-
2
-
-
0032559362
-
G proteins and small GTPases: Distant relatives keep in touch
-
Hall A (1998) G proteins and small GTPases: distant relatives keep in touch. Science 279: 509-514
-
(1998)
Science
, vol.279
, pp. 509-514
-
-
Hall, A.1
-
3
-
-
0032401757
-
All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral
-
Bos JL (1998) All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral. EMBO J. 17: 6776-6782
-
(1998)
EMBO J.
, vol.17
, pp. 6776-6782
-
-
Bos, J.L.1
-
4
-
-
0031784267
-
Regulation of Ras GRP via phorbol ester-responsive C1 domain
-
Tognon CE, Kirk HE, Passmore LA, Whitehead IP, Der CJ and Kay RJ (1998) Regulation of Ras GRP via phorbol ester-responsive C1 domain. Mol. Cell. Biol. 18: 6995-7008
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 6995-7008
-
-
Tognon, C.E.1
Kirk, H.E.2
Passmore, L.A.3
Whitehead, I.P.4
Der, C.J.5
Kay, R.J.6
-
6
-
-
0031882763
-
Regulation of Sos activity by intermolecular interactions
-
Corbalan-Garcia S, Margarit SM, Galron D, Yang SS and Bar-Sagi D (1998) Regulation of Sos activity by intermolecular interactions. Mol. Cell. Biol. 18: 880-886
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 880-886
-
-
Corbalan-Garcia, S.1
Margarit, S.M.2
Galron, D.3
Yang, S.S.4
Bar-Sagi, D.5
-
7
-
-
0031929680
-
Nterminus of Sos1 Ras exchange factor: Critical role for the Dbl and PH domains
-
Qian X, Vass WC, Papageorge AG, Anborgh PH and Lowry DR (1998) Nterminus of Sos1 Ras exchange factor: critical role for the Dbl and PH domains. Mol. Cell. Biol. 18: 771-778
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 771-778
-
-
Qian, X.1
Vass, W.C.2
Papageorge, A.G.3
Anborgh, P.H.4
Lowry, D.R.5
-
8
-
-
0030767442
-
EGF-induced Sos phosphorylation in PC12 cells involves p90 RSK2. Ras signalling and apoptosis
-
Douville E and Downward J (1997) EGF-induced Sos phosphorylation in PC12 cells involves p90 RSK2. Ras signalling and apoptosis. Oncogene 15: 373-383
-
(1997)
Oncogene
, vol.15
, pp. 373-383
-
-
Douville, E.1
Downward, J.2
-
9
-
-
0032493134
-
Inhibition of mSos activity by binding of PIP2 to the mSos PH domain
-
Jefferson AB, Klippel A and Williams LT (1998) Inhibition of mSos activity by binding of PIP2 to the mSos PH domain. Oncogene 16: 2303-2310
-
(1998)
Oncogene
, vol.16
, pp. 2303-2310
-
-
Jefferson, A.B.1
Klippel, A.2
Williams, L.T.3
-
10
-
-
13144250140
-
The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent MAP kinase pathways
-
Fan WT, Koch CA, Hoog CLD, Fam NP and Moran MF (1998) The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent MAP kinase pathways. Curr. Biol. 8: 935-938
-
(1998)
Curr. Biol.
