메뉴 건너뛰기




Volumn 17, Issue 3, 1999, Pages 1071-1079

RAS and leukemia: From basic mechanisms to gene-directed therapy

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; ALCOHOL DERIVATIVE; LIMONENE; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE METHYL ESTER; PEPTIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; TERPENE;

EID: 0033014304     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.1999.17.3.1071     Document Type: Review
Times cited : (166)

References (116)
  • 1
    • 0029148040 scopus 로고
    • Low-molecular-weight GTP-binding proteins and leukocyte signal transduction
    • Quinn MT: Low-molecular-weight GTP-binding proteins and leukocyte signal transduction. J Leukoc Biol 58:263-276, 1995
    • (1995) J Leukoc Biol , vol.58 , pp. 263-276
    • Quinn, M.T.1
  • 2
    • 0027232605 scopus 로고
    • Emerging concepts in the Ras superfamily of GTP-binding proteins
    • Bokoch GM, Der CJ: Emerging concepts in the Ras superfamily of GTP-binding proteins. FASEB J 7:750-759, 1993
    • (1993) FASEB J , vol.7 , pp. 750-759
    • Bokoch, G.M.1    Der, C.J.2
  • 3
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski MS, McCormick F: Proteins regulating Ras and its relatives. Nature 366:643-653, 1993
    • (1993) Nature , vol.366 , pp. 643-653
    • Boguski, M.S.1    McCormick, F.2
  • 4
  • 5
    • 0020556126 scopus 로고
    • Localization of c-ras oncogene family on human germ-line chromosomes
    • Jhanwar SC, Neel BG, Hayward WS, et al: Localization of c-ras oncogene family on human germ-line chromosomes. Proc Natl Acad Sci U S A 80:4794-4797, 1983
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 4794-4797
    • Jhanwar, S.C.1    Neel, B.G.2    Hayward, W.S.3
  • 6
    • 18344415308 scopus 로고
    • Isolation and mapping of a polymorphic DNa sequence for N-RAS pMCR3 on chromosome 1
    • Carlson M, Nakamura Y, O'Connell P, et al: Isolation and mapping of a polymorphic DNA sequence for N-RAS pMCR3 on chromosome 1. Nucleic Acids Res 15:9623-626, 1987
    • (1987) Nucleic Acids Res , vol.15 , pp. 9623-9626
    • Carlson, M.1    Nakamura, Y.2    O'Connell, P.3
  • 8
    • 0026619185 scopus 로고
    • The ras/cholesterol connection: Implications for Ras oncogenicity
    • Cox AD, Der CJ: The ras/cholesterol connection: Implications for Ras oncogenicity. Crit Rev Oncog 3:365-400, 1992
    • (1992) Crit Rev Oncog , vol.3 , pp. 365-400
    • Cox, A.D.1    Der, C.J.2
  • 9
    • 0019855643 scopus 로고
    • The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes
    • Ellis RW, Defeo D, Shih TY, et al: The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature 292:506-511, 1981
    • (1981) Nature , vol.292 , pp. 506-511
    • Ellis, R.W.1    Defeo, D.2    Shih, T.Y.3
  • 10
    • 0022596878 scopus 로고
    • Nucleotide sequence of the two rat cellular H-ras genes
    • Ruta M, Wolford R, Dhar R, et al: Nucleotide sequence of the two rat cellular H-ras genes. Mol Cell Biol 6:1706-1710, 1986
    • (1986) Mol Cell Biol , vol.6 , pp. 1706-1710
    • Ruta, M.1    Wolford, R.2    Dhar, R.3
  • 11
    • 0013055679 scopus 로고
    • Three human transforming genes are related to the viral oncogenes
    • Shimizu K, Goldfarb M, Suard Y, et al: Three human transforming genes are related to the viral oncogenes. Proc Natl Acad Sci U S A 80:2112-2116, 1983
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 2112-2116
    • Shimizu, K.1    Goldfarb, M.2    Suard, Y.3
  • 12
    • 0026909770 scopus 로고
    • Ras and human tumors
    • Rodenhuis S: Ras and human tumors. Semin Cancer Biol 3:241-247, 1992
    • (1992) Semin Cancer Biol , vol.3 , pp. 241-247
    • Rodenhuis, S.1
  • 13
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant K-ras genes
    • Almoguera C, Shibata D, Forrester K, et al: Most human carcinomas of the exocrine pancreas contain mutant K-ras genes. Cell 53:549-554, 1988
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3
  • 14
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinoma of the human pancreas: A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis allele-specific oligonucleotide hybridization
    • Hruban RH, van Mansfeld AD. Offerhaus GJ, et al: K-ras oncogene activation in adenocarcinoma of the human pancreas: A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis allele-specific oligonucleotide hybridization. Am J Pathol 143:545-554, 1993
    • (1993) Am J Pathol , vol.143 , pp. 545-554
    • Hruban, R.H.1    Van Mansfeld, A.D.2    Offerhaus, G.J.3
  • 15
    • 0028527347 scopus 로고
    • Gene diagnosis of pancreatic adenocarcinoma
    • Wang ZY, Liu TH, Cui QC: Gene diagnosis of pancreatic adenocarcinoma. Chin J Pathol 23:270-273, 1994
    • (1994) Chin J Pathol , vol.23 , pp. 270-273
    • Wang, Z.Y.1    Liu, T.H.2    Cui, Q.C.3
  • 16
    • 0025184539 scopus 로고
    • K-ras activation in neoplasms of the human female reproductive tract
    • Enomoto T, Inoue M, Perantoni AO, et al: K-ras activation in neoplasms of the human female reproductive tract. Cancer Res 50:6139-6145, 1990
    • (1990) Cancer Res , vol.50 , pp. 6139-6145
    • Enomoto, T.1    Inoue, M.2    Perantoni, A.O.3
  • 17
    • 0029127661 scopus 로고
