메뉴 건너뛰기




Volumn 11, Issue 19, 1997, Pages 2468-2481

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

Author keywords

Embryogenesis; Hematopoiesis; K Ras; Knockout mouse; N Ras; Oncogene

Indexed keywords

RAS PROTEIN;

EID: 0345135149     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.19.2468     Document Type: Article
Times cited : (459)

References (55)
  • 2
    • 0023898932 scopus 로고
    • The ras gene family and human carcinogenesis
    • Bos, J.L. 1988. The ras gene family and human carcinogenesis. Mutat. Res. 195: 255-271.
    • (1988) Mutat. Res. , vol.195 , pp. 255-271
    • Bos, J.L.1
  • 3
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • published erratum appears in Cancer Res 1990 Feb 15; 50 (4): 1352
    • _. 1989. ras oncogenes in human cancer: A review [published erratum appears in Cancer Res 1990 Feb 15; 50 (4): 1352]. Cancer Res. 49: 4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
  • 4
    • 0025010979 scopus 로고
    • The GT-Pase superfamily: A conserved switch for diverse cell functions
    • Bourne, H.R., D.A. Sanders, and F. McCormick. 1990. The GT-Pase superfamily: A conserved switch for diverse cell functions. Nature 348: 125-132.
    • (1990) Nature , vol.348 , pp. 125-132
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 5
    • 0000742810 scopus 로고
    • Production and analysis of Chimeric mice
    • (ed. E.J. Robertson), IRL Press, Oxford, UK
    • Bradley, A. 1987. Production and analysis of Chimeric mice. In Teratocarcinomas and embryonic stem cells: A practical approach (ed. E.J. Robertson), pp. 113-152. IRL Press, Oxford, UK.
    • (1987) Teratocarcinomas and Embryonic Stem Cells: A Practical Approach , pp. 113-152
    • Bradley, A.1
  • 6
    • 0025184759 scopus 로고
    • Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells
    • Cai, H., J. Szeberenyi, and G.M. Cooper. 1990. Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol. Cell. Biol. 10: 5314-5323.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5314-5323
    • Cai, H.1    Szeberenyi, J.2    Cooper, G.M.3
  • 8
    • 0023333003 scopus 로고
    • Expression of p21ras in normal and malignant human tissues: Lack of association with proliferation and malignancy
    • Chesa, P.G., W.J. Rettig, M.R. Melamed, L.J. Old, and H.L. Niman. 1987. Expression of p21ras in normal and malignant human tissues: Lack of association with proliferation and malignancy. Proc. Natl. Acad. Sci. 84: 3234-3238.
    • (1987) Proc. Natl. Acad. Sci. , vol.84 , pp. 3234-3238
    • Chesa, P.G.1    Rettig, W.J.2    Melamed, M.R.3    Old, L.J.4    Niman, H.L.5
  • 10
    • 0028073283 scopus 로고
    • MAPKs: New JNK expands the group
    • Davis, R.J. 1994. MAPKs: New JNK expands the group. Trends Biochem. Sci. 19: 470-473.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 470-473
    • Davis, R.J.1
  • 11
    • 0029969397 scopus 로고    scopus 로고
    • Recent advances in understanding signal transduction pathways in worms and flies
    • Duffy, J.B. and N. Perrimon. 1996. Recent advances in understanding signal transduction pathways in worms and flies. Curr. Opin. Cell Biol. 8: 231-238.
    • (1996) Curr. Opin. Cell Biol. , vol.8 , pp. 231-238
    • Duffy, J.B.1    Perrimon, N.2
  • 12
    • 0029147761 scopus 로고
    • Mouse embryonic hematopoiesis
    • Dzierzak, E. and A. Medvinsky. 1995. Mouse embryonic hematopoiesis. Trends Genet. 11: 359-366.
    • (1995) Trends Genet. , vol.11 , pp. 359-366
    • Dzierzak, E.1    Medvinsky, A.2
  • 13
    • 0019855643 scopus 로고
    • The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes
    • Ellis, R.W., D. Defeo, T.Y. Shih, M.A. Gonda, H.A. Young, N. Tsuchida, D.R. Lowy, and E.M. Scolnick. 1981. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature 292: 506-511.
