Ras-induced cellular events (Review)

Molecular Membrane Biology

Volumn 17, Issue 2, 2000, Pages 65-73

  Ayllon, V ^a   Rebollo, A ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Apoptosis; Cancer; Proliferation; Ras effectors; Ras homologues

Indexed keywords

RAS PROTEIN;

APOPTOSIS; BLOOD DISEASE; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH; CELL MEMBRANE; CELL PROLIFERATION; HUMAN; LEUKEMIA; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; REVIEW; SIGNAL TRANSDUCTION; SOLID TUMOR; TRANSLATION REGULATION;

EUKARYOTA;

EID: 0033850681     PISSN: 09687688     EISSN: None     Source Type: Journal    
DOI: 10.1080/09687680050117093     Document Type: Review

References (144)

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18. IL-2 deprivation triggers apoptosis which is mediated by c-Jun N-terminal kinase 1 activation and prevented by Bcl-2
19. Role of Akt and JNK2 in apoptosis induced by IL-4 deprivation
20. Phosphorylation of Bcl-2 protein and association with p21ras in ras-induced apoptosis
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22. Essential role for oncogenic Ras in tumour maintenance
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24. Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family
25. Protein isoprenylation and methylation at carboxyl terminal cysteine residues
26. Transient palmitoylation supports H-Ras membrane binding but only partial biological activity
27. Farnesyl transferase inhibitors and cancer treatment: Targeting simply Ras?
28. Mammalian prenylcysteine carboxyl methyltransferase is in the ER
29. Mutant N-Ras induces erythroid lineage dysplasia in human CD34+ cells
30. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
31. IL-3-induced phosphorylation of BAD through the protein kinase Akt
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35. Signalling functions of protein palmitoylation
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37. Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control
38. A single amino acid change in Raf1 inhibits Ras binding and alters Raf1 function
39. MEK kinases are regulated by EGF and selectively interact with Rac/cdc42
40. Evidence for Ras/Ral signaling cascade
41. Proliferative inhibition by dominant negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic cell death
42. PI3K: Downstream AKTion blocks apoptosis
43. Induction of the cholesterol metabolic pathway regulates the farnesylation of Ras in embryonic chick heart cells: A new role for Ras in regulating the expression of muscarinic receptors and G proteins
44. Cdc25 cell-cycle phosphatase as a target of c-Myc
45. The potential of farnesyltransferase inhibitors as cancer chemotherapeutics
46. Modulation of guanine nucleotides bound to ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
47. 1 cell cycle progression
48. Effect of insulin on farnesyl-transferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor 1, EGF and PDGF
49. Critical role or Ras in proliferation and prevention of apoptosis mediated by IL-2
50. Ras activation leads to cell proliferation or apoptotic cell detah upon IL-2-stimulation or lymphokine deprivation, respectively
51. Fas-induced apoptosis is mediated via ceramide-initiated Ras signaling pathway
52. Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation
53. G proteins and small GTPases: Distant relatives keep in touch
54. A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1
55. Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-Ras(B)
56. All ras proteins are polyisoprenylated but only some are palmitoylated
57. Cellular Ras and cyclin D1 are required during different cell cycle periods in cycling NIH 3T3 cells
58. Cyclin D1 production in cycling cells depends on ras in a cell-cycle-specific manner
59. Benzodiazepine peptidomimetics: Potent inhibitors of Ras farnesylation in animal cells
60. Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death
61. K-ras is an essential gene in the mouse with partial functional overlapping with N-Ras
62. High intensity Raf signals converts mitotic cell cycling into celular growth
63. Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells
64. Prognostic implication of FLT3 and N-Ras gene mutations in acute myeloid leukemia
65. K-ras is essential for development of mouse embryo
66. Activation of Rac protein kinase by heat shock and hyperosmolarity stress through a pathway independent of PI3K
67. Manumycin A, inhibitor of ras farnesyltransferase, inhibits proliferation and migration of rat vascular smooth muscle cells
68. Transforming activity in human tumor DNAs
69. Identification of AF-6 and canoe as putative targets for Ras
70. Nf1 deficiency causes ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
71. The retinoblastoma protein is linked to the activation of Ras
72. Lack of a role for Jun kinase and AP1 in fas-induced apoptosis
73. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras/Raf complexes
74. Inhition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranyl-geranyltransferase I inhibitor in human tumor cell lines
75. Amplification of Ki-Ras and elevation of MAP kinase activity during mammary tumor progression in C3(1)/SV40 Tag transgenic mice
