Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization

EMBO Journal

Volumn 18, Issue 12, 1999, Pages 3419-3430

  Romero, Francisco ^a,d   Martínez A, Carlos ^b   Camonis, Jacques ^c   Rebollo, Angelita ^a  

^a Hôpital Cochin ^*  (France)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c INSTITUT CURIE   (France)

^d Fac Ciencias   (Spain)

Author keywords

Aiolos; Apoptosis; Bcl 2; Phosphorylation

Indexed keywords

INTERLEUKIN 2; LUCIFERASE; PROTEIN BCL 2; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL DEATH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; REPORTER GENE; T LYMPHOCYTE; TRANSACTIVATION;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL LINE; CELL NUCLEUS; CYTOPLASM; GUANOSINE DIPHOSPHATE; HUMANS; INTERLEUKIN-2; MICE; MUTATION; PHOSPHOTYROSINE; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS P21(RAS); RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; YEASTS;

EID: 0344241921     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.12.3419     Document Type: Article

References (57)

1. Bartel, P.L. and Field, S. (1997) The Yeast Two-Hybrid System. Oxford University Press, New York, NY.
2. Bartel, P.L., Chien, C.T., Sternglanz, R. and Field, S. (1993) Using the two-hybrid system to detect protein-protein interaction. In Cellular Interactions in Development: A Practical Approach. Oxford University Press, Oxford, UK, pp. 153-179.
3. Baumon, L.E., Cazenave, P.A. and Srthou, P. (1990) Anti-immunoglobulins induce death by apoptosis in WEHI-231 B lymphoma cells. Eur. J. Immunol., 20, 1405-1407.
4. Boguski, M.S. and McCormick, F. (1993) Proteins regulating Ras and its relatives. Nature, 366, 643-654.
5. Broome, H.E., Dargan, C.M., Bressent, E.F., Krajewski, S. and Reed, J.C. (1995) Apoptosis and Bcl-2 expression in cultured murine splenic T cells, Immunology, 84, 375-381.
6. Chao, D.T. and Korsmeyer, S. (1998) Bcl-2 family: regulator of cell death. Annu. Rev. Immunol., 16, 395-419.
7. Chen, C. and Faller, D.V. (1996) Phosphorylation of Bcl-2 protein and association with p21 Ras in Ras-induced apoptosis. J. Biol. Chem., 271, 2376-2379.
8. Chen, H.M. and Boxer, L.M. (1995) P1 binding sites are negative regulators of bcl-2 expression in pre-B cells. Mol. Cell. Biol., 15, 3840-3847.
9. di-Jeso, B., Ulianich, L., Racioppi, L., D'Armiento, F., Feliciello, A., Pacifico, F., Consiglio, E. and Formisano, S. (1995) Serum withdrawal induces apoptotic cell death in K-ras transformed but not in normal differentiated thyroid cells. Biochem. Biophys. Res. Commun., 214, 819-824.
10. 1 phase in BALB-c 3T3 cells. Mol. Cell. Biol., 14, 5441-5449.
11. Duke, R.C. and Cohen, J.J. (1986) IL-2 addition: withdrawal of growth factor activates a suicide progamm in dependent T cells. Lymphokine Res., 5, 289-299.
12. Fairbairn, L.J., Cowling, G.J., Reipert, B.M. and Dexter, T.M. (1993) Suppression of apoptosis allows differentiation and development of multipotent hematopoietic cell line in the absence of added growth factors. Cell, 74, 823-832.
13. Fernandez-Sarabia, J. and Bischoff, J.R. (1993) Bcl-2 associates with the Ras-related protein R-Ras p23. Nature, 366, 274-275.
14. Ferrari, G. and Greene, L.A. (1994) Proliferative inhibition by dominant negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death. EMBO J., 13, 5922-5928.
15. Fields, S. and Song, O.K. (1989) A novel genetic system to detect protein-protein interactions. Nature, 340, 245-246.