    • (1981) Nature , vol.292 , pp. 506-511
    • Ellis, R.W.1    Defeo, D.2    Shih, T.Y.3    Gonda, M.A.4    Young, H.A.5    Tsuchida, N.6    Lowy, D.R.7    Scolnick, E.M.8
  • 14
    • 0023615744 scopus 로고
    • Expression of ras proto-oncogene proteins in normal human tissues
    • Furth, M.E., T.H. Aldrich, and C.C. Cordon. 1987. Expression of ras proto-oncogene proteins in normal human tissues. Oncogene 1: 47-58.
    • (1987) Oncogene , vol.1 , pp. 47-58
    • Furth, M.E.1    Aldrich, T.H.2    Cordon, C.C.3
  • 15
    • 0022065447 scopus 로고
    • Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells
    • George, D.L., A.F. Scott, S. Trusko, B. Glick, E. Ford, and D.J. Dorney. 1985. Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells. EMBO J. 4: 1199-1203.
    • (1985) EMBO J. , vol.4 , pp. 1199-1203
    • George, D.L.1    Scott, A.F.2    Trusko, S.3    Glick, B.4    Ford, E.5    Dorney, D.J.6
  • 16
    • 0028331587 scopus 로고
    • Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
    • Gibbs, J.B., A. Oliff, and N.E. Kohl. 1994. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell 77: 175-178.
    • (1994) Cell , vol.77 , pp. 175-178
    • Gibbs, J.B.1    Oliff, A.2    Kohl, N.E.3
  • 17
    • 0028170814 scopus 로고
    • Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes
    • Glomset, J.A. and C.C. Farnsworth. 1994. Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes. Annu. Rev. Cell Biol. 10: 181-205.
    • (1994) Annu. Rev. Cell Biol. , vol.10 , pp. 181-205
    • Glomset, J.A.1    Farnsworth, C.C.2
  • 19
    • 0028170820 scopus 로고
    • Small GTP-binding proteins and the regulation of the actin cytoskeleton
    • Hall, A. 1994. Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu. Rev. Cell Biol. 10: 31-54.
    • (1994) Annu. Rev. Cell Biol. , vol.10 , pp. 31-54
    • Hall, A.1
  • 20
    • 0027137004 scopus 로고
    • Anti-Ras drugs come of age
    • Hancock, J.F. 1993. Anti-Ras drugs come of age. Curr. Biol. 3: 770-772.
    • (1993) Curr. Biol. , vol.3 , pp. 770-772
    • Hancock, J.F.1
  • 21
    • 0024406286 scopus 로고
    • All ras proteins are polyisoprenylated but only some are palmitoylated
    • Hancock, J.F., A.I. Magee, J.E. Childs, and C.J. Marshall. 1989. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57: 1167-1177.
    • (1989) Cell , vol.57 , pp. 1167-1177
    • Hancock, J.F.1    Magee, A.I.2    Childs, J.E.3    Marshall, C.J.4
  • 22
    • 0025013547 scopus 로고
    • A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
    • Hancock, J.F., H. Paterson, and C.J. Marshall. 1990. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell 63: 133-139.
    • (1990) Cell , vol.63 , pp. 133-139
    • Hancock, J.F.1    Paterson, H.2    Marshall, C.J.3
  • 23
    • 0026037624 scopus 로고
    • A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins
    • Hancock, J.F., K. Cadwallader, H. Paterson, and C.J. Marshall. 1991. A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins. EMBO J. 10: 4033-4039.
    • (1991) EMBO J. , vol.10 , pp. 4033-4039
    • Hancock, J.F.1    Cadwallader, K.2    Paterson, H.3    Marshall, C.J.4
  • 24
    • 0028958919 scopus 로고
    • Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
    • James, G.L., J.L. Goldstein, and M.S. Brown. 1995. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. J. Biol Chem. 270: 6221-6226.
    • (1995) J. Biol Chem. , vol.270 , pp. 6221-6226
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 25
    • 0029664317 scopus 로고    scopus 로고
    • V12 proteins to farnesyltransferase inhibitors in Rat1 cells
    • V12 proteins to farnesyltransferase inhibitors in Rat1 cells. Proc. Natl. Acad. Sci. 93: 4454-4458.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 4454-4458
  • 27
  • 28
  • 29
