The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of raf to Ras family small GTPases

Molecular and Cellular Biology

Volumn 19, Issue 9, 1999, Pages 6057-6064

  Okada, Tomoyo ^a   Hu, Chang Deng ^a   Jin, Tai Guang ^a   Kariya, Ken Ichi ^a   Yamawaki Kataoka, Yuriko ^a   Kataoka, Tohru ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; RAF PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

EID: 0032784445     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.9.6057     Document Type: Article

References (53)

1. Ayruch, J. 1998. Insulin signal transduction through protein kinase cascades. Mol. Cell. Biochem. 182:31-48.
2. Bosch, E., H. Cherwinski, D. Peterson, and M. McMahon. 1997. Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1. Oncogene 15:1021-1033.
3. Brtva, T. R., J. K. Drugan, S. Ghosh, R. S. Terrell, S. Campbell-Burk, R. M. Bell, and C. J. Der. 1995. Two distinct Raf domains mediate interaction with Ras. J. Biol. Chem. 270:9809-9812.
4. Campbell, S. L., R. Khosravi-Far, K. L. Rossman, G. J. Clark, and C. J. Der. 1998. Increasing complexity of Ras signaling. Oncogene 17:1395-1413.
5. Chuang, E., D. Barnard, L. Hettich, X.-F. Zhang, J. Avruch, and M. S. Marshall. 1994. Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues. Mol. Cell. Biol. 14:5318-5325.
6. Clark, G. J., J. K. Drugan, K. L. Rossman, J. W. Carpenter, K. Rogers-Graham, H. Fu, C. J. Der, and S. L. Campbell. 1997. 14-3-3 ζ negatively regulates Raf-1 activity by interactions with the Raf-1 cysteine-rich domain. J. Biol. Chem. 272:20990-20993.
7. Cook, S. J., B. Rubinfeld, I. Albert, and F. McCormick. 1993. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblast. EMBO J. 12:3475-3485.
8. Cutler, R. E., Jr., R. M. Stephens, M. R. Saracino, and D. K. Morrison. 1998. Autoregulation of the Raf-1 serine/threonine kinase. Proc. Natl. Acad. Sci. USA 95:9214-9219.
9. Daub, M., J. Jöckel, T. Quack, C. K. Weber, F. Schmitz, U. R. Rapp, A. Wittinghofer, and C. Block. 1998. The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation. Mol. Cell. Biol. 18:6698-6710.
10. Daum, G., I. Eisenmann-Tappe, H.-W. Fries, J. Troppmair, and U. R. Rapp. 1994. The ins and outs of Raf kinases. Trends Biochem. Sci. 19:474-480.
11. Dent, P., D. B. Reardon, D. K. Morrison, and T. W. Sturgill. 1995. Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro. Mol. Cell. Biol. 15:4125-4135.
12. Drugan, J. K., R. Khosravi-Far, M. A. White, C. J. Der, Y.-J. Sung, Y.-W. Hwang, and S. L. Campbell. 1996. Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation. J. Biol. Chem. 271:233-237.
13. Ghosh, S., W. Q. Xie, A. F. G. Quest, G. M. Mabrouk, J. C. Strum, and R. M. Bell. 1994. The cysteine-rich region of Raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-Ras. J. Biol. Chem. 269:10000-10007.
14. Herrmann, C., G. Horn, M. Spaargaren, and A. Wittinghofer. 1996. Differential interaction of the Ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. J. Biol. Chem. 271:6794-6800.
15. Hu, C.-D., K. Kariya, G. Kotani, M. Shirouzu, S. Yokoyama, and T. Kataoka. 1997. Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with Ras-dependent activation of Raf-1. J. Biol. Chem. 272:11702-11705.
16. Hu, C.-D., K. Kariya, T. Okada, X. Qi, C. Song, and T. Kataoka. 1999. Effect of phosphorylation on activities of RaplA to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation. J. Biol. Chem. 274:48-51.
17. Hu, C.-D., K. Kariya, M. Tamada, K. Akasaka, M. Shirouzu, S. Yokoyama, and T. Kataoka. 1995. Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras. J. Biol. Chem. 270:30274-30277.
18. Kitayama, H., Y. Sugimoto, T. Matsuzaki, Y. Ikawa, and M. Noda. 1989. A ras-related gene with transformation suppressor activity. Cell 56:77-84.
19. Kuroda, Y., N. Suzuki, and T. Kataoka. 1993. The effect of posttranslational modifications on the interaction of Ras2 with adenylyl cyclase. Science 259: 683-686.
20. Leevers, S. J., H. F. Paterson, and C. J. Marshall. 1994. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369:411-414.
21. Luo, Z., B. Diaz, M. S. Marshall, and J. Avruch. 1997. An intact Raf zinc finger is required for optimal binding to processed Ras and for Ras-dependent Raf activation in situ. Mol. Cell. Biol, 17:46-53.
22. Marais, R., Y. Light, H. F. Paterson, and C. J. Marshall. 1995. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 14:3136-3145.
23. Marais, R., Y. Light, H. F. Paterson, C. S. Mason, and C. J. Marshall. 1997. Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic Ras and tyrosine kinases. J. Biol. Chem. 272:4378-4383.
24. Michaud, N. R., J. R. Fabian, K. D. Mathes, and D. K. Morrison. 1995. 14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner. Mol. Cell. Biol. 15:3390-3397.
