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Volumn 93, Issue 6, 1999, Pages 2043-2056

Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW CELL; COLONY FORMING UNIT S; DISEASE MODEL; ERYTHROPOIESIS; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; LEUKEMOGENESIS; LYMPHOCYTOPENIA; MOUSE; MYELODYSPLASTIC SYNDROME; MYELOPOIESIS; MYELOPROLIFERATIVE DISORDER; NONHUMAN; ONCOGENE N RAS; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; THYMUS ATROPHY;

EID: 0033559734     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.6.2043.406k17_2043_2056     Document Type: Article
Times cited : (96)

References (62)
  • 4
    • 0027337519 scopus 로고
    • Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase
    • Moodie SA, Willumsen BM, Weber MJ, Wolfman A: Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 260:1658, 1993
    • (1993) Science , vol.260 , pp. 1658
    • Moodie, S.A.1    Willumsen, B.M.2    Weber, M.J.3    Wolfman, A.4
  • 6
    • 0028577298 scopus 로고
    • Identification of the guanine nucleotide dissociation stimulator for Raf as putative effector molecule of R-ras, H-ras, K-ras, and RAP
    • Spaargaren M, Bischoff JR: Identification of the guanine nucleotide dissociation stimulator for Raf as putative effector molecule of R-ras, H-ras, K-ras, and RAP. Proc Natl Acad Sci USA 91:12609, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12609
    • Spaargaren, M.1    Bischoff, J.R.2
  • 8
    • 0024376173 scopus 로고
    • ras Oncogenes in human cancer: A review
    • Bos JL: ras Oncogenes in human cancer: A review. Cancer Res 49:4682, 1989
    • (1989) Cancer Res , vol.49 , pp. 4682
    • Bos, J.L.1
  • 11
    • 0024998851 scopus 로고
    • RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia
    • Hirsch-Ginsberg C, LeMaistre AC, Kantarjian H, Talpaz M, Cork A, Freireich EJ, Trujillo JM, Lee MS, Stass SA: RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia. Blood 76:1214, 1990
    • (1990) Blood , vol.76 , pp. 1214
    • Hirsch-Ginsberg, C.1    LeMaistre, A.C.2    Kantarjian, H.3    Talpaz, M.4    Cork, A.5    Freireich, E.J.6    Trujillo, J.M.7    Lee, M.S.8    Stass, S.A.9
  • 12
    • 0028895008 scopus 로고
    • Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation
    • Gishizky ML, Cortez D, Pendergast AM: Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation. Proc Natl Acad Sci USA 92:10889, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10889
    • Gishizky, M.L.1    Cortez, D.2    Pendergast, A.M.3
  • 13
    • 0029589929 scopus 로고
    • The BCR-ABL leukemia oncogene activates jun kinase and requires Jun for transformation
    • Raitano AB, Halpern JR, Hambuch TM, Sawyers CL: The BCR-ABL leukemia oncogene activates Jun kinase and requires Jun for transformation. Proc Natl Acad Sci USA 92:11746, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11746
    • Raitano, A.B.1    Halpern, J.R.2    Hambuch, T.M.3    Sawyers, C.L.4
  • 14
    • 0026521070 scopus 로고
    • Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
    • Basu TN, Gutman DH, Fletcher JA, Glover TW, Collins FS, Downward J: Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature 356:713, 1992
    • (1992) Nature , vol.356 , pp. 713
    • Basu, T.N.1    Gutman, D.H.2    Fletcher, J.A.3    Glover, T.W.4    Collins, F.S.5    Downward, J.6
  • 16
    • 0028224348 scopus 로고
    • Fusion of the PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • Golub TR, Barker GF, Lovett M, Gilliand DG: Fusion of the PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307, 1994
    • (1994) Cell , vol.77 , pp. 307
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3    Gilliand, D.G.4
  • 17
    • 0026500545 scopus 로고
    • Mutational activation of the N-ras oncogene assessed in primary clonogenic culture of acute myeloid leukemia (AML): Implications for the role of N-ras mutation in AML pathogenesis
    • Bashey A, Gill R, Levi S, Farr CJ, Clutterbuck R, Millar JL, Pragnell IB, Marshall CJ: Mutational activation of the N-ras oncogene assessed in primary clonogenic culture of acute myeloid leukemia (AML): Implications for the role of N-ras mutation in AML pathogenesis. Blood 79:981, 1992
    • (1992) Blood , vol.79 , pp. 981