    • 0026895892 scopus 로고
    • Protein prenylation: Key to ras function and cancer intervention?
    • Khosravi, F.R., A.D. Cox, K. Kato, and C.J. Der. 1992. Protein prenylation: Key to ras function and cancer intervention? Cell Growth Differ. 3: 461-469.
    • (1992) Cell Growth Differ. , vol.3 , pp. 461-469
    • Khosravi, F.R.1    Cox, A.D.2    Kato, K.3    Der, C.J.4
  • 32
    • 0023098381 scopus 로고
    • Differential expression of the ras gene family in mice
    • Leon, J., I. Guerrero, and A. Pellicer. 1987. Differential expression of the ras gene family in mice. Mol. Cell. Biol. 7: 1535-1540.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 1535-1540
    • Leon, J.1    Guerrero, I.2    Pellicer, A.3
  • 33
    • 0028810275 scopus 로고
    • Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor
    • Lerner, E.C., Y. Qian, A.D. Hamilton, and S.M. Sebti. 1995. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J. Biol. Chem. 270: 26770-26773.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26770-26773
    • Lerner, E.C.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 34
    • 0029910628 scopus 로고    scopus 로고
    • Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod, K.F., Y. Hu, and T. Jacks. 1996. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15: 6178-6188.
    • (1996) EMBO J. , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 35
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
    • Mansour, S.L., K.R. Thomas, and M.R. Capecchi. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes. Nature 336: 348-352.
    • (1988) Nature , vol.336 , pp. 348-352
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 36
    • 0026050653 scopus 로고
    • A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21
    • Mizuno, T., K. Kaibuchi, T. Yamamoto, M. Kawamura, T. Sakoda, H. Fujioka, Y. Matsuura, and Y. Takai. 1991. A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc. Natl. Acad. Sci. 88: 6442-6446.
    • (1991) Proc. Natl. Acad. Sci. , vol.88 , pp. 6442-6446
    • Mizuno, T.1    Kaibuchi, K.2    Yamamoto, T.3    Kawamura, M.4    Sakoda, T.5    Fujioka, H.6    Matsuura, Y.7    Takai, Y.8
  • 37
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • see comments
    • Morgenbesser, S.D., B.O. Williams, T. Jacks, and R.A. DePinho. 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens [see comments]. Nature 371: 72-74.
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    DePinho, R.A.4
  • 39
    • 0019973134 scopus 로고
    • Differential expression of cellular oncogenes during pre- and postnatal development of the mouse
    • Muller, R., D.J. Slamon, J.M. Tremblay, M.J. Cline, and I.M. Verma. 1982. Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature 299: 640-644.
    • (1982) Nature , vol.299 , pp. 640-644
    • Muller, R.1    Slamon, D.J.2    Tremblay, J.M.3    Cline, M.J.4    Verma, I.M.5
  • 41
    • 0028365660 scopus 로고
    • Different functions of Smg GDP dissociation stimulator and mammalian counterpart of yeast Cdc25
    • Nakanishi, H., K. Kaibuchi, S. Orita, N. Ueno, and Y. Takai. 1994. Different functions of Smg GDP dissociation stimulator and mammalian counterpart of yeast Cdc25. J. Biol. Chem. 269: 15085-15091.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15085-15091
    • Nakanishi, H.1    Kaibuchi, K.2    Orita, S.3    Ueno, N.4    Takai, Y.5
  • 42
    • 0027491578 scopus 로고
    • Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation
    • Orita, S., K. Kaibuchi, S. Kuroda, K. Shimizu, H. Nakanishi, and Y. Takai. 1993. Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation. J. Biol. Chem. 268: 25542-25546.
    • (1993) J. Biol. Chem. , vol.268 , pp. 25542-25546
    • Orita, S.1    Kaibuchi, K.2    Kuroda, S.3    Shimizu, K.4    Nakanishi, H.5    Takai, Y.6