    • Frequent ras gene mutations in squamous cell cervical cancer
    • Wong YF, Chung TK, Cheung TH, et al: Frequent ras gene mutations in squamous cell cervical cancer. Cancer Lett 95:29-32, 1995
    • (1995) Cancer Lett , vol.95 , pp. 29-32
    • Wong, Y.F.1    Chung, T.K.2    Cheung, T.H.3
  • 18
    • 0023773073 scopus 로고
    • Activated ras oncogenes in human thyroid cancers
    • Lemoine NR, Mayall ES, Wyllie FS, et al: Activated ras oncogenes in human thyroid cancers. Cancer Res 48:4459-4463, 1988
    • (1988) Cancer Res , vol.48 , pp. 4459-4463
    • Lemoine, N.R.1    Mayall, E.S.2    Wyllie, F.S.3
  • 19
    • 0028831165 scopus 로고
    • N-ras mutation of thyroid tumor with special reference to the follicular type
    • Oyama T, Suzuki T, Hara F, et al: N-ras mutation of thyroid tumor with special reference to the follicular type. Pathol Int 45:45-50, 1995
    • (1995) Pathol Int , vol.45 , pp. 45-50
    • Oyama, T.1    Suzuki, T.2    Hara, F.3
  • 20
    • 0025265096 scopus 로고
    • Presence of mutations in all three ras genes in human thyroid tumors
    • Suarez HG, du Villard JA, Severino M, et al: Presence of mutations in all three ras genes in human thyroid tumors. Oncogene 5:565-570, 1990
    • (1990) Oncogene , vol.5 , pp. 565-570
    • Suarez, H.G.1    Du Villard, J.A.2    Severino, M.3
  • 21
    • 0025933890 scopus 로고
    • Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique
    • Levi S, Urbano-Ispizua A. Gill R, et al: Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res 51:3497-3502, 1991
    • (1991) Cancer Res , vol.51 , pp. 3497-3502
    • Levi, S.1    Urbano-Ispizua, A.2    Gill, R.3
  • 22
    • 0025196234 scopus 로고
    • Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing
    • Tada M, Yokosuka O, Omata M, et al: Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing. Cancer 66:930-935, 1990
    • (1990) Cancer , vol.66 , pp. 930-935
    • Tada, M.1    Yokosuka, O.2    Omata, M.3
  • 23
    • 0026547213 scopus 로고
    • High incidence of ras gene mutation in intrahepatic cholangiocarcinoma
    • Tada M, Omata M, Ohto M: High incidence of ras gene mutation in intrahepatic cholangiocarcinoma. Cancer 69:1115-1118, 1992
    • (1992) Cancer , vol.69 , pp. 1115-1118
    • Tada, M.1    Omata, M.2    Ohto, M.3
  • 24
    • 0028053024 scopus 로고
    • K-ras mutation in colorectal cancer: Relations to patient age, sex, and tumor location
    • Breevik J, Meling GI, Spurkland A, et al: K-ras mutation in colorectal cancer: Relations to patient age, sex, and tumor location. Br J Cancer 69:367-371, 1994
    • (1994) Br J Cancer , vol.69 , pp. 367-371
    • Breevik, J.1    Meling, G.I.2    Spurkland, A.3
  • 25
    • 0027864056 scopus 로고
    • Detection of Ki-ras oncogene mutations in normal mucosa, adenoma and adenocarcinoma of the colon
    • Wang ZY: Detection of Ki-ras oncogene mutations in normal mucosa, adenoma and adenocarcinoma of the colon. Chin J Pathol 22:333-336, 1993
    • (1993) Chin J Pathol , vol.22 , pp. 333-336
    • Wang, Z.Y.1
  • 26
    • 0023262990 scopus 로고
    • Detection of high incidence of K-ras oncogenes during human carcinogenesis
    • Forrester K, Almoguera C, Han K, et al: Detection of high incidence of K-ras oncogenes during human carcinogenesis. Nature 327:298-303, 1987
    • (1987) Nature , vol.327 , pp. 298-303
    • Forrester, K.1    Almoguera, C.2    Han, K.3
  • 27
    • 0023256456 scopus 로고
    • Prevalence of ras mutations in human colorectal cancers
    • Bos JL, Fearon SR, Hamilton SR, et al: Prevalence of ras mutations in human colorectal cancers. Nature 327:293-297, 1987
    • (1987) Nature , vol.327 , pp. 293-297
    • Bos, J.L.1    Fearon, S.R.2    Hamilton, S.R.3
  • 28
    • 0025772556 scopus 로고
    • Ras gene mutations and amplification in human nonmelanoma skin cancers
    • Pierceall WE, Goldberg LH, Tainsky MA, et al: Ras gene mutations and amplification in human nonmelanoma skin cancers. Mol Carcinog 4:196-202, 1991
    • (1991) Mol Carcinog , vol.4 , pp. 196-202
    • Pierceall, W.E.1    Goldberg, L.H.2    Tainsky, M.A.3
  • 30
    • 0027981623 scopus 로고
    • K-ras gene point mutation: A stable tumor marker in non-small-cell lung carcinoma
    • Li S, Rosell R, Urban A, et al: K-ras gene point mutation: A stable tumor marker in non-small-cell lung carcinoma. Lung Cancer 11:19-27, 1994
    • (1994) Lung Cancer , vol.11 , pp. 19-27
    • Li, S.1    Rosell, R.2    Urban, A.3
  • 31
    • 0028958222 scopus 로고
    • Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma
    • Mills NE, Fishman CL, Rom WN, et al: Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma. Cancer Res 55:1444-1447, 1995
    • (1995) Cancer Res , vol.55 , pp. 1444-1447
    • Mills, N.E.1    Fishman, C.L.2    Rom, W.N.3
  • 32
    • 0027449904 scopus 로고
    • Studies on ras oncogene activation in endometrial carcinoma
    • Fujimoto I, Shimizu Y, Hirai Y, et al: Studies on ras oncogene activation in endometrial carcinoma. Gynecol Oncol 48:196-202, 1993
    • (1993) Gynecol Oncol , vol.48 , pp. 196-202
    • Fujimoto, I.1    Shimizu, Y.2    Hirai, Y.3
  • 33
    • 0027157844 scopus 로고
    • Mutation of the Ki-ras proto-oncogene in human endometrial hyperplasia and carcinoma