    • Bashey, A.1    Gill, R.2    Levi, S.3    Farr, C.J.4    Clutterbuck, R.5    Millar, J.L.6    Pragnell, I.B.7    Marshall, C.J.8
  • 18
    • 0028218281 scopus 로고
    • Retroviral-mediated transfer of mutant H-ras gene into normal human bone marrow alters myeloid cell proliferation and differentiation
    • Maher J, Colonna F, Baker D, Luzzato L, Roberts I: Retroviral-mediated transfer of mutant H-ras gene into normal human bone marrow alters myeloid cell proliferation and differentiation. Exp Hematol 22:8, 1994
    • (1994) Exp Hematol , vol.22 , pp. 8
    • Maher, J.1    Colonna, F.2    Baker, D.3    Luzzato, L.4    Roberts, I.5
  • 19
    • 0024454757 scopus 로고
    • Reversible abrogation of IL-3 dependence by an inducible H-ras oncogene
    • Andrejauskas E, Moroni C: Reversible abrogation of IL-3 dependence by an inducible H-ras oncogene. EMBO J 8:2575, 1989
    • (1989) EMBO J , vol.8 , pp. 2575
    • Andrejauskas, E.1    Moroni, C.2
  • 20
    • 0026099579 scopus 로고
    • Introduction of an activated ras oncogene into murine BM lymphoid progenitors via retroviral gene transfer results in thymic lymphomas
    • Dunbar CE, Crosier PS, Nienhuis AW: Introduction of an activated ras oncogene into murine BM lymphoid progenitors via retroviral gene transfer results in thymic lymphomas. Oncogene Res 6:39, 1991
    • (1991) Oncogene Res , vol.6 , pp. 39
    • Dunbar, C.E.1    Crosier, P.S.2    Nienhuis, A.W.3
  • 21
    • 0027414493 scopus 로고
    • Induction of monocytic differentiation and tumorigenicily by v-Ha-ras in differentiation-arrested hematopoietic cells
    • Hibi S, Löhler J, Friel J, Stocking C, Ostertag W: Induction of monocytic differentiation and tumorigenicily by v-Ha-ras in differentiation-arrested hematopoietic cells. Blood 81:1841, 1993
    • (1993) Blood , vol.81 , pp. 1841
    • Hibi, S.1    Löhler, J.2    Friel, J.3    Stocking, C.4    Ostertag, W.5
  • 22
    • 0028841010 scopus 로고
    • Hematopoietic transforming potential of activated ras in chimeric mice
    • Hawley RG, Fong AZC, Ngang B-Y, Hawley TS: Hematopoietic transforming potential of activated ras in chimeric mice. Oncogene 11:1113, 1995
    • (1995) Oncogene , vol.11 , pp. 1113
    • Hawley, R.G.1    Fong, A.Z.C.2    Ngang, B.-Y.3    Hawley, T.S.4
  • 23
    • 0028884084 scopus 로고
    • Evidence for cell-specific differences in transformation by N-, H- and K-ras
    • Maher J, Baker DA, Manning M, Dibb NJ, Roberts IAG: Evidence for cell-specific differences in transformation by N-, H- and K-ras. Oncogene 11:1639, 1995
    • (1995) Oncogene , vol.11 , pp. 1639
    • Maher, J.1    Baker, D.A.2    Manning, M.3    Dibb, N.J.4    Roberts, I.A.G.5
  • 25
    • 0029774270 scopus 로고    scopus 로고
    • Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis
    • Mangues R, Symmans WF, Lu S, Schwartz S, Pellicer A: Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis. Oncogene 13:1053, 1996
    • (1996) Oncogene , vol.13 , pp. 1053
    • Mangues, R.1    Symmans, W.F.2    Lu, S.3    Schwartz, S.4    Pellicer, A.5
  • 27
    • 0023177629 scopus 로고
    • Evidence that the packaging signal of Moloney murine leukaemia virus extends into the gag region
    • Bender MA, Palmer TD, Gelinas RE, Miller AD: Evidence that the packaging signal of Moloney murine leukaemia virus extends into the gag region. J Virol 61:1639, 1987
    • (1987) J Virol , vol.61 , pp. 1639
    • Bender, M.A.1    Palmer, T.D.2    Gelinas, R.E.3    Miller, A.D.4
  • 28
    • 0026609221 scopus 로고
    • An in vitro fibroblast model system to study myc driven tumour progression
    • Chisholm O, Symonds G: An in vitro fibroblast model system to study myc driven tumour progression. Int J Cancer 51:149, 1992
    • (1992) Int J Cancer , vol.51 , pp. 149
    • Chisholm, O.1    Symonds, G.2
  • 29
    • 0342463159 scopus 로고
    • Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges
    • Danos O, Mulligan RC: Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc Natl Acad Sci USA 85:6460, 1988
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6460
    • Danos, O.1    Mulligan, R.C.2
  • 31
    • 0026448962 scopus 로고
    • Both myeloproliferative disease and leukemia are induced by transplantation of bone marrow cells expressing v-myc