, vol.8
, pp. 935-938
-
-
Fan, W.T.1
Koch, C.A.2
Hoog, C.L.D.3
Fam, N.P.4
Moran, M.F.5
-
11
-
-
0030996229
-
The N terminal motif of cdc25, a GDP/GTP exchange factor for Ras, controls the activity of the catalytic domain. Modulation by calmodulin and calpain
-
Baouz S, Jacquet E, Bernardi A and Parmeggiani A (1997) The N terminal motif of cdc25, a GDP/GTP exchange factor for Ras, controls the activity of the catalytic domain. Modulation by calmodulin and calpain. J. Biol. Chem. 272: 6671-6676
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6671-6676
-
-
Baouz, S.1
Jacquet, E.2
Bernardi, A.3
Parmeggiani, A.4
-
12
-
-
0032524389
-
RasGRP, a ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
-
Ebinu JO, Bottorff DA, Chan EYW, Stang SL, Dunn RJ and Stone JC (1998) RasGRP, a ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science 280: 1082-1086
-
(1998)
Science
, vol.280
, pp. 1082-1086
-
-
Ebinu, J.O.1
Bottorff, D.A.2
Chan, E.Y.W.3
Stang, S.L.4
Dunn, R.J.5
Stone, J.C.6
-
13
-
-
0030877360
-
Activation of R-Ras by Ras guanine nucleotide releasing factor
-
Gotoh T, Niino Y, Tokuda M, Hatase O, Nakamura S, Matsuda M and Hattori S (1997) Activation of R-Ras by Ras guanine nucleotide releasing factor. J. Biol. Chem. 272: 18602-18607
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18602-18607
-
-
Gotoh, T.1
Niino, Y.2
Tokuda, M.3
Hatase, O.4
Nakamura, S.5
Matsuda, M.6
Hattori, S.7
-
14
-
-
0032559211
-
Coupling Ras and Rac through the Ras exchange factor Sos
-
Nimnual AS, Yatsula BA and Bar-Sagi D (1998) Coupling Ras and Rac through the Ras exchange factor Sos. Science 279: 560-563
-
(1998)
Science
, vol.279
, pp. 560-563
-
-
Nimnual, A.S.1
Yatsula, B.A.2
Bar-Sagi, D.3
-
15
-
-
0031054520
-
A molecular redox switch on p21ras. Structural basis for the nitric oxide-p21 ras interaction
-
Lander HM, Hajjar DP, Hempstead BL, Mirza UA, Chait BT, Campbell S and Quilliam LA (1997) A molecular redox switch on p21ras. Structural basis for the nitric oxide-p21 ras interaction. J. Biol. Chem. 272: 4323-4326
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4323-4326
-
-
Lander, H.M.1
Hajjar, D.P.2
Hempstead, B.L.3
Mirza, U.A.4
Chait, B.T.5
Campbell, S.6
Quilliam, L.A.7
-
16
-
-
0032127912
-
GTPase-activating proteins: Helping hands to complement an active site
-
Scheffzek K, Ahmadian MR and Wittinghofer A (1998) GTPase-activating proteins: helping hands to complement an active site. Trends Biochem. Sci. 23: 257-262
-
(1998)
Trends Biochem. Sci.
, vol.23
, pp. 257-262
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Wittinghofer, A.3
-
17
-
-
0028365660
-
Different functions of Smg GDP dissociation stimulator and mammalian counterpart of cdc25
-
Nakanishi H, Kaibuchi K, Orita S, Ueno N and Takai Y (1996) Different functions of Smg GDP dissociation stimulator and mammalian counterpart of cdc25. J. Biol. Chem. 269: 15085-15091
-
(1996)
J. Biol. Chem.
, vol.269
, pp. 15085-15091
-
-
Nakanishi, H.1
Kaibuchi, K.2
Orita, S.3
Ueno, N.4
Takai, Y.5
-
18
-
-
0032541650
-
Increasing complexiity of Ras signalling
-
Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ and Der CJ (1998) Increasing complexiity of Ras signalling. Oncogene 17: 1395-1413
-
(1998)
Oncogene
, vol.17
, pp. 1395-1413
-
-
Campbell, S.L.1
Khosravi-Far, R.2
Rossman, K.L.3
Clark, G.J.4
Der, C.J.5
-
19
-
-
0030854042
-
Activity of plasma membrane recruited Raf-1 is regulated by Ras via the Raf zinc finger
-
Roy S, Lane A, Yan J, McPherson R and Hancock JF (1997) Activity of plasma membrane recruited Raf-1 is regulated by Ras via the Raf zinc finger. J. Biol. Chem. 272: 20139-20145
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 20139-20145
-
-
Roy, S.1
Lane, A.2
Yan, J.3
McPherson, R.4
Hancock, J.F.5
-
20
-
-
0030890762
-
Physical association with Ras enhances activation of membrane-bound Raf (Raf-CAAX)
-
Mineo C, Anderson RG and White M (1997) Physical association with Ras enhances activation of membrane-bound Raf (Raf-CAAX). J. Biol. Chem. 272: 10345-10348
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10345-10348
-
-
Mineo, C.1
Anderson, R.G.2
White, M.3
-
22
-
-
0029968827
-
Rho family of GTPases: The cytoskeleton and beyond
-
Symons M (1996) Rho family of GTPases: the cytoskeleton and beyond. Trends Biochem. Sci. 21: 178-181
-
(1996)
Trends Biochem. Sci.
