Critical Role of Ras in the Proliferation and Prevention of Apoptosis Mediated by IL-2

Journal of Immunology

Volumn 157, Issue 6, 1996, Pages 2272-2281

  Gómez, Javier ^a,c   Martínez A , Carlos ^a   Fernández, Belén ^b   García, Alphonse ^b   Rebollo, Angelita ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b INSTITUT PASTEUR   (France)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; RAS PROTEIN; TETRACYCLINE;

ANIMAL; APOPTOSIS; ARTICLE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOUSE; MUTATION; PHYSIOLOGY; T LYMPHOCYTE;

ANIMALS; APOPTOSIS; CELL LINE; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MUTATION; RAS PROTEINS; T-LYMPHOCYTES; TETRACYCLINE; TRANSFECTION;

EID: 0030587081     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Taniguchi, T., and Y. Minami. 1993. The IL-2/IL-2 receptor system: a current overview. Cell 73:5.
2. Minami, Y., T. Kono, T. Miyazaki, and T. Taniguchi. 1993. The IL-2 receptor complex: its structure, function, and target genes. Annu. Rev. Immunol. 11:245.
3. Kishimoto, T., T. Taga, and S. Akira. 1994. Cytokine signal transduction. Cell 76:253.
4. Minami, Y., and T. Taniguchi. 1995. IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor. Curr. Opin. Cell Biol. 7:156.
5. Satoh, T., M. Nakafufu, A. Miyajima, and Y. Kaziro. 1991. Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4. Proc. Natl. Acad. Sci. USA 88:3314.
6. ras proteins in normal human T lymphocytes. J. Immunol. 148:2417.
7. ras in murine myeloid cells transfected with human IL-2 receptor β chain. Eur. J. Immunol. 22:817.
8. Satoh, T., Y. Minami, T. Kono, K. Yamada, A. Kawahara, T. Taniguchi, and Y. Kaziro. 1992. Interleukin-2 induced activation of Ras requires two domains of interleukin-2 receptor β subunit, the essential region for growth stimulation and Lck-binding domain. J. Biol. Chem. 267:25423.
9. ras during T-cell activation and growth. Immunol. Today 16:159.
10. Hall, A. 1993. Ras-related proteins. Curr. Opin. Cell Biol. 5:265.
11. Chavrier, P., J.-P. Gorvel, and J. Bertoglio. 1993. An immunologist's look at the Rho and Rab GTP-binding proteins. Immunol. Today 14:440.
12. Ridley, A. J. 1995. Rho-related proteins: actin cytoskeleton and cell cycle. Curr. Opin. Genet. Dev. 5:24.
13. Wassarman, D. A., M. Therrien, and G. M. Rubin. 1995. The Ras signaling pathway in Drosophila. Curr. Opin. Genet. Der. 5:44.
14. Kayne, P. S., and P. W. Sternberg. 1995. Ras pathways in Caenorhabditis elegans. Curr. Opin. Genet. Dev. 5:38.
15. McCormick, F. 1995. Ras signaling and NF1. Curr. Opin. Genet. Dev. 5:51.
16. McCormick, F. 1994. Activators and effectors of ras p21 proteins. Curr. Opin. Genet. Dev. 4:71.
17. Bowtell, D., P. Fu, M. Simon, and P. Senior. 1992. Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc. Natl. Acad. Sci. USA 89:6511.
18. Buday, L., S. E. Egan, P. R. Viciana, D. A. Cantrell, and J. Downward. 1994. A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J. Biol. Chem. 269:9019.
19. Coccetti, P., I. Mauri, L. Alberghina, E. Martegani, and A. Parmeggiani. 1995. The minimal active domain of the mouse ras exchange factor CDC25 Mm. Biochem. Biophys. Res. Commun. 206:253.
20. ras. Eur. J. Immunol. 23:131.
21. shc in T lymphocytes. J. Biol. Chem. 268:17659.
22. Ravichandran, K. S., and S. J. Burakoff. 1994. The adapter protein shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation. J. Biol. Chem. 269: 1599.
23. Zhu, X., K.-L. Suen, M. Barbacid, J. B. Bolen, and J. Fargnoli. 1994. Interleukin-2-induced tyrosine phosphorylation of shc proteins correlates with factor-dependent T cell proliferation. J. Biol. Chem. 269:5518.
24. Marshall, M. S. 1995. Ras target proteins in eukaryotic cells. FASEB J. 9:1311.
25. ras upon T-cell activation. Nature 346:719.