    • Sasaki H, Nishii H, Takahashi H, et al: Mutation of the Ki-ras proto-oncogene in human endometrial hyperplasia and carcinoma. Cancer Res 53:1906-1910, 1993
    • (1993) Cancer Res , vol.53 , pp. 1906-1910
    • Sasaki, H.1    Nishii, H.2    Takahashi, H.3
  • 34
    • 0028086086 scopus 로고
    • Point mutations in the N-ras oncogene in malignant melanoma and congenital naevi
    • Carr J, Mackie RM: Point mutations in the N-ras oncogene in malignant melanoma and congenital naevi. Br J Dermatol 131:72-77, 1994
    • (1994) Br J Dermatol , vol.131 , pp. 72-77
    • Carr, J.1    Mackie, R.M.2
  • 35
    • 0024407112 scopus 로고
    • N-ras mutations in human cutaneous melanoma from sun-exposed body sites
    • Van't Veer LJ, Burgering BMT, Versteeg R, et al: N-ras mutations in human cutaneous melanoma from sun-exposed body sites. Mol Cell Biol 9:3114-3116, 1989
    • (1989) Mol Cell Biol , vol.9 , pp. 3114-3116
    • Van't Veer, L.J.1    Burgering, B.M.T.2    Versteeg, R.3
  • 36
    • 0024438925 scopus 로고
    • Analysis of ras oncogenes in malignant melanoma and precursor lesions: Correlation of point mutations with different phenotype
    • Albino AP, Nanus DM, Mentle IR, et al: Analysis of ras oncogenes in malignant melanoma and precursor lesions: Correlation of point mutations with different phenotype. Oncogene 4:1363-1374, 1989
    • (1989) Oncogene , vol.4 , pp. 1363-1374
    • Albino, A.P.1    Nanus, D.M.2    Mentle, I.R.3
  • 37
    • 0030240165 scopus 로고    scopus 로고
    • Activated ras, yet another player in melanoma
    • Herlyn M, Satyamoorthy K: Activated ras, yet another player in melanoma. Am J Pathol 149:739-744, 1996
    • (1996) Am J Pathol , vol.149 , pp. 739-744
    • Herlyn, M.1    Satyamoorthy, K.2
  • 38
    • 0024998851 scopus 로고
    • Ras mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia but are prevalent in chronic myelomonocytic leukemia
    • Hirsch-Ginsberg C, Lemaistre AC, Kantarjian H, et al: Ras mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia but are prevalent in chronic myelomonocytic leukemia. Blood 76:1214-1219, 1990
    • (1990) Blood , vol.76 , pp. 1214-1219
    • Hirsch-Ginsberg, C.1    Lemaistre, A.C.2    Kantarjian, H.3
  • 39
    • 24244463850 scopus 로고    scopus 로고
    • Mutation of K-, N-, and H-RAS oncogenes in patients with myelodysplastic syndrome (MDS)
    • abstr 3559
    • Nounou R, Estey E. Beran M, et al: Mutation of K-, N-, and H-RAS oncogenes in patients with myelodysplastic syndrome (MDS). Blood 88:208b (abstr 3559) (suppl 1)
    • Blood , vol.88 , Issue.1 SUPPL.
    • Nounou, R.1    Estey, E.2    Beran, M.3
  • 40
    • 0027251510 scopus 로고
    • Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia
    • Imamura N, Kuramoto A. Ishihara H, et al: Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia. Am J Hematol 43:151-153, 1993
    • (1993) Am J Hematol , vol.43 , pp. 151-153
    • Imamura, N.1    Kuramoto, A.2    Ishihara, H.3
  • 41
    • 0025240615 scopus 로고
    • The pattern of mutational involvement of ras genes in human hematologic malignancies determined by DNA amplification and direct sequencing
    • Ahuja HG, Foti A. Bareli M, et al: The pattern of mutational involvement of ras genes in human hematologic malignancies determined by DNA amplification and direct sequencing. Blood 75:1684-1690, 1990
    • (1990) Blood , vol.75 , pp. 1684-1690
    • Ahuja, H.G.1    Foti, A.2    Bareli, M.3
  • 42
    • 0011134388 scopus 로고
    • Ras gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes
    • Janssen JWG, Steenvoorden ACM, Lyons J, et al: Ras gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes. Proc Natl Acad Sci USA 84:9228-9232, 1987
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9228-9232
    • Janssen, J.W.G.1    Steenvoorden, A.C.M.2    Lyons, J.3
  • 43
    • 0028125213 scopus 로고
    • Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras
    • Kalra R, Paderanga DC, Olson K, et al: Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras. Blood 84:3435-3439, 1994
    • (1994) Blood , vol.84 , pp. 3435-3439
    • Kalra, R.1    Paderanga, D.C.2    Olson, K.3
  • 44
    • 0028344097 scopus 로고
    • Mutations of the N-ras gene in juvenile chronic myelogenous leukemia
    • Miyauchi J, Asada M, Sasaki M, et al: Mutations of the N-ras gene in juvenile chronic myelogenous leukemia. Blood 83:2248-2254, 1994
    • (1994) Blood , vol.83 , pp. 2248-2254
    • Miyauchi, J.1    Asada, M.2    Sasaki, M.3
  • 45
    • 0025254225 scopus 로고
    • N-Ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis
    • Lubbert M, Mirro J, Miller CW, et al: N-Ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis. Blood 75:1163-1169, 1990
    • (1990) Blood , vol.75 , pp. 1163-1169
    • Lubbert, M.1    Mirro, J.2    Miller, C.W.3
  • 46
    • 0011782475 scopus 로고
    • Analysis of ras oncogene mutations in human lymphoid malignancies
    • Neri A, Knowles DM, Greco A, et al: Analysis of ras oncogene mutations in human lymphoid malignancies. Proc Natl Acad Sci U S A 85:9268-9272, 1988
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 9268-9272
    • Neri, A.1    Knowles, D.M.2    Greco, A.3
  • 47
    • 0027212420 scopus 로고
