Ras enhances Myc protein stability

Molecular Cell

Volumn 3, Issue 2, 1999, Pages 169-179

  Sears, Rosalie ^a   Leone, Gustavo ^a   DeGregori, James ^a,b   Nevins, Joseph R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; ONCOPROTEIN; PROTEASOME; RAF PROTEIN; RAS PROTEIN;

ARTICLE; CARCINOGENESIS; CELL GROWTH; CELL STRAIN; ENZYME INHIBITION; GENETIC TRANSCRIPTION; GROWTH REGULATION; MITOGENICITY; ONCOGENE MYC; ONCOGENE RAS; PROTEIN DEGRADATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

EID: 0033082892     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80308-1     Document Type: Article

References (58)

1. Aktas, H., Cai, H., and Cooper, G.M. (1997). Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and Cdk inhibitor p27KIP1. Mol. Cell. Biol. 17, 3850-3857.
2. Ayer, D.E., and Eisenman, R.N. (1993). A switch from Myc: Max to Mad: Max heterocomplexes accompanies monocyte/macrophage differentiation. Genes Dev. 7, 2110-2119.
3. Ayer, D.E., Kretzner, L., and Eisenman, R.N. (1993). Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72, 211-222.
4. Bhatia, K., Huppi, K., Spangler, G., Siwarski, D., Iyer, R., and Magrath, I. (1993). Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. Nat. Genet. 5, 56-61.
5. Blackwell, T.K., Kretzner, L., Blackwood, E.M., Eisenman, R.N., and Weintraub, H. (1990). Sequence-specific DNA-binding complex with Myc. Science 250, 1149-1151.
6. Blackwood, E.M., and Eisenman, R.N. (1991). Max: A helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251, 1211-1217.
7. Chin, L., Schreiber, A.N., Pellicer, I., Chen, K., Lee, H.W., Dudast, M., Cordon, C.C., and DePinho, R.A. (1995). Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. Proc. Natl. Acad. Sci. USA 92, 8488-8492.
8. Ciechanover, A., DiGiuseppe, J.A., Bercovich, B., Orian, A., Richter, J.D., Schwartz, A.L., and Brodeur, G.M. (1991). Degradation of nuclear oncoproteins by the ubiquitin system in vitro. Proc. Natl. Acad. Sci. USA 88, 139-143.
9. Cohn, S.L., Salwen, H., Quasney, M.W., Ikegaki, N., Cowan, J.M., Herst, C.V., Kennett, R.H., Rosen, S.T., DiGiuseppe, J.A., and Brodeur, G.M. (1990). Prolonged N-myc protein half-life in a neuroblastoma cell line lacking N-myc amplification. Oncogene 5, 1821-1827.
10. Cole, M.D. (1986). The myc oncogene: Its role in transformation and differentiation. Annu. Rev. Genet. 20, 361-384.
11. Coppola, J.A., and Cole, M.D. (1986). Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment. Nature 320, 760-763.
12. Davis, A.C., Wims, M., Spotts, G.D., Hann, S.R., and Bradley, A. (1993). A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 7, 671-682.
13. DeGregori, J., Leone, G., Miron, A., Jakoi, L., and Nevins, J.R. (1997). Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. USA 94, 7245-7250.
14. Dudley, D.T., Pang, L., Decker, S.J., Bridges, A.J., and Saltiel, A.R. (1995). A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92, 7686-7689.
15. Eilers, M., Schirm, S., and Bishop, J.M. (1991). The MYC protein activates transcription of the alpha-prothymosin gene. EMBO J. 10, 133-141.
16. Evan, G.L., Wyllie, A.H., Gilbert, C.S., Littlewood, T.D., Land, H., Brooks, M., Waters, C.M., Penn, L.Z., and Hancock, D.C. (1992). Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119-128.
17. Feig, L.A., and Cooper, G.M. (1988). Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8, 3235-3243.
18. Fenteany, G., Standaert, R.F., Lane, W.S., Choi, S., Corey, E.J., and Schreiber, R.D. (1995). Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268, 726-731.
19. Flynn, A., and Proud, C.G. (1996). The role of e1F4 in cell proliferation. Cancer Surv. 27, 293-310.
20. Galaktionov, K., Jessus, C., and Beach, D. (1995). Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Dev. 9, 1046-1058.
21. Galaktionov, K., Chen, X., and Beach, D. (1996). Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382, 511-517.
22. Gross-Mesilaty, S., Reinstein, E., Bercovich, B., Tobias, K.E., Schwartz, A.L., Kahana, C., and Ciechanover, A. (1998). Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. Proc. Natl. Acad. Sci. USA 95, 8058-8063.
23. Gu, W., Bhatia, K., Magrath, I.T., Dang, C.V., and Dalla-Favera, R. (1994). Binding and suppression of the Myc transcriptional activation domain by p107. Science 264, 251-254.
24. Hann, S.R., King, M.W., Bentley, D.L., Anderson, C.W., and Eisenman, R.N. (1988). A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas. Cell 52, 185-195.
25. Hann, S.R., Sloan-Brown, K., and Spotts, G.D. (1992). Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation. Genes Dev. 6, 1229-1240.
26. Hann, S., Dixit, M., Sears, R., and Sealy, L. (1994). The alternatively initiated c-Myc proteins differentially regulated transcription through a noncanonical DNA binding site. Genes Dev. 8, 2441-2452.
27. Hershko, A., and Ciechanover, A. (1998). The ubiquitin system. Annu. Rev. Biochem. 67, 425-479.
28. Hurlin, P.J., Queva, C., Koskinen, P.J., Steingrimsson, E., Ayer, D.E., Copeland, N.G., Jenkins, N.A., and Eisenman, R.N. (1995). Mad3 and Mad4: Novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 14, 5646-5659.