16. Frampton, J., Ramqvist, T. and Graf, T. (1996) V-Myc of E26 leukemia virus upregulates Bcl-2 expression and suppresses apoptosis in myeloid cells. Genes Dev., 10, 2720-2731.
17. Gómez, J., Martínez-A, C., Fernández, B., García, A. and Rebollo, A. (1996) Critical role for Ras the proliferation and prevention of apoptosis mediated by IL-2. J. Immunol., 157, 2772-2781.
18. Gómez, J., Martínez-A, C., Fernández, B., García, A. and Rebollo, A. (1997) Ras activation leads to cell proliferation or apoptotic cell death on IL-2-stimulated or lymphokine-deprivation, respectively. Eur. J. Immunol., 27, 1610-1618.
19. Gómez, J., Martínez-A, C., González, A., García, A. and Rebollo, A. (1998a) The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT. Oncogene, 17, 1235-1243.
20. Gómez, J., Martínez-A, C., González, A. and Rebollo, A. (1998b) Dual role of Ras and Rho proteins: at the cutting edge of life and death. Immunol. Cell Biol., 76, 125-134.
21. Gratiot-Deans, J., Ding, L., Turka, L.A. and Nuñez, G. (1993) Bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation. J. Immunol., 151, 83-91.
22. Gulbins, E., Bissonnette, R. and Mahbouhi, A. (1995) Fas-induced apoptosis is mediated via ceramide-initiated Ras signaling pathway. Immunity, 2, 341-351.
23. Hannon, G.J., Demetrick, D. and Beach, D. (1993) Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev., 7, 2378-2391.
24. Heckman, C., Mochon, E., Arcinas, M. and Boxer, L.M. (1997) The WT 1 protein is a negative regulator of the normal Bcl-2 allele in lymphomas. J. Biol. Chem., 272, 19609-19614.
25. Hewitt, S.M., Hamada, S., McDonnell, T.J., Rauscher, F.J. and Saunders, G.F. (1996) Differential spliced exon 5 of the Wilm's tumor gene WT1 modifies gene function. Cancer Res., 55, 5386-5389.
26. Kinoshita, T., Yokota, T., Arai, K. and Miyajima, A. (1995) Regulation of Bcl-2 expression by oncogenic ras protein in hematopoietic cells. Oncogene, 10, 2207-2212.
27. Lai, C.C., Bogulski, M., Broek, D. and Powers, S. (1993) Influence of guanine nucleotides complex formation between Ras and CDC25 proteins. Mol. Cell. Biol., 13, 1345-1352.
28. Maniatis, T., Frisch, E.F. and Sambrook, J. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
29. McCormick, F. (1998) Going for the GAP. Curr. Biol., 8, 673-674.
30. Minami, Y. and Taniguchi, T. (1995) IL-2 signaling: recruitment and activation of multiple protenin tyrosine kinases by components of the IL-2R. Curr. Opin. Cell Biol., 7, 156-162.
31. Miyashita, T. and Reed, J.C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human box gene. Cell, 80, 293-299.
32. Miyashita, T., Harigai, M., Hanada, M. and Reed, J.C. (1994) Identification of p53-dependent negative response element in the Bcl-2 gene. Cancer Res., 54, 3131-3135.
33. Miyazaki, T., Liu, Z.J., Kawajar, A., Minami, Y., Yamada, K., Tsujimoto, Y., Barsouimian, L., Pelmutter, R.M. and Taniguchi, T. (1995) Three distinct IL-2 signaling pathways mediated by Bcl-2, c-Myc and Lck cooperate in hemapoietic cell proliferation. Cell, 81, 223-231.
34. Morgan, B., Sun, L., Avitahl, N., Andrikopoulus, K., Ikeda, T., Gonzales, E., Wu, P., Neben, S. and Georgopoulus, K. (1997) Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J., 16, 2004-2013.
35. Nagata, S. (1997) Apoptosis by death factors. Cell, 88, 355-365.
36. Nuñez, G., London, L., Hockenbery, D., Alexander, M., McDearn, J.P. and Korsmeyer, S.J. (1990) Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell line, J. Immunol., 144, 3602-3610.