, vol.21
, pp. 178-181
-
-
Symons, M.1
-
23
-
-
0030911052
-
Role of Pl3 kinase in cell transformation and control of the actin cytoskeleton by Ras
-
Rodríguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A and Downward J (1997) Role of Pl3 kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89: 457-467
-
(1997)
Cell
, vol.89
, pp. 457-467
-
-
Rodríguez-Viciana, P.1
Warne, P.H.2
Khwaja, A.3
Marte, B.M.4
Pappin, D.5
Das, P.6
Waterfield, M.D.7
Ridley, A.8
Downward, J.9
-
24
-
-
0030869418
-
Identification and characterization of mutations in H-Ras that selectively decrease binding to Flaf1
-
Winkler DG, Johnson JC, Cooper JA and Vojtek AB (1997) Identification and characterization of mutations in H-Ras that selectively decrease binding to Flaf1. J. Biol. Chem. 272: 24402-24409
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24402-24409
-
-
Winkler, D.G.1
Johnson, J.C.2
Cooper, J.A.3
Vojtek, A.B.4
-
27
-
-
0032489384
-
Identification of Nore1 as a potential ras effector
-
Vavvas D, Li X, Avruch J and Zhang XF (1998) Identification of Nore1 as a potential ras effector. J. Biol. Chem. 273: 5439-5442
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5439-5442
-
-
Vavvas, D.1
Li, X.2
Avruch, J.3
Zhang, X.F.4
-
28
-
-
0030896307
-
Ras-GTPase activating protein: A putative effector for ras
-
Tocque B, Delumeau I, Parker F, Maurier F, Multon MC and Schweighoffer F (1997) Ras-GTPase activating protein: a putative effector for ras. Cell Signal 9: 153-158
-
(1997)
Cell Signal
, vol.9
, pp. 153-158
-
-
Tocque, B.1
Delumeau, I.2
Parker, F.3
Maurier, F.4
Multon, M.C.5
Schweighoffer, F.6
-
29
-
-
0030875602
-
MEK kinases are regulated by EGF and selectively interact with Rac/cdc42
-
Fanger GR, Johnson NJ and Johnson GL (1997) MEK kinases are regulated by EGF and selectively interact with Rac/cdc42. EMBO J. 16: 4961-4972
-
(1997)
EMBO J.
, vol.16
, pp. 4961-4972
-
-
Fanger, G.R.1
Johnson, N.J.2
Johnson, G.L.3
-
30
-
-
0345033208
-
Synergistic activation by Ras and 14-3-3 protein of a MAPKKK named Ras-dependent extracellular signal-regulated kinase kinase stimulator
-
Shimizyu K, Kuroda S and Matsuda S (1994) Synergistic activation by Ras and 14-3-3 protein of a MAPKKK named Ras-dependent extracellular signal-regulated kinase kinase stimulator. J. Biol. Chem. 269: 31706-31710
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 31706-31710
-
-
Shimizyu, K.1
Kuroda, S.2
Matsuda, S.3
-
31
-
-
0030048476
-
Phosphorylation of Bcl-2 protein and association with p21ras in ras-induced apoptosis
-
Chen CY and Faller DV (1996) Phosphorylation of Bcl-2 protein and association with p21ras in ras-induced apoptosis. J. Biol. Chem. 271: 2376-2379
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2376-2379
-
-
Chen, C.Y.1
Faller, D.V.2
-
32
-
-
0344241921
-
Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization
-
Romero F, Martínez-A C, Camonis J and Rebollo A (1999) Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. EMBO J. 18: 3719-3730
-
(1999)
EMBO J.
, vol.18
, pp. 3719-3730
-
-
Romero, F.1
Martínez-A, C.2
Camonis, J.3
Rebollo, A.4
-
33
-
-
0031936353
-
Ras signaling and apoptosis
-
Downward J (1998) Ras signaling and apoptosis. Curr. Opin. Gen. Dev. 8: 49-54
-
(1998)
Curr. Opin. Gen. Dev.
, vol.8
, pp. 49-54
-
-
Downward, J.1
-
34
-
-
0029976462
-
Increased expression of cyclin D1 and the Rb tumor suppressor gene in K-Ras transformed rat enterocytes
-
Arber N, Sutter T, Miyake M, Kahn SM, Vekatraj VS, Sobrino A, Warburton D, Holt PR and Weinstein IB (1996) Increased expression of cyclin D1 and the Rb tumor suppressor gene in K-Ras transformed rat enterocytes. Oncogene 12: 1903-1908
-
(1996)
Oncogene
, vol.12
, pp. 1903-1908
-
-
Arber, N.1
Sutter, T.2
Miyake, M.3
Kahn, S.M.4
Vekatraj, V.S.5
Sobrino, A.6
Warburton, D.7
Holt, P.R.8
Weinstein, I.B.9
-
35
-
-
0030863161
-
Induction of p27kip degradation and anchorage independence by Ras through the MAP kinase signalling pathway
-
Kawada M, Yamagoe S, Murakina Y, Suzuki K, Mizuno S and Uehara Y (1997) Induction of p27kip degradation and anchorage independence by Ras through the MAP kinase signalling pathway. Oncogene 15: 629-637
-
(1997)
Oncogene
, vol.15
, pp. 629-637
-
-
Kawada, M.1
Yamagoe, S.2
Murakina, Y.3
Suzuki, K.4
Mizuno, S.5
Uehara, Y.6
-
37
-
-
0032522816
-
High intensity Raf signals converts mitotic cell cycling into cellular growth
-
Kerkhoff E and Rapp UR (1998) High intensity Raf signals converts mitotic cell cycling into cellular growth. Cancer Res. 58: 1636-1640
-
(1998)
Cancer Res.
