Cerebrospinal Fluid Leptin in Anorexia Nervosa: Correlation with Nutritional Status and Potential Role in Resistance to Weight Gain

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 6, 1997, Pages 1845-1851

  Mantzoros, Christos ^a,e   Flier, Jeffrey S ^a,d   Lesem, Michael D ^b   Brewerton, Timothy D ^c   Jimerson, David C ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e Clin Investigators Training Program   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RODENTIA;

5 HYDROXYINDOLEACETIC ACID; LEPTIN; PROTEIN;

ADULT; ANOREXIA NERVOSA; ARTICLE; BLOOD; CEREBROSPINAL FLUID; FEMALE; HUMAN; NUTRITIONAL STATUS; PATHOPHYSIOLOGY; REFERENCE VALUE; WEIGHT GAIN;

ADULT; ANOREXIA NERVOSA; FEMALE; HUMANS; HYDROXYINDOLEACETIC ACID; LEPTIN; NUTRITIONAL STATUS; PROTEINS; REFERENCE VALUES; WEIGHT GAIN;

EID: 0031154102     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.6.1845     Document Type: Article

References (36)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994 Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
2. Pelleymounter MA, Cullen MJ, Baker MB, et al. 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:540-543.
3. Halaas JL, Gjiwala KS, Maffei M, et al. 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:543-546.
4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:546-549.
5. Frederich RC, Hamann A, Anderson S, Lollman B, Lowell BB, Flier JS. 1995 Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med. 1:1311-1314.
6. Chen H, Charlat O, Tartaglia LA, et al. 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:491-495.
7. Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS. 1996 Role of leptin in fat regulation. Nature. 380:677.
8. Maffei M, Halaas J, Ravussin E, et al. 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1:1155-1161.
9. Lonnqvist F, Arner P, Nordfors L, Shalling M. 1995 Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med. 1:950-953.
10. Hamilton BS, Paglia D, Kwan ATM, Deitel M. 1995 Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med. 1:953-956.
11. Considine RV, Sinha MK, Heiman ML, et al. 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 334:292-295.
12. McGregor GP, Desaga JF, Ehlenz K, et al. 1996 Radioimmunological measurement of leptin in plasma of obese and diabetic human subjects. Endocrinology. 137:1501-1504.
13. Rosenbaum M, Nicolson M, Hirsch J, et al. 1996 Effects of gender, body composition, and menopause on plasma concentration of leptin. J Clin Endocrinol Metab. 81:3424-3427.
14. Cusin I, Rohner-Jeanrenaud F, Stricker-Krongrad A, Jeanrenaud B. 1996 The weight-reducing effect of an intracerebro-ventricular bolus injection of leptin in genetically obese fa/fa rats. Diabetes. 45:1446-1450.
15. Tartaglia LA, Dembski M, Weng X, et al. 1995 Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1263-1271.
16. Stephens TW, Bashinski M, Bristow PK, et al. 1995 The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:530-534.
17. Malik KF, Young WS. 1996 Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice. Endocrinology. 137:1497-1500.
18. Lynn RB, Cao GY, Considine RV, Hyde TM, Caro JF. 1996 Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem Biophys Res Commun. 219:884-889.
19. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. 1996 Leptin enters the brain by a saturable system independent of insulin. Peptides. 17:305-311.
20. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte Jr D. 1996 Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med. 12:589-593.
21. Caro JF, Kolaczynski JW, Nyce MR, et al. 1996 Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 348:159-161.
22. Hebebrand J, van der Heyden J, Devos R, et al. 1995 Plasma concentrations of obese protein in anorexia nervosa [Letter]. Lancet. 346:1624-1625.
23. Grinspoon S, Gulick T, Askari H, et al. 1996 Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab. 81:3861-3863.
24. Leibowitz SF, Weiss GF, Suh JS. 1990 Medial hypothalamic nuclei mediate serotonin's inhibitory effect on feeding behavior. Pharmacol Biochem Behav. 37:735-742.
25. Endicott J, Spitzer RL. 1978 A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry. 35:837-844.
26. American Psychiatric Association. 1980 Diagnostic and statistical manual of mental disorders, 3rd ed. Washington DC: American Psychiatric Press.
27. Obarzanek E, Lesem MD, Jimerson DC. 1994 Resting metabolic rate of anorexia nervosa patients during weight gain. Am J Clin Nutr. 60:666-675.
28. Scheinin M, Chang W-H, Kirk KL, Linnoila M. 1983 Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection. Anal Biochem. 131:246-253.
29. Norusis MJ. 1993 SPSS for Windows: base system user's guide, release 6.0. Chicago: SPSS.
30. Houseknecht KL, Mantzoros CS, Kuliawat R, Hadro E, Flier JS, Kahn BB. 1996 Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes. 45:1638-1643.
31. Chehab FF, Lim ME, Lu R. 1996 Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet. 12:318-320.
32. Ahima RS, Prabakaran D, Mantzoros C, et al. 1996 Role of leptin in the neuroendocrine response to fasting. Nature. 382:250-252.
33. Chehab FF, Mounzih K, Lu R, Lim ME. 1997 Early onset of reproductive function in normal female mice treated with leptin. Science. 275:88-90.
34. Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS. 1997 Leptin accelerates the onset of puberty in normal female mice. J Clin Invest. 99:391-395.
35. Kaye WH, Ebert MH, Raleigh M, Lake CR. 1984 Abnormalities in CNS monoamine metabolism in anorexia nervosa. Arch Gen Psychiatry. 41:350-355.
36. Jimerson DC, Lesem MD, Hegg AP, Brewerton TD. 1990 Serotonin in human eating disorders. Ann NY Acad Sci. 600:532-544.