Neuronal life and death: An essential role for the p53 family

Cell Death and Differentiation

Volumn 7, Issue 10, 2000, Pages 880-888

  Miller, F D ^a   Pozniak, C D ^a   Walsh, G S ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Cell cycle; DNA damage; Excitotoxicity; Ischaemia; Neurodegeneration; Neuronal apoptosis; Neurotrophins; Oxidative stress; P53; P73

Indexed keywords

PROTEIN P53; PROTEIN P73; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CELL CYCLE; CELL DEATH; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DEGENERATIVE DISEASE; DNA DAMAGE; ENZYME ACTIVATION; ISCHEMIA; MITOSIS; MOUSE; MULTIGENE FAMILY; NERVE CELL NECROSIS; NERVE EXCITABILITY; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INJURY; NONHUMAN; NUTRITION; OXIDATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TUMOR SUPPRESSOR GENE;

EID: 0033781632     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400736     Document Type: Review

References (129)

1. Mechanisms of p53-mediated apoptosis
2. Apoptosis and the cell cycle: The p53 connection
3. p53: Puzzle and paradigm
4. Cell death during development of the nervous system
5. Neuronal life and death decisions: Functional antagonism between the Trk and p75 neurotrophin receptors
6. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors
7. A subset of p53-deficient embryos exhibit exencephaly
8. High-frequency developmental abnormalities in p53-deficient mice
9. Requirement for a functional Rb-1 gene in murine development
10. Effects of an Rb mutation in the mouse
11. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
12. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
13. A critical temporal requirement for the pRb family during neuronal determination
14. Mutation of E2F-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
15. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
16. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
17. Mitochondria and apoptosis
18. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
19. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
20. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
21. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
22. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
23. Epistatic and independent functions of caspase-3 and Bxl-X(L) in developmental programmed cell death
24. p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release
25. Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons
26. p53 expression induces apoptosis in hippocampal pyramidal neuron cultures
27. Evidence for p53-mediated modulation of neuronal viability
28. Signal transduction by the neurotrophin receptors
29. Neurotrophin signal transduction in the nervous system
30. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
31. Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons
32. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally-occurring sympathetic neuron death
33. Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin
34. p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors
35. BAX is required for neuronal death after trophic factor deprivation and during development
36. The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death
37. Role of apoptosis signal-regulating kinase in regulation of the c-Jun n-terminal kinase pathway and apoptosis in sympathetic neurons
38. Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
39. A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death
40. Role of the jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons
41. Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway
42. Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons
43. Cyclin dependent kinase inhibitor and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons
44. The ARF/p53 pathway
45. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
46. p73 is a human p53 related protein that can induce apoptosis
47. Structure, function and regulation of p63 and p73
48. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
49. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumors
50. Evidence for p53-mediated modulation of neuronal viability
51. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death
52. p53 induction is associated with neuronal damage in the central nervous system
53. Nuclear accumulation of p53 protein following kainic acid-induced seizures
54. Status epilepticus induces p53 sequence-specific DNA binding in mature rat brain
55. Induction of tumor suppressor p53 and DNA fragmentation in organotypic hippocampal cultures following excitotoxin treatment
56. Roles of p53, c-myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor
57. Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids
58. Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation
59. Increased expression of cyclin G1 and p21WAF1/CIP1 in neurons following transient forebrain ischemia: Comparison with early DNA damage
60. The tumor suppressor p53 and its response gene p21WAF1/Cip 1 are not markers of neuronal death following transient global cerebral ischemia
61. Hippocampal myc and p53 expression following transient global ischemia
62. Activation of p53 and its target genes p21 (WAF1/Cip1) and PAG608/Wig-1 in ischemic preconditioning
63. Necrosis and apoptosis after retinal ischemia: Involvement of NMDA-mediated excitotoxicity and p53
64. p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats
65. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
66. Granule cell apoptosis and protein expression in hippocampal dentate gyrus after forebrain ischemia in the rat
67. Apoptosis and protein expression after focal cerebral ischemia in rats
68. Increase in p53 protein expression following cortical infarction in the spontaneously hypertensive rat
69. Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemia
70. Hypoxia-induced apoptosis: Effect of hypoxic severity and role of p53 in neuronal cell death
71. The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury
72. Apoptosis and expression of p53 response proteins and cyclin D1 after cortical impact in rat brain
73. Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72
74. Tumor suppressor p53 induction and DNA damage in hippocampal granule cells after adrenalectomy
75. p53-deficient mice are protected against adrenalectomy-induced apoptosis
76. The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53
77. The role of free radicals and p53 in neuron apoptosis in vivo
78. Involvement of p53 in DNA strandbreak-induced apoptosis in postmitotic CNS neurons
79. Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons
80. Cerebellar degeneration caused by high-dose cytosine arabinoside: A clinicopathological study
81. Cytosine arabinoside kills postmitotic neurons in a fashion resembling trophic factor deprivation: Evidence that a deoxycytidine-dependent process may be required for nerve growth factor signal transduction
82. Cytosine arabinoside kills postmitotic neurons: Evidence that deoxycytidine may have a role in neuronal survival that is independent of DNA synthesis
83. Apoptosis is induced in post-mitotic rat sympathetic neurons by arabinosides and topoisomerase II inhibitors in the presence of NGF
84. Chemotherapeutic neuropathy
85. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: Evidence for cell cycle-independent toxicity
86. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
87. Involvement of retinoblastoma family members and E2F/EP complexes in the death of neurons evoked by DNA damage
88. G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis
89. Cyclin dependent kinases participate in death of neurons evoked by DNA damaging agents
90. A new component of the transcription factor DRTF1/E2F
91. DTRF1/E2F: An extended family of heterodimeric factors implicated in cell cycle controls
92. Bax involvement in p53-mediated neuronal cell death
93. Evidence for involvement of BAX and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons
94. Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons
95. Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation
96. Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
97. Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
98. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
99. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
100. Enhanced phosphorylation of p53 by ATM in response to DNA damage
101. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system
102. DNA damage-induced activation of p53 by the checkpoint kinase Chk2 (2000)
103. Piecing together the p53 puzzle
104. A role for MAPK/ERK in sympathetic neuron survival: Protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside
105. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
106. DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures
107. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
108. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
109. Oxidative stress induced by glutamate receptor agonists
110. Nitric oxide, superoxide and peroxynitrite: Putative mediators of NMDA-induced cell death in cerebellar granule cell
111. Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere
112. Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons
113. Epidermal growth factor prevents oxygen-triggered apoptosis and induces sustained signalling in cultured rat cerebral cortical neurons
114. Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells
115. Role of reactive oxygen species and p53 in chromium (VI)-induced apoptosis
116. Changes of p53 in the brains of patients with Alzheimer's disease
117. Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease
118. p53- And CD95-associated apoptosis in neurodegenerative diseases
119. Mitochondria, free radicals, and neurodegeneration
120. Glutamate, excitotoxicity and amyotrophic lateral sclerosis
121. Bioenergetics in Huntington's disease
122. Oxidative stress hypothesis in Alzheimer's disease
123. Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase
124. Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice
125. Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis
126. Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice
127. The amyloid beta peptide abeta (25-35) induces apoptosis independent of p53
128. E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3 (2000)
129. Induction of neuronal differentiation by p73 in a neuroblastoma cell line