The Saccharomyces cerevisiae prenylcysteine carboxyl methyltransferase Ste14p is in the endoplasmic reticulum membrane

Molecular Biology of the Cell

Volumn 9, Issue 8, 1998, Pages 2231-2247

  Romano, Julia D ^a   Schmidt, Walter K ^a   Michaelis, Susan ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; METHYLTRANSFERASE; PROTEIN STE14P; UNCLASSIFIED DRUG;

ARTICLE; CELL FRACTIONATION; ENDOPLASMIC RETICULUM; IMMUNOFLUORESCENCE; ISOPRENYLATION; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

EID: 0031858844     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.9.8.2231     Document Type: Article

References (63)

1. Abeijon, C, Orlean, P., Robbins, P.W., and Hirschberg, C.B. (1989). Topography of glycosylation in yeast: characterization of GDP mannose transport and Iumenal guanosine diphosphatase activities in Golgi-like vesicles. Proc. Natl. Acad. Sci. USA 86, 6935-6939.
2. 2+-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution. Mol. Biol. Cell 3, 633-654.
3. Backlund, P.S. (1997). Post-translational processing of RhoA. J. Biol. Chem. 272, 33175-33180.
4. Baker, T.A., Grossman, A.D., and Gross, C.A. (1984). A gene regulating the heat shock response in Escherichia coli also affects proteolysis. Proc. Natl. Acad. Sci. USA 81, 6779-6783.
5. Berkower, C., Loayza, D., and Michaelis, S. (1994). Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae. Mol. Biol. Cell 5, 1185-1198.
6. Berkower, C., and Michaelis, S. (1991). Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily. EMBO J. 10, 3777-3785.
7. Blair, L.C. (1979). Genetic analysis of mating type switching in yeast. Ph.D. Thesis. Eugene, OR: University of Oregon.
8. Boyartchuk, V., Ashby, M., and Rine, J. (1997). Modulation of Ras and a-factor function by carboxyl-terminal proteolysis. Science 275, 1796-1800.
9. Caplan, A.J., Cyr, D.M., and Douglas, M.G. (1992a). Ydj1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism. Cell 71, 1143-1155.
10. Caplan, A.J., Tsai, J., Casey, P.J., and Douglas, M.G. (1992b). Farnesylation of Ydj1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae. J. Biol. Chem. 267, 18890-18895.
11. Chen, P., Sapperstein, S.K., Choi, J.C., and Michaelis, S. (1997). Biogenesis of the Saccharomyces cerevisiae mating pheromone a-factor. J. Cell Biol. 136, 251-269.
12. Cheng, X., Kumar, S., Posfai, J., Pflugrath, J.W., and Roberts, R.J. (1993). Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine. Cell 74, 299-307.
13. Clarke, S. (1992). Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu. Rev. Biochem. 61, 355-386.
14. Clarke, S. (1993). Protein methylation. Curr. Opin. Cell Biol. 5, 977-983.
15. Cunningham, K.W., and Wickner, W.T. (1989). Yeast KEX2 protease and mannosyltransferase I are localized to distinct compartments of the secretory pathway. Yeast 5, 25-33.
16. Dai, Q., Choy, E., Chiu, V., Romano, J., Slivka, S.R., Steitz, S.A., Michaelis, S., and Philips, M.R. (1998). Human prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J. Biol. Chem. 273, 15030-15034.
17. Ehring, R., Beyreuther, K., Wright, J.K., and Overath, P. (1980). In vitro and in vivo products of E. coli lactose permease gene are identical. Nature 283, 537-540.
18. Elble, R. (1992). A simple and efficient procedure for transformation of yeasts. Biotechniques 13, 18-20.
19. Feldheim, D., and Schekman, R. (1994). Sec72p contributes to the selective recognition of signal peptides by the secretory polypeptide translocation complex. J. Cell Biol. 126, 935-943.
20. Feldman, R.I., Bernstein, M., and Schekman, R. (1987). Product of SEC53 is required for folding and glycosylation of secretory proteins in the lumen of the yeast endoplasmic reticulum. J. Biol. Chem. 262, 9332-9339.