, vol.58
, pp. 1636-1640
-
-
Kerkhoff, E.1
Rapp, U.R.2
-
38
-
-
0030835430
-
Raf induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21cip
-
Woods D, Parry D, Cherwinski H, Bosch E, Lees E and McMahon M (1997) Raf induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21cip. Mol. Cell. Biol. 17: 5598-5611
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 5598-5611
-
-
Woods, D.1
Parry, D.2
Cherwinski, H.3
Bosch, E.4
Lees, E.5
McMahon, M.6
-
39
-
-
0029052834
-
NGF regulates the PC12 cell cycle machinery through specific inhibition of cdk kinases and induction of cyclin D1
-
Yan GZ and Ziff EB (1995) NGF regulates the PC12 cell cycle machinery through specific inhibition of cdk kinases and induction of cyclin D1. J. Neurosci 15: 6200-6212
-
(1995)
J. Neurosci
, vol.15
, pp. 6200-6212
-
-
Yan, G.Z.1
Ziff, E.B.2
-
40
-
-
0030944985
-
Oncogenic Ras provokes premature senescence associated with accumulation of p53 and p16ink4A
-
Serrano M, Lian AW, McCurrach ME, Beach D and Lowe SW (1997) Oncogenic Ras provokes premature senescence associated with accumulation of p53 and p16ink4A. Cell 88: 593-602
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lian, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
41
-
-
0032504784
-
p19arf links the tumor suppressor p53 to Ras
-
Palmero I, Pantoja C and Serrano M (1998) p19arf links the tumor suppressor p53 to Ras. Nature 395: 125-126
-
(1998)
Nature
, vol.395
, pp. 125-126
-
-
Palmero, I.1
Pantoja, C.2
Serrano, M.3
-
42
-
-
0030907987
-
Pl3K: Downstream AKTion blocks apoptosis
-
Franke TF, Kaplan DR and Cantley LC (1997) Pl3K: downstream AKTion blocks apoptosis. Cell 88: 435-437
-
(1997)
Cell
, vol.88
, pp. 435-437
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
-
43
-
-
0029821721
-
Activation of Rac protein kinase by heat shock and hyperasmolarity stress through a pathway independent of Pl3K
-
Konishi H, Matsuzaki H, Tanaka M, Ono Y, Tokunaga C, Kuroda S and Kikkawa U (1996) Activation of Rac protein kinase by heat shock and hyperasmolarity stress through a pathway independent of Pl3K. Proc. Natl. Acad. Sci. USA 93: 7639-7643
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 7639-7643
-
-
Konishi, H.1
Matsuzaki, H.2
Tanaka, M.3
Ono, Y.4
Tokunaga, C.5
Kuroda, S.6
Kikkawa, U.7
-
44
-
-
0031770118
-
Role of Akt and JNK2 in apoptosis induced by IL-4 deprivation
-
Cerezo A, Martínez-A C, Lanzarot D, Fischer S, Franke T and Rebollo A (1998) Role of Akt and JNK2 in apoptosis induced by IL-4 deprivation. Mol. Biol. Cell. 8: 3107-3118
-
(1998)
Mol. Biol. Cell.
, vol.8
, pp. 3107-3118
-
-
Cerezo, A.1
Martínez-A, C.2
Lanzarot, D.3
Fischer, S.4
Franke, T.5
Rebollo, A.6
-
45
-
-
0030904561
-
The Pl3K/Akt signaling pathway delivers an anti-apoptotic signal
-
Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellascosa A, Tsichlis PN and Hay N (1997) The Pl3K/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11: 701-713
-
(1997)
Genes Dev.