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81. Ras biology in atomic detail
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83. Apoptosis: Ras to the rescue in the fly eye
84. Ras signalling is required for inactivation of the tumor suppressor pRb cell-cycle control protein
85. Mutations of the N-Ras gene in juvenile chronic myelogenous leukemia
86. None-nzymatic palmitoylation at cys 3 causes extra-activation of the alpha subunit of the stimulatory GTP-binding protein Gs
87. Oncogenic ras sensitizes cells to apoptosis by Par-4
88. Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner
89. The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases
90. 2-terminal kinase pathway in human colon cancer cells
91. Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival
92. Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas
93. Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoeskeleton
94. Novel aspects of Ras proteins biology: Regulation and implications
95. Inhibitors of the Ras signal transduction pathway as potential antitumour agents
96. Human-tumor-derived cell lines contain common and different transforming genes
97. Farnesyltransferase as a target for anticancer drug design
98. M-Ras/R-Ras3, a transforming Ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6
99. Ras proteins: Recent advances and new functions
100. Bcl-2 differentially targets K-, N- and H-Ras to mitochondria in IL-2 suplemented cells: Implications in prevention of apoptosis
101. Inhibition of purified p21ras farnesyl protein transferase by Cys-AAX tetrapeptides
102. The S. cerevisiae prenylcysteine carboxyl methyltransferase Ste 14p is in the ER membrane
103. Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization
104. Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
105. Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
106. Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma
107. Direct interaction between Ras and the kinase domain of mitogen activated protein kinase kinase kinase (MEKK1)
108. Regulation of Bc1-2 gene expression by BCR-ABL is mediated by Ras
109. Platelet-derived growth factor stimulates formation of active p21 ras-GTP complex in Swiss mouse 3T3 cells
110. Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types
111. Chronic myelomonocytic leukemia: Tel-a-kinase what ets all about
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113. Oncogenic Ras provokes premature senescence associated with accumulation of p53 and p16ink4A
114. Isolation of transforming sequence from a human bladder carcinoma cell line
115. Synergistic activation by Ras and 14-3-3 protein of a MAPKKK named Ras-dependent extracellular signal-regulated kinase kinase stimulator
116. Functional rafts in cell membranes
117. Negative regulation of p120GAP GTPase promoting activity by p210Bcr/AbI: Implication of ras-dependent Philadelphia chromosome positive cell growth
118. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
119. H-Ras signals to cytoskeletal machinery in induction of integrin-mediated adhesion of T cells
120. KSR, a novel protein kinase required for Ras signal transduction
121. Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking
122. Identification of Nore 1 as a potential ras effector
123. Membrane targeting via protein palmitoylation
124. Palmitoylation of rhodopsin with S-protein acyltransferase: Enzyme catalyzed reaction versus autocatalytic acylation
125. Structural and biochemical analysis of Ras-effector signaling via RaIGDS
126. Four human Ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility
127. The phosphorylation of the eucaryotic initiation factor IF4E in response to phorbol esters, cell stress and cytokines is mediated by distinct MAP kinase pathway
128. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
129. Identification of Ce-AF6, a novel C. elegans protein, as a putative Ras effector
130. Modulation of the immune response and tumor growth by activated Ras
131. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor
132. K-Ras and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
133. Identification and characterization of mutations in H-Ras that selectively decrease binding to cRaf-1
134. Ras caught in another affair: The exchange factors for Ral
135. Ras induced proliferation or cell cyle arrest is determinded by the level of Raf activity with arrest mediated by p21cip
136. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
137. In vivo interaction of AF-6 with activated Ras and ZO-1
138. NGF regulates the PC12 cell cycle machinery through specific inhibition of cdk kinases and induction of cyclin D1
139. Ras isoforms vary in their ability to activate Raf-1 and PI3 kinase
140. Oncogenic K-Ras, but not oncogenic H-Ras, upregulates CEA expression and disrupts basolateral polarity in colon epithelial cells
141. Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells
142. The retinoblastoma protein is linked to the activation of Ras
143. Protein prenylation: Molecular mechanisms and fuctional consequences
144. Kinase suppressor of Ras is ceramide-activated protein kinase