37. Pan, B.T., Chen, C.T. and Lin, S.M. (1994) Oncogenic Ras blocks cell cycle progression and inhibits p34 cdc2 kinase in activated Xenopus egg extracts. J. Biol. Chem., 269, 5968-5975.
38. Park, J.R. and Hockenbery, D.M. (1996) Bcl-2, a novel regulator of apoptosis. J. Cell. Biochem., 60, 12-17.
39. Pitton, C., Rebollo, A., Van Snick, J., Theze, J. and García, A. (1993) High affinity and intermediate affinity forms of the human IL-2R, expressed in an IL-9-dependent murine T cell line deliver proliferative signals via differences in their transduction pathways. Cytokine, 5, 362-371.
40. Reed, J.C. (1994) Bcl-2 and the regulation of programmed cell death. J. Cell Biol., 124, 1-6.
41. Smith, C.A., Williams, G.T., Kingston, R., Jenkinson, E.J. and Owen, J.T. (1989) Antibodies to CD3/T cell receptor complex induce cell death by apoptosis in immature T cell in thymic culture. Nature, 337, 181-184.
42. Smith, M.D., Ensor, E.A., Coffin, R.S., Boxer, L.M. and Latchman, S. (1998) Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factors. J. Biol. Chem., 273, 16715-16722.
43. Taylor, D., Badiani, P. and Weston, K. (1996) A dominant interferin Myb mutant causes apoptosis in T cells. Genes Dev., 10, 2732-2744.
44. Taylor, S.J. and Shalloway, D. (1996) Cell cycle-dependent activation of Ras. Curr. Biol., 6, 1621-1627.
45. Veis, D.J., Sentman, C.L., Bach, E.A. and Korsmeyer, S. (1993) Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol., 151, 2546-2554.
46. Vojtek, A., Hollenberg, S.M. and Cooper, J.A. (1993) Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell, 74, 205-241.
47. Wang, H.G., Millan, J.A., Cox, A.D., Der, C.J., Rapp, U.R., Beck, T., Zha, H. and Reed, J.C. (1995) R-Ras promotes apoptosis caused by growth factor deprivation via Bcl-2 suppressible mechanism. J. Cell Biol., 129, 1103-1114.
48. Wang, J.H. et al. (1998) Aiolos regulates B cell activation and maturation to effector stage. Immunity, 9, 543-553.
49. White, E. (1996) Life, death and the pursuit of apoptosis. Genes Dev., 10, 1-15.
50. Williams, G.T., Smith, C.A., Spooncer, E., Drexter, T.M. and Taylor, D.R. (1990) Haematopoietic colony-stimulating factor promotes cell survival by suppressing apoptosis. Nature, 343, 76-79.
51. Wilson, B.E., Mochon, E. and Boxer, L.B. (1996) Induction of Bcl-2 expression by phosphorylated CREB protein during B cell activation and rescue from apoptosis. Mol. Cell. Biol., 16, 5546-5556.
52. Wilson, D.J., Fortner, K.A. and Lynch, D.H. (1996) JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells. Eur. J. Immunol., 26, 989-994.
53. Winston, J.T., Coats, S.R., Wang, Y.Z. and Pledger, W.J.(1996) Regulation of the cell cycle machinery by oncogenic Ras. Oncogene, 12, 127-134.
54. Wyllie, A.H. (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous nuclease activation. Nature, 284, 555-556.
55. Yang, E. and Korsmeyer, S. (1996) Molecular thanatopsis: a discourse on the Bcl-2 family and cell death. Blood, 88, 386-402.
56. Young, R.L. and Korsmeyer, S.J. (1993) A negaitve regulatory element in the Bcl-2 5′ untranslated region inhibits expression from an upstream promoter. Mol. Cell. Biol., 13, 3683-3697.
57. Zubiaga, A.M., Muñoz, E. and Huber, B.T. (1992) IL-2 and IL-4 selectively rescue Th cells subsets from glucocorticoid-induced apoptosis. J. Immunol., 149, 107-112.