    • Mutational activation of N- And K-ras oncogenes in plasma cell dyscrasias
    • Corradini P. Ladetto M, Voena C, et al: Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias. Blood 81:2708-2713, 1993
    • (1993) Blood , vol.81 , pp. 2708-2713
    • Corradini, P.1    Ladetto, M.2    Voena, C.3
  • 48
    • 0025250602 scopus 로고
    • Oncogenes in multiple myeloma-point mutations of N-ras
    • Paquette RL, Berenson J, Lichtenstein A, et al: Oncogenes in multiple myeloma-point mutations of N-ras. Oncogene 5:1659-1663, 1990
    • (1990) Oncogene , vol.5 , pp. 1659-1663
    • Paquette, R.L.1    Berenson, J.2    Lichtenstein, A.3
  • 49
    • 0029819604 scopus 로고    scopus 로고
    • Activating mutations of N- And K-ras in multiple myeloma show different clinical associations: Analysis of the Eastern Cooperative Oncology Group Phase III Trial
    • Liu P, Leong T, Quam L, et al: Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: Analysis of the Eastern Cooperative Oncology Group Phase III Trial. Blood 88:2699-2706, 1996
    • (1996) Blood , vol.88 , pp. 2699-2706
    • Liu, P.1    Leong, T.2    Quam, L.3
  • 50
    • 0029914964 scopus 로고    scopus 로고
    • N-ras genes are not mutated in Hodgkin and Reed Sternberg cells: Results from single-cell polymerase chain reaction examinations
    • Trumper L, Pfreundschuh M, Jacobs G, et al: N-ras genes are not mutated in Hodgkin and Reed Sternberg cells: Results from single-cell polymerase chain reaction examinations. Leukemia 10:727-730, 1996
    • (1996) Leukemia , vol.10 , pp. 727-730
    • Trumper, L.1    Pfreundschuh, M.2    Jacobs, G.3
  • 51
    • 0029924788 scopus 로고    scopus 로고
    • Mutation of the ras genes is a rare genetic event in the histologic transformation of follicular lymphoma
    • Clark HM, Yano T, Sander C, et al: Mutation of the ras genes is a rare genetic event in the histologic transformation of follicular lymphoma. Leukemia 10:844-847, 1996
    • (1996) Leukemia , vol.10 , pp. 844-847
    • Clark, H.M.1    Yano, T.2    Sander, C.3
  • 52
    • 0024792688 scopus 로고
    • Increased expression of ras genes in non-Hodgkin's lymphomas is not associated with oncogenic activation of those genes by point mutation
    • Hamatani K, Nagata Y, Abe M, et al: Increased expression of ras genes in non-Hodgkin's lymphomas is not associated with oncogenic activation of those genes by point mutation. Jpn J Cancer Res 80:706-710, 1989
    • (1989) Jpn J Cancer Res , vol.80 , pp. 706-710
    • Hamatani, K.1    Nagata, Y.2    Abe, M.3
  • 53
    • 0028950123 scopus 로고
    • Genetic requirement for ras in the transformation of fibroblasts and hematopoietic cells by the bcr-abl oncogene
    • Sawyers CL, McLaughlin J, Witte ON: Genetic requirement for ras in the transformation of fibroblasts and hematopoietic cells by the bcr-abl oncogene. J Exp Med 181:307-313, 1995
    • (1995) J Exp Med , vol.181 , pp. 307-313
    • Sawyers, C.L.1    McLaughlin, J.2    Witte, O.N.3
  • 54
    • 0027368352 scopus 로고
    • BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein
    • Pendergast AM, Quilliam LA, Cripe LD, et al: BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 75:175-185, 1993
    • (1993) Cell , vol.75 , pp. 175-185
    • Pendergast, A.M.1    Quilliam, L.A.2    Cripe, L.D.3
  • 55
    • 9044251606 scopus 로고    scopus 로고
    • Loss of NFl results in activation of the ras signaling pathway and leads to aberrant growth in haematopoietic cells
    • Bollag G, Clapp DW, Shih S, et al: Loss of NFl results in activation of the ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet 12:144-148, 1996
    • (1996) Nat Genet , vol.12 , pp. 144-148
    • Bollag, G.1    Clapp, D.W.2    Shih, S.3
  • 56
    • 0028388748 scopus 로고
    • Ras regulatory interactions: Novel targets for anti-cancer intervention
    • Prendergast GC, Gibbs JB: Ras regulatory interactions: Novel targets for anti-cancer intervention. Bioessays 16:187-191, 1993
    • (1993) Bioessays , vol.16 , pp. 187-191
    • Prendergast, G.C.1    Gibbs, J.B.2
  • 57
    • 0028464349 scopus 로고
    • Regulation of the ras signaling network
    • Maruta H, Burgess W: Regulation of the ras signaling network. Bioessays 16:489-496, 1994
    • (1994) Bioessays , vol.16 , pp. 489-496
    • Maruta, H.1    Burgess, W.2
  • 58
    • 0025838675 scopus 로고
    • Regulators and effectors of Ras proteins
    • Bollagand G, McCormick F: Regulators and effectors of Ras proteins. Annu Rev Cell Biol 1991:7:601-633
    • (1991) Annu Rev Cell Biol , vol.7 , pp. 601-633
    • Bollagand, G.1    McCormick, F.2
  • 59
    • 0029761702 scopus 로고    scopus 로고
    • Signal transducing protein phosphorylation cascades mediated by Ras/Rho protein in the mammalian cell: The potential for multiplex signaling
    • Denhardt DT: Signal transducing protein phosphorylation cascades mediated by Ras/Rho protein in the mammalian cell: The potential for multiplex signaling. Biochem J 318:729-747, 1996
    • (1996) Biochem J , vol.318 , pp. 729-747
    • Denhardt, D.T.1
  • 60
    • 0027521847 scopus 로고
    • Pathways of ras function: Connections to the actin cytoskeleton
    • Prendergast GC, Gibbs JB: Pathways of ras function: Connections to the actin cytoskeleton. Adv Cancer Res 62:19-63, 1993