    • Bonham L, MacKenzie K, Wood S, Rowe PB, Symonds G: Both myeloproliferative disease and leukemia are induced by transplantation of bone marrow cells expressing v-myc. Oncogene 7:2219, 1992
    • (1992) Oncogene , vol.7 , pp. 2219
    • Bonham, L.1    MacKenzie, K.2    Wood, S.3    Rowe, P.B.4    Symonds, G.5
  • 32
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493, 1992
    • (1992) J Cell Biol , vol.119 , pp. 493
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 33
    • 0027988572 scopus 로고
    • An internal deletion enhances the transcriptional activity of a recombinant retrovirus in hematopoietic cells in vivo
    • MacKenzie KL, Bonham L, Symonds G: An internal deletion enhances the transcriptional activity of a recombinant retrovirus in hematopoietic cells in vivo. J Virol 68:6924, 1994
    • (1994) J Virol , vol.68 , pp. 6924
    • MacKenzie, K.L.1    Bonham, L.2    Symonds, G.3
  • 34
    • 0025824001 scopus 로고
    • Retroviral gene transfer of human adenosine deaminase in murine haematopoietic cells: Effect of selectable marker sequences on long-term expression
    • Apperley JF, Luskey BD, Williams DA: Retroviral gene transfer of human adenosine deaminase in murine haematopoietic cells: Effect of selectable marker sequences on long-term expression. Blood 78:310, 1991
    • (1991) Blood , vol.78 , pp. 310
    • Apperley, J.F.1    Luskey, B.D.2    Williams, D.A.3
  • 36
    • 0029785634 scopus 로고    scopus 로고
    • Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potenital and inhibits apoptosis
    • Shounan Y, Dolnikov A, MacKenzie KL, Miller M, Chan Y-Y, Symonds G: Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potenital and inhibits apoptosis. Leukemia 10:1619, 1996
    • (1996) Leukemia , vol.10 , pp. 1619
    • Shounan, Y.1    Dolnikov, A.2    MacKenzie, K.L.3    Miller, M.4    Chan, Y.-Y.5    Symonds, G.6
  • 37
    • 0031978990 scopus 로고    scopus 로고
    • v-myc in a simple, single gene retroviral vector causes rapid induction of leukemia and concomitant apoptosis following bone marrow transplantation
    • Dolnikov A, Shounan Y, Millington M, MacKenzie KL, Symonds G: v-myc in a simple, single gene retroviral vector causes rapid induction of leukemia and concomitant apoptosis following bone marrow transplantation. Leukemia 12:542, 1998
    • (1998) Leukemia , vol.12 , pp. 542
    • Dolnikov, A.1    Shounan, Y.2    Millington, M.3    MacKenzie, K.L.4    Symonds, G.5
  • 39
    • 84956427297 scopus 로고
    • A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
    • Till JE, McCulloch EA: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213, 1961
    • (1961) Radiat Res , vol.14 , pp. 213
    • Till, J.E.1    McCulloch, E.A.2
  • 40
    • 0030903188 scopus 로고    scopus 로고
    • Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells
    • Darley RL, Hoy TG, Baines P, Padua RA, Burnett AK: Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells. J Exp Med 185:1337, 1997
    • (1997) J Exp Med , vol.185 , pp. 1337
    • Darley, R.L.1    Hoy, T.G.2    Baines, P.3    Padua, R.A.4    Burnett, A.K.5
  • 41
    • 0028213722 scopus 로고
    • Infection with a Kirsten-retrovirus can induce a multiplicity of tumorigenic phenotypes in the interleukin-3-dependent FDC-P1 cells
    • Duménil D, Neel H, Lacout C, Dautry F: Infection with a Kirsten-retrovirus can induce a multiplicity of tumorigenic phenotypes in the interleukin-3-dependent FDC-P1 cells. Exp Hematol 22:178, 1994
    • (1994) Exp Hematol , vol.22 , pp. 178
    • Duménil, D.1    Neel, H.2    Lacout, C.3    Dautry, F.4
  • 42
    • 0021063848 scopus 로고
    • Cellular oncogenes and multistep carcinogenesis
    • Land H, Parada LF, Weinberg RA: Cellular oncogenes and multistep carcinogenesis. Science 222:771, 1983
    • (1983) Science , vol.222 , pp. 771
    • Land, H.1    Parada, L.F.2    Weinberg, R.A.3
  • 43
    • 0020520516 scopus 로고
    • Tumorigenic conversion of primary embryo fibroblasts requires at least two co-operating oncogenes
    • Land H, Parada LF, Weinberg RA: Tumorigenic conversion of primary embryo fibroblasts requires at least two co-operating oncogenes. Nature 304:596, 1983
    • (1983) Nature , vol.304 , pp. 596