, vol.11
, pp. 701-713
-
-
Kennedy, S.G.1
Wagner, A.J.2
Conzen, S.D.3
Jordan, J.4
Bellascosa, A.5
Tsichlis, P.N.6
Hay, N.7
-
46
-
-
1842333237
-
IL-3 induces phosphorylation of bad through protein kinase Akt
-
Peso LD, Gonzalez M, Page C, Herrera R and Nuñez G (1997) IL-3 induces phosphorylation of bad through protein kinase Akt. Science 278: 687-689
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
Peso, L.D.1
Gonzalez, M.2
Page, C.3
Herrera, R.4
Nuñez, G.5
-
47
-
-
0030702123
-
Akt phosphorylation of BAD couples cell survival signals to cell-intrinsic death machinery
-
Datt S, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME (1997) Akt phosphorylation of BAD couples cell survival signals to cell-intrinsic death machinery. Cell 91: 231-241
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datt, S.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
48
-
-
0344791649
-
IL-2 deprivation triggers apoptosis which is mediated by c-Jun N-terminal kinase: Activation and prevented by Bcl-2
-
Cerezo A, Martínez-A C, Gómez J and Rebollo A (1999) IL-2 deprivation triggers apoptosis which is mediated by c-Jun N-terminal kinase: activation and prevented by Bcl-2. Cell Death Differ. 6: 87-94
-
(1999)
Cell Death Differ.
, vol.6
, pp. 87-94
-
-
Cerezo, A.1
Martínez-A, C.2
Gómez, J.3
Rebollo, A.4
-
49
-
-
0028964917
-
Fas-induced apoptosis is mediated via ceramide-initiated Ras signaling pathway
-
Gulbins E, Bissonett R and Mahbouhi A (1995) Fas-induced apoptosis is mediated via ceramide-initiated Ras signaling pathway. Immunity 2: 341-351
-
(1995)
Immunity
, vol.2
, pp. 341-351
-
-
Gulbins, E.1
Bissonett, R.2
Mahbouhi, A.3
-
50
-
-
0028607141
-
Proliferative inhibition by dominant negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death
-
Ferrari G and Green LA (1994) Proliferative inhibition by dominant negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death. EMBO J. 13: 5922-5928
-
(1994)
EMBO J.
, vol.13
, pp. 5922-5928
-
-
Ferrari, G.1
Green, L.A.2
-
51
-
-
0030587081
-
Critical role of Ras in proliferation and prevention of apoptosis mediated by IL-2
-
Gómez J, Martínez-A C, Fernández B, García A and Rebollo A (1996) Critical role of Ras in proliferation and prevention of apoptosis mediated by IL-2. J. Immunol. 157: 2272-2281
-
(1996)
J. Immunol.
, vol.157
, pp. 2272-2281
-
-
Gómez, J.1
Martínez-A, C.2
Fernández, B.3
García, A.4
Rebollo, A.5
-
52
-
-
0030861719
-
Ras activation leads to cell proliferation or apoptotic cell death upon IL-2 stimulation or lymphokine deprivation, respectively
-
Gómez J, Martínez-A C, Fernández B, García A and Rebollo A (1997) Ras activation leads to cell proliferation or apoptotic cell death upon IL-2 stimulation or lymphokine deprivation, respectively. Eur. J. Immunol. 27: 1610-1618
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 1610-1618
-
-
Gómez, J.1
Martínez-A, C.2
Fernández, B.3
García, A.4
Rebollo, A.5
-
53
-
-
0030271387
-
NF-κB: Ten years after
-
Bauerle PA and Baltimore D (1996) NF-κB: Ten years after. Cell 87: 13-20
-
(1996)
Cell
, vol.87
, pp. 13-20
-
-
Bauerle, P.A.1
Baltimore, D.2
-
54
-
-
0029976817
-
An essential role of NF-κB in prevention of TNFχ-induced cell death
-
Beg AA and Baltimore D (1996) An essential role of NF-κB in prevention of TNFχ-induced cell death. Science 274: 782-784
-
(1996)
Science
, vol.274
, pp. 782-784
-
-
Beg, A.A.1
Baltimore, D.2
-
55
-
-
0030612937
-
Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic Ras
-
Mayo MW, Wang CY, Cogswell PC, Rogers-Graham KS, Lowe SW, Der CJ and Baldwin AS (1997) Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278: 1812-1815
-
(1997)
Science
, vol.278
, pp. 1812-1815
-
-
Mayo, M.W.1
Wang, C.Y.2
Cogswell, P.C.3
Rogers-Graham, K.S.4
Lowe, S.W.5
Der, C.J.6
Baldwin, A.S.7
-
56
-
-
0030882666
-
Oncogenic H-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation
-
Finco TS, Westwick JK, Norris JL, Bewg AA, Der CJ and Baldwin AS (1997) Oncogenic H-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation. J. Biol. Chem. 272: 24113-24116
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24113-24116
-
-
Finco, T.S.1
Westwick, J.K.2
Norris, J.L.3
Bewg, A.A.4
Der, C.J.5
Baldwin, A.S.6
-
57
-
-
0030829782
-
K-Ras is essential for development of mouse embryo
-
Koera K, Nakamura K, Nakao K, Miyoshi J, Tokoshima K, Hatta T, Otani H, Aiba A and Katsiki M (1997) K-Ras is essential for development of mouse embryo. Oncogene 15: 1151-1159
-
(1997)
Oncogene
, vol.15
, pp. 1151-1159
-
-
Koera, K.1
Nakamura, K.2
Nakao, K.3
Miyoshi, J.4
Tokoshima, K.5
Hatta, T.6
Otani, H.7
Aiba, A.8
Katsiki, M.9
-
58
-
-
0345135149
-
K-Ras is an essential gene in the mouse with partial functional overlapping with N-Ras
-
Johnson L (1997) K-Ras is an essential gene in the mouse with partial functional overlapping with N-Ras. Genes Dev. 11: 2468-2481
-
(1997)
Genes Dev.