    • (1993) Adv Cancer Res , vol.62 , pp. 19-63
    • Prendergast, G.C.1    Gibbs, J.B.2
  • 61
    • 0028099853 scopus 로고
    • Signaling pathways mediated by the mitogen-activated protein (MAP) kinase kinase/MAP kinase cascade
    • Matsuda S, Gotoh Y, Nishida E: Signaling pathways mediated by the mitogen-activated protein (MAP) kinase kinase/MAP kinase cascade. J Leukoc Biol 56:548-553, 1994
    • (1994) J Leukoc Biol , vol.56 , pp. 548-553
    • Matsuda, S.1    Gotoh, Y.2    Nishida, E.3
  • 62
    • 0025187578 scopus 로고
    • Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes
    • Demetri GD, Ernst TJ, Pratt ES, et al: Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes. J Clin Invest 86:1261-1269, 1990
    • (1990) J Clin Invest , vol.86 , pp. 1261-1269
    • Demetri, G.D.1    Ernst, T.J.2    Pratt, E.S.3
  • 63
    • 0028036746 scopus 로고
    • Lipopolysaccharide induces activation of the raf-1/MAP kinase pathway: A putative role for raf-1 in the induction of the IL-1 beta and TNF-alpha genes
    • Reimann T, Buscher D, Hipskind RA, et al: Lipopolysaccharide induces activation of the raf-1/MAP kinase pathway: A putative role for raf-1 in the induction of the IL-1 beta and TNF-alpha genes. J Immunol 153:5740-5749, 1994
    • (1994) J Immunol , vol.153 , pp. 5740-5749
    • Reimann, T.1    Buscher, D.2    Hipskind, R.A.3
  • 64
    • 0025244911 scopus 로고
    • The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae
    • Xu GF, Lin B, Tanaka K, et al: The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 63:835-841, 1990
    • (1990) Cell , vol.63 , pp. 835-841
    • Xu, G.F.1    Lin, B.2    Tanaka, K.3
  • 65
    • 0026521070 scopus 로고
    • Aberrant regulation of ras proteins in malignant tumour cells from type I neurofibromatosis patients
    • Basu TN, Gutmann DH, Fletcher JA, et al: Aberrant regulation of ras proteins in malignant tumour cells from type I neurofibromatosis patients. Nature 356:713-715, 1992
    • (1992) Nature , vol.356 , pp. 713-715
    • Basu, T.N.1    Gutmann, D.H.2    Fletcher, J.A.3
  • 66
    • 0026528368 scopus 로고
    • Abnormal regulation of mammalian p21 ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
    • DeClue JE, Papageorge AG, Fletcher JA, et al: Abnormal regulation of mammalian p21 ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. Cell 69:265-273, 1992
    • (1992) Cell , vol.69 , pp. 265-273
    • DeClue, J.E.1    Papageorge, A.G.2    Fletcher, J.A.3
  • 67
    • 0027213688 scopus 로고
    • Inhibitors of ras farnesyltransferases
    • Tamanoi F: Inhibitors of ras farnesyltransferases. Trends Biochem Sci 18:349-353, 1993
    • (1993) Trends Biochem Sci , vol.18 , pp. 349-353
    • Tamanoi, F.1
  • 68
    • 0021528719 scopus 로고
    • Harvey murine sarcoma virus p21 ras protein: Biological and biochemical significance of the cysteine nearest the carboxy terminus
    • Willumsen BM, Norris K, Papageorge AG, et al: Harvey murine sarcoma virus p21 ras protein: Biological and biochemical significance of the cysteine nearest the carboxy terminus. EMBO J 3:2581-2585, 1984
    • (1984) EMBO J , vol.3 , pp. 2581-2585
    • Willumsen, B.M.1    Norris, K.2    Papageorge, A.G.3
  • 69
    • 0025212684 scopus 로고
    • Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation
    • Jackson JH. Cochrane CG. Bourne JR, et al: Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. Proc Natl Acad Sci U S A 87:3042-3046, 1990
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 3042-3046
    • Jackson, J.H.1    Cochrane, C.G.2    Bourne, J.R.3
  • 70
    • 0028063058 scopus 로고
    • Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-RAS-transformed Rat-1 cells, but not in untransformed cells
    • James GL, Brown MS, Cobb MH, et al: Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-RAS-transformed Rat-1 cells, but not in untransformed cells. J Biol Chem 269:27705-27714, 1994
    • (1994) J Biol Chem , vol.269 , pp. 27705-27714
    • James, G.L.1    Brown, M.S.2    Cobb, M.H.3
  • 71
    • 0030911052 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
    • Rodriguez-Viciano P, Warne PH, Khwafa A, et al: Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89:457-467, 1997
    • (1997) Cell , vol.89 , pp. 457-467
    • Rodriguez-Viciano, P.1    Warne, P.H.2    Khwafa, A.3
  • 72
    • 0032054248 scopus 로고    scopus 로고
    • Therapeutic intervention and signaling
    • Heimbrook DC. Oliff A: Therapeutic intervention and signaling. Curr Opin Cell Biol 10:284-288, 1998
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 284-288
    • Heimbrook, D.C.1    Oliff, A.2
  • 73
    • 0023753576 scopus 로고
    • The molecular genetics of Philadelphia chromosome-positive leukemias
    • Kurzrock R. Gutterman JU, Talpaz M: The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 319:990-998, 1988
    • (1988) N Engl J Med , vol.319 , pp. 990-998
    • Kurzrock, R.1    Gutterman, J.U.2    Talpaz, M.3
  • 74
    • 0028263606 scopus 로고
    • Negative regulation of p120GAP GTPase promoting activity by p210Bcr/Abl: Implication of ras-dependent Philadelphia chromosome positive cell growth