25. Mineo, C., R. G. W. Anderson, and M. A. White. 1997. Physical association with Ras enhances activation of membrane-bound Raf (RafCAAX). J. Biol. Chem. 272:10345-10348.
26. Mizutani, S., H. Koide, and Y. Kaziro. 1998. Isolation of a new protein factor required for activation of Raf-1 by Ha-Ras: partial purification from rat brain cytosols. Oncogene 16:2781-2786.
27. Morrison, D. K., and R. E. Cutler, Jr. 1997. The complexity of Raf-1 regulation. Curr. Opin. Cell Biol. 9:174-179.
28. Mott, H. R., J. W. Carpenter, S. Zhong, S. Ghosh, R. M. Bell, and S. L. Campbell. 1996. The solution structure of the Raf-1 cysteine-rich domain: a novel Ras and phospholipid binding site. Proc. Natl. Acad. Sci. USA 93: 8312-8317.
29. Nassar, N., G. Horn, C. Herrmann, C. Block, R. Janknecht, and A. Wittinghofer. 1996. Ras/Rap effector specificity determined by charge reversal. Nat. Struct. Biol. 3:723-729.
30. Nassar, N., G. Horn, C. Herrmann, A. Scherer, F. McCormick, and A. Wittinghofer. 1995. The 2,2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue. Nature 375:554-560.
31. Ohtsuka, T., K. Shimizu, B. Yamamori, S. Kuroda, and Y. Takai. 1996. Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein. J. Biol. Chem. 271:1258-1261.
32. Okada, T., T. Masuda, M. Shinkai, K. Kariya, and T. Kataoka. 1996. Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf. J. Biol. Chem. 271:4671-4678.
33. Papin, C., A. Denouel-Galy, D. Laugler, G. Calothy, and A. Eychène. 1998. Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf. J. Biol. Chem. 273: 24939-24947.
34. Pizon, V., P. Chardin, I. Lerosey, B. Olofsson, and A. Tavitian. 1988. Human cDNAs rap 1 and rap 2 homologous to the Drosophila gene Dras 3 encode proteins closely related to ras in the "effector" region. Oncogene 3:201-204.
35. Rommel, C., G. Radziwill, J. Lovrić, J. Noeldeke, T. Heinicke, D. Jones, A. Aitken, and K. Moelling. 1996. Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1. Oncogene 12:609-619.
36. Roy, S., A. Lane, J. Yan, R. McPherson, and J. F. Hancock. 1997. Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger. J. Biol. Chem. 272:20139-20145.
37. Shinkai, M., T. Masuda, K. Kariya, M. Tamada, M. Shirouzu, S. Yokoyama, and T. Kataoka. 1996. Difference in the mechanism of interaction of Raf-1 and B-Raf with H-Ras. Biochem. Biophys. Res. Commun. 223:729-734.
38. Shirouzu, M., K. Morinaka, S. Koyama, C.-D. Hu, N. Hori-Tamura, T. Okada, K. Kariya, T. Kataoka, A. Kikuchi, and S. Yokoyama. 1998. Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS. J. Biol. Chem. 273:7737-7742.
39. Sithanandam, G., W. Kolch, F.-M. Duh, and U. R. Rapp. 1990. Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. Oncogene 5:1775-1780.
40. Stokoe, D., S. G. Macdonald, K. Cadwallander, M. Symons, and J. F. Hancock. 1994. Activation of Raf as a result of recruitment to the plasma membrane. Science 264:1463-1467.
41. Stokoe, D., and F. McCormick. 1997. Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro. EMBO J. 16:2384-2396.
42. Storm, S. M., J. L. Cleveland, and U. R. Rapp. 1990. Expression of raf family proto-oncogenes in normal mouse tissues. Oncogene 5:345-351.
43. Tamada, M., C.-D. Hu, K. Kariya, T. Okada, and T. Kataoka. 1997. Membrane recruitment of Raf-1 is not the only function of Ras in Raf-1 activation. Oncogene 15:2959-2964.
44. Thorson, J. A., L. W. K. Yu, A. L. Hsu, N.-Y. Shih, P. R. Graves, J. William Tanner, P. M. Allen, H. Piwnica-Worms, and A. S. Shaw. 1998. 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity. Mol. Cell. Biol. 18:5229-5238.
45. Tzivion, G., Z. Luo, and J. Avruch. 1998. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature 394:88-92.
46. Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
47. Vossler, M. R., H. Yao, R. D. York, M.-G. Pan, C. S. Rim, and P. J. S. Stork. 1997. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89:73-82.
48. Winkler, D. G., R. E. Cutler, Jr., J. K. Drugan, S. Campbell, D. K. Morrison, and A. J. Cooper. 1998. Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity. J. Biol. Chem. 273: 21578-21584.
49. Wittinghofer, A., and N. Nassar. 1996. How Ras-related proteins talk to their effectors. Trends Biochem. Sci. 21:488-491.
50. Yamamori, B., S. Kuroda, K. Shimizu, K. Fukui, T. Ohtsuka, and Y. Takai. 1995. Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins. J. Biol. Chem. 270:11723-11726.
51. York, R. D., H. Yao, T. Dillon, C. L. Elling, S. P. Eckert, E. W. McCleskey, and P. J. S. Stork. 1998. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392:622-626.
52. ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature 364:308-313.
53. Zhou, Y., X. Zhang, and R. H. Ebright. 1991. Random mutagenesis of gene-sized DNA molecules by use of PCR with Taq DNA polymerase. Nucleic Acids Res. 19:6052.