, vol.11
, pp. 2468-2481
-
-
Johnson, L.1
-
59
-
-
0030727170
-
Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking
-
Thissen JA, Gross JM, Subramanian K, Meyer T and Casey PJ (1997) Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking. J. Biol. Chem. 272: 30362-30370
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30362-30370
-
-
Thissen, J.A.1
Gross, J.M.2
Subramanian, K.3
Meyer, T.4
Casey, P.J.5
-
60
-
-
0030736630
-
Oncogenic K-Ras, but not oncogenic H-Ras upregulates CEA expression and disrupts basolateral polarity in colon epithelial cells
-
Yan Z, Deng X, Chen M, Xu Y, Ahram M, Sloane BF and Friedman E (1997) Oncogenic K-Ras, but not oncogenic H-Ras upregulates CEA expression and disrupts basolateral polarity in colon epithelial cells. J. Biol. Chem. 272: 27902-27907
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 27902-27907
-
-
Yan, Z.1
Deng, X.2
Chen, M.3
Xu, Y.4
Ahram, M.5
Sloane, B.F.6
Friedman, E.7
-
61
-
-
0031917171
-
Ras-GRF activates H-Ras, but not N-Ras or K-Ras4B protein in vivo
-
Jones MK and Jackson JH (1998) Ras-GRF activates H-Ras, but not N-Ras or K-Ras4B protein in vivo. J. Biol. Chem. 273: 1782-1787
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1782-1787
-
-
Jones, M.K.1
Jackson, J.H.2
-
62
-
-
0033546419
-
Four human Ras homologs differ in their abilities to activate Raf-1, induce transformation and stimulate cell motility
-
Voice JK, Klemke RL, Le A and Jackson JH (1999) Four human Ras homologs differ in their abilities to activate Raf-1, induce transformation and stimulate cell motility. J. Biol. Chem. 274: 17164-17170
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17164-17170
-
-
Voice, J.K.1
Klemke, R.L.2
Le, A.3
Jackson, J.H.4
-
63
-
-
0032508517
-
Ras isoforms vary in their ability to activate Raf-1 and Pl3 kinase
-
Yan J, Roy S, Apolloni A, Lane A and Hancock JF (1998) Ras isoforms vary in their ability to activate Raf-1 and Pl3 kinase. J. Biol. Chem. 273: 24052-24056
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 24052-24056
-
-
Yan, J.1
Roy, S.2
Apolloni, A.3
Lane, A.4
Hancock, J.F.5
-
64
-
-
0008573656
-
Bcl-2 differentially targets K-, N- and H-Ras to mitochondria in IL-2 supplemented cells: Implications in prevention of apoptosis
-
in press
-
Rebollo A, Pérez-Sala D and Martinez-A C (1999) Bcl-2 differentially targets K-, N- and H-Ras to mitochondria in IL-2 supplemented cells: Implications in prevention of apoptosis. Oncogene, in press
-
(1999)
Oncogene
-
-
Rebollo, A.1
Pérez-Sala, D.2
Martinez-A, C.3
-
65
-
-
0029898894
-
Protein prenylation: Molecular mechanisms and functional consequences
-
Zhang FL and Casey PJ (1996) Protein prenylation: molecular mechanisms and functional consequences. Ann. Rev. Biochem. 65: 241-269
-
(1996)
Ann. Rev. Biochem.
, vol.65
, pp. 241-269
-
-
Zhang, F.L.1
Casey, P.J.2
-
66
-
-
0031945668
-
CAAX converting enzymes
-
Ashby MN (1998) CAAX converting enzymes. Curr. Opin. Lipidol. 9: 99-102
-
(1998)
Curr. Opin. Lipidol.
