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Volumn 19, Issue 6, 1999, Pages 4279-4288

Role of phosphoinositide 3-kinase in activation of Ras and mitogen- activated protein kinase by epidermal growth factor

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN;

EID: 0033013866     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.6.4279     Document Type: Article
Times cited : (258)

References (52)
  • 5
    • 0027153103 scopus 로고
    • EGF regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein and Sos nucleotide exchange factor
    • Buday, L., and J. Downward. 1993. EGF regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein and Sos nucleotide exchange factor. Cell 73:611-620.
    • (1993) Cell , vol.73 , pp. 611-620
    • Buday, L.1    Downward, J.2
  • 6
    • 0029160069 scopus 로고
    • Protein kinase B (c-akt) in phosphatidylinositol 3-kinase signal transduction
    • Burgering, B. M. T., and P. J. Coffer. 1995. Protein kinase B (c-akt) in phosphatidylinositol 3-kinase signal transduction. Nature 376:599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.T.1    Coffer, P.J.2
  • 8
    • 0031002348 scopus 로고    scopus 로고
    • The role of the PH domain in the signal-dependent membrane targeting of Sos
    • Chen, R. H., S. Corbalan-Garcia, and D. Bar-Sagi. 1997. The role of the PH domain in the signal-dependent membrane targeting of Sos. EMBO J. 16: 1351-1359.
    • (1997) EMBO J. , vol.16 , pp. 1351-1359
    • Chen, R.H.1    Corbalan-Garcia, S.2    Bar-Sagi, D.3
  • 9
    • 0027978816 scopus 로고
    • The inhibition of glycogen synthase kinase 3 by insulin or insulin-like growth-factor-1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: Evidence that wortmannin blocks activation of the mitogen activated protein kinase pathway in L6 cells between Ras and Raf
    • Cross, D. A. E., D. R. Alessi, J. R. Vandenheede, H. E. McDowell, H. S. Hundal, and P. Cohen. 1994. The inhibition of glycogen synthase kinase 3 by insulin or insulin-like growth-factor-1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen activated protein kinase pathway in L6 cells between Ras and Raf. Biochem. J. 303:21-26.
    • (1994) Biochem. J. , vol.303 , pp. 21-26
    • Cross, D.A.E.1    Alessi, D.R.2    Vandenheede, J.R.3    McDowell, H.E.4    Hundal, H.S.5    Cohen, P.6
  • 10
    • 0030044360 scopus 로고    scopus 로고
    • Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
    • Daub, H., F. U. Weiss, C. Wallasch, and A. Ullrich. 1996. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379:557-560.
    • (1996) Nature , vol.379 , pp. 557-560
    • Daub, H.1    Weiss, F.U.2    Wallasch, C.3    Ullrich, A.4
  • 11
    • 0028925954 scopus 로고
    • She associates with an unphosphorylated form of the p21ras guanine nucleotide exchange factor mSOS
    • de Vries-Smits, A. M., G. J. Pronk, J. P. Medema, B. M. Burgering, and J. L. Bos. 1995. She associates with an unphosphorylated form of the p21ras guanine nucleotide exchange factor mSOS. Oncogene 10:919-925.
    • (1995) Oncogene , vol.10 , pp. 919-925
    • De Vries-Smits, A.M.1    Pronk, G.J.2    Medema, J.P.3    Burgering, B.M.4    Bos, J.L.5
  • 14
    • 0030786202 scopus 로고    scopus 로고
    • Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin: Dependence on signal strength
    • Duckworth, B. C., and L. C. Cantley. 1997. Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin: dependence on signal strength. J. Biol. Chem. 272:27665-27670.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27665-27670
    • Duckworth, B.C.1    Cantley, L.C.2
  • 15
    • 0030830220 scopus 로고    scopus 로고
    • Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
    • Frost, J. A., H. Steen, P. Shapiro, T. Lewis, N. Ahn, P. E. Shaw, and M. H. Cobb. 1997. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 16:6426-6438.
    • (1997) EMBO J. , vol.16 , pp. 6426-6438
    • Frost, J.A.1    Steen, H.2    Shapiro, P.3    Lewis, T.4    Ahn, N.5    Shaw, P.E.6    Cobb, M.H.7
  • 16
    • 0029950672 scopus 로고    scopus 로고
    • Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members
    • Frost, J. A., S. Xu, M. R. Hutchison, S. Marcus, and M. H. Cobb. 1996. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol. Cell. Biol. 16:3707-3713.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3707-3713
    • Frost, J.A.1    Xu, S.2    Hutchison, M.R.3    Marcus, S.4    Cobb, M.H.5
  • 17
    • 0024406286 scopus 로고
    • All ras proteins are polyisoprenylated but only some are palmitoylated
