Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras

Journal of Molecular Biology

Volumn 267, Issue 2, 1997, Pages 225-228

  Sánchez García, Isidro ^a   Martín Zanca, Dionisio ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Apoptosis; BCR ABL; Cell transformation; Gene regulation; Proliferation

Indexed keywords

BCR ABL PROTEIN; CHIMERIC PROTEIN; PROTEIN BCL 2; PROTEIN TYROSINE KINASE; RAS PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL SURVIVAL; CELL TRANSFORMATION; CHIMERA; CHROMOSOME 22; CHROMOSOME 9; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; ETIOLOGY; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE TRANSLOCATION; MITOGENESIS; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE RAS; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0031588956     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0779     Document Type: Editorial

References (15)

1. Afar D. E. H., Goga A., McLaughlin J., Witte O. N., Sawyers C. L. Differential complementation of Bcr-Abl point mutants with c-Myc. Science. 264:1994;424-426.
2. De Wet J. R., Wood K. V., de Luca M., Helinski D. R., Subramani S. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell Biol. 7:1987;725-737.
3. Feig L. A., Cooper G. M. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell Biol. 8:1988;3235-3243.
4. Kuzrock R., Gutterman J. U., Talpaz M. The molecular genetics of Philadelphia chromosome positive leukemias. New Engl. J. Med. 319:1988;990-998.
5. Land L., Parada L., Weinberg R. A. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature. 304:1983;596-602.
6. Lewin B. Oncogenic conversion by regulatory changes in transcription factors. Cell. 64:1991;303-312.
7. Lüscher B., Mitchell P. J., Williams T., Tjian R. Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers. Genes Dev. 3:1989;1507-1517.
8. Pendergast A. M., Quilliam L. A., Cripe L. D., Bassing C. H., Dai Z., Li N., Batzer A., Rabun K. M., Der C. J., Schlessinger J.,. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor. Cell. 75:1993;175-185.
9. Pozzatti R., Muschel R., Williams J., Padmanabhan R., Howard B., Liotta L., Khourg G. Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials. Science. 232:1986;223-227.
10. Puil L., Liu J., Gish G., Mbamalu G., Bowtell D., Pelicci P. G., Arlinghaus R., Pawson T. Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J. 13:1994;764-773.
11. Sánchez-García I., Grütz G. Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2. Proc. Natl Acad. Sci. USA. 92:1995;5287-5291.
12. Sánchez-García I., Rabbits T. H. Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities. Proc. Natl Acad. Sci. USA. 91:1994;7869-7873.
13. Sawyers C. L., Callahan W., Witte O. N. Dominant negative MYC blocks transformation by ABL oncogenes. Cell. 70:1992;901-910.
14. Seto M., Jaeger V., Hockett R. D., Graninger W., Bennett S., Goldman P., Korsmeyer S. J. Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J. 7:1988;123-131.
15. Spandidos D. A., Wilkie N. M. Malignant transformation of early passage rodent cells by a single mutated human oncogene. Nature. 310:1984;469-475.