, vol.9
, pp. 99-102
-
-
Ashby, M.N.1
-
67
-
-
0030923192
-
K-Ras and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
-
Whyte DB, Kirschmeier P, Hockenberry TN, Nunez-Oliva I, James L, Catino JJ, Bishop WR and Pai JK (1997) K-Ras and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J. Biol. Chem. 272: 14459-14464
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14459-14464
-
-
Whyte, D.B.1
Kirschmeier, P.2
Hockenberry, T.N.3
Nunez-Oliva, I.4
James, L.5
Catino, J.J.6
Bishop, W.R.7
Pai, J.K.8
-
68
-
-
0030952552
-
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines
-
Lerner EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD and Sebti SM (1997) Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines. Oncogene 15: 1283-1288
-
(1997)
Oncogene
, vol.15
, pp. 1283-1288
-
-
Lerner, E.C.1
Zhang, T.T.2
Knowles, D.B.3
Qian, Y.4
Hamilton, A.D.5
Sebti, S.M.6
-
69
-
-
0031452275
-
Structure of the Ras binding domain of RaIGEF and implications for Ras binding and signalling
-
Geyer M and Wittinghofer A (1997) Structure of the Ras binding domain of RaIGEF and implications for Ras binding and signalling. Curr. Opin. Struct. Biol. 7: 786-792
-
(1997)
Curr. Opin. Struct. Biol.
, vol.7
, pp. 786-792
-
-
Geyer, M.1
Wittinghofer, A.2
-
70
-
-
0031434108
-
Induction of the cholesterol metabolic pathway regulates the farnesylation of Ras in embryonic chick heart cells: A new role for Ras in regulating the expression of muscarinic receptors and G proteins
-
Gadbut AP, Wu L, Tang D, Papageorge A, Watson JA and Galper JB (1997) Induction of the cholesterol metabolic pathway regulates the farnesylation of Ras in embryonic chick heart cells: a new role for Ras in regulating the expression of muscarinic receptors and G proteins. EMBO J. 16: 7250-7260
-
(1997)
EMBO J.
, vol.16
, pp. 7250-7260
-
-
Gadbut, A.P.1
Wu, L.2
Tang, D.3
Papageorge, A.4
Watson, J.A.5
Galper, J.B.6
-
71
-
-
0030874337
-
G protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. Role of PKC-delta in the regulation of eicosanoid production
-
Pomerantz KB, Lander HM, Summers B, Robishaw JD, Balcueva E and Hajjar DP (1997) G protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. Role of PKC-delta in the regulation of eicosanoid production. Biochemistry 36: 9523-9531
-
(1997)
Biochemistry
, vol.36
, pp. 9523-9531
-
-
Pomerantz, K.B.1
Lander, H.M.2
Summers, B.3
Robishaw, J.D.4
Balcueva, E.5
Hajjar, D.P.6
-
72
-
-
0032508516
-
Effect of insulin on farnesyltransferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor 1, epidermal growth factor and platelet-derived growth factor
-
Goalstone ML, Leitner JW, Wall K, Dolgonos L, Rother KI, Accili D and Draznin B (1998) Effect of insulin on farnesyltransferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor 1, epidermal growth factor and platelet-derived growth factor. J. Biol. Chem. 273: 23892-23896
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 23892-23896
-
-
Goalstone, M.L.1
Leitner, J.W.2
Wall, K.3
Dolgonos, L.4
Rother, K.I.5
Accili, D.6
Draznin, B.7
-
73
-
-
0033524358
-
Effect of farnesyltransferase overexpression on cell growth and transformation
-
Nagase T, Kawata S, Nakajima H, Tamura S, Yamasaki E, Fukui K, Yamamoto K, Miyagawa J, Matsumura I, Matsuda Y and Matsuzawa Y (1999) Effect of farnesyltransferase overexpression on cell growth and transformation. Int. J. Cancer 80: 126-133
-
(1999)
Int. J. Cancer
, vol.80
, pp. 126-133
-
-
Nagase, T.1
Kawata, S.2
Nakajima, H.3
Tamura, S.4
Yamasaki, E.5
Fukui, K.6
Yamamoto, K.7
Miyagawa, J.8
Matsumura, I.9
Matsuda, Y.10
Matsuzawa, Y.11
-
74
-
-
0030909826
-
Crystal structure of protein farnesltransferase at 2.25 A resolution
-