21. Finegold, A.A., Johnson, D.I., Farnsworth, C.C., Gelb, M.H., Judd, S.R., Glomset, J.A., and Tamanoi, F. (1991). Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product. Proc. Natl. Acad. Sci. USA 88, 4448-4452.
22. 2-terminal processing of the yeast a-factor precursor. J. Cell Biol. 136, 271-285.
23. Gaynor, E.C., Te Heesen, S., Graham, T.R., Aebi, M., and Emr, S.D. (1994). Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast. J. Cell Biol. 127, 653-665.
24. Gotte, K., Girzalsky, W., Linkert, M., Baumgart, E., Kammerer, S., Kunau, W.H., and Erdmann, R. (1998). Pex19p, a farnesylated protein essential for peroxisome biogenesis. Mol. Cell. Biol. 18, 616-628.
25. Harris, S.L., Na, S., Zhu, X., Seto-Young, D., Perlin, D.S., Teem, J.H., and Haber, J.E. (1994). Dominant lethal mutations in the plasma membrane H(+)-ATPase gene of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 91, 10531-10535.
26. Harris, S.L., and Waters, M.G. (1996). Localization of a yeast early Golgi mannosyltransferase, Och1p, involves retrograde transport. J. Cell Biol. 132, 985-998.
27. He, B., Chen, P., Chen, S.Y., Vancura, K.L., Michaelis, S., and Powers, S. (1991). RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins. Proc. Natl. Acad. Sci. USA 88, 11373-11377.
28. Hrycyna, C.A., and Clarke, S. (1990). Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae. Mol. Cell. Biol. 10, 5071-5076.
29. Hrycyna, C.A., Sapperstein, S.K., Clarke, S., and Michaelis, S. (1991). The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins. EMBO J. 10, 1699-1709.
30. Imai, Y., Davey, J., Kawagishi-Kobayashi, M., and Yamamoto, M. (1997). Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharmyces pombe and Xenopus laevis. Mol. Cell. Biol. 17, 1543-1551.
31. Ito, H., Fukuda, Y., Murata, K., and Kimura, A. (1983). Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153, 163-168.
32. Jackson, M.R., Nilsson, T., and Peterson, P.A. (1990). Identification of a consensus motif for the retention of transmembrane proteins in the endoplasmic reticulum. EMBO J. 9, 3153-3162.
33. Jackson, M.R., Nilsson, T., and Peterson, P.A. (1993). Retrieval of transmembrane proteins to the endoplasmic reticulum. J. Cell Biol. 121, 317-333.
34. Kagan, R.M., and Clarke, S. (1994). Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes. Arch. Biochem. Biophys. 310, 417-427.
35. Kubota, S., Yoshida, Y., Kumaoka, H., and Furumichi, A. (1977). Studies on the microsomal electron-transport system of anaerobically grown yeast. V. Purification and characterization of NADPH-cytochrome c reductase. J. Biochem. (Tokyo) 81, 197-205.
36. Kunkel, T.A., Roberts, J.D., and Zakour, R.A. (1987). Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154, 367-382.
37. Kyte, J., and Doolittle, R.F. (1982). A simple method for displaying the hydropathic character of a protein. J. Mol Biol. 157, 105-132.
38. Loayza, D., and Michaelis, S. (1998). Role for the ubiquitin-protea-some system in the vacuolar degradation of Ste6p, the a-factor transporter in Saccharomyces cerevisiae. Mol. Cell. Biol. 18, 779-789.
39. Ma, H., Kunes, S., Schatz, P.J., and Botstein, D. (1987). Plasmid construction by homologous recombination in yeast. Gene 58, 201-216.
40. Marcus, S., Caldwell, G.A., Miller, D., Xue, C-B., Naider, F., and Becker, J.M. (1991). Significance of C-terminal cysteine modifications to the biological activity of the Saccharomyces cerevisiae a-factor mating pheromone. Mol. Cell. Biol. 11, 3603-3612.
41. Michaelis, S., and Herskowitz, I. (1988). The a-factor pheromone of Saccharomyces cerevisiae is essential for mating. Mol. Cell. Biol. 8, 1309-1318.