    • Hancock, J. F., A. I. Magee, J. E. Childs, and C. J. Marshall. 1989. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57: 1167-1177.
    • (1989) Cell , vol.57 , pp. 1167-1177
    • Hancock, J.F.1    Magee, A.I.2    Childs, J.E.3    Marshall, C.J.4
  • 18
    • 0029943493 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signalling pathway
    • Hawes, B. E., L. M. Luttrell, T. van Biesen, and R. J. Lefkowitz. 1996. Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signalling pathway. J. Biol. Chem. 271: 12133-12136.
    • (1996) J. Biol. Chem. , vol.271 , pp. 12133-12136
    • Hawes, B.E.1    Luttrell, L.M.2    Van Biesen, T.3    Lefkowitz, R.J.4
  • 19
    • 0028918408 scopus 로고
    • Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
    • Hu, Q., A. Klippel, A. J. Muslin, W. J. Fantl, and L T. Williams. 1995. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268:100-102.
    • (1995) Science , vol.268 , pp. 100-102
    • Hu, Q.1    Klippel, A.2    Muslin, A.J.3    Fantl, W.J.4    Williams, L.T.5
  • 20
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • Khwaja, A., P. Rodriguez-Viciana, S. Wennstrom, P. H. Warne, and J. Downward. 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16:2783-2793.
    • (1997) EMBO J. , vol.16 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 21
    • 0029154701 scopus 로고
    • Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways
    • Kinashi, T., J. A. Escobedo, L. T. Williams, K. Takatsu, and T. A. Springer. 1995. Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways. Blood 86: 2086-2090.
    • (1995) Blood , vol.86 , pp. 2086-2090
    • Kinashi, T.1    Escobedo, J.A.2    Williams, L.T.3    Takatsu, K.4    Springer, T.A.5
  • 22
    • 0030839766 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
    • King, W. G., M. D. Mattaliano, T. O. Chan, P. N. Tsichlls, and J. S. Brugge. 1997. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol. Cell. Biol. 17:4406-4418.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4406-4418
    • King, W.G.1    Mattaliano, M.D.2    Chan, T.O.3    Tsichlls, P.N.4    Brugge, J.S.5
  • 23
    • 0029831486 scopus 로고    scopus 로고
    • Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity
    • Klinghoffer, R. A., B. Duckworth, M. Valius, L. Cantley, and A. Kazlauskas. 1996. Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol. Cell. Biol. 16:5905-5914.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5905-5914
    • Klinghoffer, R.A.1    Duckworth, B.2    Valius, M.3    Cantley, L.4    Kazlauskas, A.5
  • 24
    • 0029943605 scopus 로고    scopus 로고
    • Membrane localization of Phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
    • Klippel, A., C. Reinhard, W. M. Kavanaugh, G. Apell, M.-A. Escobedo, and L. T. Williams. 1996. Membrane localization of Phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol. 16:4117-1127.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4117-11127
    • Klippel, A.1    Reinhard, C.2    Kavanaugh, W.M.3    Apell, G.4    Escobedo, M.-A.5    Williams, L.T.6
  • 26
    • 0031037296 scopus 로고    scopus 로고
    • Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
    • Lopez-Ilasaca, M., P. Crespo, P. G. Pellici, J. S. Gutkind, and R. Wetzker. 1997. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science 275:394-397.
    • (1997) Science , vol.275 , pp. 394-397
    • Lopez-Ilasaca, M.1    Crespo, P.2    Pellici, P.G.3    Gutkind, J.S.4    Wetzker, R.5
  • 27
    • 0032478610 scopus 로고    scopus 로고
    • Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C
    • Marais, R., Y. Light, C. Mason, H. Paterson, M. F. Olson, and C. J. Marshall. 1998. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science 280:109-112.
    • (1998) Science , vol.280 , pp. 109-112
    • Marais, R.1    Light, Y.2    Mason, C.3    Paterson, H.4    Olson, M.F.5    Marshall, C.J.6
  • 28
    • 0028152333 scopus 로고
    • MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
    • Marshall, C. J. 1994. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev. 4:82-89.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 82-89
    • Marshall, C.J.1
  • 30
    • 0030884103 scopus 로고    scopus 로고
    • PKB/Akt: Connecting PI 3-kinase to cell survival and beyond
    • Marte, B. M., and J. Downward. 1997. PKB/Akt: connecting PI 3-kinase to cell survival and beyond. Trends Biochem. Sci. 22:355-358.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 355-358
    • Marte, B.M.1    Downward, J.2
  • 32
    • 0027212082 scopus 로고
    • Signal transduction: How receptors turn Ras on