    • Land, H.1    Parada, L.F.2    Weinberg, R.A.3
  • 44
    • 0040433650 scopus 로고
    • Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene
    • Hirakawa T, Ruley HE: Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene. Proc Natl Acad Sci USA 85:1519, 1988
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1519
    • Hirakawa, T.1    Ruley, H.E.2
  • 45
    • 0031028381 scopus 로고    scopus 로고
    • Cell cycle arrest mediated by the MEK/mitogen activated protein kinase pathway
    • Pumiglia KM, Decker SJ: Cell cycle arrest mediated by the MEK/mitogen activated protein kinase pathway. Proc Natl Acad Sci USA 94:488, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 488
    • Pumiglia, K.M.1    Decker, S.J.2
  • 46
    • 0021955986 scopus 로고
    • Chronic myelogenous leukemia: Recent advances
    • Champlin RE, Golde DW: Chronic myelogenous leukemia: Recent advances. Blood 65:1039, 1985
    • (1985) Blood , vol.65 , pp. 1039
    • Champlin, R.E.1    Golde, D.W.2
  • 50
    • 0023761089 scopus 로고
    • Hypoplastic myelodysplastic syndrome
    • Nand S, Godin JE: Hypoplastic myelodysplastic syndrome. Cancer 62:958, 1988
    • (1988) Cancer , vol.62 , pp. 958
    • Nand, S.1    Godin, J.E.2
  • 53
    • 0025271543 scopus 로고
    • bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice
    • Elefanty AG, Hariharan IK, Cory S: bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. EMBO J 9:1069, 1990
    • (1990) EMBO J , vol.9 , pp. 1069
    • Elefanty, A.G.1    Hariharan, I.K.2    Cory, S.3
  • 54
    • 0025187837 scopus 로고
    • Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL
    • Kelliher MA, McLaughlin J, Witte ON, Rosenberg N: Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc Natl Acad Sci USA 87:6649, 1990
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6649
    • Kelliher, M.A.1    McLaughlin, J.2    Witte, O.N.3    Rosenberg, N.4
  • 55
    • 0030045594 scopus 로고    scopus 로고
    • Nfl deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukemia
    • Largaespada DA, Brannan CI, Jenkins NA, Copeland NG: Nfl deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukemia. Nat Genet 12:137, 1996
    • (1996) Nat Genet , vol.12 , pp. 137
    • Largaespada, D.A.1    Brannan, C.I.2    Jenkins, N.A.3    Copeland, N.G.4
  • 56
    • 0026576755 scopus 로고
    • Hematologic disease induced in BALB/c mice by a bcr/abl retrovirus is influenced by the infection conditions
    • Elefanty AG, Cory S: Hematologic disease induced in BALB/c mice by a bcr/abl retrovirus is influenced by the infection conditions. Mol Cell Biol 12:1755, 1992
    • (1992) Mol Cell Biol , vol.12 , pp. 1755
    • Elefanty, A.G.1    Cory, S.2
  • 57
    • 0028125213 scopus 로고
    • Genetic analysis is consistent with the hypothesis that NF1 limits myeloid growth through p21 ras
    • Karla R, Paderanga DC, Olson K, Shannon KM: Genetic analysis is consistent with the hypothesis that NF1 limits myeloid growth through p21 ras. Blood 84:3435, 1994
    • (1994) Blood , vol.84 , pp. 3435
    • Karla, R.1    Paderanga, D.C.2    Olson, K.3    Shannon, K.M.4
  • 58
    • 0025906674 scopus 로고
    • Transgenic models for haemopoietic malignancies
    • Adams JM, Cory S: Transgenic models for haemopoietic malignancies. Biochim Biophys Acta 1072:9, 1991
    • (1991) Biochim Biophys Acta , vol.1072 , pp. 9
    • Adams, J.M.1    Cory, S.2
  • 59
    • 0023631608 scopus 로고
    • Coexpression of MMTV/v-Ha-ras and MMTV/c-myr genes in transgenic mice: Synergistic action of oncogenes in vivo
    • Sinn E, Muller W, Pattengale P, Tepler I, Wallace R, Leder P: Coexpression of MMTV/v-Ha-ras and MMTV/c-myr genes in transgenic mice: Synergistic action of oncogenes in vivo. Cell 49:465, 1987
    • (1987) Cell , vol.49 , pp. 465
    • Sinn, E.1    Muller, W.2    Pattengale, P.3    Tepler, I.4    Wallace, R.5    Leder, P.6
  • 61
    • 0028607141 scopus 로고
    • Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death
    • Ferrari G, Greene LA: Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death. EMBO J 13:5922, 1994
    • (1994) EMBO J , vol.13 , pp. 5922
    • Ferrari, G.1    Greene, L.A.2


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