29. Ikeda, M.-A., Jakoi, L., and Nevins, J.R. (1996). A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc. Natl. Acad. Sci. USA 93, 3215-3220.
30. Ishizaki, J., Nevins, J.R., and Sullenger, B. (1996). Inhibition of cell proliferation by an RNA ligand that blocks E2F function. Nature Med. 2, 1386-1389.
31. Jansen-Durr, P., Meichle, A., Steiner, P., Pagano, M., Finke, K., Botz, J., Wessbecher, J., Draetta, G., and Eilers, M. (1993). Differential modulation of cyclin gene expression by MYC. Proc. Natl. Acad. Sci. USA 90, 3685-3689.
32. Jones, T.R., and Cole, M.D. (1987). Rapid cytoplasmic turnover of c-myc mRNA: Requirement of the 3′ untranslated sequences. Mol. Cell. Biol. 7, 4513-4521.
33. Kauffmann-Zeh, A., Rodriquez-Viciana, P., Elrich, E., Gilbert, C., Coffer, P., Downward, J., and Evan, G. (1997). Suppression of c-Myc-induced apoptosis by Ras signaling through PI(3)K and PKB. Nature 385, 544-548.
34. Kawada, M., Yamagoe, S., Murakami, Y., Suzuki, K., Mizuno, S., and Uehara, Y. (1997). Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene 15, 629-637.
35. Kelly, K., Cochran, B.H., Stiles, C.D., and Leder, P. (1983). Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35, 603-609.
36. Khosravi-Far, R., Solski, P.A., Clark, G.J., Kinch, M.S., and Der, C.J. (1995). Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell. Biol. 15, 6443-6453.
37. King, R.W., Deshaies, R.J., Peters, J.M., and Kirschner, M.W. (1996). How proteolysis drives the cell cycle. Science 274, 1652-1659.
38. Land, H., Parada, L.F., and Weinberg, R.A. (1983). Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304, 596-602.
39. Leone, G., DeGregori, J., Sears, R., Jakoi, L., and Nevins, J.R. (1997). Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 387, 422-426.
40. Luscher, B., and Eisenman, R.N. (1990). New light on Myc and Myb. Part I. Myc. Genes Dev. 4, 2025-2035.
41. Lutterbach, B., and Hann, S.R. (1994). Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis. Mol. Cell. Biol. 14, 5510-5522.
42. Nevins, J.R., DeGregori, J., Jakoi, L., and Leone, G. (1997). Functional analysis of E2F. Meth. Enzymol. 283, 205-219.
43. Peeper, D.S., Upton, T.M., Ladha, M.H., Neuman, E., Zalvide, J., Bernards, R., DeCaprio, J.A., and Ewen, M.E. (1997). Ras signaling linked to the cell-cycle machinery by the retinoblastoma protein. Nature 386, 177-181.
44. Perez-Roger, I., Solomon, D.L.C., Sewing, A., and Land, H. (1997). Myc activation of cyclin E /CDK2 kinase involves induction of cyclin E gene transcription and inhibition of p27Kip1 binding to newly formed complexes. Oncogene 14, 2373-2381.
45. Pulverer, B.J., Fisher, C., Vousden, K., Littlewood, T., Evan, G., and Woodgett, J.R. (1994). Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo. Oncogene 9, 59-70.
46. Ramsay, G., Stanton, L., Schwab, M., and Bishop, J.M. (1986). The human proto-oncogene N-myc encodes nuclear proteins that bind DNA. Mol. Cell. Biol. 6, 4450-4457.
47. Rock, K., Gram, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., and Goldberg, A. (1994). Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761-771.
48. Rosenwald, I.B., Rhoads, D.B., Callahan, L.D., Isselbacher, K.J., and Schmidt, E.V. (1993). Increased expression of eukaryotic translation initiation factors elF-4E and elF-2 alpha in response to growth induction by c-myc. Proc. Natl. Acad. Sci. USA 90, 6175-6178.
49. Sears, R., Ohtani, K., and Nevins, J.R. (1997). Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol. Cell. Biol. 17, 5227-5235.
50. Seth, A., Alvarez, E., Gupta, S., and Davis, R.J. (1991). A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression. J. Biol. Chem. 266, 23521-23524.
51. Shindo, H., Tani, E., Matsumuto, T., Hashimoto, T., and Furuyama, J. (1993). Stabilization of c-myc protein in human glioma cells. Acta Neuropathol. (Berl) 86, 345-352.
52. Spencer, C.A., and Groudine, M. (1991). Control of c-myc regulation in normal and neoplastic cells. Adv. Cancer Res. 56, 1-48.
53. Spotts, G.D., and Hann, S.R. (1990). Enhanced translation and increased turnover of c-myc proteins occur during differentiation of murine erythroleukemia cells. Mol. Cell. Biol. 10, 3952-3964.
54. Steiner, P., Philipp, A., Lukas, J., Godden-Kent, D., Pagano, M., Mittnacht, S., Bartek, J., and Eilers, M. (1995). Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J. 14, 4814-4826.
55. Vlach, J., Hennecke, S., Alevizopoulos, K., Conti, D., and Amati, B. (1996). Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J. 15, 6595-6604.
56. White, M.A., Nicolette, C., Minden, A., Polverino, A., Van Aeist, L., Karin, M., and Wigler, M.H. (1995). Multiple Ras functions can contribute to mammalian cell transformation. Cell 80, 533-541.
57. Wu, C.-L., Classon, M., Dyson, N., and Harlow, E. (1996). Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. Mol. Cell. Biol. 16, 3698-3706.
58. Zervos, A.S., Gyuris, J., and Brent, R. (1993). Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72, 223-232.