    • Skorski T, Kanadaraj P, Ku DH, et al: Negative regulation of p120GAP GTPase promoting activity by p210Bcr/Abl: Implication of ras-dependent Philadelphia chromosome positive cell growth. J Exp Med 179:1855-1865, 1994
    • (1994) J Exp Med , vol.179 , pp. 1855-1865
    • Skorski, T.1    Kanadaraj, P.2    Ku, D.H.3
  • 75
    • 0028862890 scopus 로고
    • Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family
    • Chuang TH, Xu X, Kaartinen B. et al: Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci U S A 92:10282-10286, 1995
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 10282-10286
    • Chuang, T.H.1    Xu, X.2    Kaartinen, B.3
  • 76
    • 0028351698 scopus 로고
    • Chronic myelomonocytic leukemia: Tel-a-kinase what Ets all about
    • Sawyers CL, Denny CT: Chronic myelomonocytic leukemia: Tel-a-kinase what Ets all about. Cell 77:171-173, 1994
    • (1994) Cell , vol.77 , pp. 171-173
    • Sawyers, C.L.1    Denny, C.T.2
  • 77
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • Golub TR, Barker GF, Lovett M, et al: Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307-316, 1994
    • (1994) Cell , vol.77 , pp. 307-316
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3
  • 78
    • 0025337018 scopus 로고
    • Platelet-derived growth factor stimulates formation of active p21 ras-GTP complex in Swiss mouse 3T3 cells
    • Satoh T, Endo M, Nakafuku M, et al: Platelet-derived growth factor stimulates formation of active p21 ras-GTP complex in Swiss mouse 3T3 cells. Proc Natl Acad Sci U S A 87:5993-5997, 1990
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 5993-5997
    • Satoh, T.1    Endo, M.2    Nakafuku, M.3
  • 79
    • 0025222844 scopus 로고
    • Modulation of guanine nucleotides bound to ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
    • Gibbs JB, Marshall MS, Scolnick EM, et al: Modulation of guanine nucleotides bound to ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP). J Biol Chem 265:20437-20442, 1990
    • (1990) J Biol Chem , vol.265 , pp. 20437-20442
    • Gibbs, J.B.1    Marshall, M.S.2    Scolnick, E.M.3
  • 80
    • 0029898682 scopus 로고    scopus 로고
    • Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia
    • Golub TR, Goga A, Barker GF, et al: Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia. Mol Cell Biol 16:4107-4116, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 4107-4116
    • Golub, T.R.1    Goga, A.2    Barker, G.F.3
  • 81
    • 0027373678 scopus 로고
    • Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation
    • Prasad R, Gu Y, Alder H, et al: Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. Cancer Res 53:5624-5628, 1993
    • (1993) Cancer Res , vol.53 , pp. 5624-5628
    • Prasad, R.1    Gu, Y.2    Alder, H.3
  • 82
    • 13344281006 scopus 로고    scopus 로고
    • Identification of AF-6 and canoe as putative targets for ras
    • Kuriyama M, Harada N, Kuroda S, et al: Identification of AF-6 and canoe as putative targets for ras. J Biol Chem 271:607-610, 1996
    • (1996) J Biol Chem , vol.271 , pp. 607-610
    • Kuriyama, M.1    Harada, N.2    Kuroda, S.3
  • 83
    • 0030045594 scopus 로고    scopus 로고
    • NF1 deficiency causes ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
    • Largaespada DA, Brannan CI, Jenkins NA, et al: NF1 deficiency causes ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia. Nat Genet 12:137-143, 1996
    • (1996) Nat Genet , vol.12 , pp. 137-143
    • Largaespada, D.A.1    Brannan, C.I.2    Jenkins, N.A.3
  • 84
    • 0027979146 scopus 로고
    • Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders
    • Shannon KM, O'Connell P, Martin GA, et al: Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N Engl J Med 330:597-601, 1994
    • (1994) N Engl J Med , vol.330 , pp. 597-601
    • Shannon, K.M.1    O'Connell, P.2    Martin, G.A.3
  • 85
    • 0029085749 scopus 로고
    • SSCP detection of N-ras promoter mutations in AML patients
    • Thorn J, Molloy P. Iland H: SSCP detection of N-ras promoter mutations in AML patients. Exp Hematol 23:1098-1103, 1995
    • (1995) Exp Hematol , vol.23 , pp. 1098-1103
    • Thorn, J.1    Molloy, P.2    Iland, H.3
  • 86
    • 0028178531 scopus 로고
    • Cytogenetic studies, ras mutation, and clinical characteristics in primary myelodysplastic syndrome: A study on 68 Chinese patients in Taiwan
    • Tien HF, Wang CH, Chuang SM, et al: Cytogenetic studies, ras mutation, and clinical characteristics in primary myelodysplastic syndrome: A study on 68 Chinese patients in Taiwan. Cancer Genet Cytogenet 74:40-49. 1994
    • (1994) Cancer Genet Cytogenet , vol.74 , pp. 40-49
    • Tien, H.F.1    Wang, C.H.2    Chuang, S.M.3
  • 87
    • 0028132906 scopus 로고
    • N-ras mutation and karyotypic evolution are closely associated with leukemic transformation in myelodysplastic syndrome
    • Horiike S, Misawa S, Hiroyuki N, et al: N-ras mutation and karyotypic evolution are closely associated with leukemic transformation in myelodysplastic syndrome. Leukemia 8:1331-1336, 1994
    • (1994) Leukemia , vol.8 , pp. 1331-1336
    • Horiike, S.1    Misawa, S.2    Hiroyuki, N.3
  • 88
    • 0029609415 scopus 로고
    • N-ras mutations: Incidence and clinical relevance in myelodysplastic syndrome and acute myelogenous leukemia