42. Oldenburg, K.R., Vo, K.T., Michaelis, S., and Paddon, C. (1997). Recombination-mediated PCR-directed plasmid construction in vivo in yeast. Nucleic Acids Res. 25, 451-452.
43. Opheim, D.J. (1978). Alpha-D-mannosidase of Saccharomyces cerevisiae. Characterization and modulation of activity. Biochim. Biophys. Acta 524, 121-130.
44. Paddon, C., Loayza, D., Vangelista, L., Solari, R., and Michaelis, S. (1996). Analysis of the localization of STE6/CFTR chimeras in a Saccharomyces cerevisiae model for the cystic fibrosis defect CFTRΔF508. Mol. Microbiol. 19, 1007-1017.
45. Payne, G.S., and Schekman, R. (1985). A test of clathrin function in protein secretion and cell growth. Science 230, 1009-1014.
46. Pelham, H.R., Hardwick, K.G., and Lewis, M.J. (1988). Sorting of soluble ER proteins in yeast. EMBO J. 7, 1757-1762.
47. Perez-Sala, D., Tan, E.W., Canada, F.J., and Rando, R.R. (1991). Methylation and demethylation reactions of guanine nucleotidebinding proteins of retinal rod outer segments. Proc. Natl. Acad. Sci. USA 88, 3043-3046.
48. Philips, M.R., and Pillinger, M.H. (1995). Prenylcysteine-directed carboxyl methyltransferase activity in human neutrophil membranes. Methods Enzymol. 256, 49-63.
49. Pillinger, M.H., Volker, C., Stock, J.B., Weissmann, G., and Philips, M.R. (1994). Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophils. J. Biol. Chem. 269, 1486-1492.
50. Rao, R., and Slayman, C. (1993). Mutagenesis of conserved residues in the phosphorylation domain of the yeast plasma membrane H(+)-ATPase. Effects on structure and function. J. Biol. Chem. 268, 6708-6713.
51. Rose, M.D., Misra, L.M., and Vogel, J.P. (1989). KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene. Cell 57, 1211-1221.
52. Sapperstein, S., Berkower, C., and Michaelis, S. (1994). Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export. Mol. Cell. Biol. 14, 1438-1449.
53. Sato, K., Sato, M., and Nakano, A. (1997). Rerlp as common machinery for the endoplasmic reticulum localization of membrane proteins. Proc. Natl. Acad. Sci. USA 94, 9693-9698.
54. Sato, M., Sato, K., and Nakano, A. (1996). Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain. J. Cell Biol. 134, 279-293.
55. Schutze, M.P., Peterson, P.A., and Jackson, M.R. (1994). An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum. EMBO J. 13, 1696-1705.
56. Sikorski, R.S., and Hieter, P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
57. Sogaard, M., Tani, K., Ye, R.R., Geromanos, S., Tempst, P., Kirchhausen, T., Rothman, J.E., and Sollner, T. (1994). A Rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell 78, 937-948.
58. Stephenson, R.C., and Clarke, S. (1990). Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate. J. Biol. Chem. 265, 16248-16254.
59. Stephenson, R.C., and Clarke, S. (1992). Characterization of a rat liver protein carboxyl methyltransferase involved in the maturation of proteins with the -CXXX C-terminal sequence motif. J. Biol. Chem. 267, 13314-13319.
60. Thompson, J.D., Higgins, D.G., and Gibson, T.J. (1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighing, position specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680.
61. Volker, C., Pillinger, M.H., Philips, M.R., and Stock, J.B. (1995). Prenylcysteine analogs to study function of carboxylmethylation in signal transduction. Methods Enzymol. 250, 216-225.
62. Wilson, K.W. (1985). Identification and regulation of cell-type-specific genes required for mating in Saccharomyces cerevisiae. Ph.D. Thesis. San Francisco, CA: University of California, San Francisco.
63. Zhang, F.L., and Casey, P.J. (1996). Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65, 241-269.