Park HW, Boduluri SR, Moomaw JF, Casey PJ and Beese LS (1997) Crystal structure of protein farnesltransferase at 2.25 A resolution. Science 275: 1800-1804
-
(1997)
Science
, vol.275
, pp. 1800-1804
-
-
Park, H.W.1
Boduluri, S.R.2
Moomaw, J.F.3
Casey, P.J.4
Beese, L.S.5
-
75
-
-
0030909336
-
Modulation of Ras and a-factor by carboxyl-terminal proteolysis
-
Boyartchuk VL, Ashby MN and Rine J (1997) Modulation of Ras and a-factor by carboxyl-terminal proteolysis. Science 275: 1796-1800
-
(1997)
Science
, vol.275
, pp. 1796-1800
-
-
Boyartchuk, V.L.1
Ashby, M.N.2
Rine, J.3
-
76
-
-
0033605743
-
Cloning and characterization of a mammalian prenyl protein-specific protease
-
Otto JC, Kim E, Young SG and Casey PJ (1999) Cloning and characterization of a mammalian prenyl protein-specific protease. J. Biol. Chem. 274: 8379-8382
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8379-8382
-
-
Otto, J.C.1
Kim, E.2
Young, S.G.3
Casey, P.J.4
-
78
-
-
0033605596
-
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells
-
Kim E, Ambroziak P, Otto JC, Taylor B, Ashby M, Shannon K, Casey PJ and Young SG (1999) Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J. Biol. Chem. 274: 8383-8390
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8383-8390
-
-
Kim, E.1
Ambroziak, P.2
Otto, J.C.3
Taylor, B.4
Ashby, M.5
Shannon, K.6
Casey, P.J.7
Young, S.G.8
-
79
-
-
0031858844
-
The S. cerevisiae prenylcysteine carboxy methyltranferase Ste14p is in the endoplasmic reticulum membrane
-
Romano JD, Schmidt WK and Michaelis S (1998) The S. cerevisiae prenylcysteine carboxy methyltranferase Ste14p is in the endoplasmic reticulum membrane. Mol. Biol. Cell 9: 2231-2247
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 2231-2247
-
-
Romano, J.D.1
Schmidt, W.K.2
Michaelis, S.3
-
80
-
-
0030610589
-
Inhibition of growth and Ras methylation in vascular endothelial cells by homocysteine, but not cysteine
-
Wang H, Yoshizumi M, Lai K, Tsai JC, Perrella MA, Haber E and Lee ME (1997) Inhibition of growth and Ras methylation in vascular endothelial cells by homocysteine, but not cysteine. J. Biol. Chem. 272: 25380-25385
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 25380-25385
-
-
Wang, H.1
Yoshizumi, M.2
Lai, K.3
Tsai, J.C.4
Perrella, M.A.5
Haber, E.6
Lee, M.E.7
-
81
-
-
0028981375
-
Selective inhibition of Ras-dependent cell growth by farnesylthiosalicylic acid
-
Marom M, Haklai R, Ben-Baruch G, Marciano D, Egozi Y and Kloog Y (1995) Selective inhibition of Ras-dependent cell growth by farnesylthiosalicylic acid. J. Biol. Chem. 270: 22263-22270
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22263-22270
-
-
Marom, M.1
Haklai, R.2
Ben-Baruch, G.3
Marciano, D.4
Egozi, Y.5
Kloog, Y.6
-
83
-
-
0030749458
-
Farnesyl transferase inhibitors and cancer treatment: Targeting simply Ras?
-
Cox AD and Der CJ (1997) Farnesyl transferase inhibitors and cancer treatment: targeting simply Ras? Biochim. Biophys. Acta. 1333: F51-F71
-
(1997)
Biochim. Biophys. Acta.
, vol.1333
-
-
Cox, A.D.1
Der, C.J.2
-
84
-
-
0029978806
-
Chemical biology of protein isoprenylation/methylation
-
Rando RR (1996) Chemical biology of protein isoprenylation/methylation. Biochim. Biophys. Acta 1300: 5-16
-
(1996)
Biochim. Biophys. Acta
, vol.1300
, pp. 5-16
-
-
Rando, R.R.1
-
85
-
-
0033556397
-
A non farnesylated H-Ras protein can be palmitoylated and trigger potent differentiation and transformation
-
Booden MA, Baker TL, Solski PA, Der CJ, Punke SG and Buss JE (1999) A non farnesylated H-Ras protein can be palmitoylated and trigger potent differentiation and transformation. J. Biol. Chem. 274: 1423-1431
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1423-1431
-
-
Booden, M.A.1
Baker, T.L.2
Solski, P.A.3
Der, C.J.4
Punke, S.G.5
Buss, J.E.6
|