    • Santon A, Arranz E, Robledo M, et al: N-ras mutations: Incidence and clinical relevance in myelodysplastic syndrome and acute myelogenous leukemia. Am J Hematol 50:315-316, 1995
    • (1995) Am J Hematol , vol.50 , pp. 315-316
    • Santon, A.1    Arranz, E.2    Robledo, M.3
  • 89
    • 0028210052 scopus 로고
    • Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes
    • Neubauer A, Greenberg P, Negrin R, et al: Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes. Leukemia 8:638-641, 1994
    • (1994) Leukemia , vol.8 , pp. 638-641
    • Neubauer, A.1    Greenberg, P.2    Negrin, R.3
  • 90
    • 0028229978 scopus 로고
    • Molecular mechanisms of tumor progression in chronic myeloproliferative disorders
    • Gaidano G, Guerrasio A, Serra A, et al: Molecular mechanisms of tumor progression in chronic myeloproliferative disorders. Leukemia 8:27-29, 1994
    • (1994) Leukemia , vol.8 , pp. 27-29
    • Gaidano, G.1    Guerrasio, A.2    Serra, A.3
  • 91
    • 0027286420 scopus 로고
    • N-ras mutation in acute myeloid leukemia: Incidence, prognostic significance and use as a marker of minimal residual disease
    • Casey G, Rudzki Z, Roberts M, et al: N-ras mutation in acute myeloid leukemia: Incidence, prognostic significance and use as a marker of minimal residual disease. Pathology 2:57-62, 1993
    • (1993) Pathology , vol.2 , pp. 57-62
    • Casey, G.1    Rudzki, Z.2    Roberts, M.3
  • 92
    • 0028114788 scopus 로고
    • The incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemia
    • Coghlan DW, Morley AA, Matthews J, et al: The incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemia. Leukemia 8:1682-1687, 1994
    • (1994) Leukemia , vol.8 , pp. 1682-1687
    • Coghlan, D.W.1    Morley, A.A.2    Matthews, J.3
  • 93
    • 0028214608 scopus 로고
    • Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia
    • Neubauer A, Dodge RK, George SL, et al: Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia. Blood 83:1603-1611, 1994
    • (1994) Blood , vol.83 , pp. 1603-1611
    • Neubauer, A.1    Dodge, R.K.2    George, S.L.3
  • 94
    • 0031053856 scopus 로고    scopus 로고
    • N-ras gene point mutations in Brazilian acute myelogenous leukemia patients correlated with a poor prognosis
    • De Melo MB, Lorand-Metze I, Lima CS, et al: N-ras gene point mutations in Brazilian acute myelogenous leukemia patients correlated with a poor prognosis. Leuk Lymphoma 24:309-317, 1997
    • (1997) Leuk Lymphoma , vol.24 , pp. 309-317
    • De Melo, M.B.1    Lorand-Metze, I.2    Lima, C.S.3
  • 95
    • 0029088646 scopus 로고
    • Analysis of mutations of neurofibromatosis type 1 gene and N-ras gene in acute myelogenous leukemia
    • Lee YY, Kim WS, Bang YJ, et al: Analysis of mutations of neurofibromatosis type 1 gene and N-ras gene in acute myelogenous leukemia. Stem Cells 13:556-563, 1995
    • (1995) Stem Cells , vol.13 , pp. 556-563
    • Lee, Y.Y.1    Kim, W.S.2    Bang, Y.J.3
  • 96
    • 0028331587 scopus 로고
    • Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
    • Gibbs JB, Oliff A. Kohl NE: Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell 77:175-178, 1994
    • (1994) Cell , vol.77 , pp. 175-178
    • Gibbs, J.B.1    Oliff, A.2    Kohl, N.E.3
  • 97
    • 0030962347 scopus 로고    scopus 로고
    • The potential of farnesyltransferase inhibitors as cancer chemotherapeutics
    • Gibbs JB, Oliff A: The potential of farnesyltransferase inhibitors as cancer chemotherapeutics. Annu Rev Pharmacol Toxicol 37:143-166, 1997
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 143-166
    • Gibbs, J.B.1    Oliff, A.2
  • 98
    • 0028343655 scopus 로고
    • Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation
    • Crowell PL, Ren Z, Lin S, et al: Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. Biochem Pharmacol 47:1405-1415, 1994
    • (1994) Biochem Pharmacol , vol.47 , pp. 1405-1415
    • Crowell, P.L.1    Ren, Z.2    Lin, S.3
  • 99
    • 0025952954 scopus 로고
    • Selective inhibition of isoprenylation of 21-26kd proteins by the anticarcinogen d-limonene and its metabolites
    • Crowell PL, Chang RR, Ren Z, et al: Selective inhibition of isoprenylation of 21-26kd proteins by the anticarcinogen d-limonene and its metabolites. J Biol Chem 266:17679-17685, 1991
    • (1991) J Biol Chem , vol.266 , pp. 17679-17685
    • Crowell, P.L.1    Chang, R.R.2    Ren, Z.3
  • 100
    • 0029125753 scopus 로고
    • Differential effects of monoterpenes and lovastatin on ras processing
    • Hohl RJ, Lewis K: Differential effects of monoterpenes and lovastatin on ras processing. J Biol Chem 270:17508-17512, 1995
    • (1995) J Biol Chem , vol.270 , pp. 17508-17512
    • Hohl, R.J.1    Lewis, K.2
  • 101
    • 0022574881 scopus 로고
    • Regression of rat primary mammary tumors following dietary d-limonene
    • Elegbede JA, Elson CE, Tanner MA, et al: Regression of rat primary mammary tumors following dietary d-limonene. J Natl Cancer Inst 76:323-327, 1986
    • (1986) J Natl Cancer Inst , vol.76 , pp. 323-327
    • Elegbede, J.A.1    Elson, C.E.2    Ma, T.3
  • 102
    • 0026636635 scopus 로고
    • Limonene-induced regression of mammary carcinomas
