. Frederich RC, Lollmann B, Hamann A, et al. Expression of ob mRNA and its encoded protein in rodents: impact of nutrition and obesity. J Clin Invest 1995;96:1658-63.
14. Boden G, Chen X, Mozzoli M, Ryan I. Effect of fasting on scrum leptin in normal human subjects. J Clin Endocrinol Metab 1996;81:3419-23.
15. Campficld LA, Smith FI, Guiscz Y, Devos R, Burn P Rccombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546-9.
16. Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269;543-6.
17. Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269:540-3.
18. Chua SC Jr, Chung WK, Wu-Peng XS, et al. Phenotypes of mouse diabetes rat fatty due to mutations in the OB (leptin) receptor. Science 1996;271:994-6.
19. Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996;379:632-5.
20. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D Jr. Cerebro- spinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 1996;2:589-93.
21. Woods SC, Porte D Jr, Bobbioni E, et al. Insulin: its relationship to the central nervous system and to the control of food intake and body weight. Am J Clin Nutr 1985;42;Suppl;1063-71.
22. Bagdade JD, Bicrman EL, Porte D Jr. The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J Clin Invest 1967;46:1549-57.
23. Baura GD, Foster DM, Porte D Jr, et al. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo: a mechanism for regulated insulin delivery to the brain. J Clin Invest 1993;92:1824-30.
24. Pardridge WM. Receptor-mediated peptidc transport through the blood-brain barrier. Endocr Rev 1986;7:314-30.
25. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturablc system independent of insulin. Peptides 1996;17: 305-11.
26. Scrnvartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996; 98:1101-6.
27. Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte D Jr. Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev 1992; 13:387-414.
28. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEES Lett 1996;387:113-6.
29. Stanley BG. Neuropcptide Y in multiple hypothalamic sites controls eating behavior, endocrine, and autonomic systems for body energy balance. In: Colmers WF, Wahlestcdt C, eds. The biology of neuropeptide Y and related peptides. Totowa, N.J.: Humana Press, 1993:457-509.
30. O'Donohue TL, Chronwall BM, Pruss RM, et al. Neuropeptide Y and pcptide YY neuronal and endocrine systems. Peptides 1985;6:755-68.
31. Clark JT, Kalra PS, Crowley WR, Kalra SP. Neuropcptide Y and human pancreatic polypeptide stimulate feeding behavior in rats, Endocrinology 1984;115:427-9.
32. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 1986;7:1189-92.
33. Bray G. Peptides affect the intake of specific nutrients and the sympathetic nervous system. Am J Clin Nutr 1992;55:Suppl:265S-271S.
34. Billington CJ, Briggs JE, Grace M, Levine AS. Effects of mtracercbroventricular injection of neuropeptide Y on energy metabolism. Am J Physiol 1991;260:R321-R327.
35. Zarjevski N, Cusin I, Vcttor R, Rohner-Jeanrenaud F, Jeanrenaud B. Chronic intracercbrovcntricular ncuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 1993;133:1753-8.
36. Sahu A, Kalra PS, Kalra SP. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 1988;9:83-6.
37. White JD, Kershaw M. Increased hypothalamic neuropeptide Y expression following food deprivation. Mol Cell Neurosci 1989;1:41-8.
38. Schwartz MW, Sipols AJ, Marks JL, et al. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 1992;130: 3608-16.
39. Brady LS, Smith MA, Gold PW, Herkcnham M. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats, Neuroendocrinology 1990;52:441-7.
40. Chua SC Jr, Brown AW, Kim J, Henncssey KL, Leibel RL, Hirsch J. Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation, Brain Res Mol Brain Res 1991;11:291-9.
41. Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra PS. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci U S A 1991;88:10931-5.
42. Ahima RS, Prabakaran D, Manrzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382:250-2.
43. Ponsalle P, Srivastava LS, Uht RM, White JD. Glucocorticoids are required for food deprivation-induced increases in hypothalamic neuropeptide Y expression. J Neuroendocrinol 1993;4:585-91.
44. Strack AM, Sebastian RJ, Schwartz MW, Dallman MF. Glucocorticoids and insulin: reciprocal signals for energy balance. Am J Physiol 1995;268: R142-R149.
45. Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 1996;381:415-21.
46. Clifton DK, Sawyer CH. Positive and negative feedback effects of ovarian steroids on luteinizing hormone release in ovariectomized rats following chronic depletion of hypothalamic norcpinephrine. Endocrinology 1980;106;1099-102.
47. Clifton DK, Steiner RA. Recovery of pulsatile luteinizing hormone secretion following permanent disruption of the ascending noradrenergic fiber tract in the ovariectomized rat. Biol Reprod 1985;33:808-14.
48. Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996;274: 1704-7.
49. Barash IA, Chcung CC, Weigle DS, et al. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996;137:3144-7.
50. Suemaru S, Hashimoto K, Hattori T, Inouc H, Kageyama J, Ota Z. Starvation-induced changes in rat brain corticotropin-releasing factor (CRF) and pituitary-adrenocortical response. Life Sci 1986;39:1161-6.
51. Sccley RJ, Matson CA, Chavez M, Woods SC, Dallman MF, Schwartz MW. Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding. Am J Physiol 1996;271;R819-R823.
52. Dallman MF. Stress update: adaptation of the hypothalamic-pituitaryadrenal axis to chronic stress. Trends Endocrinol Mctab 1993;4:62-9.