26. ras in human T lymphocytes. J. Immunol. 146:3709.
27. ras regulatory pathways coexist in T cells. Mol. Cell. Biol. 12:3305.
28. Koide, H., T. Satoh, M. Nakafuku, and Y. Kaziro. 1993. GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells. Proc. Natl. Acad. Sci. USA 90:8683.
29. ras in activation of extracellular signal-regulated kinase 2. Nature 357:602.
30. Marshall, C. J. 1994. MAP kinase kinase kinase, MAP kinase kinase, and MAP kinase. Curr. Opin. Genet. Dev. 4:82.
31. ras mediates control of IL-2 gene promoter function in T cell activation. EMBO J. 11:4549.
32. ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells. J. Immunol. 150:3853.
33. Stokoe, D., S. G. Macdonald, K. Cadwallader, M. Symons, and J. F. Hancock. 1994. Activation of Raf as a result of recruitment to the plasma membrane. Science 264:1463.
34. Leevers, S. J., H. F. Paterson, and C. J. Marshall. 1994. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369:411.
35. Ward, Y., S. Gupta, P. Jensen, M. Wartmann, R. J. Davis, and K. Kelly. 1994. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PACI. Nature 367:651.
36. Feig, L. A., and G. M. Cooper. 1988. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8:3235.
37. ras GTPase-activating protein. Proc. Natl. Acad. Sci. USA 89:1587.
38. Pitton, C., A. Rebollo, J. Van Snick, J. Theze, and A. García. 1993. High-affinity and intermediate-affinity forms of the human interleukin 2 receptor, expressed in an interleukin 9-dependent murine T cell line, deliver proliferative signals via differences in their transduction pathways. Cytokine 5:362.
39. Szeberényi, J., H. Cai, and G. M. Cooper. 1990. Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol. Cell. Biol. 10: 5324.
40. Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547.
41. Dolbeare, F., H. Gratzner, M. G. Pallavicini, and J. W. Gray. 1983. Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc. Natl. Acad. Sci. USA 60:5573.
42. Gómez, J., A. de la Hera, A. Silva, C. Pitton, A. García, and A. Rebollo. 1994. Implication of protein kinase C in IL-2 mediated proliferation and apoptosis in a murine T cell clone. Exp. Cell Res. 213:178.
43. ras distinguishes positive and negative selection in thymocytes. EMBO J. 14:276.
44. Rodríguez-Viciana, P., P. H. Warne, R. Dhand, B. Vanhaesebroeck, I. Gout, M. J. Fry, M. D. Waterfield, and J. Downward. 1994. Phosphatidylinositol-3-OH-kinase as a direct target of Ras. Nature 370:527.
45. Mérida, I., E. Díez, and G. N. Gaulton. 1991. IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase. J. Immunol. 147:2202.
46. Díaz-Meco, M. T., J. Lozano, M. M. Municio, E. Berra, S. Frutos, L. Sanz, and J. Moscat. 1994. Evidence for the in vitro and in vivo interaction of Ras with protein kinase C ζ. J. Biol. Chem. 269:31706.
47. Miyazaki, T., Z.-J. Liu, A. Kawahara, Y. Minami, K. Yamada, Y. Tsujimoto, E. L. Barsoumian, R. M. Perlmutter, and T. Taniguchi. 1995. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81:223.
48. Wyllie, A. H. 1995. The genetic regulation of apoptosis. Curr. Opin. Genet. Dev. 5:97.
49. Hatakeyama, M., H. Mori, T. Doi, and T. Taniguchi. 1989. A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization. Cell 59:837.
50. Gulbins, E., R. Bissonnette, A. Mahboubi, S. Martin, W. Nishioka, T. Brunner, G. Baier, G. Baier-Bitterlich, C. Byrd, F. Lang, R. Kolesnick, A. Altman, and D. Green. 1995. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity 2:341.
51. Ferrari, G., and L. A. Greene. 1994. Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death. EMBO J. 13:5922.
52. Shi, Y., J. M. Glynn, L. J. Guilbert, T. G. Cotter, R. P. Bissonnette, and D. R. Green. 1992. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257:212.