    • Haag JD, Lindstrom MJ. Gould MN: Limonene-induced regression of mammary carcinomas. Cancer Res 52:4021-4026, 1992
    • (1992) Cancer Res , vol.52 , pp. 4021-4026
    • Haag, J.D.1    Lindstrom, M.J.2    Gould, M.N.3
  • 103
    • 0029132661 scopus 로고
    • Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol
    • Stark MJ, Burke YD, McKinzie JH, et al: Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol. Cancer Lett 96:15-21, 1995
    • (1995) Cancer Lett , vol.96 , pp. 15-21
    • Stark, M.J.1    Burke, Y.D.2    McKinzie, J.H.3
  • 104
    • 0026353346 scopus 로고
    • Sequence dependence of protein isoprenylation
    • Moores SL, Schaber MD. Mosser SD, et al: Sequence dependence of protein isoprenylation. J Biol Chem 266:14603-14610, 1991
    • (1991) J Biol Chem , vol.266 , pp. 14603-14610
    • Moores, S.L.1    Schaber, M.D.2    Mosser, S.D.3
  • 105
    • 0027323459 scopus 로고
    • Benzodiazepine peptidomimetics: Potent inhibitors of ras farnesylation in animal cells
    • James GL, Goldstein JL, Brown MS, et al: Benzodiazepine peptidomimetics: Potent inhibitors of ras farnesylation in animal cells. Science 260:1937-1942, 1993
    • (1993) Science , vol.260 , pp. 1937-1942
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 106
    • 0027248872 scopus 로고
    • Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor
    • Kohl NE, Mosser SD, deSolms SJ, et al: Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science 260:1934-1937, 1993
    • (1993) Science , vol.260 , pp. 1934-1937
    • Kohl, N.E.1    Mosser, S.D.2    DeSolms, S.J.3
  • 107
    • 0027320616 scopus 로고
    • Peptidomimetic inhibitors of ras farnesylation and function in whole cells
    • Garcia M, Rowell C, Ackermann K, et al: Peptidomimetic inhibitors of ras farnesylation and function in whole cells. J Biol Chem 268:18415-18418, 1993
    • (1993) J Biol Chem , vol.268 , pp. 18415-18418
    • Garcia, M.1    Rowell, C.2    Ackermann, K.3
  • 108
    • 0029055687 scopus 로고
    • The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol
    • Gelb MH, Tamanoi F, Yokoyama K, et al: The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol. Cancer Lett 91:169-175, 1995
    • (1995) Cancer Lett , vol.91 , pp. 169-175
    • Gelb, M.H.1    Tamanoi, F.2    Yokoyama, K.3
  • 109
    • 0029150669 scopus 로고
    • Inhibition of farnesyl-transferase induces regression of mammary and salivary carcinomas in ras transgenic mice
    • Kohl NE, Omer CA, Conner MW, et al: Inhibition of farnesyl-transferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat Med 1:792-797, 1995
    • (1995) Nat Med , vol.1 , pp. 792-797
    • Kohl, N.E.1    Omer, C.A.2    Conner, M.W.3
  • 110
    • 0032521211 scopus 로고    scopus 로고
    • Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice
    • Mangues R, Corral T, Kohl NE, et al: Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice. Cancer Res 58:1253-1259, 1998
    • (1998) Cancer Res , vol.58 , pp. 1253-1259
    • Mangues, R.1    Corral, T.2    Kohl, N.E.3
  • 111
    • 0028603395 scopus 로고
    • Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice
    • Kohl NE, Wilson FR, Mosser SD, et al: Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc Natl Acad Sci U S A 91:9141-9145, 1994
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 9141-9145
    • Kohl, N.E.1    Wilson, F.R.2    Mosser, S.D.3
  • 112
    • 0029000897 scopus 로고
    • Bisubstrate inhibitors of farnesyltransferase: A novel class of specific inhibitors of ras transformed cells
    • Manne V, Yan N, Carboni JM, et al: Bisubstrate inhibitors of farnesyltransferase: A novel class of specific inhibitors of ras transformed cells. Oncogene 10:1763-1779, 1995
    • (1995) Oncogene , vol.10 , pp. 1763-1779
    • Manne, V.1    Yan, N.2    Carboni, J.M.3
  • 113
    • 0029154458 scopus 로고
    • Farnesyltransferase inhibitors block the neurofibromatosis type 1 (NF1) malignant phenotype
    • Yan N. Ricca C, Fletcher J, et al: Farnesyltransferase inhibitors block the neurofibromatosis type 1 (NF1) malignant phenotype. Cancer Res 55:3569-3575, 1995
    • (1995) Cancer Res , vol.55 , pp. 3569-3575
    • Yan, N.1    Ricca, C.2    Fletcher, J.3
  • 114
    • 0032493812 scopus 로고    scopus 로고
    • Increasing complexity of the Ras signaling pathway
    • Bojtek AB, Der CJ: Increasing complexity of the Ras signaling pathway. J Biol Chem 273:19925-19928, 1998
    • (1998) J Biol Chem , vol.273 , pp. 19925-19928
    • Bojtek, A.B.1    Der, C.J.2
  • 115
    • 0029329510 scopus 로고
    • The Ras signaling pathway and the molecular basis of myeloid leukemiogenesis
    • Shannon K: The Ras signaling pathway and the molecular basis of myeloid leukemiogenesis. Curr Opin Hematol 2:305-308, 1995
    • (1995) Curr Opin Hematol , vol.2 , pp. 305-308
    • Shannon, K.1
  • 116
    • 0030903188 scopus 로고    scopus 로고
    • Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells
    • Darley RL, Hoy TG, Baines P, et al: Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells. J Exp Med 1337-1347, 1997
    • (1997) J Exp Med , pp. 1337-1347
    • Darley, R.L.1    Hoy, T.G.2    Baines, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.