Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas

EMBO Journal

Volumn 18, Issue 7, 1999, Pages 1824-1831

  Peli, Janos ^a   Schröter, Michael ^b   Rudaz, Claude ^a   Hahne, Michael ^b   Meyer, Christine ^a   Reichmann, Ernst ^a   Tschopp, Jürg ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Apoptosis; Fas (Apo 1 CD95); Oncogene; Tumorigenesis

Indexed keywords

FAS LIGAND;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; FIBROBLAST; GENE EXPRESSION; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; TUMOR GROWTH;

ANIMALIA;

EID: 0345148793     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.7.1824     Document Type: Article

References (54)

1. Ambrosini, G., Adida, C. and Altieri, D.C. (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nature Med., 3. 917-921.
2. Behrmann, I., Walczak, H. and Krammer, P.H. (1994) Structure of the human APO-1 gene. Eur. J, Immunol., 24, 3057-3062.
3. Cardi, G., Heaney, J.A., Schned, A.R. and Ernstoff, M.S. (1998) Expression of Fas (APO-1/CD95) in tumor-infiltrating and peripheral blood lymphocytes in patients with renal cell carcinoma. Cancer Res., 58, 2078-2080.
4. Cheng, J., Liu, C., Koopman, W.J. and Mountz, J.D. (1995) Characterization of human Fas gene. Exon/intron organization and promoter region. J. Immunol., 154, 1239-1245.
5. Cory, S. (1994) Apoptosis-fascinating death factor Nature, 367, 317-318.
6. Dixit, V.M. (1996) The cell-death machine. Curr. Biol. 6, 555-562.
7. Downward, J. (1997) Cell cycle: routine role for Ras. Curr. Biol., 7, 258-260.
8. Downward, J. (1998) Ras signalling and apoptosis. Curr. Opin. Genet. Dev. 8, 49-55.
9. Evan, G. (1997) Cancer - a matter of life and cell death. Int. J. Cancer, 71, 709-711.
10. Faris, M., Kokot, N., Latinis, K., Kasibhatla, S., Green, D.R., Koretzky, G.A. and Nel, A. (1998) The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression. J. Immunol., 160, 134-144.
11. Fenton, R.G., Hixon, J.A., Wright, P.W., Brooks, A.D. and Sayers, T.J. (1998) Inhibition of Fas (CD95) expression and Fas-mediated apoptosis by oncogenic Ras. Cancer Res., 58, 3391-3400.
12. Fialka, I., Schwarz, H., Reichmann, E., Oft, M., Busslinger, M. and Beug, H. (1996) The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions. J. Cell Biol., 132, 1115-1132.
13. French, L.E., Hahne, M., Viard, I., Radlgruber, G., Zanone, R., Becker, K., Muller, C. and Tschopp, J. (1996) Fas and Fas ligand in embryos and adult mice-ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J. Cell Biol., 133, 335-343.
14. French, L.E., Wilson, A., Hahne, M., Viard, I., Tschopp, J. and MacDonald, H.R. (1997) Fas ligand expression is restricted to nonlymphoid thymic components in situ. J. Immunol., 159, 2196-2202.
15. Friesen, C., Herr, I., Krammer, P.H. and Debatin, K.M. (1996) Involvement of the CD95 (Apo-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nature Med., 2, 574-577.
16. Green, D.R., McGahon, A. and Martin, S.J. (1996) Regulation of apoptosis by oncogenes. J. Cell. Biochem., 60, 33-38.
17. Gulbins, E. et al. (1995) Fas-induced apoptosis is mediated via a Ceramide-initiated ras signaling pathway. Immunity, 2, 341-351.
18. Hahne, M. et al. (1996) Melanoma cell expression of Fas (Apo-1/CD95) ligand: implications for tumor immune escape. Science, 274, 1363-1366.
19. Herr, I., Wilhelm, D., Bohler, T., Angel, P. and Debatin, K.M. (1997) Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J., 16, 6200-6208.
20. Hueber, A.O., Zornig, M., Lyon, D., Suda, T., Nagata, S. and Evan, G.I. (1997) Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis [see comments]. Science, 278, 1305-1309.
21. Irmler, M. et al. (1997) Inhibition of death receptor signals by cellular FLIP. Nature, 388, 190-195.
22. Kashibatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A. and Green, D. (1998) DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kB and AP-1. Mol. Cell, 1, 543-551.
23. Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J. and Evan, G. (1997) Suppression of c-Myc-induced apoptosis by Ras signalling through PI (3)K and PKB. Nature, 385, 544-548.
24. Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P.H. and Downward, J. (1997) Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J., 16, 2783-2793.
25. Korsmeyer, S.J. (1995) Regulators of cell death. Trends Genet., 11, 101-105.
26. Krammer, P.H. (1996) The CD95 (Apo-1/Fas) receptor/ligand system-death signals and diseases. Cell Death Differ., 3, 159-160.