53. Vaughan J, Donaldson C, Bittencourt J, et al. Urocortin, a mammalian neuropeptide related to fish urotcnsin I and to corticotropin-releasing factor. Nature 1995;378:287-92.
54. Harbuz MS, Recs RG, Eckland D, Jessop DS, Brewerton D, Lightman SL. Paradoxical responses of hypothalamic corticotropin-releasing factor (CRF) messenger ribonucleic acid (mRNA) and CRF-41 peptide and adenohypophysial proopiomelanocortin mRNA during chronic inflammatory stress. Endocrinology 1992;130:1394-400.
55. Liu JP, Clarke IJ, Funder JW, Engler D. Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysialportal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamicpituitary-adrenal activation: potential involvement in the pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa. J Clin Invest 1994;93:1439-50.
56. Bray GA, Fisler J, York DA. Neuroendocrine control of the development of obesity: understanding gained from studies of experimental animal models. Front Neuroendocrinol 1990;11:128-81.
57. Schwartz MW, Dallman MF, Woods SC. Hypothalamic response to starvation: implications for the study of wasting disorders. Am J Physiol 1995;269:R949-R957.
58. Picrroz DD, Catzcflis C, Aebi A, Rivier JE, Aubert ML. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats. Endocrinology 1996;137:3-12,
59. Rothwell NJ. Central effects of CRF on metabolism and energy balance. Neurosci Biobehav Rev 1990;14:263-71.
60. Donaldson CJ, Sutton SW, Perrin MH, et al. Cloning and characterization of human urocortin. Endocrinology 1996;137:2167-70.
61. Spina M, Merlo-Pich E, Chan RKW, et al. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science 1996;273:1561-4.
62. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997;385:165-8.
63. Krahn DD, Gosnell BA, Levine AS, Morley JE. Behavioral effects of corticotropin-releasing factor: localization and characterization of central effects. Brain Res 1988;443:63-9.
64. Sipols AJ, Baskin DG, Schwartz MW. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 1995;44:147-51.
65. Chueng CC, Thornton JE, Kuijper JL, Weigle DS, Clifton DK, Steiner RA. Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology 1997;138:855-8.
66. Chehab FF, Mounzih K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with Ieptin. Science 1997;275:88-90.
67. Anima RS, Dushay J, Flier SN, Prabakaran D, Flier JS. Leptin accelerates the onset of puberty in normal female mice. J Clin Invest 1997;99: 391-5.
68. Schweiger U, Laessle R, Schweiger M, Herrmann F, Ricdel W Pirkc KM. Calorie intake, stress, and menstrual function in athletes. Fertil Steril 1988;49:447-50.
69. Leedom LJ, Meehan WP. The pgychoncuroendocrinology of diabetes mcllitus in rodents. Psychoneuroendocrinology 1989;14:275-94.
70. Brunzell JD, Schwartz RS, Eckel RH, Goldberg AP Insulin and adipose tissue lipoprotcin lipase activity in humans. Int J Obcs 1981;5:68594.
71. Garner DM, Wooley SC. Confronting the failure of behavioral and dietary treatments for obesity. Clin Psychol Rev 1991;11:729-80.
72. Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Mcd 1995;332:621-8.
73. Keesey RE, Powley TL. The regulation of body weight. Annu Rev Psychol 1986;37:109-33.
74. GrunfeId C, Feingold KR. Metabolic disturbances and wasting in the acquired immunodeficiency syndrome. N Engl J Med 1992;327:329- 37
75. Plata-Salaman CR, Immunoregulators in the nervous system. Neurosci Biobchav Rev 1991;15:185-215.
76. Sapolsky R, Rivier C, Yamamoto G, Plotsky P, Vale W. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 1987,238:522-4.
77. Hellerstein MK, Meydani SN, Meydani M, Wu K, Dinarello CA. Interlcukin-1-induced anorexia in the rat: influence of prostaglandins. J Clin Invest 1989;84:228-35,
78. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-71.
79. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A 1996;93;6231-5.
80. VanderWeele DA, Haraczkiewicz E, Van Itallic TB. Elevated insulin and satiety in obese and normal-weight rats. Appetite 1982;3:99-109.
81. Sahu A, Dube MG, Phelps CP, Sninsky CA, Kalra SP. Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminais in the paraventricul nucleus: a putative hypothalamic site for energy homeostasis. Endocrinology l995;136:5718-24,
82. Schwartz MW, Boyko EJ, Kahn SE, Ravussin E, Bogardus C. Reduced insulin secretion: an independent predictor of body weight gain. J Clin Endocrinol Metab 1995;80:1571-6.
83. Boyko EJ, Lconetti DL, Bergstrom RW, Newell-Morris L, Fujimoto WY. Low insulin secretion and high fasting insulin and C-peptide levels predict increased visceral adiposity; 5-year follow-up among initially nondiabetic Japanese-American men. Diabetes 1996;45:1010-5,
84. Grunfeld C, Pang M, Shigenaga JK, et al. Serum leptin levels in the acquired immunodeficiency syndrome. J Clin Endocrinol Metab 1996;81: 4342-6.
85. Grunfeld C, Zhao C, Fuller J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest 1996; 97:2152-7.
86. Neel JV. Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 1962;14:353-62.
87. Reed DR, Ding Y, Xu W, Gather C, Green ED, Price RA. Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 1996;45:691-4.