    • McCormick, F. 1993. Signal transduction: how receptors turn Ras on. Nature 363:15-16.
    • (1993) Nature , vol.363 , pp. 15-16
    • McCormick, F.1
  • 33
    • 0032582646 scopus 로고    scopus 로고
    • Activation of the rap1 GTPase by the B cell antigen receptor
    • McLeod, S. J., R. J. Ingham, J. L. Bos, T. Kurosaki, and M. R. Gold. 1998. Activation of the rap1 GTPase by the B cell antigen receptor. J. Biol. Chem. 273:29218-29223.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29218-29223
    • McLeod, S.J.1    Ingham, R.J.2    Bos, J.L.3    Kurosaki, T.4    Gold, M.R.5
  • 36
    • 0028892253 scopus 로고
    • Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins
    • Rameh, L. E., C. S. Chen, and L. C. Cantley. 1995. Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell 83:821-830.
    • (1995) Cell , vol.83 , pp. 821-830
    • Rameh, L.E.1    Chen, C.S.2    Cantley, L.C.3
  • 37
    • 0031037912 scopus 로고    scopus 로고
    • Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen-activated protein kinase pathway
    • Rausch, O., and C. J. Marshall. 1997. Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen-activated protein kinase pathway. Mol. Cell. Biol. 17:1170-1179.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1170-1179
    • Rausch, O.1    Marshall, C.J.2
  • 38
    • 0030766846 scopus 로고    scopus 로고
    • Growth factor activation of MAP kinase requires cell adhesion
    • Renshaw, M. W., X. D. Ren, and M. A. Schwartz. 1997. Growth factor activation of MAP kinase requires cell adhesion. EMBO J. 16:5592-5599.
    • (1997) EMBO J. , vol.16 , pp. 5592-5599
    • Renshaw, M.W.1    Ren, X.D.2    Schwartz, M.A.3
  • 41
  • 42
    • 0039791449 scopus 로고    scopus 로고
    • Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
    • Schonwasser, D. C., R. M. Marais, C. J. Marshall, and P. J. Parker. 1998. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol. 18:790-798.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 790-798
    • Schonwasser, D.C.1    Marais, R.M.2    Marshall, C.J.3    Parker, P.J.4
  • 44
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger, R., and E. G. Krebs. 1995. The MAPK signaling cascade. FASEB J. 9:726-735.
    • (1995) FASEB J. , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 45
    • 0029583193 scopus 로고
    • A role for Phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen
    • Shimizu, Y., J. L. Mobley, L. D. Finkelstein, and A. S. Chan. 1995. A role for Phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen. J. Cell Biol. 131:1867-1880.
    • (1995) J. Cell Biol. , vol.131 , pp. 1867-1880
    • Shimizu, Y.1    Mobley, J.L.2    Finkelstein, L.D.3    Chan, A.S.4
  • 46
    • 0028237504 scopus 로고
    • Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites
    • Soler, C., C. V. Alvarez, L. Beguinot, and G. Carpenter. 1994. Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites. Oncogene 9:2207-2215.
    • (1994) Oncogene , vol.9 , pp. 2207-2215
    • Soler, C.1    Alvarez, C.V.2    Beguinot, L.3    Carpenter, G.4
  • 47
    • 0027366440 scopus 로고
    • Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: A new intracellular signalling system
    • Stephens, L. R., T. R. Jackson, and P. T. Hawkins. 1993. Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system. Biochim. Biophys. Acta 1179:27-75.
    • (1993) Biochim. Biophys. Acta , vol.1179 , pp. 27-75
    • Stephens, L.R.1    Jackson, T.R.2    Hawkins, P.T.3
  • 48
    • 0030747146 scopus 로고    scopus 로고
    • Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors
    • Sugden, P. H., and A. Clerk. 1997. Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors. Cell. Signal. 9:337-351.
    • (1997) Cell. Signal. , vol.9 , pp. 337-351
    • Sugden, P.H.1    Clerk, A.2
  • 49
    • 0030461098 scopus 로고    scopus 로고
    • Cell cycle-dependent activation of Ras
    • Taylor, S. J., and D. Shalloway. 1996. Cell cycle-dependent activation of Ras. Curr. Biol. 6:1621-1627.
    • (1996) Curr. Biol. , vol.6 , pp. 1621-1627
    • Taylor, S.J.1    Shalloway, D.2
  • 51
    • 0031948845 scopus 로고    scopus 로고
    • Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras
    • van Weering, D. H., J. de Rooij, B. Marte, J. Downward, J. L. Bos, and B. M. Burgering. 1998. Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras. Mol. Cell. Biol. 18:1802-1811.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1802-1811
    • Van Weering, D.H.1    De Rooij, J.2    Marte, B.3    Downward, J.4    Bos, J.L.5    Burgering, B.M.6


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