27. Latinis, K.M. and Koretzky, G.A. (1996) Fas ligation induces apoptosis and jun kinase activation independently of cd45 and lck in human T cells. Blood, 87, 871-875.
28. Lebel, M., Bertrand, R. and Mes-Masson, A.M. (1996) Decreased Fas antigen receptor expression in testicular tumor cell lines derived from polyomavirus large T-antigen transgenic mice. Oncngene, 12, 1127-1135.
29. Leithauser, F. et al. (1993) Constitutive and induced expression of APO-1. a new member of the nerve growth factor/tumor necrosis factor receptor superfamily. in normal and neoplastic cells. Lab. Invest., 69, 415-429.
30. Levine, A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323-331.
31. Liston, P. et al. (1996) Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature, 379, 349-353.
32. Macara, I.G., Lounsbury, K.M., Richards, S.A., McKiernan, C. and Bar-Sagi, D. (1996) The Ras superfamily of GTPases. FASEB J., 10, 625-630.
33. MacLeod, A.R., Rouleau, J. and Szyf, M. (1995) Regulation of DNA methylation by the Ras signaling pathway. J. Biol. Chem., 270, 11327-11337.
34. Marshall, C. and Wyllie, A. (1996) Oncogenes and cell proliferation. Curr. Opin. Genet. Dev., 6, 1-3.
35. Marte, B.M. and Downward, J. (1997) PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biol. Sci., 22, 355-358.
36. Moller, P., Koretz, K., Leithauser, F., Bruderlein, S., Henne, C., Quentmeier, A. and Krammer, P.H. (1994) Expression of APO-1 (CD95). a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium. Int. J. Cancer, 57, 371-377.
37. Mostoslavsky, R. and Bergman, Y. (1997) DNA methylation: regulation of gene expression and role in the immune system. Biochim. Biophys. Acta, 1333, 29-50.
38. Nagata, S. (1997) Apoptosis by death factor. Cell, 88, 355-365.
39. Nagata, S. and Golstein, P. (1995) The Fas death factor. Science, 267, 1449-1456.
40. Pear, W.S., Nolan, G.R, Scott, M.L. and Baltimore, D. (1993) Production of high-liter helper-free retroviruses by transient transfection. Proc. Natl Acad. Sci. USA, 90, 8392-8396.
41. Peng, S.L., Robert, M.E., Hayday, A.C. and Craft, J. (1996) A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice. J. Exp. Med., 184, 1149-1154.
42. Raff, M.C., Barres, B.A., Burne, J.F., Coles, H.S., Ishizaki, Y. and Jacobson, M.D. (1993) Programmed cell death and the control of cell survival - lessons from the nervous system. Science, 262, 695-700.
43. Reed, J.C. (1997) Double identity for proteins of the Bcl-2 family. Nature, 387, 773-776.
44. Reichmann, E. (1994) Oncogenes and epithelial cell transformation. Semin. Cancer Biol., 5, 157-165.
45. Reichmann, E., Schwarz, H., Deiner, E.M., Leitner, I., Eilers, M., Berger, J., Busslinger, M. and Beug, H. (1992) Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelialfibroblastoid cell conversion. Cell, 71, 1103-1116.
46. Rodriguez-Viciana, P., Warne, P.H., Khwaja, A., Marte, B.M., Pappin, D., Das, P., Waterfield, M.D., Ridley, A. and Downward, J. (1997) Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell, 89, 457-467.
47. Rudert, F., Visser, E., Forbes, L., Lindridge, E., Wang, Y. and Watson, J. (1995) Identification of a silencer, enhancer and basal promoter region in the human CD95 (Fas/Apo-1) gene. DNA Cell Biol., 14, 931-937.
48. Strand, S. et al. (1996) Lymphocyte apoptosis induced by CD95 (Apo-1/Fas) ligand-expressing tumor cells - A mechanism of immune evasion? Nature Med., 2, 1361-1366.
49. Strasser, A., Harris, A.W., Huang, D.C.S., Krammer, P.H. and Cory, S. (1995) Bcl-2 and Fas/Apo-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J., 14, 6136-6147.
50. Tollefson, A.E. et al. (1998) Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells. Nature, 392, 726-730.
51. Tschopp, J., Thome, M., Hofmann, K. and Meinl, E. (1998) The fight of viruses against apoptosis. Curr. Opin. Genet. Dev., 8, 82-87.
52. Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E. and Croce, C.M. (1985) The t (14:18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science, 229, 1390-1393.
53. Ward, R.L., Todd, A.V., Santiago, F., O'Connor, T. and Hawkins, N.J. (1997) Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis. Cancer, 79, 1106-1113.
54. Zornig, M., Grzeschiczek, A., Kowalski, M.B., Hartmann, K.U. and Moroy, T. (1995) Loss of Fas/Apo-1 receptor accelerates lymphoma-genesis in E mu L-MYC transgenic mice but not in animals infected with MoMuLV. Oncogene, 10, 2397-2401.