  • 43
    • 0028851523 scopus 로고
    • Hematopoiesis: How does it happen?
    • Orkin, S.H. 1995. Hematopoiesis: How does it happen? Curr. Opin. Cell Biol. 7: 870-877.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 870-877
    • Orkin, S.H.1
  • 44
    • 0021274917 scopus 로고
    • Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins
    • Powers, S., T. Kataoka, O. Fasano, M. Goldfarb, J. Strathern, J. Broach, and M. Wigler. 1984. Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell 36: 607-612.
    • (1984) Cell , vol.36 , pp. 607-612
    • Powers, S.1    Kataoka, T.2    Fasano, O.3    Goldfarb, M.4    Strathern, J.5    Broach, J.6    Wigler, M.7
  • 45
    • 0025194466 scopus 로고
    • Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides
    • Reiss, Y., J.L. Goldstein, M.C. Seabra, P.J. Casey, and M.S. Brown. 1990. Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell 62: 81-88.
    • (1990) Cell , vol.62 , pp. 81-88
    • Reiss, Y.1    Goldstein, J.L.2    Seabra, M.C.3    Casey, P.J.4    Brown, M.S.5
  • 46
    • 0028858855 scopus 로고
    • Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
    • Shivdasani, R.A., E.L. Mayer, and S.H. Orkin. 1995. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 373: 432-434.
    • (1995) Nature , vol.373 , pp. 432-434
    • Shivdasani, R.A.1    Mayer, E.L.2    Orkin, S.H.3
  • 47
    • 84956427297 scopus 로고
    • A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
    • Till, J.E. and E.A. McCulloch. 1961. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Rad. Res. 14: 213-222.
    • (1961) Rad. Res. , vol.14 , pp. 213-222
    • Till, J.E.1    McCulloch, E.A.2
  • 48
    • 0025780879 scopus 로고
    • Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl protooncogene
    • Tybulewicz, V.L., C.E. Crawford, P.K. Jackson, R.T. Bronson, and R.C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl protooncogene. Cell 65: 1153-1163.
    • (1991) Cell , vol.65 , pp. 1153-1163
    • Tybulewicz, V.L.1    Crawford, C.E.2    Jackson, P.K.3    Bronson, R.T.4    Mulligan, R.C.5
  • 51
    • 0027968207 scopus 로고
    • Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences
    • Williams, B.O., E.M. Schmitt, L. Remington, R.T. Bronson, D.M. Albert, R.A. Weinberg, and T. Jacks. 1994. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J. 13: 4251-4259.
    • (1994) EMBO J. , vol.13 , pp. 4251-4259
    • Williams, B.O.1    Schmitt, E.M.2    Remington, L.3    Bronson, R.T.4    Albert, D.M.5    Weinberg, R.A.6    Jacks, T.7
  • 53
    • 0029914238 scopus 로고    scopus 로고
    • Plugging it in: Signaling circuits and the yeast cell cycle
    • Wittenberg, C. and S.I. Reed. 1996. Plugging it in: Signaling circuits and the yeast cell cycle. Curr. Opin. Cell Biol. 8: 223-230.
    • (1996) Curr. Opin. Cell Biol. , vol.8 , pp. 223-230
    • Wittenberg, C.1    Reed, S.I.2
  • 54
    • 0022479617 scopus 로고
    • Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac
    • Wong, P.M., S.W. Chung, D.H. Chui, and C.J. Eaves. 1986. Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac. Proc. Natl. Acad. Sci. 83: 3851-3854.
    • (1986) Proc. Natl. Acad. Sci. , vol.83 , pp. 3851-3854
    • Wong, P.M.1    Chung, S.W.2    Chui, D.H.3    Eaves, C.J.4
  • 55
    • 0028108964 scopus 로고
    • The Ras/ Raf signaling pathway is required for progression of mouse embryos through the two-cell stage
    • Yamauchi, N., A.A. Kiessling, and G.M. Cooper. 1994. The Ras/ Raf signaling pathway is required for progression of mouse embryos through the two-cell stage. Mol. Cell. Biol. 14: 6655-6662.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6655-6662
    • Yamauchi, N.1    Kiessling, A.A.2    Cooper, G.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.